A role for B cells in facilitating defense against an NK cell-sensitive lung metastatic tumor is revealed by stress

Harlan Jones, Beau Aldridge, Katherine Boss-Williams, Jay M. Weiss

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Stressors impair immune defenses and pose risks among cancer patients. Natural Killer cells are not the sole immune defense against tumor development. Utilizing an NK-sensitive tumor model, this study evaluated immune effects to stress and determined whether lung metastasis resulted from B cells' inability to augment tumorlytic function. Lung metastasis directly correlated with delayed lung B cell accumulation compared to NK, and T cells. Decreased interleukin-12 cytokine and CD80+ molecule expression by B cells correlated with decreased tumor lysis and increased tumor development. Thus, tumor defenses in the lung given stress exposure can depend on the B cell function.

Original languageEnglish
Pages (from-to)99-108
Number of pages10
JournalJournal of Neuroimmunology
Volume313
DOIs
StatePublished - 15 Dec 2017

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Natural Killer Cells
B-Lymphocytes
Lung
Neoplasms
Neoplasm Metastasis
Interleukin-12
Cytokines
T-Lymphocytes

Keywords

  • Immunity
  • Lung
  • Metastasis
  • Stress

Cite this

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title = "A role for B cells in facilitating defense against an NK cell-sensitive lung metastatic tumor is revealed by stress",
abstract = "Stressors impair immune defenses and pose risks among cancer patients. Natural Killer cells are not the sole immune defense against tumor development. Utilizing an NK-sensitive tumor model, this study evaluated immune effects to stress and determined whether lung metastasis resulted from B cells' inability to augment tumorlytic function. Lung metastasis directly correlated with delayed lung B cell accumulation compared to NK, and T cells. Decreased interleukin-12 cytokine and CD80+ molecule expression by B cells correlated with decreased tumor lysis and increased tumor development. Thus, tumor defenses in the lung given stress exposure can depend on the B cell function.",
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A role for B cells in facilitating defense against an NK cell-sensitive lung metastatic tumor is revealed by stress. / Jones, Harlan; Aldridge, Beau; Boss-Williams, Katherine; Weiss, Jay M.

In: Journal of Neuroimmunology, Vol. 313, 15.12.2017, p. 99-108.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - A role for B cells in facilitating defense against an NK cell-sensitive lung metastatic tumor is revealed by stress

AU - Jones, Harlan

AU - Aldridge, Beau

AU - Boss-Williams, Katherine

AU - Weiss, Jay M.

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AB - Stressors impair immune defenses and pose risks among cancer patients. Natural Killer cells are not the sole immune defense against tumor development. Utilizing an NK-sensitive tumor model, this study evaluated immune effects to stress and determined whether lung metastasis resulted from B cells' inability to augment tumorlytic function. Lung metastasis directly correlated with delayed lung B cell accumulation compared to NK, and T cells. Decreased interleukin-12 cytokine and CD80+ molecule expression by B cells correlated with decreased tumor lysis and increased tumor development. Thus, tumor defenses in the lung given stress exposure can depend on the B cell function.

KW - Immunity

KW - Lung

KW - Metastasis

KW - Stress

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