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  • Robert Luedtke

Analogues of Arylamide Phenylpiperazine Ligands to Investigate the Factors Influencing D3 Dopamine Receptor Bitropic Binding and Receptor Subtype Selectivity

Hayatshahi, H. S., Xu, K., Griffin, S. A., Taylor, M., Mach, R. H., Liu, J. & Luedtke, R. R., 19 Dec 2018, In : ACS Chemical Neuroscience. 9, 12, p. 2972-2983 12 p.

Research output: Contribution to journalArticle

6 Scopus citations

Bitropic D3 dopamine receptor selective compounds as potential antipsychotics

Luedtke, R. R., Rangel-Barajas, C., Malik, M., Reichert, D. E. & Mach, R. H., 1 Sep 2015, In : Current Pharmaceutical Design. 21, 26, p. 3700-3724 25 p.

Research output: Contribution to journalArticle

8 Scopus citations
6 Scopus citations

Characterization of [3H]LS-3-134, a novel arylamide phenylpiperazine D3 dopamine receptor selective radioligand

Rangel-Barajas, C., Malik, M., Taylor, M., Neve, K. A., Mach, R. H. & Luedtke, R. R., 1 Nov 2014, In : Journal of Neurochemistry. 131, 4, p. 418-431 14 p.

Research output: Contribution to journalArticle

10 Scopus citations

Comparison of the binding and functional properties of two structurally different D2 dopamine receptor subtype selective compounds

Luedtke, R. T., Mishra, Y., Wang, Q., Griffin, S. A., Bell-Horner, C., Taylor, M., Vangveravong, S., Dillon, G. H., Huang, R-Q., Reichert, D. E. & MacH, R. H., 19 Dec 2012, In : ACS Chemical Neuroscience. 3, 12, p. 1050-1062 13 p.

Research output: Contribution to journalArticle

26 Scopus citations

Decreased striatal dopamine receptor binding in primary focal dystonia: A D2 or D3 defect?

Karimi, M., Moerlein, S. M., Videen, T. O., Luedtke, R. R., Taylor, M., Mach, R. H. & Perlmutter, J. S., 1 Jan 2011, In : Movement Disorders. 26, 1, p. 100-106 7 p.

Research output: Contribution to journalArticle

32 Scopus citations

Design, synthesis, and evaluation of N-(4-(4-phenyl piperazin-1-yl)butyl)-4-(thiophen-3-yl)benzamides as selective dopamine D3 receptor ligands

Chen, P. J., Taylor, M., Griffin, S. A., Amani, A., Hayatshahi, H., Korzekwa, K., Ye, M., Mach, R. H., Liu, J., Luedtke, R. R., Gordon, J. C. & Blass, B. E., 15 Sep 2019, In : Bioorganic and Medicinal Chemistry Letters. 29, 18, p. 2690-2694 5 p.

Research output: Contribution to journalArticle

Design, synthesis, and structure-activity relationship studies of a series of [4-(4-carboxamidobutyl)]-1-arylpiperazines: Insights into structural features contributing to dopamine D3 versus D2 receptor subtype selectivity

Ananthan, S., Saini, S. K., Zhou, G., Hobrath, J. V., Padmalayam, I., Zhai, L., Bostwick, J. R., Antonio, T., Reith, M. E. A., McDowell, S., Cho, E., McAleer, L., Taylor, M. & Luedtke, R. R., 28 Aug 2014, In : Journal of Medicinal Chemistry. 57, 16, p. 7042-7060 19 p.

Research output: Contribution to journalArticle

29 Scopus citations

Dissociation of striatal dopamine and tyrosine hydroxylase expression from aging-related motor decline: Evidence from calorie restriction intervention

Salvatore, M. F., Terrebonne, J., Cantu, M. A., McInnis, T. R., Venable, K., Kelley, P., Kasanga, E. A., Latimer, B., Owens, C. L., Pruett, B. S., Yu, Y., Luedtke, R., Forster, M. J., Sumien, N. & Ingram, D. K., 1 Jan 2018, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 73, 1, p. 11-20 10 p.

Research output: Contribution to journalArticle

14 Scopus citations

Dopamine D3 receptor partial agonist LS-3-134 attenuates cocaine-motivated behaviors

Powell, G. L., Bonadonna, J. P., Vannan, A., Xu, K., Mach, R. H., Luedtke, R. R. & Neisewander, J. L., Dec 2018, In : Pharmacology Biochemistry and Behavior. 175, p. 123-129 7 p.

Research output: Contribution to journalArticle

Dopamine D3 receptor partial agonist LS-3-134 attenuates cocaine-motivated behaviors

Powell, G. L., Bonadonna, J. P., Vannan, A., Xu, K., Mach, R. H., Luedtke, R. R. & Neisewander, J. L., Aug 2018, In : Pharmacology Biochemistry and Behavior. 171, p. 46-53 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Drug Design for Addiction - Molecular Determinants of Selectivity and Efficacy at the Dopamine D3 Receptor

Newman, A. H., Banala, A. K., Donthamsetti, P., Cao, J., Michino, M., Luedtke, R. T., Javitch, J. A. & Shi, L., 1 Dec 2013, Catecholamine Research in the 21st Century: Abstracts and Graphical Abstracts, 10th International Catecholamine Symposium, 2012. Elsevier Inc., p. 181-182 2 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Dysregulated corticostriatal activity in open-field behavior and the head-twitch response induced by the hallucinogen 2,5-dimethoxy-4-iodoamphetamine

Rangel-Barajas, C., Estrada-Sánchez, A. M., Barton, S. J., Luedtke, R. R. & Rebec, G. V., 1 Feb 2017, In : Neuropharmacology. 113, p. 502-510 9 p.

Research output: Contribution to journalArticle

1 Scopus citations

Effect of cyclosporin A on the uptake of D3-selective PET radiotracers in rat brain

Tu, Z., Li, S., Xu, J., Chu, W., Jones, L. A., Luedtke, R. R. & Mach, R. H., 1 Jul 2011, In : Nuclear Medicine and Biology. 38, 5, p. 725-739 15 p.

Research output: Contribution to journalArticle

8 Scopus citations

Endogenous dopamine (DA) competes with the binding of a radiolabeled D3 receptor partial agonist in vivo: A positron emission tomography study

Mach, R. H., Tu, Z., Xu, J., Li, S., Jones, L. A., Taylor, M., Luedtke, R. R., Derdeyn, C. P., Perlmutter, J. S. & Mintun, M. A., 1 Aug 2011, In : Synapse. 65, 8, p. 724-732 9 p.

Research output: Contribution to journalArticle

30 Scopus citations

Endothelin b receptors contribute to retinal ganglion cell loss in a rat model of glaucoma

Minton, A. Z., Phatak, N. R., Stankowska, D. L., He, S., Ma, H. Y., Mueller, B. H., Jiang, M., Luedtke, R., Yang, S., Brownlee, C. & Krishnamoorthy, R. R., 20 Aug 2012, In : PLoS ONE. 7, 8, e43199.

Research output: Contribution to journalArticle

41 Scopus citations

Erratum: Influence of cocaine history on the behavioral effects of dopamine d3 receptor-selective compounds in monkeys (Neuropsychopharmacology (2011) 36 (1104-1113) DOI: 10.1038/npp.2010.248)

Blaylock, B. L., Gould, R. W., Banala, A., Grundt, P., Luedtke, R. R., Newman, A. H. & Nader, M. A., 1 Oct 2012, In : Neuropsychopharmacology. 37, 11, 1 p.

Research output: Contribution to journalComment/debate

Evaluation of N-phenyl homopiperazine analogs as potential dopamine D 3 receptor selective ligands

Li, A., Mishra, Y., Malik, M., Wang, Q., Li, S., Taylor, M., Reichert, D. E., Luedtke, R. R. & MacH, R. H., 1 Jun 2013, In : Bioorganic and Medicinal Chemistry. 21, 11, p. 2988-2998 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

Evaluation of the D3 dopamine receptor selective agonist/partial agonist PG01042 on l-dopa dependent animal involuntary movements in rats

Riddle, L. R., Kumar, R., Griffin, S. A., Grundt, P., Newman, A. H. & Luedtke, R. T., 1 Feb 2011, In : Neuropharmacology. 60, 2-3, p. 284-294 11 p.

Research output: Contribution to journalArticle

11 Scopus citations

Fos expression in response to dopamine d3-preferring phenylpiperazine drugs given with and without cocaine

Nolan, B. C., Liu, S., Hammerslag, L. R., Cheung, T. H. C., Lenz, J., Mach, R. H., Luedtke, R. R. & Neisewander, J. L., 1 Dec 2013, In : Synapse. 67, 12, p. 847-855 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

Highly Selective Dopamine D3 Receptor Antagonists with Arylated Diazaspiro Alkane Cores

Reilly, S. W., Griffin, S., Taylor, M., Sahlholm, K., Weng, C. C., Xu, K., Jacome, D. A., Luedtke, R. R. & Mach, R. H., 14 Dec 2017, In : Journal of Medicinal Chemistry. 60, 23, p. 9905-9910 6 p.

Research output: Contribution to journalArticle

7 Scopus citations

Influence of cocaine history on the behavioral effects of dopamine D 3 receptor-selective compounds in monkeys

Blaylock, B. L., Gould, R. W., Banala, A., Grundt, P., Luedtke, R. R., Newman, A. H. & Nader, M. A., Apr 2011, In : Neuropsychopharmacology. 36, 5, p. 1104-1113 10 p.

Research output: Contribution to journalArticle

17 Scopus citations

Leveraging a Low-Affinity Diazaspiro Orthosteric Fragment to Reduce Dopamine D3 Receptor (D3R) Ligand Promiscuity across Highly Conserved Aminergic G-Protein-Coupled Receptors (GPCRs)

Reilly, S. W., Riad, A. A., Hsieh, C. J., Sahlholm, K., Jacome, D. A., Griffin, S., Taylor, M., Weng, C. C., Xu, K., Kirschner, N., Luedtke, R. R., Parry, C., Malhotra, S., Karanicolas, J. & Mach, R. H., 23 May 2019, In : Journal of Medicinal Chemistry. 62, 10, p. 5132-5147 16 p.

Research output: Contribution to journalArticle

1 Scopus citations

Molecular determinants of selectivity and efficacy at the dopamine D3 receptor

Newman, A. H., Beuming, T., Banala, A. K., Donthamsetti, P., Pongetti, K., Labounty, A., Levy, B., Cao, J., Michino, M., Luedtke, R. R., Javitch, J. A. & Shi, L., 9 Aug 2012, In : Journal of Medicinal Chemistry. 55, 15, p. 6689-6699 11 p.

Research output: Contribution to journalArticle

112 Scopus citations

N -(3-Fluoro-4-(4-(2-methoxy or 2,3-dichlorophenyl)piperazine-1-yl)butyl) arylcarboxamides as selective dopamine D3 receptor ligands: Critical role of the carboxamide linker for d3 receptor selectivity

Banala, A. K., Levy, B. A., Khatri, S. S., Furman, C. A., Roof, R. A., Mishra, Y., Griffin, S. A., Sibley, D. R., Luedtke, R. T. & Newman, A. H., 26 May 2011, In : Journal of Medicinal Chemistry. 54, 10, p. 3581-3594 14 p.

Research output: Contribution to journalArticle

53 Scopus citations

Neuroprotective effects of high affinity sigma 1 receptor selective compounds

Luedtke, R. R., Perez, E., Yang, S. H., Liu, R., Vangveravong, S., Tu, Z., MacH, R. H. & Simpkins, J. W., 2 Mar 2012, In : Brain Research. 1441, p. 17-26 10 p.

Research output: Contribution to journalArticle

18 Scopus citations

Pharmacological modulation of abnormal involuntary DOI-induced head twitch response in male DBA/2J mice: I. Effects of D2/D3 and D2 dopamine receptor selective compounds

Rangel-Barajas, C., Malik, M., Vangveravong, S., Mach, R. H. & Luedtke, R. R., Aug 2014, In : Neuropharmacology. 83, p. 18-27 10 p.

Research output: Contribution to journalArticle

13 Scopus citations

Pharmacological modulation of abnormal involuntary DOI-induced head twitch response movements in male DBA/2J mice: II. Effects of D3 dopamine receptor selective compounds

Rangel-Barajas, C., Malik, M., Mach, R. H. & Luedtke, R. R., Jun 2015, In : Neuropharmacology. 93, p. 179-190 12 p.

Research output: Contribution to journalArticle

5 Scopus citations

Phenylpiperazine derivatives with selectivity for dopamine D3 receptors modulate cocaine self-administration in rats

Cheung, T. H. C., Nolan, B. C., Hammerslag, L. R., Weber, S. M., Durbin, J. P., Peartree, N. A., MacH, R. H., Luedtke, R. R. & Neisewander, J. L., 1 Dec 2012, In : Neuropharmacology. 63, 8, p. 1346-1359 14 p.

Research output: Contribution to journalArticle

16 Scopus citations

Reduction of cocaine self-administration and D3 receptor-mediated behavior by two novel dopamine D3 receptor-selective partial agonists, OS-3-106 and WW-III-55

Cheung, T. H. C., Loriaux, A. L., Weber, S. M., Chandler, K. N., Lenz, J. D., Schaan, R. F., Mach, R. H., Luedtke, R. R. & Neisewander, J. L., 1 Nov 2013, In : Journal of Pharmacology and Experimental Therapeutics. 347, 2, p. 410-423 14 p.

Research output: Contribution to journalArticle

19 Scopus citations

Synthesis, pharmacological evaluation and molecular modeling studies of triazole containing dopamine D3 receptor ligands

Peng, X., Wang, Q., Mishra, Y., Xu, J., Reichert, D. E., Malik, M., Taylor, M., Luedtke, R. R. & Mach, R. H., 1 Feb 2015, In : Bioorganic and Medicinal Chemistry Letters. 25, 3, p. 519-523 5 p.

Research output: Contribution to journalArticle

8 Scopus citations

Synthesis and characterization of selective dopamine D2 receptor ligands using aripiprazole as the lead compound

Vangveravong, S., Zhang, Z., Taylor, M., Bearden, M., Xu, J., Cui, J., Wang, W., Luedtke, R. R. & MacH, R. H., 1 Jun 2011, In : Bioorganic and Medicinal Chemistry. 19, 11, p. 3502-3511 10 p.

Research output: Contribution to journalArticle

27 Scopus citations

Synthesis and in vitro biological evaluation of carbonyl group-containing analogues for σ1 receptors

Wang, W., Cui, J., Lu, X., Padakanti, P. K., Xu, J., Parsons, S. M., Luedtke, R. R., Rath, N. P. & Tu, Z., 11 Aug 2011, In : Journal of Medicinal Chemistry. 54, 15, p. 5362-5372 11 p.

Research output: Contribution to journalArticle

14 Scopus citations

Synthesis and in vitro pharmacological evaluation of indolyl carboxylic amide analogues as D3 dopamine receptor selective ligands

Tu, Z., Li, S., Li, A., Taylor, M., Ho, D., Malik, M., Luedtke, R. R. & Mach, R. H., Sep 2013, In : MedChemComm. 4, 9, p. 1283-1289 7 p.

Research output: Contribution to journalArticle

1 Scopus citations

Synthesis and pharmacological evaluation of fluorine-containing D 3 dopamine receptor ligands

Tu, Z., Li, S., Cui, J., Xu, J., Taylor, M., Ho, D., Luedtke, R. R. & MacH, R. H., 24 Mar 2011, In : Journal of Medicinal Chemistry. 54, 6, p. 1555-1564 10 p.

Research output: Contribution to journalArticle

31 Scopus citations

The effect of SV 293, a D2 dopamine receptor-selective antagonist, on D2 receptor-mediated GIRK channel activation and adenylyl cyclase inhibition

Huang, R., Griffin, S. A., Taylor, M., Vangveravong, S., Mach, R. H., Dillon, G. H. & Luedtke, R. R., 1 Jan 2013, In : Pharmacology. 92, 1-2, p. 84-89 6 p.

Research output: Contribution to journalArticle

3 Scopus citations

The effect of the sigma-1 receptor selective compound LS-1-137 on the DOI-induced head twitch response in mice

Malik, M., Rangel-Barajas, C., Mach, R. H. & Luedtke, R. R., 1 Sep 2016, In : Pharmacology Biochemistry and Behavior. 148, p. 136-144 9 p.

Research output: Contribution to journalArticle

1 Scopus citations

The effects of sigma (σ1) receptor-selective ligands on muscarinic receptor antagonist-induced cognitive deficits in mice

Malik, M., Rangel-Barajas, C., Sumien, N., Su, C., Singh, M., Chen, Z., Huang, R. Q., Meunier, J., Maurice, T., Mach, R. H. & Luedtke, R. R., 1 May 2015, In : British Journal of Pharmacology. 172, 10, p. 2519-2531 13 p.

Research output: Contribution to journalArticle

17 Scopus citations