A neuroglobin-overexpressing transgenic mouse

Adil A. Khan, Yunjuan Sun, Kunlin Jin, Xiao Ou Mao, Sylvia Chen, Lisa M. Ellerby, David A. Greenberg

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Neuroglobin (Ngb) is a recently discovered vertebrate globin expressed primarily in neurons. Ngb expression is induced by hypoxia and ischemia, and Ngb protects neurons from these insults. However, its normal physiological role and the mechanism underlying its neuroprotective action are uncertain. We report production of a transgenic mouse in which Ngb is overexpressed under the control of the chicken β-actin promoter. This mouse should prove helpful for studying Ngb-mediated effects in vitro and in vivo.

Original languageEnglish
Pages (from-to)172-176
Number of pages5
JournalGene
Volume398
Issue number1-2 SPEC. ISS.
DOIs
StatePublished - 15 Aug 2007

Keywords

  • Brain
  • Globin
  • Hypoxia
  • Ischemia
  • Neuron
  • Oxygen

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    Khan, A. A., Sun, Y., Jin, K., Mao, X. O., Chen, S., Ellerby, L. M., & Greenberg, D. A. (2007). A neuroglobin-overexpressing transgenic mouse. Gene, 398(1-2 SPEC. ISS.), 172-176. https://doi.org/10.1016/j.gene.2007.02.044