Abstract
(Chemical Equation Presented) A stereoselective synthesis of the BCDE fragment of brevetoxin A has been completed. anti-Glycolate aldol, glycolate alkylation, and ring-closing metathesis reactions were employed as key bond-forming events. A convergent assembly strategy was employed that relied on a Horner-Wadsworth-Emmons union of two complex fragments. Subsequent cyclization and dehydration led to efficient generation of an intermediate endocyclic enol ether, which was advanced to a tetracyclic fragment.
Original language | English |
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Pages (from-to) | 4033-4036 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 7 |
Issue number | 18 |
DOIs | |
State | Published - 1 Sep 2005 |