Abstract
Stressors impair immune defenses and pose risks among cancer patients. Natural Killer cells are not the sole immune defense against tumor development. Utilizing an NK-sensitive tumor model, this study evaluated immune effects to stress and determined whether lung metastasis resulted from B cells' inability to augment tumorlytic function. Lung metastasis directly correlated with delayed lung B cell accumulation compared to NK, and T cells. Decreased interleukin-12 cytokine and CD80+ molecule expression by B cells correlated with decreased tumor lysis and increased tumor development. Thus, tumor defenses in the lung given stress exposure can depend on the B cell function.
Original language | English |
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Pages (from-to) | 99-108 |
Number of pages | 10 |
Journal | Journal of Neuroimmunology |
Volume | 313 |
DOIs | |
State | Published - 15 Dec 2017 |
Keywords
- Immunity
- Lung
- Metastasis
- Stress