A proteomic signature for dementia with Lewy bodies

Sid E. O'Bryant, Tanis J. Ferman, Fan Zhang, James Hall, Otto Pedraza, Zbigniew K. Wszolek, Tori Como, David Julovich, Sravan Mattevada, Leigh A. Johnson, Melissa Edwards, Neill R. Graff-Radford

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Abstract

Introduction: We sought to determine if a proteomic profile approach developed to detect Alzheimer's disease would distinguish patients with Lewy body disease from normal controls, and if it would distinguish dementia with Lewy bodies (DLB) from Parkinson's disease (PD). Methods: Stored plasma samples were obtained from 145 patients (DLB n = 57, PD without dementia n = 32, normal controls n = 56) enrolled from patients seen in the Behavioral Neurology or Movement Disorders clinics at the Mayo Clinic, Florida. Proteomic assays were conducted and analyzed as per our previously published protocols. Results: In the first step, the proteomic profile distinguished the DLB-PD group from controls with a diagnostic accuracy of 0.97, sensitivity of 0.91, and specificity of 0.86. In the second step, the proteomic profile distinguished the DLB from PD groups with a diagnostic accuracy of 0.92, sensitivity of 0.94, and specificity of 0.88. Discussion: These data provide evidence of the potential utility of a multitiered blood-based proteomic screening method for detecting DLB and distinguishing DLB from PD.

Original languageEnglish
Pages (from-to)270-276
Number of pages7
JournalAlzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Volume11
DOIs
StatePublished - Dec 2019

Keywords

  • Biomarker screening
  • Blood biomarkers
  • Dementia with Lewy bodies
  • Detection
  • Diagnostic accuracy
  • Parkinson's disease
  • Proteomics

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    O'Bryant, S. E., Ferman, T. J., Zhang, F., Hall, J., Pedraza, O., Wszolek, Z. K., Como, T., Julovich, D., Mattevada, S., Johnson, L. A., Edwards, M., & Graff-Radford, N. R. (2019). A proteomic signature for dementia with Lewy bodies. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 11, 270-276. https://doi.org/10.1016/j.dadm.2019.01.006