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Author

  • Laszlo Prokai
2020
Open Access
1 Scopus citations

Next generation sequencing and functional pathway analysis to understand the mechanism of action of copper-tolfenamic acid against pancreatic cancer cells

Hurtado, M., Prokai, L., Sankpal, U. T., Levesque, B., Maram, R., Chhabra, J., Brown, D. T., Gurung, R. K., Holder, A. A., Vishwanatha, J. K. & Basha, R., Feb 2020, In : Process Biochemistry. 89, p. 155-164 10 p.

Research output: Contribution to journalArticle

2019

[ 99 mTc-HYNIC-N-dodecylamide]:a new hydrophobic tracer for labelling reconstituted high-density lipoproteins (rHDL) for radioimaging

Isaac-Olivé, K., Ocampo-García, B. E., Aranda-Lara, L., Santos-Cuevas, C. L., Jiménez-Mancilla, N. P., Luna-Gutiérrez, M. A., Medina, L. A., Nagarajan, B., Sabnis, N., Raut, S., Prokai, L. & Lacko, A. G., 14 Jan 2019, In : Nanoscale. 11, 2, p. 541-551 11 p.

Research output: Contribution to journalArticle

1 Scopus citations

A novel prodrug approach for central nervous system-selective estrogen therapy

Prokai-Tatrai, K. & Prokai, L., 19 Nov 2019, In : Molecules. 24, 22, 4197.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Brain delivery of thyrotropin-releasing hormone via a novel prodrug approach

Prokai-Tatrai, K., De La Cruz, D. L., Nguyen, V., Ross, B. P., Toth, I. & Prokai, L., Jul 2019, In : Pharmaceutics. 11, 7, 349.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Different reactivity to glutathione but similar tumor cell toxicity of chalcones and their quinolinone analogues

d’Oliveira, G. D. C., Custodio, J. M. F., Moura, A. F., Napolitano, H. B., Pérez, C. N., Moraes, M. O., Prókai, L. & Perjési, P., 1 Sep 2019, In : Medicinal Chemistry Research. 28, 9, p. 1448-1460 13 p.

Research output: Contribution to journalArticle

Open Access
2018
2 Scopus citations

An exploratory investigation of brain-selective estrogen treatment in males using a mouse model of Alzheimer's disease

Tschiffely, A. E., Schuh, R. A., Prokai-Tatrai, K., Ottinger, M. A. & Prokai, L., Feb 2018, In : Hormones and Behavior. 98, p. 16-21 6 p.

Research output: Contribution to journalArticle

9 Scopus citations

Risk-associated and pathway-based method to detect association with Alzheimer's disease

Mitchel, J., Prokai, L., Deng, Y., Zhang, F. & Barber, R., 1 Jan 2018, In : International Journal of Computational Biology and Drug Design. 11, 1-2

Research output: Contribution to journalEditorial

2017

Effect of short-term DHEA supplementation on serum and hippocampal estrogen concentrations in perimenopausal female rhesus macaques

Urbanski, H. F., Sorwell, K. G., Prokai, L. & Kohama, S. G., Jul 2017, In : Neurobiology of Aging. 55, p. 172-174 3 p.

Research output: Contribution to journalArticle

1 Scopus citations

Mannich Ketones as Possible Antimycobacterial Agents

Lutz, Z., Orbán, K., Bóna, Á., Márk, L., Maász, G., Prókai, L., Seress, L. & Lóránd, T., Sep 2017, In : Archiv der Pharmazie. 350, 9, 1700102.

Research output: Contribution to journalArticle

1 Scopus citations

Targeting alpha toxin to mitigate its lethal toxicity in ferret and rabbit models of Staphylococcus aureus necrotizing pneumonia

Diep, B. A., Hilliard, J. J., Le, V. T. M., Tkaczyk, C., Le, H. N., Tran, V. G., Rao, R. L., Dip, E. C., Pereira-Franchi, E. P., Cha, P., Jacobson, S., Broome, R., Cheng, L. I., Weiss, W., Prokai, L., Nguyen, V., Stover, C. K. & Sellman, B. R., Apr 2017, In : Antimicrobial agents and chemotherapy. 61, 4, 02456-16.

Research output: Contribution to journalArticle

17 Scopus citations
2016

A comparative evaluation of treatments with 17β-estradiol and its brain-selective prodrug in a double-transgenic mouse model of Alzheimer's disease

Tschiffely, A. E., Schuh, R. A., Prokai-Tatrai, K., Prokai, L. & Ottinger, M. A., 1 Jul 2016, In : Hormones and Behavior. 83, p. 39-44 6 p.

Research output: Contribution to journalArticle

9 Scopus citations

Cholinergic neurons in the basal forebrain promote wakefulness by actions on neighboring non-cholinergic neurons: An opto-dialysis study

Zant, J. C., Kim, T., Prokai, L., Szarka, S., McNally, J., McKenna, J. T., Shukla, C., Yang, C., Kalinchuk, A. V., McCarley, R. W., Brown, R. E. & Basheer, R., 10 Feb 2016, In : Journal of Neuroscience. 36, 6, p. 2057-2067 11 p.

Research output: Contribution to journalArticle

41 Scopus citations

Critical role of alpha-toxin and protective effects of its neutralization by a human antibody in acute bacterial skin and skin structure infections

Le, V. T. M., Tkaczyk, C., Chau, S., Rao, R. L., Dip, E. C., Pereira-Franchi, E. P., Cheng, L., Lee, S., Koelkebeck, H., Hilliard, J. J., Yu, X. Q., Datta, V., Nguyen, V., Weiss, W., Prokai, L., O'Day, T., Stover, C. K., Sellman, B. R. & Diep, B. A., 1 Oct 2016, In : Antimicrobial agents and chemotherapy. 60, 10, p. 5640-5648 9 p.

Research output: Contribution to journalArticle

17 Scopus citations
2 Scopus citations

Mass spectrometric analysis of carisoprodol and meprobamate in rat brain microdialysates

Prokai, L., Fryčák, P., Nguyen, V. & Forster, M. J., 1 Oct 2016, In : Journal of Mass Spectrometry. 51, 10, p. 900-907 8 p.

Research output: Contribution to journalArticle

Treatment with an orally bioavailable prodrug of 17β-estradiol alleviates hot flushes without hormonal effects in the periphery

Merchenthaler, I., Lane, M., Sabnis, G., Brodie, A., Nguyen, V., Prokai, L. & Prokai-Tatrai, K., 1 Aug 2016, In : Scientific Reports. 6, 30721.

Research output: Contribution to journalArticle

7 Scopus citations
2015

Anti-alpha-toxin monoclonal antibody and antibiotic combination therapy improves disease outcome and accelerates healing in a staphylococcus aureus dermonecrosis model

Hilliard, J. J., Datta, V., Tkaczyk, C., Hamilton, M., Sadowska, A., Jones-Nelson, O., O'Day, T., Weiss, W. J., Szarka, S., Nguyen, V., Prokai, L., Suzich, J. A., Stover, C. K. & Sellmana, B. R., 1 Jan 2015, In : Antimicrobial agents and chemotherapy. 59, 1, p. 299-308 10 p.

Research output: Contribution to journalArticle

33 Scopus citations

A survey of the impact of deyolking on biological processes covered by shotgun proteomic analyses of zebrafish embryos

Rahlouni, F., Szarka, S., Shulaev, V. & Prokai, L., 1 Dec 2015, In : Zebrafish. 12, 6, p. 398-407 10 p.

Research output: Contribution to journalArticle

1 Scopus citations
4 Scopus citations

The prodrug DHED selectively delivers 17β-estradiol to the brain for treating estrogen-responsive disorders

Prokai, L., Nguyen, V., Szarka, S., Garg, P., Sabnis, G., Bimonte-Nelson, H. A., McLaughlin, K. J., Talboom, J. S., Conrad, C. D., Shughrue, P. J., Gould, T. D., Brodie, A., Merchenthaler, I., Koulen, P. & Prokai-Tatrai, K., 22 Jul 2015, In : Science Translational Medicine. 7, 297, 297ra113.

Research output: Contribution to journalArticle

21 Scopus citations
2014
16 Scopus citations

Label-free LC-MS/MS identification of phosphatidylglycerol-regulated proteins in Synechocystis sp. PCC6803

Talamantes, T., Ughy, B., Domonkos, I., Kis, M., Gombos, Z. & Prokai, L., May 2014, In : Proteomics. 14, 9, p. 1053-1057 5 p.

Research output: Contribution to journalArticle

7 Scopus citations

Selective chemoprecipitation to enrich nitropeptides from complex proteomes for mass-spectrometric analysis

Prokai, L., Guo, J. & Prokai-Tatrai, K., Apr 2014, In : Nature Protocols. 9, 4, p. 882-895 14 p.

Research output: Contribution to journalArticle

5 Scopus citations
2013

17β-estradiol eye drops protect the retinal ganglion cell layer and preserve visual function in an in vivo model of glaucoma

Prokai-Tatrai, K., Xin, H., Nguyen, V., Szarka, S., Blazics, B., Prokai, L. & Koulen, P., 5 Aug 2013, In : Molecular Pharmaceutics. 10, 8, p. 3253-3261 9 p.

Research output: Contribution to journalArticle

38 Scopus citations

An exploratory evaluation of tyrosine hydroxylase inhibition in planaria as a model for parkinsonism

Prokai, D., Nguyen, T., Kamrowski, K., Chandra, A., Talamantes, T., Baxter, L. R. & Prokai, L., 26 Nov 2013, In : International journal of molecular sciences. 14, 12, p. 23289-23296 8 p.

Research output: Contribution to journalArticle

6 Scopus citations

Antifungal Activity of Fused Mannich Ketones Triggers an Oxidative Stress Response and Is Cap1-Dependent in Candida albicans

Rossignol, T., Kocsis, B., Bouquet, O., Kustos, I., Kilár, F., Nyul, A., Jakus, P. B., Rajbhandari, K., Prókai, L., d'Enfert, C. & Lóránd, T., 30 Apr 2013, In : PLoS ONE. 8, 4, e62142.

Research output: Contribution to journalArticle

2 Scopus citations

Design and exploratory neuropharmacological evaluation of novel thyrotropin-releasing hormone analogs and their brain-targeting bioprecursor prodrugs

Prokai-Tatrai, K., Nguyen, V., Szarka, S., Konya, K. & Prokai, L., 22 May 2013, In : Pharmaceutics. 5, 2, p. 318-328 11 p.

Research output: Contribution to journalArticle

3 Scopus citations

Proteomic Analysis of Signaling Network Regulation in Renal Cell Carcinomas with Differential Hypoxia-Inducible Factor-2α Expression

Da Nagaprashantha, L., Talamantes, T., Singhal, J., Guo, J., Vatsyayan, R., Rauniyar, N., Awasthi, S., Singhal, S. S. & Prokai, L., 5 Aug 2013, In : PLoS ONE. 8, 8, e71654.

Research output: Contribution to journalArticle

10 Scopus citations
9 Scopus citations
23 Scopus citations

Tissue penetration and antimicrobial activity of standard- and high-dose trimethoprim/sulfamethoxazole and linezolid in patients with diabetic foot infection

Stein, G. E., Throckmorton, J. K., Scharmen, A. E., Weiss, W. J., Prokai, L., Smith, C. L. & Havlichek, D. H., 1 Dec 2013, In : Journal of Antimicrobial Chemotherapy. 68, 12, p. 2852-2858 7 p., dkt267.

Research output: Contribution to journalArticle

14 Scopus citations
2012
18 Scopus citations
3 Scopus citations

Mass Spectrometry-Based Methods to Investigate Posttranslational Protein Modifications by Lipid Peroxidation Products

Rauniyar, N. & Prokai, L., 21 May 2012, Mass Spectrometry Handbook. John Wiley and Sons, p. 23-40 18 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

9 Scopus citations

RimJ-mediated context-dependent N-terminal acetylation of the recombinant Z-domain protein in Escherichia coli

Bernal-Perez, L. F., Sahyouni, F., Prokai, L. & Ryu, Y., 1 Mar 2012, In : Molecular BioSystems. 8, 4, p. 1128-1130 3 p.

Research output: Contribution to journalArticle

3 Scopus citations

Selective N-terminal fluorescent labeling of proteins using 4-chloro-7-nitrobenzofurazan: A method to distinguish protein N-terminal acetylation

Bernal-Perez, L. F., Prokai, L. & Ryu, Y., 1 Sep 2012, In : Analytical Biochemistry. 428, 1, p. 13-15 3 p.

Research output: Contribution to journalArticle

20 Scopus citations
2011

2′-Hydroxyflavanone inhibits proliferation, tumor vascularization and promotes normal differentiation in VHL-mutant renal cell carcinoma

Nagaprashantha, L. D., Vatsyayan, R., Singhal, J., Lelsani, P., Prokai, L., Awasthi, S. & Singhal, S. S., 1 Apr 2011, In : Carcinogenesis. 32, 4, p. 568-575 8 p.

Research output: Contribution to journalArticle

28 Scopus citations

Cognitive-impairing effects of medroxyprogesterone acetate in the rat: Independent and interactive effects across time

Braden, B. B., Garcia, A. N., Mennenga, S. E., Prokai, L., Villa, S. R., Acosta, J. I., Lefort, N., Simard, A. R. & Bimonte-Nelson, H. A., 1 Nov 2011, In : Psychopharmacology. 218, 2, p. 405-418 14 p.

Research output: Contribution to journalArticle

34 Scopus citations
18 Scopus citations

Prodrug design for brain delivery of small- and medium-sized neuropeptides

Prokai-Tatrai, K. & Prokai, L., 24 Oct 2011, Neuropeptides: Methods and Protocols. Merighi, A. (ed.). p. 313-336 24 p. (Methods in Molecular Biology; vol. 789).

Research output: Chapter in Book/Report/Conference proceedingChapter

8 Scopus citations

Protein targets for carbonylation by 4-hydroxy-2-nonenal in rat liver mitochondria

Guo, J., Prokai-Tatrai, K., Nguyen, V., Rauniyar, N., Ughy, B. & Prokai, L., 19 Oct 2011, In : Journal of Proteomics. 74, 11, p. 2370-2379 10 p.

Research output: Contribution to journalArticle

27 Scopus citations
23 Scopus citations

Targeted delivery of small interfering RNA using reconstituted high-density lipoprotein nanoparticles

Shahzad, M. M. K., Mangala, L. S., Han, H. D., Lu, C., Bottsford-Miller, J., Nishimura, M., Mora, E. M., Lee, J. W., Stone, R. L., Pecot, C. V., Thanapprapasr, D., Roh, J. W., Gaur, P., Nair, M. P., Park, Y. Y., Sabnis, N., Deavers, M. T., Lee, J. S., Ellis, L. M., Lopez-Berestei, G. & 4 others, McConathy, W. J., Prokai, L., Lacko, A. G. & Sood, A. K., Apr 2011, In : Neoplasia. 13, 4, p. 309-319 11 p.

Research output: Contribution to journalArticle

146 Scopus citations

Tonic Premarin dose-dependently enhances memory, affects neurotrophin protein levels and alters gene expression in middle-aged rats

Engler-Chiurazzi, E., Tsang, C., Nonnenmacher, S., Liang, W. S., Corneveaux, J. J., Prokai, L., Huentelman, M. J. & Bimonte-Nelson, H. A., 1 Apr 2011, In : Neurobiology of Aging. 32, 4, p. 680-697 18 p.

Research output: Contribution to journalArticle

40 Scopus citations
27 Scopus citations