@article{e54c02f243f54c908655d409883dc065,
title = "Activation of peripheral group III metabotropic glutamate receptors suppressed formalin-induced nociception",
abstract = "Intraplantar injection of formalin produces persistent spontaneous nociception and hyperalgesia. The underlying mechanism, however, remains unclear. The present study was, therefore, designed to determine the roles of peripheral group III metabotropic glutamate receptors (mGluRs) in formalin-evoked spontaneous nociception. Pre-treatment with intraplantar injections of L-serine-O-phosphate (L-SOP), a group III mGluRs agonist, significantly inhibited formalin-induced nociceptive behaviours and decreased Fos production in the spinal dorsal horn. The inhibitory effects of L-SOP were abolished completely by pre-treatment with the group III mGluR antagonist (RS)-a-methylserine-O-phosphate (M-SOP). These data suggest that the activation of group III mGluRs in the periphery may play a differential role in formalin-induced nociception. In addition, L-SOP decreased the formalin-induced upregulation of tumour necrosis factor-α (TNF-α) as well as interleukine-1β (IL-1β) expression in the spinal cord, suggesting that activation of peripheral group III mGluRs reduces formalin-induced nociception through inhibition of the pro-inflammatory cytokines in the spinal cord. Therefore, the agonists acting peripheral group III mGluRs possess therapeutic effectiveness in chronic pain.",
author = "Li, {Yan Li} and Chang, {Xin Rui} and Ma, {Jin Teng} and Xin Zhao and Yin, {Li Tian} and Yan, {Liang Jun} and Guo, {Jun Hong} and Ce Zhang and Yang, {Xiao Rong}",
note = "Funding Information: National Natural Science Foundation of China, Grant/Award Number: 31000481; Research Project Supported by Shanxi Scholarship Council of China, Grant/Award Number: HGKY2019054; Natural Science Foundation of Shanxi Province, China, Grant/Award Numbers: 201801D121316, 2011011040‐2; Open Fund from Key Laboratory of Cellular Physiology (Shanxi Medical University), Ministry of Education, China (No. KLMEC/SXMU‐202010); Shanxi {\textquoteleft}1331 Project{\textquoteright} Key Subjects Construction, Grant/Award Number: 1331KSC Funding Information: This work was supported by the National Natural Science Foundation of China (grant number 31000481); Research Project Supported by Shanxi Scholarship Council of China (HGKY2019054); the Natural Science Foundation of Shanxi Province, China (grant numbers 201801D121316, 2011011040‐2) ; Open Fund from Key Laboratory of Cellular Physiology (Shanxi Medical University), Ministry of Education, China (No. KLMEC/SXMU‐202010) and Shanxi {\textquoteleft}1331 Project{\textquoteright} Key Subjects Construction (1331KSC). Publisher Copyright: {\textcopyright} 2021 John Wiley & Sons Australia, Ltd",
year = "2022",
month = feb,
doi = "10.1111/1440-1681.13602",
language = "English",
volume = "49",
pages = "319--326",
journal = "Clinical and Experimental Pharmacology and Physiology",
issn = "0305-1870",
publisher = "Wiley-Blackwell Publishing Ltd",
number = "2",
}