A comparative analysis of two different sets of Y-chromosome short tandem repeats (Y-STRs) on a common population panel

Julie L. Maybruck, Erin Hanson, Jack Ballantyne, Bruce Budowle, Paul A. Fuerst

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

A comparative analysis of two Y-STR loci sets was conducted on a population sample of 224 individuals, 114 Caucasians and 110 African Americans. One set of loci, designated the OSU 10-locus set, comprises variable, single copy, male-specific loci that are dispersed across the Y-chromosome. Parallel evaluations were performed using the 10 Y-chromosome loci most frequently used for forensic analysis, the loci chosen as the SWGDAM Y-STR loci. The OSU 10-locus set had a greater average number of alleles per locus and higher average gene diversity than the SWGDAM loci. The OSU 10-locus set found 220 unique haplotypes in 224 individuals. In ∼6000 pairwise haplotype comparisons for each population with each set of loci, the OSU 10-locus set also yielded a greater average number of allelic differences per pair than the SWGDAM loci. Finally, the overall linkage disequilibrium levels were lower for the OSU 10-locus set in the Caucasian population. In general, the OSU 10-locus set revealed a higher power of discrimination than the SWGDAM set.

Original languageEnglish
Pages (from-to)11-20
Number of pages10
JournalForensic Science International: Genetics
Volume4
Issue number1
DOIs
StatePublished - 1 Jan 2009

Keywords

  • Forensic science
  • Microsatellites
  • Short tandem repeats
  • Y-STR
  • Y-chromosome

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