Activity of meropenem-vaborbactam against carbapenem- resistant enterobacteriaceae in a murine model of pyelonephritis

William J. Weiss; Mark E. Pulse; Phung Nguyen; Kelly Peterson; Jessica Silva; Jerry W. Simecka; David Valtierra; Mojgan Sabet; David C. Griffith

doi:10.1128/AAC.01439-17

Activity of meropenem-vaborbactam against carbapenem- resistant enterobacteriaceae in a murine model of pyelonephritis

William J. Weiss, Mark E. Pulse, Phung Nguyen, Kelly Peterson, Jessica Silva, Jerry W. Simecka, David Valtierra, Mojgan Sabet, David C. Griffith

Pharmaceutical Sciences

Research output: Contribution to journal › Article

7 Scopus citations

Abstract

The recently approved combination of meropenem and vaborbactam (Vabomere) is highly active against Gram-negative pathogens, especially Klebsiella pneumoniae carbapenemase (KPC)-producing, carbapenem-resistant Enterobacteriaceae. We evaluated the efficacy of meropenem-vaborbactam against three clinically relevant isolates in a murine pyelonephritis model. The data indicate that the combination of meropenem and vaborbactam significantly increased bacterial killing compared to that with the untreated controls. These data suggest that this combination may have utility in the treatment of complicated urinary tract infections due to KPCproducing, carbapenem-resistant Enterobacteriaceae.

Original language	English
Article number	e01439
Journal	Antimicrobial agents and chemotherapy
Volume	62
Issue number	1
DOIs	https://doi.org/10.1128/AAC.01439-17
State	Published - Jan 2018

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Keywords

KPC
Klebsiella pneumoniae carbapenemase
Meropenem
Pyelonephritis
Vaborbactam

Cite this

Weiss, W. J., Pulse, M. E., Nguyen, P., Peterson, K., Silva, J., Simecka, J. W., Valtierra, D., Sabet, M., & Griffith, D. C. (2018). Activity of meropenem-vaborbactam against carbapenem- resistant enterobacteriaceae in a murine model of pyelonephritis. Antimicrobial agents and chemotherapy, 62(1), [e01439]. https://doi.org/10.1128/AAC.01439-17

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abstract = "The recently approved combination of meropenem and vaborbactam (Vabomere) is highly active against Gram-negative pathogens, especially Klebsiella pneumoniae carbapenemase (KPC)-producing, carbapenem-resistant Enterobacteriaceae. We evaluated the efficacy of meropenem-vaborbactam against three clinically relevant isolates in a murine pyelonephritis model. The data indicate that the combination of meropenem and vaborbactam significantly increased bacterial killing compared to that with the untreated controls. These data suggest that this combination may have utility in the treatment of complicated urinary tract infections due to KPCproducing, carbapenem-resistant Enterobacteriaceae.",

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Activity of meropenem-vaborbactam against carbapenem- resistant enterobacteriaceae in a murine model of pyelonephritis. / Weiss, William J.; Pulse, Mark E.; Nguyen, Phung; Peterson, Kelly; Silva, Jessica; Simecka, Jerry W.; Valtierra, David; Sabet, Mojgan; Griffith, David C.

In: Antimicrobial agents and chemotherapy, Vol. 62, No. 1, e01439, 01.2018.

Research output: Contribution to journal › Article

TY - JOUR

T1 - Activity of meropenem-vaborbactam against carbapenem- resistant enterobacteriaceae in a murine model of pyelonephritis

AU - Weiss, William J.

AU - Pulse, Mark E.

AU - Nguyen, Phung

AU - Peterson, Kelly

AU - Silva, Jessica

AU - Simecka, Jerry W.

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AU - Griffith, David C.

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AB - The recently approved combination of meropenem and vaborbactam (Vabomere) is highly active against Gram-negative pathogens, especially Klebsiella pneumoniae carbapenemase (KPC)-producing, carbapenem-resistant Enterobacteriaceae. We evaluated the efficacy of meropenem-vaborbactam against three clinically relevant isolates in a murine pyelonephritis model. The data indicate that the combination of meropenem and vaborbactam significantly increased bacterial killing compared to that with the untreated controls. These data suggest that this combination may have utility in the treatment of complicated urinary tract infections due to KPCproducing, carbapenem-resistant Enterobacteriaceae.

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KW - Klebsiella pneumoniae carbapenemase

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10.1128/AAC.01439-17

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