A neuroglobin-overexpressing transgenic mouse

Adil A. Khan; Yunjuan Sun; Kunlin Jin; Xiao Ou Mao; Sylvia Chen; Lisa M. Ellerby; David A. Greenberg

doi:10.1016/j.gene.2007.02.044

A neuroglobin-overexpressing transgenic mouse

Adil A. Khan, Yunjuan Sun, Kunlin Jin, Xiao Ou Mao, Sylvia Chen, Lisa M. Ellerby, David A. Greenberg

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Neuroglobin (Ngb) is a recently discovered vertebrate globin expressed primarily in neurons. Ngb expression is induced by hypoxia and ischemia, and Ngb protects neurons from these insults. However, its normal physiological role and the mechanism underlying its neuroprotective action are uncertain. We report production of a transgenic mouse in which Ngb is overexpressed under the control of the chicken β-actin promoter. This mouse should prove helpful for studying Ngb-mediated effects in vitro and in vivo.

Original language	English
Pages (from-to)	172-176
Number of pages	5
Journal	Gene
Volume	398
Issue number	1-2 SPEC. ISS.
DOIs	https://doi.org/10.1016/j.gene.2007.02.044
State	Published - 15 Aug 2007

Keywords

Brain
Globin
Hypoxia
Ischemia
Neuron
Oxygen

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10.1016/j.gene.2007.02.044

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title = "A neuroglobin-overexpressing transgenic mouse",

abstract = "Neuroglobin (Ngb) is a recently discovered vertebrate globin expressed primarily in neurons. Ngb expression is induced by hypoxia and ischemia, and Ngb protects neurons from these insults. However, its normal physiological role and the mechanism underlying its neuroprotective action are uncertain. We report production of a transgenic mouse in which Ngb is overexpressed under the control of the chicken β-actin promoter. This mouse should prove helpful for studying Ngb-mediated effects in vitro and in vivo.",

keywords = "Brain, Globin, Hypoxia, Ischemia, Neuron, Oxygen",

author = "Khan, {Adil A.} and Yunjuan Sun and Kunlin Jin and Mao, {Xiao Ou} and Sylvia Chen and Ellerby, {Lisa M.} and Greenberg, {David A.}",

note = "Funding Information: Supported by National Institutes of Health grant NS35965 (D.A.G.) and by the Buck Institute for Age Research.",

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T1 - A neuroglobin-overexpressing transgenic mouse

AU - Khan, Adil A.

AU - Sun, Yunjuan

AU - Jin, Kunlin

AU - Mao, Xiao Ou

AU - Chen, Sylvia

AU - Ellerby, Lisa M.

AU - Greenberg, David A.

N1 - Funding Information: Supported by National Institutes of Health grant NS35965 (D.A.G.) and by the Buck Institute for Age Research.

PY - 2007/8/15

Y1 - 2007/8/15

N2 - Neuroglobin (Ngb) is a recently discovered vertebrate globin expressed primarily in neurons. Ngb expression is induced by hypoxia and ischemia, and Ngb protects neurons from these insults. However, its normal physiological role and the mechanism underlying its neuroprotective action are uncertain. We report production of a transgenic mouse in which Ngb is overexpressed under the control of the chicken β-actin promoter. This mouse should prove helpful for studying Ngb-mediated effects in vitro and in vivo.

AB - Neuroglobin (Ngb) is a recently discovered vertebrate globin expressed primarily in neurons. Ngb expression is induced by hypoxia and ischemia, and Ngb protects neurons from these insults. However, its normal physiological role and the mechanism underlying its neuroprotective action are uncertain. We report production of a transgenic mouse in which Ngb is overexpressed under the control of the chicken β-actin promoter. This mouse should prove helpful for studying Ngb-mediated effects in vitro and in vivo.

KW - Brain

KW - Globin

KW - Hypoxia

KW - Ischemia

KW - Neuron

KW - Oxygen

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VL - 398

SP - 172

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JO - Gene

JF - Gene

IS - 1-2 SPEC. ISS.

ER -

A neuroglobin-overexpressing transgenic mouse

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Keywords

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