A murine model of stress controllability attenuates Th2-dominant airway inflammatory responses

Aniket Deshmukh, Byung Jin Kim, Xavier Gonzales, James Caffrey, Jamboor Vishwanatha, Harlan P. Jones

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Epidemiological and experimental studies suggest a positive correlation between chronic respiratory inflammatory disease and the ability to cope with adverse stress. Interactions between neuroendocrine and immune systems are believed to provide insight toward the biological mechanisms of action. The utility of an experimental murine model was employed to investigate the immunological consequences of stress-controllability and ovalbumin-induced airway inflammation. Pre-conditioned uncontrollable stress exacerbated OVA-induced lung histopathological changes that were typical of Th2-predominant inflammatory response along respiratory tissues. Importantly, mice given the ability to exert control over aversive stress attenuated inflammatory responses and reduced lung pathology. This model represents a means of investigating the neuro-immune axis in defining mechanisms of stress and respiratory disease.

Original languageEnglish
Pages (from-to)13-21
Number of pages9
JournalJournal of Neuroimmunology
Volume225
Issue number1-2
DOIs
StatePublished - Aug 2010

Keywords

  • Asthma
  • Controllability
  • Immunity
  • Stress

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