@article{abee7745f406457882af91c05c45e10d,
title = "A comparative analysis of two different sets of Y-chromosome short tandem repeats (Y-STRs) on a common population panel",
abstract = "A comparative analysis of two Y-STR loci sets was conducted on a population sample of 224 individuals, 114 Caucasians and 110 African Americans. One set of loci, designated the OSU 10-locus set, comprises variable, single copy, male-specific loci that are dispersed across the Y-chromosome. Parallel evaluations were performed using the 10 Y-chromosome loci most frequently used for forensic analysis, the loci chosen as the SWGDAM Y-STR loci. The OSU 10-locus set had a greater average number of alleles per locus and higher average gene diversity than the SWGDAM loci. The OSU 10-locus set found 220 unique haplotypes in 224 individuals. In ∼6000 pairwise haplotype comparisons for each population with each set of loci, the OSU 10-locus set also yielded a greater average number of allelic differences per pair than the SWGDAM loci. Finally, the overall linkage disequilibrium levels were lower for the OSU 10-locus set in the Caucasian population. In general, the OSU 10-locus set revealed a higher power of discrimination than the SWGDAM set.",
keywords = "Forensic science, Microsatellites, Short tandem repeats, Y-STR, Y-chromosome",
author = "Maybruck, {Julie L.} and Erin Hanson and Jack Ballantyne and Bruce Budowle and Fuerst, {Paul A.}",
note = "Funding Information: We would like to thank everyone in the States of Ohio and Virginia who provided samples for this study. We particularly appreciate the non-criminal samples provided by Dr. Roger Kahn, from the State of Ohio BCI laboratory. We value the contributions of Brian Mark who designed software for the pairwise comparison study and Dr. Laura Kubatko who conducted the statistical analysis which determined the significance of the pairwise comparison study. We are additionally grateful to Dr. Arthur HM Burghes, Dr. Thomas W Prior, and Dr. Amanda Simcox for discussion and editorial comments. We also appreciate the editorial comments of Dr. Lizhao Wu, Dr. Greg Booton, Dr. Roger Kahn and Judith S. Maybruck. We are thankful for the helpful comments and exchanges with the reviewers that improved the manuscript, especially with respect to DYS385. A research award from The Ohio State University supported this work. Portions of this work were supported under Award number 2005-MU-MU-K044 from the Office of Justice Programs, National Institute of Justice, Department of Justice. The points of view in this document are those of the authors and do not necessarily represent the official position of the U.S. Department of Justice. ",
year = "2009",
month = jan,
doi = "10.1016/j.fsigen.2009.03.004",
language = "English",
volume = "4",
pages = "11--20",
journal = "Forensic Science International: Genetics",
issn = "1872-4973",
publisher = "Elsevier Ireland Ltd",
number = "1",
}