A diminished aortic-cardiac reflex during hypotension in aerobically fit young men

Xiangrong Shi, Craig G. Crandall, Jeffrey T. Potts, Jon W. Williamson, Brian H. Foresman, Peter B. Raven

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

We compared the aortic-cardiac baroreflex sensitivity in eight average fit (AF: VO2max = 44.7 ± 1.3 ml•kg-1•min-1) and seven high fit (HF: VO2max = 64.1 ± 1.7 ml • min-1 • kg-1) healthy young men during hypotension elicited by steady state sodium nitroprusside (SN) infusion. During SN mean arterial pressure (MAP) was similarly decreased in AF (-12.6 ± 1.0 mm Hg) and HF (-12.1 ± 1.1 mm Hg). However, the increases in heart rate (HR) were less (P< 0.023) in HF (15 ± 3 bpm) than AF (25 ± 1 bpm). When sustained neck suction (NS, -22 ± 1 torr in AF and -20 ± 1 torr in HF, P > 0.05) was applied to counteract the decreased carotid sinus transmural pressure during SN, thereby isolating the aortic baroreceptors, the increased HR remained less (P < 0.021) in HF (8 ± 2 bpm) than AF (16 ± 2 bpm). During both SN infusion and SN+NS, the calculated gains (i.e., AHR/AMAP) were significantly greater in AF (2.1 ± 0.3 and 1.3 ± 0.2 bpm•mm Hg-1) than HF (1.2 ± 0.2 and 0.6 ± 0.2 bpm•mm Hg-1). However, the estimated carotid-cardiac baroreflex sensitivity (i.e., the gain difference between the stage SN and SN+NS) was not different between AF (0.7 ± 0.2 bpm•mm Hg-1) and HF (0.6 ± 0.1 bpm•mm Hg-1). These data indicated that the aortic-cardiac baroreflex sensitivity during hypotension was significantly diminished with endurance exercise training.

Original languageEnglish
Pages (from-to)1024-1030
Number of pages7
JournalMedicine and Science in Sports and Exercise
Volume25
Issue number9
StatePublished - 1 Jan 1993

Fingerprint

Nitroprusside
Hypotension
Reflex
Baroreflex
Furylfuramide
Heart Rate
Carotid Sinus
Pressoreceptors
Arterial Pressure
Exercise
Pressure

Keywords

  • Adaptation
  • Baroreceptor sensitivity
  • Exercise training
  • Neck suction
  • Nitroprusside

Cite this

Shi, X., Crandall, C. G., Potts, J. T., Williamson, J. W., Foresman, B. H., & Raven, P. B. (1993). A diminished aortic-cardiac reflex during hypotension in aerobically fit young men. Medicine and Science in Sports and Exercise, 25(9), 1024-1030.
Shi, Xiangrong ; Crandall, Craig G. ; Potts, Jeffrey T. ; Williamson, Jon W. ; Foresman, Brian H. ; Raven, Peter B. / A diminished aortic-cardiac reflex during hypotension in aerobically fit young men. In: Medicine and Science in Sports and Exercise. 1993 ; Vol. 25, No. 9. pp. 1024-1030.
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Shi, X, Crandall, CG, Potts, JT, Williamson, JW, Foresman, BH & Raven, PB 1993, 'A diminished aortic-cardiac reflex during hypotension in aerobically fit young men', Medicine and Science in Sports and Exercise, vol. 25, no. 9, pp. 1024-1030.

A diminished aortic-cardiac reflex during hypotension in aerobically fit young men. / Shi, Xiangrong; Crandall, Craig G.; Potts, Jeffrey T.; Williamson, Jon W.; Foresman, Brian H.; Raven, Peter B.

In: Medicine and Science in Sports and Exercise, Vol. 25, No. 9, 01.01.1993, p. 1024-1030.

Research output: Contribution to journalArticle

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T1 - A diminished aortic-cardiac reflex during hypotension in aerobically fit young men

AU - Shi, Xiangrong

AU - Crandall, Craig G.

AU - Potts, Jeffrey T.

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AB - We compared the aortic-cardiac baroreflex sensitivity in eight average fit (AF: VO2max = 44.7 ± 1.3 ml•kg-1•min-1) and seven high fit (HF: VO2max = 64.1 ± 1.7 ml • min-1 • kg-1) healthy young men during hypotension elicited by steady state sodium nitroprusside (SN) infusion. During SN mean arterial pressure (MAP) was similarly decreased in AF (-12.6 ± 1.0 mm Hg) and HF (-12.1 ± 1.1 mm Hg). However, the increases in heart rate (HR) were less (P< 0.023) in HF (15 ± 3 bpm) than AF (25 ± 1 bpm). When sustained neck suction (NS, -22 ± 1 torr in AF and -20 ± 1 torr in HF, P > 0.05) was applied to counteract the decreased carotid sinus transmural pressure during SN, thereby isolating the aortic baroreceptors, the increased HR remained less (P < 0.021) in HF (8 ± 2 bpm) than AF (16 ± 2 bpm). During both SN infusion and SN+NS, the calculated gains (i.e., AHR/AMAP) were significantly greater in AF (2.1 ± 0.3 and 1.3 ± 0.2 bpm•mm Hg-1) than HF (1.2 ± 0.2 and 0.6 ± 0.2 bpm•mm Hg-1). However, the estimated carotid-cardiac baroreflex sensitivity (i.e., the gain difference between the stage SN and SN+NS) was not different between AF (0.7 ± 0.2 bpm•mm Hg-1) and HF (0.6 ± 0.1 bpm•mm Hg-1). These data indicated that the aortic-cardiac baroreflex sensitivity during hypotension was significantly diminished with endurance exercise training.

KW - Adaptation

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KW - Nitroprusside

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Shi X, Crandall CG, Potts JT, Williamson JW, Foresman BH, Raven PB. A diminished aortic-cardiac reflex during hypotension in aerobically fit young men. Medicine and Science in Sports and Exercise. 1993 Jan 1;25(9):1024-1030.