Activation of mTOR: A culprit of Alzheimer’s disease?

Zhiyou Cai, Guanghui Chen, Wenbo He, Ming Xiao, Liang Jun Yan

Research output: Contribution to journalArticle

54 Scopus citations

Abstract

Alzheimer’s disease (AD) is characterized by cognitive impairment in clinical presentation, and by β-amyloid (Aβ) production and the hyper-phosphorylation of tau in basic research. More highlights demonstrate that the activation of the mammalian target of rapamycin (mTOR) enhances Aβ generation and deposition by modulating amyloid precursor protein (APP) metabolism and upregulating β- and γ-secretases. mTOR, an inhibitor of autophagy, decreases Aβ clearance by scissoring autophagy function. mTOR regulates Aβ generation or Aβ clearance by regulating several key signaling pathways, including phosphoinositide 3-kinase (PI3-K)/protein kinase B (Akt), glycogen synthase kinase 3 [GSK-3], AMP-activated protein kinase (AMPK), and insulin/insulin-like growth factor 1 (IGF-1). The activation of mTOR is also a contributor to aberrant hyperphosphorylated tau. Rapamycin, the inhibitor of mTOR, may mitigate cognitive impairment and inhibit the pathologies associated with amyloid plaques and neurofibrillary tangles by promoting autophagy. Furthermore, the upstream and downstream components of mTOR signaling are involved in the pathogenesis and progression of AD. Hence, inhibiting the activation of mTOR may be an important therapeutic target for AD.

Original languageEnglish
Pages (from-to)1015-1030
Number of pages16
JournalNeuropsychiatric Disease and Treatment
Volume11
DOIs
StatePublished - 9 Apr 2015

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Keywords

  • Alzheimer’s disease
  • Mammalian target of rapamycin
  • Neurofibrillary tangles
  • Rapamycin
  • Signaling
  • β-amyloid

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