Acceleration of tissue plasminogen activator-mediated thrombolysis by magnetically powered nanomotors

Rui Cheng; Weijie Huang; Lijie Huang; Bo Yang; Leidong Mao; Kunlin Jin; Qichuan Zhuge; Yiping Zhao

doi:10.1021/nn5029955

Acceleration of tissue plasminogen activator-mediated thrombolysis by magnetically powered nanomotors

Rui Cheng, Weijie Huang, Lijie Huang, Bo Yang, Leidong Mao, Kunlin Jin, Qichuan Zhuge, Yiping Zhao

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135 Scopus citations

Abstract

Dose control and effectiveness promotion of tissue plasminogen activator (t-PA) for thrombolysis are vitally important to alleviate serious side effects such as hemorrhage in stroke treatments. In order to increase the effectiveness and reduce the risk of stroke treatment, we use rotating magnetic nanomotors to enhance the mass transport of t-PA molecules at the blood clot interface for local ischemic stroke therapy. The in vitro experiments demonstrate that, when combined with magnetically activated nanomotors, the thrombolysis speed of low-concentration t-PA (50 μg mL^-1) can be enhanced up to 2-fold, to the maximum lysis speed at high t-PA concentration. Based on the convection enhanced transport theory due to rotating magnetic nanomotors, a theoretical model is proposed and predicts the experimental results reasonably well. The validity and efficiency of this enhanced treatment has been demonstrated in a rat embolic model.

Original language	English
Pages (from-to)	7746-7754
Number of pages	9
Journal	ACS Nano
Volume	8
Issue number	8
DOIs	https://doi.org/10.1021/nn5029955
State	Published - 26 Aug 2014

Keywords

acceleration of thrombolysis
enhanced mass transport
magnetic nanorods
nanomotor
stroke

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10.1021/nn5029955

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title = "Acceleration of tissue plasminogen activator-mediated thrombolysis by magnetically powered nanomotors",

abstract = "Dose control and effectiveness promotion of tissue plasminogen activator (t-PA) for thrombolysis are vitally important to alleviate serious side effects such as hemorrhage in stroke treatments. In order to increase the effectiveness and reduce the risk of stroke treatment, we use rotating magnetic nanomotors to enhance the mass transport of t-PA molecules at the blood clot interface for local ischemic stroke therapy. The in vitro experiments demonstrate that, when combined with magnetically activated nanomotors, the thrombolysis speed of low-concentration t-PA (50 μg mL-1) can be enhanced up to 2-fold, to the maximum lysis speed at high t-PA concentration. Based on the convection enhanced transport theory due to rotating magnetic nanomotors, a theoretical model is proposed and predicts the experimental results reasonably well. The validity and efficiency of this enhanced treatment has been demonstrated in a rat embolic model.",

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author = "Rui Cheng and Weijie Huang and Lijie Huang and Bo Yang and Leidong Mao and Kunlin Jin and Qichuan Zhuge and Yiping Zhao",

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T1 - Acceleration of tissue plasminogen activator-mediated thrombolysis by magnetically powered nanomotors

AU - Cheng, Rui

AU - Huang, Weijie

AU - Huang, Lijie

AU - Yang, Bo

AU - Mao, Leidong

AU - Jin, Kunlin

AU - Zhuge, Qichuan

AU - Zhao, Yiping

PY - 2014/8/26

Y1 - 2014/8/26

N2 - Dose control and effectiveness promotion of tissue plasminogen activator (t-PA) for thrombolysis are vitally important to alleviate serious side effects such as hemorrhage in stroke treatments. In order to increase the effectiveness and reduce the risk of stroke treatment, we use rotating magnetic nanomotors to enhance the mass transport of t-PA molecules at the blood clot interface for local ischemic stroke therapy. The in vitro experiments demonstrate that, when combined with magnetically activated nanomotors, the thrombolysis speed of low-concentration t-PA (50 μg mL-1) can be enhanced up to 2-fold, to the maximum lysis speed at high t-PA concentration. Based on the convection enhanced transport theory due to rotating magnetic nanomotors, a theoretical model is proposed and predicts the experimental results reasonably well. The validity and efficiency of this enhanced treatment has been demonstrated in a rat embolic model.

AB - Dose control and effectiveness promotion of tissue plasminogen activator (t-PA) for thrombolysis are vitally important to alleviate serious side effects such as hemorrhage in stroke treatments. In order to increase the effectiveness and reduce the risk of stroke treatment, we use rotating magnetic nanomotors to enhance the mass transport of t-PA molecules at the blood clot interface for local ischemic stroke therapy. The in vitro experiments demonstrate that, when combined with magnetically activated nanomotors, the thrombolysis speed of low-concentration t-PA (50 μg mL-1) can be enhanced up to 2-fold, to the maximum lysis speed at high t-PA concentration. Based on the convection enhanced transport theory due to rotating magnetic nanomotors, a theoretical model is proposed and predicts the experimental results reasonably well. The validity and efficiency of this enhanced treatment has been demonstrated in a rat embolic model.

KW - acceleration of thrombolysis

KW - enhanced mass transport

KW - magnetic nanorods

KW - nanomotor

KW - stroke

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Acceleration of tissue plasminogen activator-mediated thrombolysis by magnetically powered nanomotors

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Keywords

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