A new family of regulators of G-protein-coupled receptors?

David P. Siderovski, Andrew Hessel, Stephen Chung, Tak W. Mak, Michael Tyers

Research output: Contribution to journalArticlepeer-review

180 Scopus citations


Organisms as diverse as fungi and humans use G-protein-coupled receptors to control signal transduction pathways responsive to various hormones, neuroregulatory molecules and other sensory stimuli [1]. Continual stimulation of these receptors often leads to their desensitization, which is mediated in part by the consecutive actions of two families of proteins - the G-protein-coupled receptor kinases, which phosphorylate the agonist-occupied receptors [2], and the arrestin proteins, which subsequently bind to the receptors [3]. We now present evidence that a group of proteins - the G0S8/Sst2p family - may be a third class of receptor-desensitizing factors.

Original languageEnglish
Pages (from-to)211-212
Number of pages2
JournalCurrent Biology
Issue number2
StatePublished - 1996


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