A role for B cells in facilitating defense against an NK cell-sensitive lung metastatic tumor is revealed by stress

Harlan P. Jones, Beau Aldridge, Katherine Boss-Williams, Jay M. Weiss

Research output: Contribution to journalArticle

Abstract

Stressors impair immune defenses and pose risks among cancer patients. Natural Killer cells are not the sole immune defense against tumor development. Utilizing an NK-sensitive tumor model, this study evaluated immune effects to stress and determined whether lung metastasis resulted from B cells' inability to augment tumorlytic function. Lung metastasis directly correlated with delayed lung B cell accumulation compared to NK, and T cells. Decreased interleukin-12 cytokine and CD80+ molecule expression by B cells correlated with decreased tumor lysis and increased tumor development. Thus, tumor defenses in the lung given stress exposure can depend on the B cell function.

Original languageEnglish
Pages (from-to)99-108
Number of pages10
JournalJournal of Neuroimmunology
Volume313
DOIs
StatePublished - 15 Dec 2017

Keywords

  • Immunity
  • Lung
  • Metastasis
  • Stress

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