Abstract
We have recently demonstrated that mutation of the transforming growth factor-β (TGF-β) receptor type II (RH) gene is characteristic of colon cancers exhibiting microsatellite instability or replication errors (RER+). Moreover, we have shown that RH mutations in these RER+ colon cancers are characteristically frameshift mutations within a 10-bp polyadenine repeat present in the RII-coding region. We now show that RH gene mutations in this polyadenine repeat are also commonly present in RER+ gastric cancers (71%). In contrast, we find these same RH gene mutations are distinctly uncommon in RER+ endometrial cancers (17%, P < 0.02). These results suggest that RH gene mutations confer a growth advantage and are selected for in RER+ cancers of both the upper and lower gastrointestinal tract. The genesis of RER+ endometrial tumors must, however, be by a different route.
Original language | English |
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Pages (from-to) | 5545-5547 |
Number of pages | 3 |
Journal | Cancer Research |
Volume | 55 |
Issue number | 23 |
State | Published - 1 Dec 1995 |