A proteomic signature for dementia with Lewy bodies

Sidney O'Bryant, Tanis J. Ferman, Fan Zhang, James Hall, Otto Pedraza, Zbigniew K. Wszolek, Tori Como, David Julovich, Sravan Mattevada, Leigh A. Johnson, Melissa Edwards, Neill R. Graff-Radford

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Introduction: We sought to determine if a proteomic profile approach developed to detect Alzheimer's disease would distinguish patients with Lewy body disease from normal controls, and if it would distinguish dementia with Lewy bodies (DLB) from Parkinson's disease (PD). Methods: Stored plasma samples were obtained from 145 patients (DLB n = 57, PD without dementia n = 32, normal controls n = 56) enrolled from patients seen in the Behavioral Neurology or Movement Disorders clinics at the Mayo Clinic, Florida. Proteomic assays were conducted and analyzed as per our previously published protocols. Results: In the first step, the proteomic profile distinguished the DLB-PD group from controls with a diagnostic accuracy of 0.97, sensitivity of 0.91, and specificity of 0.86. In the second step, the proteomic profile distinguished the DLB from PD groups with a diagnostic accuracy of 0.92, sensitivity of 0.94, and specificity of 0.88. Discussion: These data provide evidence of the potential utility of a multitiered blood-based proteomic screening method for detecting DLB and distinguishing DLB from PD.

Original languageEnglish
Pages (from-to)270-276
Number of pages7
JournalAlzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Volume11
DOIs
StatePublished - 1 Dec 2019

Fingerprint

Lewy Body Disease
Proteomics
Parkinson Disease
Dementia
Sensitivity and Specificity
Movement Disorders
Neurology
Alzheimer Disease
Control Groups

Keywords

  • Biomarker screening
  • Blood biomarkers
  • Dementia with Lewy bodies
  • Detection
  • Diagnostic accuracy
  • Parkinson's disease
  • Proteomics

Cite this

O'Bryant, Sidney ; Ferman, Tanis J. ; Zhang, Fan ; Hall, James ; Pedraza, Otto ; Wszolek, Zbigniew K. ; Como, Tori ; Julovich, David ; Mattevada, Sravan ; Johnson, Leigh A. ; Edwards, Melissa ; Graff-Radford, Neill R. / A proteomic signature for dementia with Lewy bodies. In: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 2019 ; Vol. 11. pp. 270-276.
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abstract = "Introduction: We sought to determine if a proteomic profile approach developed to detect Alzheimer's disease would distinguish patients with Lewy body disease from normal controls, and if it would distinguish dementia with Lewy bodies (DLB) from Parkinson's disease (PD). Methods: Stored plasma samples were obtained from 145 patients (DLB n = 57, PD without dementia n = 32, normal controls n = 56) enrolled from patients seen in the Behavioral Neurology or Movement Disorders clinics at the Mayo Clinic, Florida. Proteomic assays were conducted and analyzed as per our previously published protocols. Results: In the first step, the proteomic profile distinguished the DLB-PD group from controls with a diagnostic accuracy of 0.97, sensitivity of 0.91, and specificity of 0.86. In the second step, the proteomic profile distinguished the DLB from PD groups with a diagnostic accuracy of 0.92, sensitivity of 0.94, and specificity of 0.88. Discussion: These data provide evidence of the potential utility of a multitiered blood-based proteomic screening method for detecting DLB and distinguishing DLB from PD.",
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author = "Sidney O'Bryant and Ferman, {Tanis J.} and Fan Zhang and James Hall and Otto Pedraza and Wszolek, {Zbigniew K.} and Tori Como and David Julovich and Sravan Mattevada and Johnson, {Leigh A.} and Melissa Edwards and Graff-Radford, {Neill R.}",
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O'Bryant, S, Ferman, TJ, Zhang, F, Hall, J, Pedraza, O, Wszolek, ZK, Como, T, Julovich, D, Mattevada, S, Johnson, LA, Edwards, M & Graff-Radford, NR 2019, 'A proteomic signature for dementia with Lewy bodies' Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, vol. 11, pp. 270-276. https://doi.org/10.1016/j.dadm.2019.01.006

A proteomic signature for dementia with Lewy bodies. / O'Bryant, Sidney; Ferman, Tanis J.; Zhang, Fan; Hall, James; Pedraza, Otto; Wszolek, Zbigniew K.; Como, Tori; Julovich, David; Mattevada, Sravan; Johnson, Leigh A.; Edwards, Melissa; Graff-Radford, Neill R.

In: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, Vol. 11, 01.12.2019, p. 270-276.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - A proteomic signature for dementia with Lewy bodies

AU - O'Bryant, Sidney

AU - Ferman, Tanis J.

AU - Zhang, Fan

AU - Hall, James

AU - Pedraza, Otto

AU - Wszolek, Zbigniew K.

AU - Como, Tori

AU - Julovich, David

AU - Mattevada, Sravan

AU - Johnson, Leigh A.

AU - Edwards, Melissa

AU - Graff-Radford, Neill R.

PY - 2019/12/1

Y1 - 2019/12/1

N2 - Introduction: We sought to determine if a proteomic profile approach developed to detect Alzheimer's disease would distinguish patients with Lewy body disease from normal controls, and if it would distinguish dementia with Lewy bodies (DLB) from Parkinson's disease (PD). Methods: Stored plasma samples were obtained from 145 patients (DLB n = 57, PD without dementia n = 32, normal controls n = 56) enrolled from patients seen in the Behavioral Neurology or Movement Disorders clinics at the Mayo Clinic, Florida. Proteomic assays were conducted and analyzed as per our previously published protocols. Results: In the first step, the proteomic profile distinguished the DLB-PD group from controls with a diagnostic accuracy of 0.97, sensitivity of 0.91, and specificity of 0.86. In the second step, the proteomic profile distinguished the DLB from PD groups with a diagnostic accuracy of 0.92, sensitivity of 0.94, and specificity of 0.88. Discussion: These data provide evidence of the potential utility of a multitiered blood-based proteomic screening method for detecting DLB and distinguishing DLB from PD.

AB - Introduction: We sought to determine if a proteomic profile approach developed to detect Alzheimer's disease would distinguish patients with Lewy body disease from normal controls, and if it would distinguish dementia with Lewy bodies (DLB) from Parkinson's disease (PD). Methods: Stored plasma samples were obtained from 145 patients (DLB n = 57, PD without dementia n = 32, normal controls n = 56) enrolled from patients seen in the Behavioral Neurology or Movement Disorders clinics at the Mayo Clinic, Florida. Proteomic assays were conducted and analyzed as per our previously published protocols. Results: In the first step, the proteomic profile distinguished the DLB-PD group from controls with a diagnostic accuracy of 0.97, sensitivity of 0.91, and specificity of 0.86. In the second step, the proteomic profile distinguished the DLB from PD groups with a diagnostic accuracy of 0.92, sensitivity of 0.94, and specificity of 0.88. Discussion: These data provide evidence of the potential utility of a multitiered blood-based proteomic screening method for detecting DLB and distinguishing DLB from PD.

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KW - Blood biomarkers

KW - Dementia with Lewy bodies

KW - Detection

KW - Diagnostic accuracy

KW - Parkinson's disease

KW - Proteomics

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DO - 10.1016/j.dadm.2019.01.006

M3 - Article

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SP - 270

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JO - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring

JF - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring

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ER -