A comparative evaluation of treatments with 17β-estradiol and its brain-selective prodrug in a double-transgenic mouse model of Alzheimer's disease

Keyphrases

• Transgenic Mouse Model 100%
• Alzheimer's Disease Model 100%
• 17-estradiol 100%
• Prodrug 100%
• Treatment Evaluation 100%
• Double Transgenic Mice 100%
• Ovariectomized 60%
• Alzheimer's Disease 40%
• Double Transgenic 40%
• Neuroprotective 20%
• Estrogen 20%
• Amyloid-β Peptide 20%
• Amyloid Precursor Protein 20%
• Mouse Model 20%
• Treatment Group 20%
• Ovariectomy 20%
• Estradiol 20%
• Prolonged Treatment 20%
• Therapeutic Candidates 20%
• Clinical Application 20%
• Potential Therapeutics 20%
• Cognitive Performance 20%
• Hormone Therapy 20%
• Estradiol Treatment 20%
• Brain Amyloid 20%
• Uterine Tissue 20%
• Patient Benefit 20%
• APPswe 20%
• APPswePS1dE9 20%
• Osmotic Pump 20%
• Systemic Impact 20%
• Peripheral Effects 20%
• Uterine Weight 20%

Pharmacology, Toxicology and Pharmaceutical Science

• Alzheimer's Disease 100%
• Mouse Model 100%
• Transgenic Mouse 100%
• Diethylstilbestrol 100%
• Prodrug 100%
• Neuroprotective Agent 16%
• Disease 16%
• Endocrine Therapy 16%
• Amyloid Precursor Protein 16%
• Amyloid Protein 16%

Neuroscience

• Alzheimer's Disease 100%
• Diethylstilbestrol 100%
• Prodrug 100%
• Neuroprotective Agent 16%
• Amyloid Precursor Protein 16%
• Hormone Therapy 16%
• Amyloid Protein 16%