A genome-wide search for human non-insulin-dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2

C. L. Hanis, E. Boerwinkle, R. Chakraborty, D. L. Ellsworth, P. Concannon, B. Stirling, V. A. Morrison, B. Wapelhorst, R. S. Spielman, K. J. Gogolin-Ewens, J. M. Shephard, S. R. Williams, N. Risch, D. Hinds, N. Iwasaki, M. Ogata, Y. Omori, C. Petzold, H. Rietzsch, H. E. SchröderJ. Schulze, N. J. Cox, S. Menzel, V. V. Boriraj, X. Chen, L. R. Lim, T. Lindner, L. E. Mereu, Y. Q. Wang, K. Xiang, K. Yamagata, Y. Yang, G. I. Bell

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Abstract

Non-insulin-dependent (type 2) diabetes mellitus (NIDDM) is a common disorder of middle-aged individuals characterized by high blood glucose levels which, if untreated, can cause serious medical complications and lead to early death. Genetic factors play an important role in determining susceptibility to this disorder. However, the number of genes involved, their chromosomal location and the magnitude of their effect on NIDDM susceptibility are unknown. We have screened the human genome for susceptibility genes for NIDDM using non- and quasi-parametric linkage analysis methods in a group of Mexican American affected sib pairs. One marker, D2S125, showed significant evidence of linkage to NIDDM and appears to be a major factor affecting the development of diabetes mellitus in Mexican Americans. We propose that this locus be designated NIDDM1.

Original languageEnglish
Pages (from-to)161-166
Number of pages6
JournalNature Genetics
Volume13
Issue number2
DOIs
StatePublished - 1 Jun 1996

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Chromosomes, Human, Pair 2
Type 2 Diabetes Mellitus
Genome
Genes
Human Genome
Blood Glucose
Diabetes Mellitus

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Hanis, C. L., Boerwinkle, E., Chakraborty, R., Ellsworth, D. L., Concannon, P., Stirling, B., ... Bell, G. I. (1996). A genome-wide search for human non-insulin-dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2. Nature Genetics, 13(2), 161-166. https://doi.org/10.1038/ng0696-161
Hanis, C. L. ; Boerwinkle, E. ; Chakraborty, R. ; Ellsworth, D. L. ; Concannon, P. ; Stirling, B. ; Morrison, V. A. ; Wapelhorst, B. ; Spielman, R. S. ; Gogolin-Ewens, K. J. ; Shephard, J. M. ; Williams, S. R. ; Risch, N. ; Hinds, D. ; Iwasaki, N. ; Ogata, M. ; Omori, Y. ; Petzold, C. ; Rietzsch, H. ; Schröder, H. E. ; Schulze, J. ; Cox, N. J. ; Menzel, S. ; Boriraj, V. V. ; Chen, X. ; Lim, L. R. ; Lindner, T. ; Mereu, L. E. ; Wang, Y. Q. ; Xiang, K. ; Yamagata, K. ; Yang, Y. ; Bell, G. I. / A genome-wide search for human non-insulin-dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2. In: Nature Genetics. 1996 ; Vol. 13, No. 2. pp. 161-166.
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Hanis, CL, Boerwinkle, E, Chakraborty, R, Ellsworth, DL, Concannon, P, Stirling, B, Morrison, VA, Wapelhorst, B, Spielman, RS, Gogolin-Ewens, KJ, Shephard, JM, Williams, SR, Risch, N, Hinds, D, Iwasaki, N, Ogata, M, Omori, Y, Petzold, C, Rietzsch, H, Schröder, HE, Schulze, J, Cox, NJ, Menzel, S, Boriraj, VV, Chen, X, Lim, LR, Lindner, T, Mereu, LE, Wang, YQ, Xiang, K, Yamagata, K, Yang, Y & Bell, GI 1996, 'A genome-wide search for human non-insulin-dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2', Nature Genetics, vol. 13, no. 2, pp. 161-166. https://doi.org/10.1038/ng0696-161

A genome-wide search for human non-insulin-dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2. / Hanis, C. L.; Boerwinkle, E.; Chakraborty, R.; Ellsworth, D. L.; Concannon, P.; Stirling, B.; Morrison, V. A.; Wapelhorst, B.; Spielman, R. S.; Gogolin-Ewens, K. J.; Shephard, J. M.; Williams, S. R.; Risch, N.; Hinds, D.; Iwasaki, N.; Ogata, M.; Omori, Y.; Petzold, C.; Rietzsch, H.; Schröder, H. E.; Schulze, J.; Cox, N. J.; Menzel, S.; Boriraj, V. V.; Chen, X.; Lim, L. R.; Lindner, T.; Mereu, L. E.; Wang, Y. Q.; Xiang, K.; Yamagata, K.; Yang, Y.; Bell, G. I.

In: Nature Genetics, Vol. 13, No. 2, 01.06.1996, p. 161-166.

Research output: Contribution to journalArticle

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T1 - A genome-wide search for human non-insulin-dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2

AU - Hanis, C. L.

AU - Boerwinkle, E.

AU - Chakraborty, R.

AU - Ellsworth, D. L.

AU - Concannon, P.

AU - Stirling, B.

AU - Morrison, V. A.

AU - Wapelhorst, B.

AU - Spielman, R. S.

AU - Gogolin-Ewens, K. J.

AU - Shephard, J. M.

AU - Williams, S. R.

AU - Risch, N.

AU - Hinds, D.

AU - Iwasaki, N.

AU - Ogata, M.

AU - Omori, Y.

AU - Petzold, C.

AU - Rietzsch, H.

AU - Schröder, H. E.

AU - Schulze, J.

AU - Cox, N. J.

AU - Menzel, S.

AU - Boriraj, V. V.

AU - Chen, X.

AU - Lim, L. R.

AU - Lindner, T.

AU - Mereu, L. E.

AU - Wang, Y. Q.

AU - Xiang, K.

AU - Yamagata, K.

AU - Yang, Y.

AU - Bell, G. I.

PY - 1996/6/1

Y1 - 1996/6/1

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AB - Non-insulin-dependent (type 2) diabetes mellitus (NIDDM) is a common disorder of middle-aged individuals characterized by high blood glucose levels which, if untreated, can cause serious medical complications and lead to early death. Genetic factors play an important role in determining susceptibility to this disorder. However, the number of genes involved, their chromosomal location and the magnitude of their effect on NIDDM susceptibility are unknown. We have screened the human genome for susceptibility genes for NIDDM using non- and quasi-parametric linkage analysis methods in a group of Mexican American affected sib pairs. One marker, D2S125, showed significant evidence of linkage to NIDDM and appears to be a major factor affecting the development of diabetes mellitus in Mexican Americans. We propose that this locus be designated NIDDM1.

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