A method to shorten the training phase of drug discrimination

C. M. Harris, D. M. Wood, H. Lal, M. W. Emmett-Oglesby

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Rats were trained to discriminate "drug" from "no drug" in a two-lever, food-reinforced task. One group was trained with cocaine (10 mg/kg) and a second group was trained with pentylenetetrazol (20 mg/kg). A method designed to shorten the time required for the training phase of drug discrimination experiments was assessed in subgroups for each drug. In one subgroup, single training sessions were conducted daily. In the other subgroup, a second session (either drug or saline) was conducted on days for which the first condition was saline. The training conditions were presented in an irregular sequence, with the same condition occurring in no more than two consecutive sessions. Rats trained by the accelerated method learned the discrimination in fewer days, with no decrement in acquisition per session, suggesting that drug discrimination training can be accomplished more rapidly by reducing inter-session interval.

Original languageEnglish
Pages (from-to)435-436
Number of pages2
JournalPsychopharmacology
Volume93
Issue number4
DOIs
StatePublished - Dec 1987

Keywords

  • Cocaine
  • Drug discrimination
  • Learning
  • Pentylenetetrazol

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