The metabolism of 14C-arachidonic acid (AA) to aortic 6-keto-PGF(1α) or platelet TXB2 was evaluated in female rats chronically exposed to cigarette smoke for 8 or 12 weeks. Because of recent interests concerning the health consequences of passive smoking, 14C-AA metabolism was also measured following 12 weeks of sidestream smoke exposure. Carboxyhemoglobin levels in the mainstream and sidestream smoke exposed groups were increased 7 and 10 fold compared to shams, respectively. Aortic 6-keto-PGF(1α) generation was diminished 26% and 30% (p <0.05) compared to shams as a result of chronic smoke exposure for 8 and 12 weeks, respectively. Whole smoke exposure also increased platelet TXB2 synthesis 28% and 49% above shams, following 8 and 12 weeks, respectively. Aortic 6-keto-PGF(1α) levels from sidestream smoke exposed rats were 65% of shams (p <0.05). Platelet TXB2 synthesis was increased relative to shams by sidestream smoke but was not statistically significant. Mainstream cigarette smoking as well as chronic sidestream smoke exposure were shown to alter PGI2-TXA2 generation in female rats.
|Number of pages||8|
|Journal||Research Communications in Substances of Abuse|
|State||Published - 1 Dec 1984|