A genome-wide search for human non-insulin-dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2

C. L. Hanis; E. Boerwinkle; R. Chakraborty; D. L. Ellsworth; P. Concannon; B. Stirling; V. A. Morrison; B. Wapelhorst; R. S. Spielman; K. J. Gogolin-Ewens; J. M. Shephard; S. R. Williams; N. Risch; D. Hinds; N. Iwasaki; M. Ogata; Y. Omori; C. Petzold; H. Rietzsch; H. E. Schröder; J. Schulze; N. J. Cox; S. Menzel; V. V. Boriraj; X. Chen; L. R. Lim; T. Lindner; L. E. Mereu; Y. Q. Wang; K. Xiang; K. Yamagata; Y. Yang; G. I. Bell

doi:10.1038/ng0696-161

A genome-wide search for human non-insulin-dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2

C. L. Hanis, E. Boerwinkle, R. Chakraborty, D. L. Ellsworth, P. Concannon, B. Stirling, V. A. Morrison, B. Wapelhorst, R. S. Spielman, K. J. Gogolin-Ewens, J. M. Shephard, S. R. Williams, N. Risch, D. Hinds, N. Iwasaki, M. Ogata, Y. Omori, C. Petzold, H. Rietzsch, H. E. SchröderJ. Schulze, N. J. Cox, S. Menzel, V. V. Boriraj, X. Chen, L. R. Lim, T. Lindner, L. E. Mereu, Y. Q. Wang, K. Xiang, K. Yamagata, Y. Yang, G. I. Bell

School of Biomedical Sciences

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Abstract

Non-insulin-dependent (type 2) diabetes mellitus (NIDDM) is a common disorder of middle-aged individuals characterized by high blood glucose levels which, if untreated, can cause serious medical complications and lead to early death. Genetic factors play an important role in determining susceptibility to this disorder. However, the number of genes involved, their chromosomal location and the magnitude of their effect on NIDDM susceptibility are unknown. We have screened the human genome for susceptibility genes for NIDDM using non- and quasi-parametric linkage analysis methods in a group of Mexican American affected sib pairs. One marker, D2S125, showed significant evidence of linkage to NIDDM and appears to be a major factor affecting the development of diabetes mellitus in Mexican Americans. We propose that this locus be designated NIDDM1.

Original language	English
Pages (from-to)	161-166
Number of pages	6
Journal	Nature Genetics
Volume	13
Issue number	2
DOIs	https://doi.org/10.1038/ng0696-161
State	Published - Jun 1996

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Hanis, C. L., Boerwinkle, E., Chakraborty, R., Ellsworth, D. L., Concannon, P., Stirling, B., Morrison, V. A., Wapelhorst, B., Spielman, R. S., Gogolin-Ewens, K. J., Shephard, J. M., Williams, S. R., Risch, N., Hinds, D., Iwasaki, N., Ogata, M., Omori, Y., Petzold, C., Rietzsch, H., ... Bell, G. I. (1996). A genome-wide search for human non-insulin-dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2. Nature Genetics, 13(2), 161-166. https://doi.org/10.1038/ng0696-161

@article{0407896227c246f89e73c6f2d1dbdefe,

title = "A genome-wide search for human non-insulin-dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2",

abstract = "Non-insulin-dependent (type 2) diabetes mellitus (NIDDM) is a common disorder of middle-aged individuals characterized by high blood glucose levels which, if untreated, can cause serious medical complications and lead to early death. Genetic factors play an important role in determining susceptibility to this disorder. However, the number of genes involved, their chromosomal location and the magnitude of their effect on NIDDM susceptibility are unknown. We have screened the human genome for susceptibility genes for NIDDM using non- and quasi-parametric linkage analysis methods in a group of Mexican American affected sib pairs. One marker, D2S125, showed significant evidence of linkage to NIDDM and appears to be a major factor affecting the development of diabetes mellitus in Mexican Americans. We propose that this locus be designated NIDDM1.",

author = "Hanis, {C. L.} and E. Boerwinkle and R. Chakraborty and Ellsworth, {D. L.} and P. Concannon and B. Stirling and Morrison, {V. A.} and B. Wapelhorst and Spielman, {R. S.} and Gogolin-Ewens, {K. J.} and Shephard, {J. M.} and Williams, {S. R.} and N. Risch and D. Hinds and N. Iwasaki and M. Ogata and Y. Omori and C. Petzold and H. Rietzsch and Schr{\"o}der, {H. E.} and J. Schulze and Cox, {N. J.} and S. Menzel and Boriraj, {V. V.} and X. Chen and Lim, {L. R.} and T. Lindner and Mereu, {L. E.} and Wang, {Y. Q.} and K. Xiang and K. Yamagata and Y. Yang and Bell, {G. I.}",

year = "1996",

month = jun,

doi = "10.1038/ng0696-161",

language = "English",

volume = "13",

pages = "161--166",

journal = "Nature Genetics",

issn = "1061-4036",

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Hanis, CL, Boerwinkle, E, Chakraborty, R, Ellsworth, DL, Concannon, P, Stirling, B, Morrison, VA, Wapelhorst, B, Spielman, RS, Gogolin-Ewens, KJ, Shephard, JM, Williams, SR, Risch, N, Hinds, D, Iwasaki, N, Ogata, M, Omori, Y, Petzold, C, Rietzsch, H, Schröder, HE, Schulze, J, Cox, NJ, Menzel, S, Boriraj, VV, Chen, X, Lim, LR, Lindner, T, Mereu, LE, Wang, YQ, Xiang, K, Yamagata, K, Yang, Y & Bell, GI 1996, 'A genome-wide search for human non-insulin-dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2', Nature Genetics, vol. 13, no. 2, pp. 161-166. https://doi.org/10.1038/ng0696-161

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T1 - A genome-wide search for human non-insulin-dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2

AU - Hanis, C. L.

AU - Boerwinkle, E.

AU - Chakraborty, R.

AU - Ellsworth, D. L.

AU - Concannon, P.

AU - Stirling, B.

AU - Morrison, V. A.

AU - Wapelhorst, B.

AU - Spielman, R. S.

AU - Gogolin-Ewens, K. J.

AU - Shephard, J. M.

AU - Williams, S. R.

AU - Risch, N.

AU - Hinds, D.

AU - Iwasaki, N.

AU - Ogata, M.

AU - Omori, Y.

AU - Petzold, C.

AU - Rietzsch, H.

AU - Schröder, H. E.

AU - Schulze, J.

AU - Cox, N. J.

AU - Menzel, S.

AU - Boriraj, V. V.

AU - Chen, X.

AU - Lim, L. R.

AU - Lindner, T.

AU - Mereu, L. E.

AU - Wang, Y. Q.

AU - Xiang, K.

AU - Yamagata, K.

AU - Yang, Y.

AU - Bell, G. I.

PY - 1996/6

Y1 - 1996/6

N2 - Non-insulin-dependent (type 2) diabetes mellitus (NIDDM) is a common disorder of middle-aged individuals characterized by high blood glucose levels which, if untreated, can cause serious medical complications and lead to early death. Genetic factors play an important role in determining susceptibility to this disorder. However, the number of genes involved, their chromosomal location and the magnitude of their effect on NIDDM susceptibility are unknown. We have screened the human genome for susceptibility genes for NIDDM using non- and quasi-parametric linkage analysis methods in a group of Mexican American affected sib pairs. One marker, D2S125, showed significant evidence of linkage to NIDDM and appears to be a major factor affecting the development of diabetes mellitus in Mexican Americans. We propose that this locus be designated NIDDM1.

AB - Non-insulin-dependent (type 2) diabetes mellitus (NIDDM) is a common disorder of middle-aged individuals characterized by high blood glucose levels which, if untreated, can cause serious medical complications and lead to early death. Genetic factors play an important role in determining susceptibility to this disorder. However, the number of genes involved, their chromosomal location and the magnitude of their effect on NIDDM susceptibility are unknown. We have screened the human genome for susceptibility genes for NIDDM using non- and quasi-parametric linkage analysis methods in a group of Mexican American affected sib pairs. One marker, D2S125, showed significant evidence of linkage to NIDDM and appears to be a major factor affecting the development of diabetes mellitus in Mexican Americans. We propose that this locus be designated NIDDM1.

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U2 - 10.1038/ng0696-161

DO - 10.1038/ng0696-161

M3 - Article

C2 - 8640221

AN - SCOPUS:9044243415

SN - 1061-4036

VL - 13

SP - 161

EP - 166

JO - Nature Genetics

JF - Nature Genetics

IS - 2

ER -

A genome-wide search for human non-insulin-dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2

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