Find Research Outputs

2018

2 Citations (Scopus)

Cataract Preventive Role of Isolated Phytoconstituents: Findings from a Decade of Research

Lim, V., Schneider, E., Wu, H. & Pang, I. H., 26 Oct 2018, In : Nutrients. 10, 11

Research output: Contribution to journal › Review article

chemical constituents of plants

cataract

Cataract

Research

eye lens

2 Citations (Scopus)

Central Sensitization: A Brief Overview

Gatchel, R. J. & Neblett, R., 1 Jun 2018, In : Journal of Applied Biobehavioral Research. 23, 2, e12138.

Research output: Contribution to journal › Article

Central Nervous System Sensitization

sensitization

Chronic Pain

pain

Somatoform Disorders

10 Citations (Scopus)

Cerebral ischemia induces angiogenesis in the peri-infarct regions via Notch1 signaling activation

Ren, C., Yao, Y., Han, R., Huang, Q., Li, H., Wang, B., Li, S., Li, M., Mao, Y., Mao, X., Xie, L., Zhou, L., Hu, J., Ji, X. & Jin, K., Jun 2018, In : Experimental Neurology. 304, p. 30-40 11 p.

Research output: Contribution to journal › Article

Brain Ischemia

Stroke

Brain

Ischemia

Lentivirus

52 Citations (Scopus)

Cerebrospinal fluid and blood biomarkers for neurodegenerative dementias: An update of the Consensus of the Task Force on Biological Markers in Psychiatry of the World Federation of Societies of Biological Psychiatry

on Behalf of the Members of the WFSBP Task Force Working on this Topic: Peter Riederer, Carla Gallo, Dimitrios Kapogiannis, Andrea Lopez Mato, Florence Thibaut, 19 May 2018, In : World Journal of Biological Psychiatry. 19, 4, p. 244-328 85 p.

Research output: Contribution to journal › Review article

Biological Psychiatry

Advisory Committees

Psychiatry

Cerebrospinal Fluid

Dementia

7 Citations (Scopus)

Ceruloplasmin, a Potential Therapeutic Agent for Alzheimer's Disease

Zhao, Y. S., Zhang, L. H., Yu, P. P., Gou, Y. J., Zhao, J., You, L. H., Wang, Z. Y., Zheng, X., Yan, L-J., Yu, P. & Chang, Y. Z., 10 May 2018, In : Antioxidants and Redox Signaling. 28, 14, p. 1323-1337 15 p.

Research output: Contribution to journal › Article

Ceruloplasmin

Alzheimer Disease

Therapeutics

Iron

Hippocampus

Challenges in investigation of diabetes-related aviation fatalities—an analysis of 1491 subsequent aviation fatalities in USA during 2011–2016

Junttila, I. S., Vuorio, A., Budowle, B., Laukkala, T. & Sajantila, A., 1 Nov 2018, In : International journal of legal medicine. 132, 6, p. 1713-1718 6 p.

Research output: Contribution to journal › Article

Aviation

Diabetes Mellitus

Glucose

Diabetes Complications

Hypoglycemia

6 Citations (Scopus)

Challenges in the development of dopamine D2- and D3-selective radiotracers for PET imaging studies

Mach, R. H. & Luedtke, R. T., 1 Mar 2018, In : Journal of Labelled Compounds and Radiopharmaceuticals. 61, 3, p. 291-298 8 p.

Research output: Contribution to journal › Article

Positron emission tomography

Positron-Emission Tomography

Dopamine D2 Receptors

Dopamine

Dopamine D3 Receptors

Changes in ganglioside GM1 expression in glaucomic retina

Pappenhagen, N. & Inman, D. M., 1 Oct 2018, In : Journal of Neuroscience Research. 96, 10, p. 1627-1630 4 p.

Research output: Contribution to journal › Letter

G(M1) Ganglioside

Retina

5 Citations (Scopus)

Changes in HPV Knowledge Among College Women from 2008 to 2015

Thompson, E. L., Vamos, C. A., Griner, S. B. & Daley, E. M., 1 Apr 2018, In : Journal of Cancer Education. 33, 2, p. 278-283 6 p.

Research output: Contribution to journal › Article

Papillomavirus Vaccines

Condylomata Acuminata

Young Adult

Vaccination

Vaccines

1 Citation (Scopus)

Characteristic patterns of inter- and intra-hemispheric metabolic connectivity in patients with stable and progressive mild cognitive impairment and Alzheimer’s disease

For the Alzheimer’s Disease Neuroimaging Initiative, 1 Dec 2018, In : Scientific Reports. 8, 1, 13807.

Research output: Contribution to journal › Article

Alzheimer Disease

Metabolic Networks and Pathways

Brain

Fluorodeoxyglucose F18

Occipital Lobe

2 Citations (Scopus)

Characteristics of cognitively normal Mexican-Americans with cognitive complaints

Hall, J., Wiechmann, A. R., Johnson, L. A., Edwards, M. & O'Bryant, S., 1 Jan 2018, In : Journal of Alzheimer's Disease. 61, 4, p. 1485-1492 8 p.

Research output: Contribution to journal › Article

Affective Symptoms

Research

Proteomics

Cognition

Population

11 Citations (Scopus)

Characterization of the neurochemical and behavioral effects of solriamfetol (JZP-110), a selective dopamine and norepinephrine reuptake inhibitor

Baladi, M. G., Forster, M. J., Gatch, M. B., Mailman, R. B., Hyman, D. L., Carter, L. P. & Janowsky, A., 1 Aug 2018, In : Journal of Pharmacology and Experimental Therapeutics. 366, 2, p. 367-376 10 p.

Research output: Contribution to journal › Article

Dopamine Uptake Inhibitors

Narcolepsy

Obstructive Sleep Apnea

Inhibitory Concentration 50

Norepinephrine

4 Citations (Scopus)

Children’s healthy eating habits and parents’ socio-demographic characteristics in rural Texas, USA

Chen, X., Cisse-Egbuonye, N., Spears, E. C., Mkuu, R. & McKyer, E. L. J., 1 Jun 2018, In : Health Education Journal. 77, 4, p. 444-457 14 p.

Research output: Contribution to journal › Article

Feeding Behavior

Parents

Demography

Hispanic Americans

Food

5 Citations (Scopus)

Chromobacterium spp. mediate their anti-Plasmodium activity through secretion of the histone deacetylase inhibitor romidepsin

Saraiva, R. G., Huitt-Roehl, C. R., Tripathi, A., Cheng, Y. Q., Bosch, J., Townsend, C. A. & Dimopoulos, G., 1 Dec 2018, In : Scientific Reports. 8, 1, 6176.

Research output: Contribution to journal › Article

Chromobacterium

histone deacetylase

Plasmodium

secretion

antimalarials

2 Citations (Scopus)

Chronic benzodiazepine suppresses translocator protein and elevates amyloid β in mice

Tan, S., Metzger, D. B. & Jung, E., 1 Sep 2018, In : Pharmacology Biochemistry and Behavior. 172, p. 59-67 9 p.

Research output: Contribution to journal › Article

Amyloidogenic Proteins

Presenilin-1

Benzodiazepines

Neprilysin

Membranes

6 Citations (Scopus)

Chronic intermittent hypoxia induces hormonal and male sexual behavioral changes: Hypoxia as an advancer of aging

Wilson, E. N., Anderson, M., Snyder, B., Duong, P., Trieu, J., Schreihofer, D. & Cunningham, R. L., 15 May 2018, In : Physiology and Behavior. 189, p. 64-73 10 p.

Research output: Contribution to journal › Article

Sleep Apnea Syndromes

Oxidative Stress

Testosterone

Sexual Behavior

Hypoxia

6 Citations (Scopus)

CLARITY for high-resolution imaging and quantification of vasculature in the whole mouse brain

Zhang, L. Y., Lin, P., Pan, J., Ma, Y., Wei, Z., Jiang, L., Wang, L., Song, Y., Wang, Y., Zhang, Z., Jin, K., Wang, Q. & Yang, G. Y., 1 Apr 2018, In : Aging and Disease. 9, 2, p. 262-272 11 p.

Research output: Contribution to journal › Article

Blood Vessels

Brain

Three-Dimensional Imaging

Middle Cerebral Artery Infarction

Normal Distribution

3 Citations (Scopus)

College Students’ Underestimation of Blood Alcohol Concentration from Hypothetical Consumption of Supersized Alcopops: Results from a Cluster-Randomized Classroom Study

Rossheim, M. E., Thombs, D. L., Krall, J. R. & Jernigan, D. H., 1 Jul 2018, In : Alcoholism: Clinical and Experimental Research. 42, 7, p. 1271-1280 10 p.

Research output: Contribution to journal › Article

Blood

Alcohols

Students

Beer

Beverages

7 Citations (Scopus)

Combined measurement of plasma cystatin C and low-density lipoprotein cholesterol: A valuable tool for evaluating progressive supranuclear palsy

Weng, R., Wei, X., Yu, B., Zhu, S., Yang, X., Xie, F., Zhang, M., Jiang, Y., Feng, Z. P., Sun, H. S., Xia, Y., Jin, K., Chan, P., Wang, Q. & Gao, X., 1 Jul 2018, In : Parkinsonism and Related Disorders. 52, p. 37-42 6 p.

Research output: Contribution to journal › Article

Progressive Supranuclear Palsy

Cystatin C

LDL Cholesterol

Healthy Volunteers

Parkinsonian Disorders

7 Citations (Scopus)

Comparative tolerance of two massively parallel sequencing systems to common PCR inhibitors

Elwick, K., Zeng, X., King, J., Budowle, B. & Hughes-Stamm, S., 1 Jul 2018, In : International journal of legal medicine. 132, 4, p. 983-995 13 p.

Research output: Contribution to journal › Article

High-Throughput Nucleotide Sequencing

Hemin

Melanins

Polymerase Chain Reaction

Microsatellite Repeats

Complementing T Regulatory Cells to Combat Hypertension

Mathis, K. W., 30 Mar 2018, In : Circulation Research. 122, 7, p. 911-912 2 p.

Research output: Contribution to journal › Review article

Regulatory T-Lymphocytes

Hypertension

9 Citations (Scopus)

Consensus recommendations for trabecular meshwork cell isolation, characterization and culture

Keller, K. E., Bhattacharya, S. K., Borrás, T., Brunner, T. M., Chansangpetch, S., Clark, A., Dismuke, W. M., Du, Y., Elliott, M. H., Ethier, C. R., Faralli, J. A., Freddo, T. F., Fuchshofer, R., Giovingo, M., Gong, H., Gonzalez, P., Huang, A., Johnstone, M. A., Kaufman, P. L., Kelley, M. J. & 37 others, Knepper, P. A., Kopczynski, C. C., Kuchtey, J. G., Kuchtey, R. W., Kuehn, M. H., Lieberman, R. L., Lin, S. C., Liton, P., Liu, Y., Lütjen-Drecoll, E., Mao, W., Masis-Solano, M., McDonnell, F., McDowell, C. M., Overby, D. R., Pattabiraman, P. P., Raghunathan, V. K., Rao, P. V., Rhee, D. J., Chowdhury, U. R., Russell, P., Samples, J. R., Schwartz, D., Stubbs, E. B., Tamm, E. R., Tan, J. C., Toris, C. B., Torrejon, K. Y., Vranka, J. A., Wirtz, M. K., Yorio, T., Zhang, J., Zode, G., Fautsch, M. P., Peters, D. M., Acott, T. S. & Stamer, W. D., 1 Jun 2018, In : Experimental eye research. 171, p. 164-173 10 p.

Research output: Contribution to journal › Short survey

Trabecular Meshwork

Cell Separation

Cell Culture Techniques

Ocular Hypertension

Intraocular Pressure

1 Citation (Scopus)

Consideration of future consequences as a moderator of the willingness-behavior relationship for young adult marijuana use and consequences

Lewis, M. A., Litt, D. M., King, K. M., Garcia, T. A., Waldron, K. A. & Lee, C. M., 1 Dec 2018, In : Addictive Behaviors. 87, p. 8-16 9 p.

Research output: Contribution to journal › Article

Moderators

Cannabis

Young Adult

Health risks

Risk-Taking

2 Citations (Scopus)

Constitutive Ret signaling leads to long-lasting expression of amphetamine-induced place conditioning via elevation of mesolimbic dopamine

Kopra, J., Villarta-Aguilera, M., Savolainen, M., Weingerl, S., Myöhänen, T. T., Rannanpää, S., Salvatore, M. F., Andressoo, J. O. & Piepponen, T. P., 1 Jan 2018, In : Neuropharmacology. 128, p. 221-230 10 p.

Research output: Contribution to journal › Article

Glial Cell Line-Derived Neurotrophic Factor

Amphetamine

Dopamine

Dopaminergic Neurons

Tyrosine 3-Monooxygenase

2 Citations (Scopus)

Continuous Infusion Nonsteroidal Anti-Inflammatory Drugs for Perioperative Pain Management

Howard, M., Isaacs, A. N. & Nisly, S. A., 1 Feb 2018, In : Journal of Pharmacy Practice. 31, 1, p. 66-81 16 p.

Research output: Contribution to journal › Review article

Pain Management

Anti-Inflammatory Agents

Pharmaceutical Preparations

Pain

Ketorolac

2 Citations (Scopus)

Contraceptive Use Effectiveness and Pregnancy Prevention Information Preferences Among Heterosexual and Sexual Minority College Women

Blunt-Vinti, H. D., Thompson, E. L. & Griner, S. B., 1 Jul 2018, In : Women's Health Issues. 28, 4, p. 342-349 8 p.

Research output: Contribution to journal › Article

Heterosexuality

Contraceptive Agents

contraceptive

pregnancy

minority

3 Citations (Scopus)

Copycats in pilot aircraft-assisted suicides after the germanwings incident

Laukkala, T., Vuorio, A., Bor, R., Budowle, B., Navathe, P., Pukkala, E. & Sajantila, A., 11 Mar 2018, In : International Journal of Environmental Research and Public Health. 15, 3, 491.

Research output: Contribution to journal › Article

Assisted Suicide

Aircraft

Databases

Safety

Suicide

1 Citation (Scopus)

Core Entrustable Professional Activities in Clinical Pharmacology for Entering Residency: Value of Interprofessional Health-Care Teams in Medication Prescribing and Medication Error Prevention

Cohen, L. J., Donnenberg, V. S., Wiernik, P. H., Newman, W. C. & Amankulor, N., 1 Jul 2018, In : Journal of Clinical Pharmacology. 58, 7, p. 843-848 6 p.

Research output: Contribution to journal › Article

Medication Errors

Patient Care Team

Clinical Pharmacology

Patient Safety

Internship and Residency

Correction to: Long-Acting Injectable Second-Generation Antipsychotics: An Update and Comparison Between Agents (CNS Drugs, (2018), 32, 3, (241-257), 10.1007/s40263-018-0508-6)

Jann, M. W. & Penzak, S. R., 1 Jun 2018, In : CNS Drugs. 32, 6, 1 p.

Research output: Contribution to journal › Comment/debate

Antipsychotic Agents

Injections

Pharmaceutical Preparations

Schizophrenia

Pharmacokinetics

Cost and cost-effectiveness of computerized vs. in-person motivational interventions in the criminal justice system

Cowell, A. J., Zarkin, G. A., Wedehase, B. J., Lerch, J., Walters, S. T. & Taxman, F. S., 1 Apr 2018, In : Journal of Substance Abuse Treatment. 87, p. 42-49 8 p.

Research output: Contribution to journal › Article

Criminal Law

Motivational Interviewing

Cost-Benefit Analysis

Costs and Cost Analysis

Health Care Costs

Creatine, creatine kinase, and aging

Sumien, N., Shetty, R. A. & Gonzales, E. B., 1 Jan 2018, Subcellular Biochemistry. Springer New York, p. 145-168 24 p. (Subcellular Biochemistry; vol. 90).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Creatine

Creatine Kinase

Aging of materials

Dietary supplements

Physiology

3 Citations (Scopus)

CRHR2 (corticotropin-releasing hormone receptor 2) in the nucleus of the solitary tract contributes to intermittent hypoxia-induced hypertension

Wang, L. A., Nguyen, D. H. & Mifflin, S. W., 1 Jan 2018, In : Hypertension. 72, 4, p. 994-1001 8 p.

Research output: Contribution to journal › Article

Corticotropin-Releasing Hormone Receptors

Solitary Nucleus

Hypertension

Calcium

Urocortins

3 Citations (Scopus)

Criminal Justice System Involvement Among Homeless Adults

Gonzalez, J. R., Jetelina, K. K., Roberts, M., Reitzel, L. R., Kendzor, D., Walters, S. T. & Businelle, M. S., 1 Jun 2018, In : American Journal of Criminal Justice. 43, 2, p. 158-166 9 p.

Research output: Contribution to journal › Article

justice

offense

housing

drug

history

3 Citations (Scopus)

CRISPR deletion of MIEN1 in breast cancer cells

Van Treuren, T. & Vishwanatha, J. K., Oct 2018, In : PLoS ONE. 13, 10, e0204976.

Research output: Contribution to journal › Article

Clustered Regularly Interspaced Short Palindromic Repeats

breast neoplasms

Genes

Cells

Breast Neoplasms

33 Citations (Scopus)

Current state of Alzheimer’s fluid biomarkers

Molinuevo, J. L., Ayton, S., Batrla, R., Bednar, M. M., Bittner, T., Cummings, J., Fagan, A. M., Hampel, H., Mielke, M. M., Mikulskis, A., O’Bryant, S., Scheltens, P., Sevigny, J., Shaw, L. M., Soares, H. D., Tong, G., Trojanowski, J. Q., Zetterberg, H. & Blennow, K., 1 Jan 2018, (Accepted/In press) In : Acta Neuropathologica.

Research output: Contribution to journal › Article

Alzheimer Disease

Biomarkers

Patient Selection

Cerebrospinal Fluid

Neurogranin

10 Citations (Scopus)

Current state-of-art of STR sequencing in forensic genetics

Alonso, A., Barrio, P. A., Müller, P., Köcher, S., Berger, B., Martin, P., Bodner, M., Willuweit, S., Parson, W., Roewer, L. & Budowle, B., 1 Nov 2018, In : Electrophoresis. 39, 21, p. 2655-2668 14 p.

Research output: Contribution to journal › Review article

Forensic Genetics

High-Throughput Nucleotide Sequencing

Terminology

Standardization

Commercial Catalogs

59 Citations (Scopus)

Current strategies for brain drug delivery

Dong, X., 1 Jan 2018, In : Theranostics. 8, 6, p. 1481-1493 13 p.

Research output: Contribution to journal › Review article

Blood-Brain Barrier

Brain

Pharmaceutical Preparations

Nanoparticles

Multiple Sclerosis

1 Citation (Scopus)

Decomposing Pearson's χ² test: A linear regression and its departure from linearity

Zhou, Z., Ku, H. C., Xing, G. & Xing, C., 1 Sep 2018, In : Annals of Human Genetics. 82, 5, p. 318-324 7 p.

Research output: Contribution to journal › Article

Linear Models

Genetic Association Studies

3 Citations (Scopus)

Determinants of opioid prescribing for nonmalignant chronic pain in US outpatient settings

Rasu, R. S. & Knell, M. E., 1 Mar 2018, In : Pain Medicine (United States). 19, 3, p. 524-532 9 p.

Research output: Contribution to journal › Article

Chronic Pain

Opioid Analgesics

Outpatients

International Classification of Diseases

Health Care Surveys

2 Citations (Scopus)

Developing text messages to reduce community college student alcohol use

Lewis, M. A., Cadigan, J. M., Cronce, J. M., Kilmer, J. R., Suffoletto, B., Walter, T. & Lee, C. M., Jul 2018, In : American Journal of Health Behavior. 42, 4, p. 70-79 10 p.

Research output: Contribution to journal › Article

Text Messaging

Drinking

alcohol

Alcohols

Research Personnel

2 Citations (Scopus)

Diabetes Prevention for African-Americans: a Scoping Review

Spears, E. C., Foster, M. J. & Bonner, T. J., 1 Oct 2018, In : Journal of racial and ethnic health disparities. 5, 5, p. 947-965 19 p.

Research output: Contribution to journal › Article

African Americans

chronic illness

Type 2 Diabetes Mellitus

Research

Education

1 Citation (Scopus)

Differences in the spatial distribution of actin in the left and right ventricles of functioning rabbit hearts

Nagwekar, J., Duggal, D., Rich, R., Fudala, R., Gryczynski, I., Raut, S. L., Gryczynski, Z. & Borejdo, J., 1 Mar 2018, In : Medical Photonics. 27, p. 1-8 8 p.

Research output: Contribution to journal › Article

Heart Ventricles

Actins

Myosins

Rabbits

Muscles

11 Citations (Scopus)

Dimensionality and Reliability of the Central Sensitization Inventory in a Pooled Multicountry Sample

Cuesta-Vargas, A. I., Neblett, R., Chiarotto, A., Kregel, J., Nijs, J., van Wilgen, C. P., Pitance, L., Knezevic, A., Gatchel, R. J., Mayer, T. G., Viti, C., Roldan-Jiménez, C., Testa, M., Caumo, W., Jeremic-Knezevic, M. & Luciano, J. V., 1 Mar 2018, In : Journal of Pain. 19, 3, p. 317-329 13 p.

Research output: Contribution to journal › Article

Central Nervous System Sensitization

Equipment and Supplies

Reproducibility of Results

Statistical Factor Analysis

Principal Component Analysis

6 Citations (Scopus)

Direct Oral Anticoagulants in Cardioversion: A Review of Current Evidence

Gibson, C. M., Basto, A. N. & Howard, M., 1 Mar 2018, In : Annals of Pharmacotherapy. 52, 3, p. 277-284 8 p.

Research output: Contribution to journal › Review article

Electric Countershock

Anticoagulants

Warfarin

Embolism

Stroke

17 Citations (Scopus)

Direct PCR amplification of DNA from human bloodstains, saliva, and touch samples collected with microFLOQ^® swabs

Ambers, A., Wiley, R., Novroski, N. & Budowle, B., Jan 2018, In : Forensic Science International: Genetics. 32, p. 80-87 8 p.

Research output: Contribution to journal › Article

Touch

Saliva

Polymerase Chain Reaction

Coloring Agents

Workflow

Discovery of 6-(pyrimidin-5-ylmethyl)quinoline-8-carboxamide negative allosteric modulators of metabotropic glutamate receptor subtype 5

Felts, A. S., Rodriguez, A. L., Morrison, R. D., Blobaum, A. L., Byers, F. W., Daniels, J. S., Niswender, C. M., Conn, P. J., Lindsley, C. W. & Emmitte, K. A., 1 Jun 2018, In : Bioorganic and Medicinal Chemistry Letters. 28, 10, p. 1679-1685 7 p.

Research output: Contribution to journal › Article

Metabotropic Glutamate 5 Receptor

Metabotropic Glutamate Receptors

Modulators

Assays

Metabolism

13 Citations (Scopus)

Dissociation of striatal dopamine and tyrosine hydroxylase expression from aging-related motor decline: Evidence from calorie restriction intervention

Salvatore, M. F., Terrebonne, J., Cantu, M. A., McInnis, T. R., Venable, K., Kelley, P., Kasanga, E. A., Latimer, B., Owens, C. L., Pruett, B. S., Yu, Y., Luedtke, R. T., Forster, M. J., Sumien, N. & Ingram, D. K., 1 Jan 2018, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 73, 1, p. 11-20 10 p.

Research output: Contribution to journal › Article

Corpus Striatum

Tyrosine 3-Monooxygenase

Dopamine

Locomotion

Hypokinesia

Distinguishing Comorbidity, Disability, and Frailty

Espinoza, S. E., Quiben, M. C. & Hazuda, H. P., 1 Dec 2018, In : Current Geriatrics Reports. 7, 4, p. 201-209 9 p.

Research output: Contribution to journal › Review article

Comorbidity

Chronic Disease

Public Health

Cross-Sectional Studies

Delivery of Health Care

2 Citations (Scopus)

Distinguishing genetically between the germlines of male monozygotic twins

Krawczak, M., Budowle, B., Weber-Lehmann, J. & Rolf, B., 1 Dec 2018, In : PLoS Genetics. 14, 12, e1007756.

Research output: Contribution to journal › Article

Monozygotic Twins

paternity

germ cells

Paternity

Tissue Donors

2 Citations (Scopus)

Does the Length of Disability between Injury and Functional Restoration Program Entry Affect Treatment Outcomes for Patients with Chronic Disabling Occupational Musculoskeletal Disorders?

Asih, S., Neblett, R., Mayer, T. G. & Gatchel, R. J., 1 Mar 2018, In : Journal of Occupational Rehabilitation. 28, 1, p. 57-67 11 p.

Research output: Contribution to journal › Article

Wounds and Injuries

Therapeutics

Rehabilitation