A potentially significant interaction between efavirenz and phenytoin: a case report and review of the literature.

Sarah M. Robertson; Scott R. Penzak; Jason Lane; Alice K. Pau; Jo Ann M. Mican

doi:10.1086/431208

A potentially significant interaction between efavirenz and phenytoin: a case report and review of the literature.

Sarah M. Robertson, Scott R. Penzak, Jason Lane, Alice K. Pau, Jo Ann M. Mican

UNT System College of Pharmacy

Research output: Contribution to journal › Review article › peer-review

20 Scopus citations

Abstract

Although it has not been demonstrated yet, phenytoin is expected to reduce efavirenz exposure through coinduction of cytochrome P450 (CYP) 3A4 and CYP2B6. Conversely, efavirenz has been shown in vitro to inhibit the enzymes responsible for phenytoin metabolism, CYP2C9 and CYP2C19. We report a case in which a potential bidirectional drug interaction between phenytoin and efavirenz resulted in lower-than-expected efavirenz concentrations and elevated phenytoin levels. Therapeutic drug monitoring was used in this case to ensure adequate efavirenz exposure.

Original language	English
Pages (from-to)	e15-18
Journal	Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Volume	41
Issue number	2
DOIs	https://doi.org/10.1086/431208
State	Published - 15 Jul 2005

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10.1086/431208

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title = "A potentially significant interaction between efavirenz and phenytoin: a case report and review of the literature.",

abstract = "Although it has not been demonstrated yet, phenytoin is expected to reduce efavirenz exposure through coinduction of cytochrome P450 (CYP) 3A4 and CYP2B6. Conversely, efavirenz has been shown in vitro to inhibit the enzymes responsible for phenytoin metabolism, CYP2C9 and CYP2C19. We report a case in which a potential bidirectional drug interaction between phenytoin and efavirenz resulted in lower-than-expected efavirenz concentrations and elevated phenytoin levels. Therapeutic drug monitoring was used in this case to ensure adequate efavirenz exposure.",

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A potentially significant interaction between efavirenz and phenytoin : a case report and review of the literature. / Robertson, Sarah M.; Penzak, Scott R.; Lane, Jason et al.

In: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, Vol. 41, No. 2, 15.07.2005, p. e15-18.

Research output: Contribution to journal › Review article › peer-review

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A potentially significant interaction between efavirenz and phenytoin: a case report and review of the literature.

Abstract

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