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2019

A novel serum free primary astrocyte culture method that mimic quiescent astrocyte phenotype

Prah, J., Winters, A., Chaudhari, K., Hersh, J., Liu, R. & Yang, S., 15 May 2019, In : Journal of Neuroscience Methods. 320, p. 50-63 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Astrocytes
Phenotype
Serum
Fibroblast Growth Factor 2
Epidermal Growth Factor
2018
1 Citation (Scopus)

Aging health and R & D for healthy longevity must be included into the WHO work program

Stambler, I., Jin, K., Lederman, S., Barzilai, N., Jay Olshansky, S., Omokaro, E., Barratt, J., Anisimov, V. N., Rattan, S., Yang, S., Forster, M. J. & Byles, J., 1 Apr 2018, In : Aging and Disease. 9, 2, p. 331-333 3 p.

Research output: Contribution to journalEditorialResearch

Health
3 Citations (Scopus)

Artemisinin prevents glutamate-induced neuronal cell death via Akt pathway activation

Lin, S. P., Li, W., Winters, A., Liu, R. & Yang, S., 20 Apr 2018, In : Frontiers in Cellular Neuroscience. 12, 108.

Research output: Contribution to journalArticleResearchpeer-review

Glutamic Acid
Cell Death
artemisinine
Mitochondrial Membrane Potential
Antimalarials
2 Citations (Scopus)

Experimental ischemic stroke induces long-term T cell activation in the brain

Xie, L., Li, W., Hersh, J., Liu, R. & Yang, S., 1 Jan 2018, (Accepted/In press) In : Journal of Cerebral Blood Flow and Metabolism.

Research output: Contribution to journalArticleResearchpeer-review

Stroke
T-Lymphocytes
Brain
Perforin
Interleukin-17

Glia–immune interactions post-ischemic stroke and potential therapies

Hersh, J. & Yang, S., 1 Dec 2018, In : Experimental Biology and Medicine. 243, 17-18, p. 1302-1312 11 p.

Research output: Contribution to journalReview articleResearchpeer-review

Immune system
Brain
Neuroglia
Stroke
Immune System
3 Citations (Scopus)

High-Throughput data of circular RNA profiles in human temporal cortex tissue reveals novel insights into temporal lobe epilepsy

Li, J., Lin, H., Sun, Z., Kong, G., Yan, X., Wang, Y., Wang, X., Wen, Y., Liu, X., Zheng, H., Jia, M., Shi, Z., Xu, R., Yang, S. & Yuan, F., 1 Feb 2018, In : Cellular Physiology and Biochemistry. 45, 2, p. 677-691 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Temporal Lobe Epilepsy
Temporal Lobe
Epilepsy
circular RNA
Long Noncoding RNA
3 Citations (Scopus)

Hyperglycemia alters astrocyte metabolism and inhibits astrocyte proliferation

Li, W., Choudhury, G. R., Winters, A., Prah, J., Lin, W., Liu, R. & Yang, S., 1 Jan 2018, In : Aging and Disease. 9, 4, p. 674-684 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Astrocytes
Hyperglycemia
Glucose
Energy Metabolism
Cyclin D3
2 Citations (Scopus)

Insulin and heparin-binding epidermal growth factor-like growth factor synergistically promote astrocyte survival and proliferation in serum-free medium

Jia, M., Shi, Z., Yan, X., Xu, L., Dong, L., Li, J., Wang, Y., Yang, S. & Yuan, F., 1 Sep 2018, In : Journal of Neuroscience Methods. 307, p. 240-247 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Serum-Free Culture Media
Epidermal Growth Factor
Astrocytes
Heparin
Intercellular Signaling Peptides and Proteins
1 Citation (Scopus)

Precision Medicine for Ischemic Stroke, Let Us Move Beyond Time Is Brain

Yang, S., Lou, M., Luo, B., Jiang, W. J. & Liu, R., 1 Apr 2018, In : Translational Stroke Research. 9, 2, p. 93-95 3 p.

Research output: Contribution to journalEditorialResearch

Precision Medicine
Stroke
Brain

Surgical management of giant intrapetrous internal carotid aneurysm presenting with coil exposure after endovascular treatment

Yu, L. B., Zhang, D., Yang, S. & Zhao, J. Z., 1 Jul 2018, In : Neurosurgical Review. 41, 3, p. 891-894 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Aneurysm
Otoscopes
Therapeutics
Digital Subtraction Angiography
Referral and Consultation
2017
4 Citations (Scopus)

Administration of 5-methoxyindole-2-carboxylic acid that potentially targets mitochondrial dihydrolipoamide dehydrogenase confers cerebral preconditioning against ischemic stroke injury

Wu, J., Li, R., Li, W., Ren, M., Thangthaeng, N., Sumien, N., Liu, R., Yang, S., Simpkins, J. W., Forster, M. J. & Yan, L-J., 1 Dec 2017, In : Free Radical Biology and Medicine. 113, p. 244-254 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Dihydrolipoamide Dehydrogenase
Ischemic Preconditioning
Stroke
Wounds and Injuries
5-methoxyindole-2-carboxylic acid
15 Citations (Scopus)

Alternative mitochondrial electron transfer for the treatment of neurodegenerative diseases and cancers: Methylene blue connects the dots

Yang, S., Li, W., Sumien, N., Forster, M. J., Simpkins, J. W. & Liu, R., 1 Oct 2017, In : Progress in Neurobiology. 157, p. 273-291 19 p.

Research output: Contribution to journalReview articleResearchpeer-review

Methylene Blue
Neurodegenerative Diseases
Electrons
Energy Metabolism
Oxidative Phosphorylation
10 Citations (Scopus)

Aquaporin 4-mediated glutamate-induced astrocyte swelling is partially mediated through metabotropic glutamate receptor 5 activation

Shi, Z., Zhang, W., Lu, Y., Lu, Y., Xu, L., Fang, Q., Wu, M., Jia, M., Wang, Y., Dong, L., Yan, X., Yang, S. & Yuan, F., 28 Apr 2017, In : Frontiers in Cellular Neuroscience. 11, 116.

Research output: Contribution to journalArticleResearchpeer-review

Metabotropic Glutamate 5 Receptor
Aquaporin 4
Astrocytes
Glutamic Acid
Brain Edema
1 Citation (Scopus)

Cerebral Autoregulation

Yang, S. & Liu, R., 7 Mar 2017, Primer on Cerebrovascular Diseases: Second Edition. Elsevier Inc., p. 57-60 4 p.

Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review

Homeostasis
Cerebrovascular Circulation
Arterial Pressure
Blood Pressure
Brain
8 Citations (Scopus)

Combining injectable plasma scaffold with mesenchymal stem/stromal cells for repairing infarct cavity after ischemic stroke

Zhang, H., Sun, F., Wang, J., Xie, L., Pan, M., Shao, B., Yang, G. Y., Yang, S., ZhuGe, Q. & Jin, K., 1 Jan 2017, In : Aging and Disease. 8, 2, p. 203-214 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Mesenchymal Stromal Cells
Stroke
Injections
Neural Stem Cells
Brain
7 Citations (Scopus)

Control of cerebral ischemia with magnetic nanoparticles

Jia, J. M., Chowdary, P. D., Gao, X., Ci, B., Li, W., Mulgaonkar, A., Plautz, E. J., Hassan, G., Kumar, A., Stowe, A. M., Yang, S., Zhou, W., Sun, X., Cui, B. & Ge, W. P., 1 Feb 2017, In : Nature Methods. 14, 2, p. 160-166 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Brain Ischemia
Nanoparticles
Blood
Ischemia
Microcirculation
9 Citations (Scopus)

Glutamate Impairs Mitochondria Aerobic Respiration Capacity and Enhances Glycolysis in Cultured Rat Astrocytes

YAN, X., SHI, Z. F., XU, L. X., LI, J. X., WU, M., WANG, X. X., JIA, M., DONG, L. P., Yang, S. & YUAN, F., 1 Jan 2017, In : Biomedical and Environmental Sciences. 30, 1, p. 44-51 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Glycolysis
Astrocytes
Glutamic Acid
Mitochondria
Respiration

Methylene blue inhibits GABAA receptors by interaction with GABA binding site

Chen, Z., Liu, R., Yang, S., Dillon, G. H. & Huang, R-Q., 1 Jun 2017, In : Neuropharmacology. 119, p. 100-110 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Methylene Blue
GABA-A Receptors
gamma-Aminobutyric Acid
Binding Sites
Picrotoxin
2016
7 Citations (Scopus)

Brain globins in physiology and pathology

Xie, L. K. & Yang, S., 1 Jul 2016, In : Medical Gas Research. 6, 3, p. 154-163 10 p.

Research output: Contribution to journalReview articleResearchpeer-review

Globins
Pathology
Nervous System Diseases
Brain
Myoglobin
1 Citation (Scopus)

For the pursuit of oxygen and carbon dioxide channels in mitochondria

Yang, S. & Liu, R., 1 Oct 2016, In : Medical Gas Research. 6, 4, p. 237-238 2 p.

Research output: Contribution to journalEditorialResearch

Carbon Dioxide
Mitochondria
Oxygen
10 Citations (Scopus)

Heat Shock Protein 47 Promotes Glioma Angiogenesis

Wu, Z. B., Cai, L., Lin, S. J., Leng, Z. G., Guo, Y. H., Yang, W. L., Chu, Y. W., Yang, S. & Zhao, W. G., 1 Jan 2016, In : Brain Pathology. 26, 1, p. 31-42 12 p.

Research output: Contribution to journalArticleResearchpeer-review

HSP47 Heat-Shock Proteins
Glioma
Human Umbilical Vein Endothelial Cells
Microvessels
Tumor Burden
8 Citations (Scopus)

Methylene blue ameliorates ischemia/reperfusion-induced cerebral edema: An MRI and transmission electron microscope study

Fang, Q., Yan, X., Li, S., Sun, Y., Xu, L., Shi, Z., Wu, M., Lu, Y., Dong, L., Liu, R., Yuan, F. & Yang, S., 1 Jan 2016, Acta Neurochirurgica, Supplementum. Springer-Verlag Wien, p. 227-236 10 p. (Acta Neurochirurgica, Supplementum; vol. 121).

Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review

Methylene Blue
Middle Cerebral Artery Infarction
Transient Ischemic Attack
Brain Edema
Neuroprotective Agents
6 Citations (Scopus)

Neuroglobin Overexpression Inhibits AMPK Signaling and Promotes Cell Anabolism

Cai, B., Li, W., Mao, X. O., Winters, A., Ryou, M. G., Liu, R., Greenberg, D. A., Wang, N., Jin, K. & Yang, S., 1 Mar 2016, In : Molecular Neurobiology. 53, 2, p. 1254-1265 12 p.

Research output: Contribution to journalArticleResearchpeer-review

AMP-Activated Protein Kinases
Glycogen
Globins
Neurons
Brain
2015
41 Citations (Scopus)

Cerebral regulatory T cells restrain microglia/macrophage-mediated inflammatory responses via IL-10

Xie, L., Choudhury, G. R., Winters, A., Yang, S. & Jin, K., 1 Jan 2015, In : European Journal of Immunology. 45, 1, p. 180-191 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Microglia
Regulatory T-Lymphocytes
Interleukin-10
Macrophages
Cerebrum
14 Citations (Scopus)

Chemotherapeutic effect of tamoxifen on temozolomide-resistant gliomas

He, W., Liu, R., Yang, S. & Yuan, F., 1 Jan 2015, In : Anti-Cancer Drugs. 26, 3, p. 293-300 8 p.

Research output: Contribution to journalArticleResearchpeer-review

temozolomide
Tamoxifen
Glioma
Cell Line
Apoptosis
8 Citations (Scopus)

Downregulation of Aquaporin 4 Expression through Extracellular Signal-regulated Kinases1/2 Activation in Cultured Astrocytes Following Scratch-injury

Shi, Z. F. A., Zhao, W. J. I., Xu, L. X. I., Dong, L. P. I., Yang, S. & Yuan, F., 1 Mar 2015, In : Biomedical and environmental sciences : BES. 28, 3, p. 199-205 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Aquaporin 4
Astrocytes
Down-Regulation
Wounds and Injuries
L-Lactate Dehydrogenase
20 Citations (Scopus)

Interaction of astrocytes and T cells in physiological and pathological conditions

Xie, L. & Yang, S., 1 Jan 2015, In : Brain Research. 1623, p. 63-73 11 p.

Research output: Contribution to journalReview articleResearchpeer-review

Astrocytes
Central Nervous System
T-Lymphocytes
Virus Diseases
Blood-Brain Barrier
30 Citations (Scopus)

Methylene blue-induced neuronal protective mechanism against hypoxia-reoxygenation stress

Ryou, M. G., Choudhury, G. R., Li, W., Winters, A., Yuan, F., Liu, R. & Yang, S., 1 Aug 2015, In : Neuroscience. 301, p. 193-203 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Hypoxia-Inducible Factor 1
Methylene Blue
Glucose
Erythropoietin
Oxygen
14 Citations (Scopus)

Methylene blue protects astrocytes against glucose oxygen deprivation by improving cellular respiration

Choudhury, G. R., Winters, A., Rich, R. M., Ryou, M. G., Gryczynski, Z., Yuan, F., Yang, S. & Liu, R., 7 Apr 2015, In : PLoS ONE. 10, 4, e0123096.

Research output: Contribution to journalArticleResearchpeer-review

Cell Respiration
methylene blue
Methylene Blue
astrocytes
cell respiration
29 Citations (Scopus)

Stress induces p38 MAPK-mediated phosphorylation and inhibition of drosha-dependent cell survival

Yang, Q., Li, W., She, H., Dou, J., Duong, D. M., Du, Y., Yang, S., Seyfried, N. T., Fu, H., Gao, G. & Mao, Z., 1 Jan 2015, In : Molecular Cell. 57, 4, p. 721-734 14 p.

Research output: Contribution to journalArticleResearchpeer-review

p38 Mitogen-Activated Protein Kinases
MicroRNAs
Cell Survival
Phosphorylation
Ribonuclease III