A blood screening test for Alzheimer's disease

Sidney O'Bryant, Melissa Edwards, Leigh A. Johnson, James Hall, Alcibiades E. Villarreal, Gabrielle B. Britton, Mary Ellen Quiceno, C. Munro Cullum, Neill R. Graff-Radford

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Abstract

Introduction: This study combined data across four independent cohorts to examine the positive and negative predictive values of an Alzheimer's disease (AD) blood test if implemented in primary care. Methods: Blood samples from 1329 subjects from multiple independent, multiethnic, community-based, and clinic-based cohorts were analyzed. A "locked-down" referent group of 1128 samples was generated with 201 samples randomly selected for validation purposes. Random forest analyses were used to create the AD blood screen. Positive (PPV) and negative (NPV) predictive values were calculated. Results: In detecting AD, PPV was 0.81, and NPV was 0.95 while using the full AD blood test. When detecting mild cognitive impairment, PPV and NPV were 0.74 and 0.93, respectively. Preliminary analyses were conducted to detect any "neurodegenerative disease". The full 21-protein AD blood test yielded a PPV of 0.85 and NPV of 0.94. Discussion: The present study creates the first-ever multiethnic referent sample that spans community-based and clinic-based populations for implementation of an AD blood screen.

Original languageEnglish
Pages (from-to)83-90
Number of pages8
JournalAlzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Volume3
DOIs
StatePublished - 1 Jan 2016

Fingerprint

Hematologic Tests
Alzheimer Disease
Neurodegenerative Diseases
Primary Health Care
Population
Proteins

Keywords

  • Alzheimer's disease
  • Blood test
  • Diagnosis
  • Predictive power
  • Primary care
  • Screening

Cite this

O'Bryant, Sidney ; Edwards, Melissa ; Johnson, Leigh A. ; Hall, James ; Villarreal, Alcibiades E. ; Britton, Gabrielle B. ; Quiceno, Mary Ellen ; Cullum, C. Munro ; Graff-Radford, Neill R. / A blood screening test for Alzheimer's disease. In: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 2016 ; Vol. 3. pp. 83-90.
@article{5319275fb92b43579b25e155fa3dd568,
title = "A blood screening test for Alzheimer's disease",
abstract = "Introduction: This study combined data across four independent cohorts to examine the positive and negative predictive values of an Alzheimer's disease (AD) blood test if implemented in primary care. Methods: Blood samples from 1329 subjects from multiple independent, multiethnic, community-based, and clinic-based cohorts were analyzed. A {"}locked-down{"} referent group of 1128 samples was generated with 201 samples randomly selected for validation purposes. Random forest analyses were used to create the AD blood screen. Positive (PPV) and negative (NPV) predictive values were calculated. Results: In detecting AD, PPV was 0.81, and NPV was 0.95 while using the full AD blood test. When detecting mild cognitive impairment, PPV and NPV were 0.74 and 0.93, respectively. Preliminary analyses were conducted to detect any {"}neurodegenerative disease{"}. The full 21-protein AD blood test yielded a PPV of 0.85 and NPV of 0.94. Discussion: The present study creates the first-ever multiethnic referent sample that spans community-based and clinic-based populations for implementation of an AD blood screen.",
keywords = "Alzheimer's disease, Blood test, Diagnosis, Predictive power, Primary care, Screening",
author = "Sidney O'Bryant and Melissa Edwards and Johnson, {Leigh A.} and James Hall and Villarreal, {Alcibiades E.} and Britton, {Gabrielle B.} and Quiceno, {Mary Ellen} and Cullum, {C. Munro} and Graff-Radford, {Neill R.}",
year = "2016",
month = "1",
day = "1",
doi = "10.1016/j.dadm.2016.06.004",
language = "English",
volume = "3",
pages = "83--90",
journal = "Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring",
issn = "2352-8729",
publisher = "Elsevier BV",

}

A blood screening test for Alzheimer's disease. / O'Bryant, Sidney; Edwards, Melissa; Johnson, Leigh A.; Hall, James; Villarreal, Alcibiades E.; Britton, Gabrielle B.; Quiceno, Mary Ellen; Cullum, C. Munro; Graff-Radford, Neill R.

In: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, Vol. 3, 01.01.2016, p. 83-90.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - A blood screening test for Alzheimer's disease

AU - O'Bryant, Sidney

AU - Edwards, Melissa

AU - Johnson, Leigh A.

AU - Hall, James

AU - Villarreal, Alcibiades E.

AU - Britton, Gabrielle B.

AU - Quiceno, Mary Ellen

AU - Cullum, C. Munro

AU - Graff-Radford, Neill R.

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Introduction: This study combined data across four independent cohorts to examine the positive and negative predictive values of an Alzheimer's disease (AD) blood test if implemented in primary care. Methods: Blood samples from 1329 subjects from multiple independent, multiethnic, community-based, and clinic-based cohorts were analyzed. A "locked-down" referent group of 1128 samples was generated with 201 samples randomly selected for validation purposes. Random forest analyses were used to create the AD blood screen. Positive (PPV) and negative (NPV) predictive values were calculated. Results: In detecting AD, PPV was 0.81, and NPV was 0.95 while using the full AD blood test. When detecting mild cognitive impairment, PPV and NPV were 0.74 and 0.93, respectively. Preliminary analyses were conducted to detect any "neurodegenerative disease". The full 21-protein AD blood test yielded a PPV of 0.85 and NPV of 0.94. Discussion: The present study creates the first-ever multiethnic referent sample that spans community-based and clinic-based populations for implementation of an AD blood screen.

AB - Introduction: This study combined data across four independent cohorts to examine the positive and negative predictive values of an Alzheimer's disease (AD) blood test if implemented in primary care. Methods: Blood samples from 1329 subjects from multiple independent, multiethnic, community-based, and clinic-based cohorts were analyzed. A "locked-down" referent group of 1128 samples was generated with 201 samples randomly selected for validation purposes. Random forest analyses were used to create the AD blood screen. Positive (PPV) and negative (NPV) predictive values were calculated. Results: In detecting AD, PPV was 0.81, and NPV was 0.95 while using the full AD blood test. When detecting mild cognitive impairment, PPV and NPV were 0.74 and 0.93, respectively. Preliminary analyses were conducted to detect any "neurodegenerative disease". The full 21-protein AD blood test yielded a PPV of 0.85 and NPV of 0.94. Discussion: The present study creates the first-ever multiethnic referent sample that spans community-based and clinic-based populations for implementation of an AD blood screen.

KW - Alzheimer's disease

KW - Blood test

KW - Diagnosis

KW - Predictive power

KW - Primary care

KW - Screening

UR - http://www.scopus.com/inward/record.url?scp=84977649614&partnerID=8YFLogxK

U2 - 10.1016/j.dadm.2016.06.004

DO - 10.1016/j.dadm.2016.06.004

M3 - Article

VL - 3

SP - 83

EP - 90

JO - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring

JF - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring

SN - 2352-8729

ER -