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2020

Overexpression of somatostatin receptor type 2 in neuroendocrine tumors for improved Ga68-DOTATATE imaging and treatment

Guenter, R., Aweda, T., Carmona Matos, D. M., Jang, S., Whitt, J., Cheng, Y. Q., Liu, X. M., Chen, H., Lapi, S. E. & Jaskula-Sztul, R., Jan 2020, In : Surgery (United States). 167, 1, p. 189-196 8 p.

Research output: Contribution to journalArticle

Neuroendocrine Tumors
Histone Deacetylase Inhibitors
Neuroendocrine Cells
Therapeutics
Tumor Cell Line
2019

Origin and bioactivities of thiosulfinated FK228

Liu, X., Currens, G. C., Xue, L. & Cheng, Y., 1 Jan 2019, In : MedChemComm. 10, 4, p. 538-542 5 p.

Research output: Contribution to journalArticle

Bioactivity
Silica Gel
Burkholderia
Histone Deacetylases
romidepsin

Pulmonary carcinoid surface receptor modulation using histone deacetylase inhibitors

Guenter, R. E., Aweda, T., Matos, D. M. C., Whitt, J., Chang, A. W., Cheng, E. Y., Liu, X. M., Chen, H., Lapi, S. E. & Jaskula-Sztul, R., Jun 2019, In : Cancers. 11, 6, 767.

Research output: Contribution to journalArticle

Open Access
Histone Deacetylase Inhibitors
Carcinoid Tumor
Lung
Somatostatin
Positron-Emission Tomography

The ADEP biosynthetic gene cluster in Streptomyces hawaiiensis NRRL 15010 reveals an accessory clpP gene as a novel antibiotic resistance factor

Thomy, D., Culp, E., Adamek, M., Cheng, E. Y., Ziemert, N., Wright, G. D., Sass, P. & Brötz-Oesterhelt, H., 1 Jan 2019, In : Applied and Environmental Microbiology. 85, 20, e01292-19.

Research output: Contribution to journalArticle

antibiotic resistance
R Factors
Streptomyces
Multigene Family
Microbial Drug Resistance
2018
6 Citations (Scopus)

Chromobacterium spp. mediate their anti-Plasmodium activity through secretion of the histone deacetylase inhibitor romidepsin

Saraiva, R. G., Huitt-Roehl, C. R., Tripathi, A., Cheng, Y. Q., Bosch, J., Townsend, C. A. & Dimopoulos, G., 1 Dec 2018, In : Scientific Reports. 8, 1, 6176.

Research output: Contribution to journalArticle

Chromobacterium
histone deacetylase
Plasmodium
secretion
antimalarials
3 Citations (Scopus)

Genomics-guided discovery of a new and significantly better source of anticancer natural drug FK228

Liu, X., Xie, F., Doughty, L. B., Wang, Q., Zhang, L., Liu, X. & Cheng, Y. Q., Dec 2018, In : Synthetic and Systems Biotechnology. 3, 4, p. 268-274 7 p.

Research output: Contribution to journalArticle

Genomics
Fermentation
Genes
Pharmaceutical Preparations
Bioreactors
2 Citations (Scopus)

Mechanistic studies of DepR in regulating FK228 biosynthesis in Chromobacterium violaceum no. 968

Qiao, Y., Tong, T., Xue, J., Lin, W., Deng, Z., Cheng, Y. Q. & Zhu, D., Apr 2018, In : PLoS ONE. 13, 4, e0196173.

Research output: Contribution to journalArticle

Chromobacterium
Chromobacterium violaceum
Biosynthesis
biosynthesis
Assays
2017
7 Citations (Scopus)

Developing new targeting strategy for androgen receptor variants in castration resistant prostate cancer

Wang, B., Lo, U. G., Wu, K., Kapur, P., Liu, X., Huang, J., Chen, W., Hernandez, E., Santoyo, J., Ma, S. H., Pong, R. C., He, D., Cheng, Y. Q. & Hsieh, J. T., 15 Nov 2017, In : International Journal of Cancer. 141, 10, p. 2121-2130 10 p.

Research output: Contribution to journalArticle

Castration
Androgen Receptors
Prostatic Neoplasms
RNA Splice Sites
Survival
6 Citations (Scopus)

Histone deacetylase inhibitor thailandepsin-A activates Notch signaling and suppresses neuroendocrine cancer cell growth in vivo

Jang, S., Janssen, A., Aburjania, Z., Robers, M. B., Harrison, A., Dammalapati, A., Cheng, Y. Q., Chen, H. & Jaskula-Sztul, R., 1 Jan 2017, In : Oncotarget. 8, 41, p. 70828-70840 13 p.

Research output: Contribution to journalArticle

Neuroendocrine Cells
Histone Deacetylase Inhibitors
Growth
Neoplasms
Protein Isoforms
2016
3 Citations (Scopus)

HDAC inhibitor-mediated epigenetic regulation of glaucoma-associated TGFβ2 in the trabecular meshwork

Bermudez, J. Y., Webber, H. C., Patel, G. C., Liu, X., Cheng, Y. Q., Clark, A. F. & Mao, W., Jul 2016, In : Investigative Ophthalmology and Visual Science. 57, 8, p. 3698-3707 10 p.

Research output: Contribution to journalArticle

Trabecular Meshwork
Histone Deacetylase Inhibitors
Epigenomics
Glaucoma
Acetylation
4 Citations (Scopus)
Burkholderia
Metabolic engineering
Metabolic Engineering
Fermentation
Purification
29 Citations (Scopus)

KE108-conjugated unimolecular micelles loaded with a novel HDAC inhibitor thailandepsin-A for targeted neuroendocrine cancer therapy

Chen, G., Jaskula-Sztul, R., Harrison, A., Dammalapati, A., Xu, W., Cheng, Y., Chen, H. & Gong, S., 1 Aug 2016, In : Biomaterials. 97, p. 22-33 12 p.

Research output: Contribution to journalArticle

Histone Deacetylase Inhibitors
Micelles
Neoplasms
Neuroendocrine Cells
Therapeutics
29 Citations (Scopus)

Thailandepsin A-loaded and octreotide-functionalized unimolecular micelles for targeted neuroendocrine cancer therapy

Jaskula-Sztul, R., Xu, W., Chen, G., Harrison, A., Dammalapati, A., Nair, R., Cheng, Y., Gong, S. & Chen, H., 1 Jun 2016, In : Biomaterials. 91, p. 1-10 10 p.

Research output: Contribution to journalArticle

Octreotide
Micelles
Neoplasms
Glycols
Bearings (structural)