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2019

Design, synthesis, and evaluation of N-(4-(4-phenyl piperazin-1-yl)butyl)-4-(thiophen-3-yl)benzamides as selective dopamine D3 receptor ligands

Chen, P. J., Taylor, M., Griffin, S. A., Amani, A., Hayatshahi, H., Korzekwa, K., Ye, M., Mach, R. H., Liu, J., Luedtke, R. R., Gordon, J. C. & Blass, B. E., 15 Sep 2019, In : Bioorganic and Medicinal Chemistry Letters. 29, 18, p. 2690-2694 5 p.

Research output: Contribution to journalArticle

Benzamides
Dopamine D3 Receptors
Pharmacokinetics
Dopamine Receptors
Substance-Related Disorders
1 Citation (Scopus)

Leveraging a Low-Affinity Diazaspiro Orthosteric Fragment to Reduce Dopamine D3 Receptor (D3R) Ligand Promiscuity across Highly Conserved Aminergic G-Protein-Coupled Receptors (GPCRs)

Reilly, S. W., Riad, A. A., Hsieh, C. J., Sahlholm, K., Jacome, D. A., Griffin, S., Taylor, M., Weng, C. C., Xu, K., Kirschner, N., Luedtke, R. R., Parry, C., Malhotra, S., Karanicolas, J. & Mach, R. H., 23 May 2019, In : Journal of Medicinal Chemistry. 62, 10, p. 5132-5147 16 p.

Research output: Contribution to journalArticle

Dopamine D3 Receptors
G-Protein-Coupled Receptors
Ligands
Adrenergic Agents
Pharmaceutical Preparations
Biochemistry
Dopamine Receptors
Cocaine
Animal Care Committees
Pharmacology
2018
5 Citations (Scopus)

Analogues of Arylamide Phenylpiperazine Ligands to Investigate the Factors Influencing D3 Dopamine Receptor Bitropic Binding and Receptor Subtype Selectivity

Hayatshahi, H. S., Xu, K., Griffin, S. A., Taylor, M., Mach, R. H., Liu, J. & Luedtke, R. R., 19 Dec 2018, In : ACS Chemical Neuroscience. 9, 12, p. 2972-2983 12 p.

Research output: Contribution to journalArticle

Dopamine D3 Receptors
Ligands
Dopamine D2 Receptors
Dopamine Receptors
Nitrogen
6 Citations (Scopus)
Positron emission tomography
Positron-Emission Tomography
Dopamine D2 Receptors
Dopamine
Dopamine D3 Receptors
13 Citations (Scopus)

Dissociation of striatal dopamine and tyrosine hydroxylase expression from aging-related motor decline: Evidence from calorie restriction intervention

Salvatore, M. F., Terrebonne, J., Cantu, M. A., McInnis, T. R., Venable, K., Kelley, P., Kasanga, E. A., Latimer, B., Owens, C. L., Pruett, B. S., Yu, Y., Luedtke, R., Forster, M. J., Sumien, N. & Ingram, D. K., 1 Jan 2018, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 73, 1, p. 11-20 10 p.

Research output: Contribution to journalArticle

Corpus Striatum
Tyrosine 3-Monooxygenase
Dopamine
Locomotion
Hypokinesia

Dopamine D3 receptor partial agonist LS-3-134 attenuates cocaine-motivated behaviors

Powell, G. L., Bonadonna, J. P., Vannan, A., Xu, K., Mach, R. H., Luedtke, R. R. & Neisewander, J. L., Dec 2018, In : Pharmacology Biochemistry and Behavior. 175, p. 123-129 7 p.

Research output: Contribution to journalArticle

Dopamine D3 Receptors
Cocaine
Reinforcement Schedule
Reinforcement
Locomotion
1 Citation (Scopus)

Dopamine D3 receptor partial agonist LS-3-134 attenuates cocaine-motivated behaviors

Powell, G. L., Bonadonna, J. P., Vannan, A., Xu, K., Mach, R. H., Luedtke, R. R. & Neisewander, J. L., Aug 2018, In : Pharmacology Biochemistry and Behavior. 171, p. 46-53 8 p.

Research output: Contribution to journalArticle

Dopamine D3 Receptors
Cocaine
Reinforcement Schedule
Reinforcement
Locomotion
2017

Dysregulated corticostriatal activity in open-field behavior and the head-twitch response induced by the hallucinogen 2,5-dimethoxy-4-iodoamphetamine

Rangel-Barajas, C., Estrada-Sánchez, A. M., Barton, S. J., Luedtke, R. T. & Rebec, G. V., 1 Feb 2017, In : Neuropharmacology. 113, p. 502-510 9 p.

Research output: Contribution to journalArticle

Hallucinogens
Head
Neurons
Motor Cortex
Amphetamine
5 Citations (Scopus)

Highly Selective Dopamine D3 Receptor Antagonists with Arylated Diazaspiro Alkane Cores

Reilly, S. W., Griffin, S., Taylor, M., Sahlholm, K., Weng, C. C., Xu, K., Jacome, D. A., Luedtke, R. R. & Mach, R. H., 14 Dec 2017, In : Journal of Medicinal Chemistry. 60, 23, p. 9905-9910 6 p.

Research output: Contribution to journalArticle

Dopamine D3 Receptors
Alkanes
Dopamine Antagonists
Ligands
2016
1 Citation (Scopus)

The effect of the sigma-1 receptor selective compound LS-1-137 on the DOI-induced head twitch response in mice

Malik, M., Rangel-Barajas, C., Mach, R. H. & Luedtke, R. R., 1 Sep 2016, In : Pharmacology Biochemistry and Behavior. 148, p. 136-144 9 p.

Research output: Contribution to journalArticle

Head
Receptor, Serotonin, 5-HT2C
sigma Receptors
sigma-1 receptor
N-(1-benzylpiperidin-4-yl)phenylacetamide