A pain severity-hypothalamic-pituitary-adrenocortical axis interaction: The effects on pain pathways

John P. Garofalo, Richard C. Robinson, Robert Joseph Gatchel, Zhongyun Wang

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Recent efforts have identified psychosocial and biological factors influencing the pathogenesis of chronic pain. The present study attempted to identify whether these two variables interact and, in turn, represent an underlying mechanism in the transition from acute to chronic pain. Salivary cortisol samples were collected upon waking up and 20 minutes later daily for 2 weeks from acute pain patients. Analyses revealed a direct relationship between pain severity and hypothalamic-pituitary-adrenocortical activity for temporomandibular disorder, and a negative relationship between these variables for low back pain populations. These results highlight the possible interaction between neuroendocrine and psychological factors to increase the risk for chronic pain.

Original languageEnglish
Pages (from-to)35-42
Number of pages8
JournalJournal of Applied Biobehavioral Research
Volume12
Issue number1
DOIs
StatePublished - 1 Jan 2007

Fingerprint

Chronic Pain
pain
Pain
interaction
Psychology
Temporomandibular Joint Disorders
Acute Pain
Biological Factors
Low Back Pain
Hydrocortisone
biological factors
psychosocial factors
psychological factors
Population

Cite this

Garofalo, John P. ; Robinson, Richard C. ; Gatchel, Robert Joseph ; Wang, Zhongyun. / A pain severity-hypothalamic-pituitary-adrenocortical axis interaction : The effects on pain pathways. In: Journal of Applied Biobehavioral Research. 2007 ; Vol. 12, No. 1. pp. 35-42.
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A pain severity-hypothalamic-pituitary-adrenocortical axis interaction : The effects on pain pathways. / Garofalo, John P.; Robinson, Richard C.; Gatchel, Robert Joseph; Wang, Zhongyun.

In: Journal of Applied Biobehavioral Research, Vol. 12, No. 1, 01.01.2007, p. 35-42.

Research output: Contribution to journalArticle

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