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  • Shaohua Yang
2020
Open Access

Metformin and cognition from the perspectives of sex, age, and disease

Chaudhari, K., Reynolds, C. D. & Yang, S. H., 1 Feb 2020, In : GeroScience. 42, 1, p. 97-116 20 p.

Research output: Contribution to journalReview article

1 Scopus citations
2019

A novel serum free primary astrocyte culture method that mimic quiescent astrocyte phenotype

Prah, J., Winters, A., Chaudhari, K., Hersh, J., Liu, R. & Yang, S. H., 15 May 2019, In : Journal of Neuroscience Methods. 320, p. 50-63 14 p.

Research output: Contribution to journalArticle

1 Scopus citations

Cholesterol sulfate alters astrocyte metabolism and provides protection against oxidative stress

Prah, J., Winters, A., Chaudhari, K., Hersh, J., Liu, R. & Yang, S. H., 15 Nov 2019, In : Brain Research. 1723, 146378.

Research output: Contribution to journalArticle

1 Scopus citations

Experimental ischemic stroke induces long-term T cell activation in the brain

Xie, L., Li, W., Hersh, J., Liu, R. & Yang, S. H., 1 Nov 2019, In : Journal of Cerebral Blood Flow and Metabolism. 39, 11, p. 2268-2276 9 p.

Research output: Contribution to journalArticle

13 Scopus citations

Metformin alters locomotor and cognitive function and brain metabolism in normoglycemic mice

Li, W., Chaudhari, K., Shetty, R., Winters, A., Gao, X., Hu, Z., Ge, W. P., Sumien, N., Forster, M., Liu, R. & Yang, S. H., 1 Jan 2019, In : Aging and Disease. 10, 5, p. 949-963 15 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2018

Aging health and R & D for healthy longevity must be included into the WHO work program

Stambler, I., Jin, K., Lederman, S., Barzilai, N., Jay Olshansky, S., Omokaro, E., Barratt, J., Anisimov, V. N., Rattan, S., Yang, S., Forster, M. & Byles, J., 1 Apr 2018, In : Aging and Disease. 9, 2, p. 331-333 3 p.

Research output: Contribution to journalEditorial

4 Scopus citations

Artemisinin prevents glutamate-induced neuronal cell death via Akt pathway activation

Lin, S. P., Li, W., Winters, A., Liu, R. & Yang, S. H., 20 Apr 2018, In : Frontiers in Cellular Neuroscience. 12, 108.

Research output: Contribution to journalArticle

7 Scopus citations

Glia–immune interactions post-ischemic stroke and potential therapies

Hersh, J. & Yang, S. H., 1 Dec 2018, In : Experimental Biology and Medicine. 243, 17-18, p. 1302-1312 11 p.

Research output: Contribution to journalReview article

1 Scopus citations

High-Throughput data of circular RNA profiles in human temporal cortex tissue reveals novel insights into temporal lobe epilepsy

Li, J., Lin, H., Sun, Z., Kong, G., Yan, X., Wang, Y., Wang, X., Wen, Y., Liu, X., Zheng, H., Jia, M., Shi, Z., Xu, R., Yang, S. & Yuan, F., Feb 2018, In : Cellular Physiology and Biochemistry. 45, 2, p. 677-691 15 p.

Research output: Contribution to journalArticle

8 Scopus citations

Hyperglycemia alters astrocyte metabolism and inhibits astrocyte proliferation

Li, W., Choudhury, G. R., Winters, A., Prah, J., Lin, W., Liu, R. & Yang, S. H., 1 Jan 2018, In : Aging and Disease. 9, 4, p. 674-684 11 p.

Research output: Contribution to journalArticle

6 Scopus citations

Insulin and heparin-binding epidermal growth factor-like growth factor synergistically promote astrocyte survival and proliferation in serum-free medium

Jia, M., Shi, Z., Yan, X., Xu, L., Dong, L., Li, J., Wang, Y., Yang, S. & Yuan, F., 1 Sep 2018, In : Journal of Neuroscience Methods. 307, p. 240-247 8 p.

Research output: Contribution to journalArticle

4 Scopus citations

Precision Medicine for Ischemic Stroke, Let Us Move Beyond Time Is Brain

Yang, S. H., Lou, M., Luo, B., Jiang, W. J. & Liu, R., 1 Apr 2018, In : Translational Stroke Research. 9, 2, p. 93-95 3 p.

Research output: Contribution to journalEditorial

2 Scopus citations

Surgical management of giant intrapetrous internal carotid aneurysm presenting with coil exposure after endovascular treatment

Yu, L. B., Zhang, D., Yang, S. H. & Zhao, J. Z., 1 Jul 2018, In : Neurosurgical Review. 41, 3, p. 891-894 4 p.

Research output: Contribution to journalArticle

1 Scopus citations
2017
5 Scopus citations
24 Scopus citations

Aquaporin 4-mediated glutamate-induced astrocyte swelling is partially mediated through metabotropic glutamate receptor 5 activation

Shi, Z., Zhang, W., Lu, Y., Lu, Y., Xu, L., Fang, Q., Wu, M., Jia, M., Wang, Y., Dong, L., Yan, X., Yang, S. & Yuan, F., 28 Apr 2017, In : Frontiers in Cellular Neuroscience. 11, 116.

Research output: Contribution to journalArticle

14 Scopus citations

Cerebral Autoregulation

Yang, S. & Liu, R., 7 Mar 2017, Primer on Cerebrovascular Diseases: Second Edition. Elsevier Inc., p. 57-60 4 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations

Combining injectable plasma scaffold with mesenchymal stem/stromal cells for repairing infarct cavity after ischemic stroke

Zhang, H., Sun, F., Wang, J., Xie, L., Pan, M., Shao, B., Yang, G. Y., Yang, S. H., ZhuGe, Q. & Jin, K., 1 Jan 2017, In : Aging and Disease. 8, 2, p. 203-214 12 p.

Research output: Contribution to journalArticle

11 Scopus citations

Control of cerebral ischemia with magnetic nanoparticles

Jia, J. M., Chowdary, P. D., Gao, X., Ci, B., Li, W., Mulgaonkar, A., Plautz, E. J., Hassan, G., Kumar, A., Stowe, A. M., Yang, S. H., Zhou, W., Sun, X., Cui, B. & Ge, W. P., 1 Feb 2017, In : Nature Methods. 14, 2, p. 160-166 7 p.

Research output: Contribution to journalArticle

13 Scopus citations

Glutamate Impairs Mitochondria Aerobic Respiration Capacity and Enhances Glycolysis in Cultured Rat Astrocytes

YAN, X., SHI, Z. F., XU, L. X., LI, J. X., WU, M., WANG, X. X., JIA, M., DONG, L. P., YANG, S. H. & YUAN, F., 1 Jan 2017, In : Biomedical and Environmental Sciences. 30, 1, p. 44-51 8 p.

Research output: Contribution to journalArticle

13 Scopus citations

Methylene blue inhibits GABAA receptors by interaction with GABA binding site

Chen, Z., Liu, R., Yang, S. H., Dillon, G. H. & Huang, R., 1 Jun 2017, In : Neuropharmacology. 119, p. 100-110 11 p.

Research output: Contribution to journalArticle

1 Scopus citations
2016

Brain globins in physiology and pathology

Xie, L. K. & Yang, S. H., 1 Jul 2016, In : Medical Gas Research. 6, 3, p. 154-163 10 p.

Research output: Contribution to journalReview article

11 Scopus citations

For the pursuit of oxygen and carbon dioxide channels in mitochondria

Yang, S. H. & Liu, R., 1 Oct 2016, In : Medical Gas Research. 6, 4, p. 237-238 2 p.

Research output: Contribution to journalEditorial

1 Scopus citations

Heat Shock Protein 47 Promotes Glioma Angiogenesis

Wu, Z. B., Cai, L., Lin, S. J., Leng, Z. G., Guo, Y. H., Yang, W. L., Chu, Y. W., Yang, S. H. & Zhao, W. G., 1 Jan 2016, In : Brain Pathology. 26, 1, p. 31-42 12 p.

Research output: Contribution to journalArticle

14 Scopus citations

Methylene blue ameliorates ischemia/reperfusion-induced cerebral edema: An MRI and transmission electron microscope study

Fang, Q., Yan, X., Li, S., Sun, Y., Xu, L., Shi, Z., Wu, M., Lu, Y., Dong, L., Liu, R., Yuan, F. & Yang, S. H., 1 Jan 2016, Acta Neurochirurgica, Supplementum. Springer-Verlag Wien, p. 227-236 10 p. (Acta Neurochirurgica, Supplementum; vol. 121).

Research output: Chapter in Book/Report/Conference proceedingChapter

10 Scopus citations

Neuroglobin Overexpression Inhibits AMPK Signaling and Promotes Cell Anabolism

Cai, B., Li, W., Mao, X. O., Winters, A., Ryou, M. G., Liu, R., Greenberg, D. A., Wang, N., Jin, K. & Yang, S. H., 1 Mar 2016, In : Molecular Neurobiology. 53, 2, p. 1254-1265 12 p.

Research output: Contribution to journalArticle

10 Scopus citations
2015

Cerebral regulatory T cells restrain microglia/macrophage-mediated inflammatory responses via IL-10

Xie, L., Choudhury, G. R., Winters, A., Yang, S. H. & Jin, K., 1 Jan 2015, In : European Journal of Immunology. 45, 1, p. 180-191 12 p.

Research output: Contribution to journalArticle

56 Scopus citations

Chemotherapeutic effect of tamoxifen on temozolomide-resistant gliomas

He, W., Liu, R., Yang, S. H. & Yuan, F., Mar 2015, In : Anti-Cancer Drugs. 26, 3, p. 293-300 8 p.

Research output: Contribution to journalArticle

19 Scopus citations

Downregulation of Aquaporin 4 Expression through Extracellular Signal-regulated Kinases1/2 Activation in Cultured Astrocytes Following Scratch-injury

Shi, Z. F. A., Zhao, W. J. I., Xu, L. X. I., Dong, L. P. I., Yang, S. H. U. & Yuan, F., 1 Mar 2015, In : Biomedical and environmental sciences : BES. 28, 3, p. 199-205 7 p.

Research output: Contribution to journalArticle

11 Scopus citations

Interaction of astrocytes and T cells in physiological and pathological conditions

Xie, L. & Yang, S., 1 Jan 2015, In : Brain Research. 1623, p. 63-73 11 p.

Research output: Contribution to journalReview article

25 Scopus citations

Methylene blue-induced neuronal protective mechanism against hypoxia-reoxygenation stress

Ryou, M. G., Choudhury, G. R., Li, W., Winters, A., Yuan, F., Liu, R. & Yang, S. H., 1 Aug 2015, In : Neuroscience. 301, p. 193-203 11 p.

Research output: Contribution to journalArticle

35 Scopus citations

Methylene blue protects astrocytes against glucose oxygen deprivation by improving cellular respiration

Choudhury, G. R., Winters, A., Rich, R. M., Ryou, M. G., Gryczynski, Z., Yuan, F., Yang, S. H. & Liu, R., 7 Apr 2015, In : PLoS ONE. 10, 4, e0123096.

Research output: Contribution to journalArticle

17 Scopus citations

Stress induces p38 MAPK-mediated phosphorylation and inhibition of drosha-dependent cell survival

Yang, Q., Li, W., She, H., Dou, J., Duong, D. M., Du, Y., Yang, S. H., Seyfried, N. T., Fu, H., Gao, G. & Mao, Z., 19 Feb 2015, In : Molecular Cell. 57, 4, p. 721-734 14 p.

Research output: Contribution to journalArticle

33 Scopus citations
2014

Cancer-Associated isocitrate dehydrogenase 1 (IDH1) R132H mutation and D-2-hydroxyglutarate stimulate glutamine metabolism under hypoxia

Reitman, Z. J., Duncan, C. G., Poteet, E., Winters, A., Yan, L. J., Gooden, D. M., Spasojevic, I., Boros, L. G., Yang, S. H. & Yan, H., 1 Jan 2014, In : Journal of Biological Chemistry. 289, 34, p. 23318-23328 11 p.

Research output: Contribution to journalArticle

47 Scopus citations

Exome sequencing identifies somatic gain-of-function PPM1D mutations in brainstem gliomas

Zhang, L., Chen, L. H., Wan, H., Yang, R., Wang, Z., Feng, J., Yang, S., Jones, S., Wang, S., Zhou, W., Zhu, H., Killela, P. J., Zhang, J., Wu, Z., Li, G., Hao, S., Wang, Y., Webb, J. B., Friedman, H. S., Friedman, A. H. & 5 others, McLendon, R. E., He, Y., Reitman, Z. J., Bigner, D. D. & Yan, H., Jul 2014, In : Nature Genetics. 46, 7, p. 726-730 5 p.

Research output: Contribution to journalArticle

80 Scopus citations

Interleaved imaging of cerebral hemodynamics and blood flow index to monitor ischemic stroke and treatment in rat by volumetric diffuse optical tomography

Lin, Z. J., Ren, M., Li, L., Liu, Y., Su, J., Yang, S. H. & Liu, H., 15 Jan 2014, In : NeuroImage. 85, p. 566-582 17 p.

Research output: Contribution to journalArticle

7 Scopus citations

In vitro protection by pyruvate against cadmium-induced cytotoxicity in hippocampal HT-22 cells

Poteet, E., Winters, A., Xie, L., Ryou, M. G., Liu, R. & Yang, S., 1 Jan 2014, In : Journal of Applied Toxicology. 34, 8, p. 903-913 11 p.

Research output: Contribution to journalArticle

10 Scopus citations

Involvement of p38 MAPK in reactive astrogliosis induced by ischemic stroke

Roy Choudhury, G., Ryou, M. G., Poteet, E., Wen, Y., He, R., Sun, F., Yuan, F., Jin, K. & Yang, S. H., 10 Mar 2014, In : Brain Research. 1551, p. 45-58 14 p.

Research output: Contribution to journalArticle

50 Scopus citations

Methylene blue promotes quiescence of rat neural progenitor cells

Xie, L., Choudhury, G. R., Wang, J., Park, Y., Liu, R., Yuan, F., Zhang, C. L., Yorio, T., Jin, K. & Yang, S. H., 7 Oct 2014, In : Frontiers in Cellular Neuroscience. 8, OCT, 315.

Research output: Contribution to journalArticle

4 Scopus citations

MTOR Signaling inhibition modulates macrophage/microglia-mediated neuroinflammation and secondary injury via regulatory T cells after focal ischemia

Xie, L., Sun, F., Wang, J., Mao, X. O., Xie, L., Yang, S. H., Su, D. M., Simpkins, J. W., Greenberg, D. A. & Jin, K., 15 Jun 2014, In : Journal of Immunology. 192, 12, p. 6009-6019 11 p.

Research output: Contribution to journalArticle

90 Scopus citations

PTEN degradation after ischemic stroke: A double-edged sword

Li, W., Huang, R., Chen, Z., Yan, L. J., Simpkins, J. W. & Yang, S. H., 22 Aug 2014, In : Neuroscience. 274, p. 153-161 9 p.

Research output: Contribution to journalArticle

17 Scopus citations

Silencing AQP4 gene in the astrocytes through siRNA transfection by lipofectamine RNAiMAX

Zhang, W., Xu, L. X., Yang, S. H., Shi, Z. F., Dong, L. P. & Yuan, F., Apr 2014, In : Acta Anatomica Sinica. 45, 2, p. 161-165 5 p.

Research output: Contribution to journalArticle

1 Scopus citations
2013

Astroglial PTEN loss disrupts neuronal lamination by dysregulating radial glia-guided neuronal migration

Wen, Y., Li, W., Choudhury, G. R., He, R., Yang, T., Liu, R., Jin, K. & Yang, S., 1 Jan 2013, In : Aging and Disease. 4, 3, p. 113-126 14 p.

Research output: Contribution to journalArticle

10 Scopus citations

Involvement of estrogen receptor β5 in the progression of glioma

Li, W., Winters, A., Poteet, E., Ryou, M. G., Lin, S., Hao, S., Wu, Z., Yuan, F., Hatanpaa, K. J., Simpkins, J. W. & Yang, S. H., 29 Mar 2013, In : Brain Research. 1503, p. 97-107 11 p.

Research output: Contribution to journalArticle

23 Scopus citations
27 Scopus citations

PRDM1 is directly targeted by miR-30a-5p and modulates the Wnt/β-catenin pathway in a Dkk1-dependent manner during glioma growth

Wang, X., Wang, K., Han, L., Zhang, A., Shi, Z., Zhang, K., Zhang, H., Yang, S., Pu, P., Shen, C., Yu, C. & Kang, C., 1 May 2013, In : Cancer Letters. 331, 2, p. 211-219 9 p.

Research output: Contribution to journalArticle

39 Scopus citations

Pyruvate minimizes rtPA toxicity from in vitro oxygen-glucose deprivation and reoxygenation

Ryou, M. G., Choudhury, G. R., Winters, A., Xie, L., Mallet, R. T. & Yang, S. H., 12 Sep 2013, In : Brain Research. 1530, p. 66-75 10 p.

Research output: Contribution to journalArticle

9 Scopus citations

Reversing the Warburg effect as a treatment for glioblastoma

Poteet, E., Choudhury, G. R., Winters, A., Li, W., Ryou, M. G., Liu, R., Tang, L., Ghorpade, A., Wen, Y., Yuan, F., Keir, S. T., Yan, H., Bigner, D. D., Simpkins, J. W. & Yang, S. H., 29 Mar 2013, In : Journal of Biological Chemistry. 288, 13, p. 9153-9164 12 p.

Research output: Contribution to journalArticle

45 Scopus citations

Transient focal cerebral ischemia induces long-term cognitive function deficit in an experimental ischemic stroke model

Li, W., Huang, R., Shetty, R. A., Thangthaeng, N., Liu, R., Chen, Z., Sumien, N., Rutledge, M., Dillon, G. H., Yuan, F., Forster, M. J., Simpkins, J. W. & Yang, S. H., 1 Nov 2013, In : Neurobiology of Disease. 59, p. 18-25 8 p.

Research output: Contribution to journalArticle

56 Scopus citations