Find Research Outputs

Search concepts
Selected Filters

Publication Year

  • 2020
  • 2019
  • 2018
  • 2017
  • 2016
  • 2015
  • 2014
  • 2013
  • 2012
  • 2011

Author

  • Yiqiang (Eric) Cheng
2020

Overexpression of somatostatin receptor type 2 in neuroendocrine tumors for improved Ga68-DOTATATE imaging and treatment

Guenter, R., Aweda, T., Carmona Matos, D. M., Jang, S., Whitt, J., Cheng, Y. Q., Liu, X. M., Chen, H., Lapi, S. E. & Jaskula-Sztul, R., Jan 2020, In : Surgery (United States). 167, 1, p. 189-196 8 p.

Research output: Contribution to journalArticle

2019

Origin and bioactivities of thiosulfinated FK228

Liu, X., Currens, G. C., Xue, L. & Cheng, Y. Q., 1 Jan 2019, In : MedChemComm. 10, 4, p. 538-542 5 p.

Research output: Contribution to journalArticle

Pulmonary carcinoid surface receptor modulation using histone deacetylase inhibitors

Guenter, R. E., Aweda, T., Matos, D. M. C., Whitt, J., Chang, A. W., Cheng, E. Y., Liu, X. M., Chen, H., Lapi, S. E. & Jaskula-Sztul, R., Jun 2019, In : Cancers. 11, 6, 767.

Research output: Contribution to journalArticle

Open Access

The ADEP biosynthetic gene cluster in Streptomyces hawaiiensis NRRL 15010 reveals an accessory clpP gene as a novel antibiotic resistance factor

Thomy, D., Culp, E., Adamek, M., Cheng, E. Y., Ziemert, N., Wright, G. D., Sass, P. & Brötz-Oesterhelt, H., 1 Jan 2019, In : Applied and Environmental Microbiology. 85, 20, e01292-19.

Research output: Contribution to journalArticle

2018

Chromobacterium spp. mediate their anti-Plasmodium activity through secretion of the histone deacetylase inhibitor romidepsin

Saraiva, R. G., Huitt-Roehl, C. R., Tripathi, A., Cheng, Y. Q., Bosch, J., Townsend, C. A. & Dimopoulos, G., 1 Dec 2018, In : Scientific Reports. 8, 1, 6176.

Research output: Contribution to journalArticle

6 Scopus citations

Genomics-guided discovery of a new and significantly better source of anticancer natural drug FK228

Liu, X., Xie, F., Doughty, L. B., Wang, Q., Zhang, L., Liu, X. & Cheng, Y. Q., Dec 2018, In : Synthetic and Systems Biotechnology. 3, 4, p. 268-274 7 p.

Research output: Contribution to journalArticle

4 Scopus citations

Mechanistic studies of DepR in regulating FK228 biosynthesis in Chromobacterium violaceum no. 968

Qiao, Y., Tong, T., Xue, J., Lin, W., Deng, Z., Cheng, Y. Q. & Zhu, D., Apr 2018, In : PLoS ONE. 13, 4, e0196173.

Research output: Contribution to journalArticle

2 Scopus citations
2017

Developing new targeting strategy for androgen receptor variants in castration resistant prostate cancer

Wang, B., Lo, U. G., Wu, K., Kapur, P., Liu, X., Huang, J., Chen, W., Hernandez, E., Santoyo, J., Ma, S. H., Pong, R. C., He, D., Cheng, Y. Q. & Hsieh, J. T., 15 Nov 2017, In : International Journal of Cancer. 141, 10, p. 2121-2130 10 p.

Research output: Contribution to journalArticle

9 Scopus citations

Histone deacetylase inhibitor thailandepsin-A activates Notch signaling and suppresses neuroendocrine cancer cell growth in vivo

Jang, S., Janssen, A., Aburjania, Z., Robers, M. B., Harrison, A., Dammalapati, A., Cheng, Y. Q., Chen, H. & Jaskula-Sztul, R., 1 Jan 2017, In : Oncotarget. 8, 41, p. 70828-70840 13 p.

Research output: Contribution to journalArticle

6 Scopus citations
2016

HDAC inhibitor-mediated epigenetic regulation of glaucoma-associated TGFβ2 in the trabecular meshwork

Bermudez, J. Y., Webber, H. C., Patel, G. C., Liu, X., Cheng, Y. Q., Clark, A. F. & Mao, W., Jul 2016, In : Investigative Ophthalmology and Visual Science. 57, 8, p. 3698-3707 10 p.

Research output: Contribution to journalArticle

3 Scopus citations
4 Scopus citations

KE108-conjugated unimolecular micelles loaded with a novel HDAC inhibitor thailandepsin-A for targeted neuroendocrine cancer therapy

Chen, G., Jaskula-Sztul, R., Harrison, A., Dammalapati, A., Xu, W., Cheng, Y., Chen, H. & Gong, S., 1 Aug 2016, In : Biomaterials. 97, p. 22-33 12 p.

Research output: Contribution to journalArticle

30 Scopus citations

Thailandepsin A-loaded and octreotide-functionalized unimolecular micelles for targeted neuroendocrine cancer therapy

Jaskula-Sztul, R., Xu, W., Chen, G., Harrison, A., Dammalapati, A., Nair, R., Cheng, Y., Gong, S. & Chen, H., 1 Jun 2016, In : Biomaterials. 91, p. 1-10 10 p.

Research output: Contribution to journalArticle

31 Scopus citations
2015

Determination of thailandepsin B in rat plasma with a LC-MS/MS method

Cheng, Z., Ding, L., Zhang, Y., Chen, G., Chen, C., Cheng, Y. Q. & Jiang, H., 1 Jan 2015, In : Bioanalysis. 7, 1, p. 39-52 14 p.

Research output: Contribution to journalArticle

4 Scopus citations

Disulfide cross-linked micelles of novel HDAC inhibitor thailandepsin A for the treatment of breast cancer

Xiao, K., Li, Y. P., Wang, C., Ahmad, S., Vu, M., Kuma, K., Cheng, Y. Q. & Lam, K. S., 1 Oct 2015, In : Biomaterials. 67, p. 183-193 11 p.

Research output: Contribution to journalArticle

19 Scopus citations

Minimum Information about a Biosynthetic Gene cluster

Medema, M. H., Kottmann, R., Yilmaz, P., Cummings, M., Biggins, J. B., Blin, K., De Bruijn, I., Chooi, Y. H., Claesen, J., Coates, R. C., Cruz-Morales, P., Duddela, S., Düsterhus, S., Edwards, D. J., Fewer, D. P., Garg, N., Geiger, C., Gomez-Escribano, J. P., Greule, A., Hadjithomas, M. & 134 others, Haines, A. S., Helfrich, E. J. N., Hillwig, M. L., Ishida, K., Jones, A. C., Jones, C. S., Jungmann, K., Kegler, C., Kim, H. U., Kötter, P., Krug, D., Masschelein, J., Melnik, A. V., Mantovani, S. M., Monroe, E. A., Moore, M., Moss, N., Nützmann, H. W., Pan, G., Pati, A., Petras, D., Reen, F. J., Rosconi, F., Rui, Z., Tian, Z., Tobias, N. J., Tsunematsu, Y., Wiemann, P., Wyckoff, E., Yan, X., Yim, G., Yu, F., Xie, Y., Aigle, B., Apel, A. K., Balibar, C. J., Balskus, E. P., Barona-Gómez, F., Bechthold, A., Bode, H. B., Borriss, R., Brady, S. F., Brakhage, A. A., Caffrey, P., Cheng, Y. Q., Clardy, J., Cox, R. J., De Mot, R., Donadio, S., Donia, M. S., Van Der Donk, W. A., Dorrestein, P. C., Doyle, S., Driessen, A. J. M., Ehling-Schulz, M., Entian, K. D., Fischbach, M. A., Gerwick, L., Gerwick, W. H., Gross, H., Gust, B., Hertweck, C., Höfte, M., Jensen, S. E., Ju, J., Katz, L., Kaysser, L., Klassen, J. L., Keller, N. P., Kormanec, J., Kuipers, O. P., Kuzuyama, T., Kyrpides, N. C., Kwon, H. J., Lautru, S., Lavigne, R., Lee, C. Y., Linquan, B., Liu, X., Liu, W., Luzhetskyy, A., Mahmud, T., Mast, Y., Méndez, C., Metsä-Ketelä, M., Micklefield, J., Mitchell, D. A., Moore, B. S., Moreira, L. M., Müller, R., Neilan, B. A., Nett, M., Nielsen, J., O'Gara, F., Oikawa, H., Osbourn, A., Osburne, M. S., Ostash, B., Payne, S. M., Pernodet, J. L., Petricek, M., Piel, J., Ploux, O., Raaijmakers, J. M., Salas, J. A., Schmitt, E. K., Scott, B., Seipke, R. F., Shen, B., Sherman, D. H., Sivonen, K., Smanski, M. J., Sosio, M., Stegmann, E., Süssmuth, R. D., Tahlan, K., Thomas, C. M., Tang, Y., Truman, A. W., Viaud, M., Walton, J. D., Walsh, C. T., Weber, T., Van Wezel, G. P., Wilkinson, B., Willey, J. M., Wohlleben, W., Wright, G. D., Ziemert, N., Zhang, C., Zotchev, S. B., Breitling, R., Takano, E. & Glöckner, F. O., 18 Aug 2015, In : Nature Chemical Biology. 11, 9, p. 625-631 7 p.

Research output: Contribution to journalReview article

287 Scopus citations

Production of Thailandepsin a from burkholderia thailandensis E264/pBMTL3-tdpR fermentation

Hui, J. Y., Wang, W., Cheng, Y. Q. & Zhang, X. H., 1 Jun 2015, In : Gao Xiao Hua Xue Gong Cheng Xue Bao/Journal of Chemical Engineering of Chinese Universities. 29, 3, p. 593-599 7 p.

Research output: Contribution to journalArticle

Target engagement and drug residence time can be observed in living cells with BRET

Robers, M. B., Dart, M. L., Woodroofe, C. C., Zimprich, C. A., Kirkland, T. A., Machleidt, T., Kupcho, K. R., Levin, S., Hartnett, J. R., Zimmerman, K., Niles, A. L., Ohana, R. F., Daniels, D. L., Slater, M., Wood, M. G., Cong, M., Cheng, Y. Q. & Wood, K. V., 3 Dec 2015, In : Nature Communications. 6, 10091.

Research output: Contribution to journalArticle

92 Scopus citations
2014

Genome-guided discovery of diverse natural products from Burkholderia sp.

Liu, X. & Cheng, Y. Q., 1 Feb 2014, In : Journal of Industrial Microbiology and Biotechnology. 41, 2, p. 275-284 10 p.

Research output: Contribution to journalReview article

40 Scopus citations
4 Scopus citations

The novel histone deacetylase inhibitor thailandepsin A inhibits anaplastic thyroid cancer growth

Weinlander, E., Somnay, Y., Harrison, A. D., Wang, C., Cheng, Y. Q., Jaskula-Sztul, R., Yu, X. M. & Chen, H., Jul 2014, In : Journal of Surgical Research. 190, 1, p. 191-197 7 p.

Research output: Contribution to journalArticle

19 Scopus citations

The structural basis of an NADP+-independent dithiol oxidase in FK228 biosynthesis

Li, J., Wang, C., Zhang, Z. M., Cheng, Y. Q. & Zhou, J., 20 Feb 2014, In : Scientific Reports. 4, 4145.

Research output: Contribution to journalArticle

7 Scopus citations
2013

Activation of ClpP protease by ADEP antibiotics: Insights from hydrogen exchange mass spectrometry

Sowole, M. A., Alexopoulos, J. A., Cheng, Y. Q., Ortega, J. & Konermann, L., 15 Nov 2013, In : Journal of Molecular Biology. 425, 22, p. 4508-4519 12 p.

Research output: Contribution to journalArticle

27 Scopus citations

Effects of thailanstatins on glucocorticoid response in trabecular meshwork and steroid-induced glaucoma

Jain, A., Liu, X., Wordinger, R. J., Yorio, T., Cheng, Y. Q. & Clark, A. F., 10 May 2013, In : Investigative Ophthalmology and Visual Science. 54, 5, p. 3137-3142 6 p.

Research output: Contribution to journalArticle

11 Scopus citations

Genomics-guided discovery of thailanstatins A, B, and C as pre-mRNA splicing inhibitors and antiproliferative agents from Burkholderia thailandensis MSMB43

Liu, X., Biswas, S., Berg, M. G., Antapli, C. M., Xie, F., Wang, Q., Tang, M. C., Tang, G. L., Zhang, L., Dreyfuss, G. & Cheng, Y. Q., 26 Apr 2013, In : Journal of Natural Products. 76, 4, p. 685-693 9 p.

Research output: Contribution to journalArticle

72 Scopus citations

Inactivation of cyclic di-GMP binding protein TDE0214 affects the motility, biofilm formation, and virulence of Treponema denticola

Bian, J., Liu, X., Cheng, Y. Q. & Li, C., 11 Sep 2013, In : Journal of Bacteriology. 195, 17, p. 3897-3905 9 p.

Research output: Contribution to journalArticle

25 Scopus citations

Isolation and characterization of spliceostatin B, a new analogue of FR901464, from Pseudomonas sp. No. 2663

Liu, X., Biswas, S., Tang, G. L. & Cheng, Y. Q., 1 Sep 2013, In : Journal of Antibiotics. 66, 9, p. 555-558 4 p.

Research output: Contribution to journalArticle

14 Scopus citations

Structural determinants stabilizing the axial channel of ClpP for substrate translocation

Alexopoulos, J., Ahsan, B., Homchaudhuri, L., Husain, N., Cheng, Y. Q. & Ortega, J., 1 Oct 2013, In : Molecular Microbiology. 90, 1, p. 167-180 14 p.

Research output: Contribution to journalArticle

13 Scopus citations
2012

Cyclo(-l-prolyl-l-valinyl-) from Burkholderia thailandensis MSMB43

Liu, X. Y., Wang, C. & Cheng, Y. Q., 1 Nov 2012, In : Acta Crystallographica Section E: Structure Reports Online. 68, 11, p. o3182-o3183

Research output: Contribution to journalArticle

1 Scopus citations

Discovery and activity profiling of thailandepsins A through F, potent histone deacetylase inhibitors, from Burkholderia thailandensis E264

Wang, C., Flemming, C. J. & Cheng, Y. Q., Aug 2012, In : MedChemComm. 3, 8, p. 976-981 6 p.

Research output: Contribution to journalArticle

28 Scopus citations
8 Scopus citations

FK228 from Burkholderia thailandensis MSMB43

Liu, X. Y., Wang, C. & Cheng, Y., 1 Sep 2012, In : Acta Crystallographica Section E: Structure Reports Online. 68, 9

Research output: Contribution to journalArticle

6 Scopus citations

Revised genome sequence of Burkholderia thailandensis MSMB43 with improved annotation

Zhuo, Y., Liu, L., Wang, Q., Liu, X., Ren, B., Liu, M., Ni, P., Cheng, Y. Q. & Zhang, L., 1 Sep 2012, In : Journal of Bacteriology. 194, 17, p. 4749-4750 2 p.

Research output: Contribution to journalComment/debate

12 Scopus citations
22 Scopus citations
2011

Activators of Cylindrical Proteases as Antimicrobials: Identification and Development of Small Molecule Activators of ClpP Protease

Leung, E., Datti, A., Cossette, M., Goodreid, J., McCaw, S. E., Mah, M., Nakhamchik, A., Ogata, K., El Bakkouri, M., Cheng, Y. Q., Wodak, S. J., Eger, B. T., Pai, E. F., Liu, J., Gray-Owen, S., Batey, R. A. & Houry, W. A., 23 Sep 2011, In : Chemistry and Biology. 18, 9, p. 1167-1178 12 p.

Research output: Contribution to journalArticle

45 Scopus citations

Biosynthesis of himastatin: Assembly line and characterization of three cytochrome P450 enzymes involved in the post-tailoring oxidative steps

Ma, J., Wang, Z., Huang, H., Luo, M., Zuo, D., Wang, B., Sun, A., Cheng, Y. Q., Zhang, C. & Ju, J., 16 Aug 2011, In : Angewandte Chemie - International Edition. 50, 34, p. 7797-7802 6 p.

Research output: Contribution to journalArticle

48 Scopus citations

New insights into the genetic organization of the FK228 biosynthetic gene cluster in chromobacterium violaceum No. 968

Potharla, V. Y., Wesener, S. R. & Cheng, Y. Q., Feb 2011, In : Applied and Environmental Microbiology. 77, 4, p. 1508-1511 4 p.

Research output: Contribution to journalArticle

14 Scopus citations

Reconstitution of the FK228 biosynthetic pathway reveals cross talk between modular polyketide synthases and fatty acid synthase

Wesener, S. R., Potharla, V. Y. & Cheng, Y. Q., 1 Feb 2011, In : Applied and Environmental Microbiology. 77, 4, p. 1501-1507 7 p.

Research output: Contribution to journalArticle

25 Scopus citations

Thailandepsin A

Wang, C. & Cheng, Y. Q., 1 Nov 2011, In : Acta Crystallographica Section E: Structure Reports Online. 67, 11, p. o2948-o2949

Research output: Contribution to journalArticle

5 Scopus citations

Thailandepsins: Bacterial products with potent histone deacetylase inhibitory activities and broad-spectrum antiproliferative activities

Wang, C., Henkes, L. M., Doughty, L. B., He, M., Wang, D., Meyer-Almes, F. J. & Cheng, Y. Q., 28 Oct 2011, In : Journal of Natural Products. 74, 10, p. 2031-2038 8 p.

Research output: Contribution to journalArticle

80 Scopus citations