TY - JOUR
T1 - A population genetic study of six VNTR loci in three ethnically defined populations
AU - Deka, Ranjan
AU - Chakraborty, Ranajit
AU - Ferrell, Robert E.
N1 - Funding Information:
The authors thank Drs. J. C. Long, P. E. Smouse, and J. W. Wood for providing samples from the Kalam and Gainj populations of Papua New Guinea and Dr. Emijke J. E. Szathmary for samples from the Dogrib Indians. We thank Drs. C. Aston, A. Chakravarti, and C. C. Li for helpful discussions of these data. This work was supported in part by NIH Grant GM 41399 from the National Institute of Health and Grant 90-IJ-CX-0038 from the U.S. National Institute of Justice. We thank Deborah Biemesser for expert manuscript preparation.
PY - 1991/9
Y1 - 1991/9
N2 - To investigate the population genetic characteristics of VNTR polymorphisms in human populations, we have studied the allele frequency distribution of six VNTR loci (D1S57, RB1, D1S77, D1S61, α-globin 5′HVR, D1S76) in three well-defined populations (Kachari of Northeast India; Dogrib Indian of Canada; and New Guinea Highlander of Papua New Guinea). Even though the number of alleles sampled is limited, 48 to 92 alleles per locus per population, significant variation is noticed in the number of alleles per locus for all the populations. Using alternate summary measures, we have observed that genotype distributions at the six VNTR loci apparently conform to their respective Hardy-Weinberg predictions. Multilocus genotype profiles of the individuals in each of the three populations suggest that the VNTR alleles are independently segregating with the exception of the two linked loci D1S76 and D1S77. Lack of fit of all VNTR loci to one particular model of mutational change, either the Infinite Allele Model or the Stepwise Mutation Model, suggests more than one mechanism for production of new VNTR alleles. This study also indicates that increased heterozygosity at VNTR loci in comparison to protein and blood group loci may lead to more accurate estimates of genetic distance.
AB - To investigate the population genetic characteristics of VNTR polymorphisms in human populations, we have studied the allele frequency distribution of six VNTR loci (D1S57, RB1, D1S77, D1S61, α-globin 5′HVR, D1S76) in three well-defined populations (Kachari of Northeast India; Dogrib Indian of Canada; and New Guinea Highlander of Papua New Guinea). Even though the number of alleles sampled is limited, 48 to 92 alleles per locus per population, significant variation is noticed in the number of alleles per locus for all the populations. Using alternate summary measures, we have observed that genotype distributions at the six VNTR loci apparently conform to their respective Hardy-Weinberg predictions. Multilocus genotype profiles of the individuals in each of the three populations suggest that the VNTR alleles are independently segregating with the exception of the two linked loci D1S76 and D1S77. Lack of fit of all VNTR loci to one particular model of mutational change, either the Infinite Allele Model or the Stepwise Mutation Model, suggests more than one mechanism for production of new VNTR alleles. This study also indicates that increased heterozygosity at VNTR loci in comparison to protein and blood group loci may lead to more accurate estimates of genetic distance.
UR - http://www.scopus.com/inward/record.url?scp=0026072502&partnerID=8YFLogxK
U2 - 10.1016/0888-7543(91)90104-M
DO - 10.1016/0888-7543(91)90104-M
M3 - Article
C2 - 1765387
AN - SCOPUS:0026072502
SN - 0888-7543
VL - 11
SP - 83
EP - 92
JO - Genomics
JF - Genomics
IS - 1
ER -