A comparative study of genetic variation at five VNTR loci in three ethnic groups of Houston, Texas

B. R. Sharma, M. Thompson, J. R. Bolding, Y. Zhong, L. Jin, R. Chakraborty

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Following the technique of Southern blot restriction fragment length polymorphisms (RFLP) analysis, we generated a database of DNA profiles at five Variable Number of Tandem Repeats loci (D1S7, D2S44, D4S139, D10S28, and D17S79) for 669 individuals of three major ethnic populations (Caucasians, Blacks, and Hispanics) of Houston, Texas. Analysis of fragment sizes at these loci within each sample, as well as their fixed bin analyses, reveal that the assumptions of independence of allelic occurrences within and between loci are valid for this database. Fixed-bin allele frequency tables, therefore, are the best descriptors of this database for conservative forensic calculations. Finally, we demonstrate that this regional database from Houston, Texas, does not yield any meaningfully different forensic inference than the one obtained from the National database of the respective ethnic groups.

Original languageEnglish
Pages (from-to)933-942
Number of pages10
JournalJournal of Forensic Sciences
Volume40
Issue number6
DOIs
StatePublished - 1995

Keywords

  • DNA
  • Hardy Weinberg expectation
  • RFLP data base
  • forensic science
  • genetic variation
  • linkage equilibrium
  • population studies

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    Sharma, B. R., Thompson, M., Bolding, J. R., Zhong, Y., Jin, L., & Chakraborty, R. (1995). A comparative study of genetic variation at five VNTR loci in three ethnic groups of Houston, Texas. Journal of Forensic Sciences, 40(6), 933-942. https://doi.org/10.1520/jfs13860j