Abstract
Organisms as diverse as fungi and humans use G-protein-coupled receptors to control signal transduction pathways responsive to various hormones, neuroregulatory molecules and other sensory stimuli [1]. Continual stimulation of these receptors often leads to their desensitization, which is mediated in part by the consecutive actions of two families of proteins - the G-protein-coupled receptor kinases, which phosphorylate the agonist-occupied receptors [2], and the arrestin proteins, which subsequently bind to the receptors [3]. We now present evidence that a group of proteins - the G0S8/Sst2p family - may be a third class of receptor-desensitizing factors.
Original language | English |
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Pages (from-to) | 211-212 |
Number of pages | 2 |
Journal | Current Biology |
Volume | 6 |
Issue number | 2 |
DOIs | |
State | Published - 1996 |