A Transforming Growth Factor β Receptor Type II Gene Mutation Common in Colon and Gastric but Rare in Endometrial Cancers with Microsatellite Instability

Lois L. Myeroff, Ramon Parsons, Seong Jin Kim, Lora Hedrick, Kathleen R. Cho, Kim Orth, Michael Mathis, Kenneth W. Kinzler, James Lutterbaugh, Keunchil Park, Yung Jue Bang, Hwa Young Lee, Jae Gahb Park, Henry T. Lynch, Anita B. Roberts, Bert Vogelstein, Sanford D. Markowitz

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Abstract

We have recently demonstrated that mutation of the transforming growth factor-β (TGF-β) receptor type II (RH) gene is characteristic of colon cancers exhibiting microsatellite instability or replication errors (RER+). Moreover, we have shown that RH mutations in these RER+ colon cancers are characteristically frameshift mutations within a 10-bp polyadenine repeat present in the RII-coding region. We now show that RH gene mutations in this polyadenine repeat are also commonly present in RER+ gastric cancers (71%). In contrast, we find these same RH gene mutations are distinctly uncommon in RER+ endometrial cancers (17%, P < 0.02). These results suggest that RH gene mutations confer a growth advantage and are selected for in RER+ cancers of both the upper and lower gastrointestinal tract. The genesis of RER+ endometrial tumors must, however, be by a different route.

Original languageEnglish
Pages (from-to)5545-5547
Number of pages3
JournalCancer Research
Volume55
Issue number23
StatePublished - 1 Dec 1995

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    Myeroff, L. L., Parsons, R., Kim, S. J., Hedrick, L., Cho, K. R., Orth, K., Mathis, M., Kinzler, K. W., Lutterbaugh, J., Park, K., Bang, Y. J., Lee, H. Y., Park, J. G., Lynch, H. T., Roberts, A. B., Vogelstein, B., & Markowitz, S. D. (1995). A Transforming Growth Factor β Receptor Type II Gene Mutation Common in Colon and Gastric but Rare in Endometrial Cancers with Microsatellite Instability. Cancer Research, 55(23), 5545-5547.