@article{612c6c4feb804032ad45fd0c39ea096b,
title = "Activity of meropenem-vaborbactam against carbapenem- resistant enterobacteriaceae in a murine model of pyelonephritis",
abstract = "The recently approved combination of meropenem and vaborbactam (Vabomere) is highly active against Gram-negative pathogens, especially Klebsiella pneumoniae carbapenemase (KPC)-producing, carbapenem-resistant Enterobacteriaceae. We evaluated the efficacy of meropenem-vaborbactam against three clinically relevant isolates in a murine pyelonephritis model. The data indicate that the combination of meropenem and vaborbactam significantly increased bacterial killing compared to that with the untreated controls. These data suggest that this combination may have utility in the treatment of complicated urinary tract infections due to KPCproducing, carbapenem-resistant Enterobacteriaceae.",
keywords = "KPC, Klebsiella pneumoniae carbapenemase, Meropenem, Pyelonephritis, Vaborbactam",
author = "Weiss, {William J.} and Pulse, {Mark E.} and Phung Nguyen and Kelly Peterson and Jessica Silva and Simecka, {Jerry W.} and David Valtierra and Mojgan Sabet and Griffith, {David C.}",
note = "Funding Information: Writing and editorial assistance was provided by Quentin O{\textquoteright}Brien of Health and Wellness Partners, Upper Saddle River, NJ, funded by The Medicines Company. Funding Information: The studies and the efforts of W. J. Weiss, M. E. Pulse, P. Nguyen, K. Peterson, J. Silva, J. W. Simecka, and D. Valtierra were funded by The Medicines Company. The efforts of M. Sabet and D. C. Griffith were funded in part by the Department of Health and Human Services, the Office of the Assistant Secretary for Preparedness and Response, and the Biomedical Advanced Research and Development Authority (BARDA), under contract HHSO100201400002C. Publisher Copyright: Copyright {\textcopyright} 2017 American Society for Microbiology. All Rights Reserved.",
year = "2018",
month = jan,
doi = "10.1128/AAC.01439-17",
language = "English",
volume = "62",
journal = "Antimicrobial Agents and Chemotherapy",
issn = "0066-4804",
publisher = "American Society for Microbiology",
number = "1",
}