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  • Abe Clark
2020

Inducible rodent models of glaucoma

Pang, I. H. & Clark, A. F., Mar 2020, In : Progress in Retinal and Eye Research. 75, 100799.

Research output: Contribution to journalReview article

1 Scopus citations
2019

Effect of ocular hypertension on the pattern of retinal ganglion cell subtype loss in a mouse model of early-onset glaucoma

Daniel, S., Meyer, K. J., Clark, A. F., Anderson, M. G. & McDowell, C. M., Aug 2019, In : Experimental eye research. 185, 107703.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

RE: “Letter to the Editor concerning Webber et al. Exp Eye Res. 148:97–102, 2016”

Webber, H. C., Bermudez, J. Y., Sethi, A., Clark, A. F. & Mao, W., Jan 2019, In : Experimental eye research. 178, 1 p.

Research output: Contribution to journalLetter

2018

Activation of the NFAT-calcium signaling pathway in human lamina cribrosa cells in glaucoma

Irnaten, M., Zhdanov, A., Brennan, D., Crotty, T., Clark, A., Papkovsky, D. & O’Brien, C., Feb 2018, In : Investigative Ophthalmology and Visual Science. 59, 2, p. 831-842 12 p.

Research output: Contribution to journalArticle

10 Scopus citations

BMP and activin membrane bound inhibitor regulates the extracellular matrix in the trabecular meshwork

Hernandez, H., Cameron Millar, J., Curry, S. M., Clark, A. F. & McDowell, C. M., Apr 2018, In : Investigative Ophthalmology and Visual Science. 59, 5, p. 2154-2166 13 p.

Research output: Contribution to journalArticle

9 Scopus citations

Consensus recommendations for trabecular meshwork cell isolation, characterization and culture

Keller, K. E., Bhattacharya, S. K., Borrás, T., Brunner, T. M., Chansangpetch, S., Clark, A. F., Dismuke, W. M., Du, Y., Elliott, M. H., Ethier, C. R., Faralli, J. A., Freddo, T. F., Fuchshofer, R., Giovingo, M., Gong, H., Gonzalez, P., Huang, A., Johnstone, M. A., Kaufman, P. L., Kelley, M. J. & 37 others, Knepper, P. A., Kopczynski, C. C., Kuchtey, J. G., Kuchtey, R. W., Kuehn, M. H., Lieberman, R. L., Lin, S. C., Liton, P., Liu, Y., Lütjen-Drecoll, E., Mao, W., Masis-Solano, M., McDonnell, F., McDowell, C. M., Overby, D. R., Pattabiraman, P. P., Raghunathan, V. K., Rao, P. V., Rhee, D. J., Chowdhury, U. R., Russell, P., Samples, J. R., Schwartz, D., Stubbs, E. B., Tamm, E. R., Tan, J. C., Toris, C. B., Torrejon, K. Y., Vranka, J. A., Wirtz, M. K., Yorio, T., Zhang, J., Zode, G. S., Fautsch, M. P., Peters, D. M., Acott, T. S. & Stamer, W. D., Jun 2018, In : Experimental eye research. 171, p. 164-173 10 p.

Research output: Contribution to journalShort survey

35 Scopus citations

Establishment of a conditionally immortalized mouse optic nerve astrocyte line

Liu, Y., Patel, G. C., Mao, W. & Clark, A. F., Nov 2018, In : Experimental eye research. 176, p. 188-195 8 p.

Research output: Contribution to journalArticle

Glucocorticoid receptor GRβ regulates glucocorticoid-induced ocular hypertension in mice

Patel, G. C., Liu, Y., Millar, J. C. & Clark, A. F., 1 Dec 2018, In : Scientific Reports. 8, 1, 862.

Research output: Contribution to journalArticle

8 Scopus citations

Histological investigation of human glaucomatous eyes: Extracellular fibrotic changes and galectin 3 expression in the trabecular meshwork and optic nerve head

Belmares, R., Raychaudhuri, U., Maansson, S. & Clark, A. F., Oct 2018, In : Clinical Anatomy. 31, 7, p. 1031-1049 19 p.

Research output: Contribution to journalArticle

1 Scopus citations
4 Scopus citations

The role of wnt/β-catenin signaling and k-cadherin in the regulation of intraocular pressure

Webber, H. C., Bermudez, J. Y., Millar, J. C., Mao, W. & Clark, A. F., Mar 2018, In : Investigative Ophthalmology and Visual Science. 59, 3, p. 1454-1466 13 p.

Research output: Contribution to journalArticle

5 Scopus citations
2017

A comparison of gene expression profiles between glucocorticoid responder and non-responder bovine trabecular meshwork cells using RNA sequencing

Bermudez, J. Y., Webber, H. C., Brown, B., Braun, T. A., Clark, A. F. & Mao, W., Jan 2017, In : PLoS ONE. 12, 1, e0169671.

Research output: Contribution to journalArticle

6 Scopus citations

Anterior chamber perfusion versus posterior chamber perfusion does not influence measurement of aqueous outflow facility in living mice by constant flow infusion

Lopez, N. N., Patel, G. C., Raychaudhuri, U., Aryal, S., Phan, T. N., Clark, A. F. & Millar, J. C., Nov 2017, In : Experimental eye research. 164, p. 95-108 14 p.

Research output: Contribution to journalArticle

1 Scopus citations

CRISPR-Cas9–based treatment of myocilin-associated glaucoma

Jain, A., Zode, G., Kasetti, R. B., Ran, F. A., Yan, W., Sharma, T. P., Bugge, K., Searby, C. C., Fingert, J. H., Zhang, F., Clark, A. F. & Sheffield, V. C., 17 Oct 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 42, p. 11199-11204 6 p.

Research output: Contribution to journalArticle

37 Scopus citations

Cross-linked actin networks (CLANs) in glaucoma

Bermudez, J. Y., Montecchi-Palmer, M., Mao, W. & Clark, A. F., 1 Jun 2017, In : Experimental eye research. 159, p. 16-22 7 p.

Research output: Contribution to journalReview article

12 Scopus citations

Crosstalk between transforming growth factor beta-2 and toll-like receptor 4 in the trabecular meshwork

Hernandez, H., Medina-Ortiz, W. E., Luan, T., Clark, A. F. & McDowell, C. M., Mar 2017, In : Investigative Ophthalmology and Visual Science. 58, 3, p. 1811-1823 13 p.

Research output: Contribution to journalArticle

16 Scopus citations

Dexamethasone-Induced Ocular Hypertension in Mice: Effects of Myocilin and Route of Administration

Patel, G. C., Phan, T. N., Maddineni, P., Kasetti, R. B., Millar, J. C., Clark, A. F. & Zode, G. S., 1 Apr 2017, In : American Journal of Pathology. 187, 4, p. 713-723 11 p.

Research output: Contribution to journalArticle

18 Scopus citations
10 Scopus citations

Rapid repeatable in vivo detection of retinal reactive oxygen species

Fan, N., Silverman, S. M., Liu, Y., Wang, X., Kim, B. J., Tang, L., Clark, A. F., Liu, X. & Pang, I. H., Aug 2017, In : Experimental eye research. 161, p. 71-81 11 p.

Research output: Contribution to journalShort survey

2 Scopus citations

Role of ID proteins in BMP4 inhibition of profibrotic effects of TGF-β2 in human TM cells

Mody, A. A., Wordinger, R. J. & Clark, A. F., 1 Feb 2017, In : Investigative Ophthalmology and Visual Science. 58, 2, p. 849-859 11 p.

Research output: Contribution to journalArticle

7 Scopus citations

TGFβ2 induces the formation of cross-linked actin networks (CLANs) in human trabecular meshwork cells through the smad and non-smad dependent pathways

Montecchi-Palmer, M., Bermudez, J. Y., Webber, H. C., Patel, G. C., Clark, A. F. & Mao, W., Feb 2017, In : Investigative Ophthalmology and Visual Science. 58, 2, p. 1288-1295 8 p.

Research output: Contribution to journalArticle

12 Scopus citations

The many faces of the trabecular meshwork cell

Stamer, W. D. & Clark, A. F., 1 May 2017, In : Experimental eye research. 158, p. 112-123 12 p.

Research output: Contribution to journalReview article

40 Scopus citations

Tissue transglutaminase elevates intraocular pressure in mice

Raychaudhuri, U., Millar, J. C. & Clark, A. F., Dec 2017, In : Investigative Ophthalmology and Visual Science. 58, 14, p. 6197-6211 15 p.

Research output: Contribution to journalArticle

6 Scopus citations
2016

C1q propagates microglial activation and neurodegeneration in the visual axis following retinal ischemia/reperfusion injury

Silverman, S. M., Kim, B. J., Howell, G. R., Miller, J., John, S. W. M., Wordinger, R. J. & Clark, A. F., 24 Mar 2016, In : Molecular Neurodegeneration. 11, 1, 24.

Research output: Contribution to journalArticle

23 Scopus citations

Crosstalk between TGFβ and Wnt signaling pathways in the human trabecular meshwork

Webber, H. C., Bermudez, J. Y., Sethi, A., Clark, A. F. & Mao, W., 1 Jul 2016, In : Experimental eye research. 148, p. 97-102 6 p.

Research output: Contribution to journalArticle

10 Scopus citations

HDAC inhibitor-mediated epigenetic regulation of glaucoma-associated TGFβ2 in the trabecular meshwork

Bermudez, J. Y., Webber, H. C., Patel, G. C., Liu, X., Cheng, Y. Q., Clark, A. F. & Mao, W., Jul 2016, In : Investigative Ophthalmology and Visual Science. 57, 8, p. 3698-3707 10 p.

Research output: Contribution to journalArticle

3 Scopus citations

Human trabecular meshwork cells express BMP antagonist mRNAs and proteins

Tovar-Vidales, T., Fitzgerald, A. M. & Clark, A. F., 1 Jun 2016, In : Experimental eye research. 147, p. 156-160 5 p.

Research output: Contribution to journalArticle

10 Scopus citations

Hypoxia-induced changes in DNA methylation alter RASAL1 and TGFβ1 expression in human trabecular meshwork cells

McDonnell, F., Irnaten, M., Clark, A. F., O'Brien, C. J. & Wallace, D. M., Apr 2016, In : PLoS ONE. 11, 4, e0153354.

Research output: Contribution to journalArticle

21 Scopus citations

Identification and localization of lamina cribrosa cells in the human optic nerve head

Tovar-Vidales, T., Wordinger, R. J. & Clark, A., 1 Jun 2016, In : Experimental Eye Research. 147, p. 94-97 4 p.

Research output: Contribution to journalArticle

8 Scopus citations

Increased global DNA methylation and decreased TGFβ1 promoter methylation in glaucomatous lamina cribrosa cells

McDonnell, F. S., Mcnally, S. A., Clark, A. F., O'brien, C. J. & Wallace, D. M., 1 Oct 2016, In : Journal of Glaucoma. 25, 10, p. e834-e842

Research output: Contribution to journalArticle

7 Scopus citations

In vitro and in vivo neuroprotective effects of cJun N-terminal kinase inhibitors on retinal ganglion cells

Kim, B. J., Silverman, S. M., Liu, Y., Wordinger, R. J., Pang, I. H. & Clark, A. F., 21 Apr 2016, In : Molecular Neurodegeneration. 11, 1, 93.

Research output: Contribution to journalArticle

16 Scopus citations

Novel therapeutic targets for reduction of intraocular pressure in primary open angle glaucoma

Mao, W., Liu, Y., Wordinger, R. J., Clark, A. F. & Pang, I. H., 11 Jun 2016, In : Chinese Journal of Ophthalmology. 52, 6, p. 471-475 5 p.

Research output: Contribution to journalReview article

The novel triterpenoid RTA 408 protects human retinal pigment epithelial cells against H2O2-induced cell injury via NF-E2-related factor 2 (Nrf2) activation

Liu, X., Ward, K., Xavier, C., Jann, J., Clark, A. F., Pang, I. H. & Wu, H., 1 Aug 2016, In : Redox Biology. 8, p. 98-109 12 p.

Research output: Contribution to journalArticle

27 Scopus citations