A review of cellularization strategies for tissue engineering of whole organs

Michelle E. Scarritt, Nicholas C. Pashos, Bruce A. Bunnell

Research output: Contribution to journalReview article

86 Scopus citations

Abstract

With the advent of whole organ decellularization, extracellular matrix scaffolds suitable for organ engineering were generated from numerous tissues, including the heart, lung, liver, kidney, and pancreas, for use as alternatives to traditional organ transplantation. Biomedical researchers now face the challenge of adequately and efficiently recellularizing these organ scaffolds. Herein, an overview of whole organ decellularization and a thorough review of the current literature for whole organ recellularization are presented. The cell types, delivery methods, and bioreactors employed for recellularization are discussed along with commercial and clinical considerations, such as immunogenicity, biocompatibility, and Food and Drug Administartion regulation.

Original languageEnglish
Article number43
JournalFrontiers in Bioengineering and Biotechnology
Volume3
Issue numberMAR
DOIs
StatePublished - 2015

Keywords

  • Cellularization
  • Decellularization
  • Matrices
  • Native scaffolds
  • Recellularization
  • Tissue engineering
  • Whole organs

Fingerprint Dive into the research topics of 'A review of cellularization strategies for tissue engineering of whole organs'. Together they form a unique fingerprint.

  • Cite this