TY - CHAP
T1 - A Molecular Information Method to Estimate Population Admixture
AU - Bertoni, Bernardo
AU - Velazquez, Tatiana
AU - Sans, Mónica
AU - Chakraborty, Ranajit
N1 - Funding Information:
We thank Carolina Bonilla and Pedro Hidalgo for a helpful discussion and commentaries. This research was partially supported by the Programa de Desarrollo de las Ciencias Básicas (PEDECIBA), Uruguay.
PY - 2012
Y1 - 2012
N2 - Admixture contributions are widely studied in human populations and several methods are available based on allele frequencies or, more recently, on molecular information. We developed the allelic variance method (AVM) based on the molecular information extracted from the microsatellites under the single stepwise mutation model (SSMM). AVM circumvents the allele methods limitation of a lineal model and focus on the θ(4N e μ) parameter properties. Compared to allele frequency methods (AFMs), AVM has more accurate estimations and no systemic bias under different simulated scenarios. When it is applied to human data, the results of the analysis of three populations from Latin America (Argentina, Brazil, and Colombia) indicate a correct inference of a trihybrid model, confirmed by other three different methods. However, the estimates from AVM seem to discriminate better the admixture demographic histories of the Brazilian and Colombian populations.
AB - Admixture contributions are widely studied in human populations and several methods are available based on allele frequencies or, more recently, on molecular information. We developed the allelic variance method (AVM) based on the molecular information extracted from the microsatellites under the single stepwise mutation model (SSMM). AVM circumvents the allele methods limitation of a lineal model and focus on the θ(4N e μ) parameter properties. Compared to allele frequency methods (AFMs), AVM has more accurate estimations and no systemic bias under different simulated scenarios. When it is applied to human data, the results of the analysis of three populations from Latin America (Argentina, Brazil, and Colombia) indicate a correct inference of a trihybrid model, confirmed by other three different methods. However, the estimates from AVM seem to discriminate better the admixture demographic histories of the Brazilian and Colombian populations.
KW - Admixture
KW - Allelic variance method
KW - Human migration
KW - Microsatellites
KW - Molecular information
KW - Population structure
UR - http://www.scopus.com/inward/record.url?scp=84866271079&partnerID=8YFLogxK
U2 - 10.1016/B978-0-44-451875-0.00013-0
DO - 10.1016/B978-0-44-451875-0.00013-0
M3 - Chapter
AN - SCOPUS:84866271079
T3 - Handbook of Statistics
SP - 339
EP - 352
BT - Handbook of Statistics
PB - Elsevier B.V.
ER -