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2019

Hybrid compound sa-2 is neuroprotective in animal models of retinal ganglion cell death

Stankowska, D. L., Dibas, A., Li, L., Zhang, W., Krishnamoorthy, V. R., Chavala, S., Nguyen, T. P., Yorio, T., Ellis, D. Z. & Acharya, S., 1 Jul 2019, In : Investigative Ophthalmology and Visual Science. 60, 8, p. 3064-3073 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Retinal Ganglion Cells
Cell Death
Nerve Crush
Animal Models
Retina
2018
9 Citations (Scopus)

Consensus recommendations for trabecular meshwork cell isolation, characterization and culture

Keller, K. E., Bhattacharya, S. K., Borrás, T., Brunner, T. M., Chansangpetch, S., Clark, A., Dismuke, W. M., Du, Y., Elliott, M. H., Ethier, C. R., Faralli, J. A., Freddo, T. F., Fuchshofer, R., Giovingo, M., Gong, H., Gonzalez, P., Huang, A., Johnstone, M. A., Kaufman, P. L., Kelley, M. J. & 37 others, Knepper, P. A., Kopczynski, C. C., Kuchtey, J. G., Kuchtey, R. W., Kuehn, M. H., Lieberman, R. L., Lin, S. C., Liton, P., Liu, Y., Lütjen-Drecoll, E., Mao, W., Masis-Solano, M., McDonnell, F., McDowell, C. M., Overby, D. R., Pattabiraman, P. P., Raghunathan, V. K., Rao, P. V., Rhee, D. J., Chowdhury, U. R., Russell, P., Samples, J. R., Schwartz, D., Stubbs, E. B., Tamm, E. R., Tan, J. C., Toris, C. B., Torrejon, K. Y., Vranka, J. A., Wirtz, M. K., Yorio, T., Zhang, J., Zode, G., Fautsch, M. P., Peters, D. M., Acott, T. S. & Stamer, W. D., 1 Jun 2018, In : Experimental eye research. 171, p. 164-173 10 p.

Research output: Contribution to journalShort surveyResearchpeer-review

Trabecular Meshwork
Cell Separation
Cell Culture Techniques
Ocular Hypertension
Intraocular Pressure

Introduction to volume 1 of JOPT special issue

Sharif, N., Ohia, S. & Yorio, T., 1 Jan 2018, In : Journal of Ocular Pharmacology and Therapeutics. 34, 1-2, p. 1-2 2 p.

Research output: Contribution to journalEditorialResearch

Introduction to volume 2 of JOPT special issue

Sharif, N., Ohia, S. & Yorio, T., 1 Jan 2018, In : Journal of Ocular Pharmacology and Therapeutics. 34, 1-2, 1 p.

Research output: Contribution to journalEditorialResearch

3 Citations (Scopus)

Neuroprotective Effects of Psalmotoxin-1, an Acid-Sensing Ion Channel (ASIC) Inhibitor, in Ischemia Reperfusion in Mouse Eyes

Dibas, A., Millar, J. C., Al-Farra, A. & Yorio, T., 3 Jul 2018, In : Current Eye Research. 43, 7, p. 921-933 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Acid Sensing Ion Channel Blockers
Retinal Ganglion Cells
Neuroprotective Agents
Reperfusion
Ischemia
4 Citations (Scopus)

Targets of neuroprotection in glaucoma

He, S., Stankowska, D. L., Ellis, D. Z., Krishnamoorthy, R. & Yorio, T., 1 Jan 2018, In : Journal of Ocular Pharmacology and Therapeutics. 34, 1-2, p. 85-106 22 p.

Research output: Contribution to journalArticleResearchpeer-review

Glaucoma
Retinal Diseases
Western World
Retinal Ganglion Cells
Aqueous Humor
2017

A feed-forward regulation of endothelin receptors by c-Jun in human non-pigmented ciliary epithelial cells and retinal ganglion cells

Wang, J., Ma, H. Y., Krishnamoorthy, R., Yorio, T. & He, S., 1 Sep 2017, In : PLoS ONE. 12, 9, e0185390.

Research output: Contribution to journalArticleResearchpeer-review

CCAAT-Enhancer-Binding Proteins
Endothelin Receptors
food law
endothelins
Endothelin B Receptors

Principles of ocular pharmacology

Park, Y., Ellis, D. Z., Mueller, B., Stankowska, D. L. & Yorio, T., 1 Jan 2017, Handbook of Experimental Pharmacology. Springer New York LLC, p. 3-30 28 p. (Handbook of Experimental Pharmacology; vol. 242).

Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review

Eye Diseases
Pharmacology
Pharmaceutical Preparations
Memory Disorders
Macular Degeneration
4 Citations (Scopus)

Sigma-1 receptor regulates mitochondrial function in glucose-and oxygen-deprived retinal ganglion cells

Ellis, D. Z., Li, L., Park, Y., He, S., Mueller, B. & Yorio, T., 1 May 2017, In : Investigative Ophthalmology and Visual Science. 58, 5, p. 2755-2764 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Retinal Ganglion Cells
Oxygen
Glucose
Mitochondrial Membrane Potential
Electron Transport Complex IV
2016
4 Citations (Scopus)

Design and synthesis of novel hybrid sydnonimine and prodrug useful for glaucomatous optic neuropathy

Acharya, S., Rogers, P., Krishnamoorthy, R., Stankowska, D. L., Dias, H. V. R. & Yorio, T., 1 Mar 2016, In : Bioorganic and Medicinal Chemistry Letters. 26, 5, p. 1490-1494 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Optic Nerve Diseases
Prodrugs
Optics
Photoreceptor Cells
Molecules
14 Citations (Scopus)

Glucocorticoid therapy and ocular hypertension

Dibas, A. & Yorio, T., 1 Jan 2016, In : European Journal of Pharmacology. 787, p. 57-71 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Ocular Hypertension
Glucocorticoids
Macular Degeneration
Diabetic Retinopathy
Glaucoma
4 Citations (Scopus)

Involvement of ampa receptor and its flip and flop isoforms in retinal ganglion cell death following oxygen/glucose deprivation

Park, Y. H., Broyles, H. V., He, S., McGrady, N. R., Li, L. & Yorio, T., 1 Feb 2016, In : Investigative Ophthalmology and Visual Science. 57, 2, p. 508-526 19 p.

Research output: Contribution to journalArticleResearchpeer-review

AMPA Receptors
Retinal Ganglion Cells
Protein Isoforms
Cell Death
Oxygen

Thank you to our reviewers

Yorio, T., 1 Jun 2016, In : Investigative Ophthalmology and Visual Science. 57, 7, 1 p.

Research output: Contribution to journalEditorialResearch

2015
11 Citations (Scopus)

AMPA receptor desensitization is the determinant of AMPA receptor mediated excitotoxicity in purified retinal ganglion cells

Park, Y. H., Mueller, B. H., McGrady, N. R., Ma, H. Y. & Yorio, T., 1 Mar 2015, In : Experimental eye research. 132, p. 136-150 15 p.

Research output: Contribution to journalArticleResearchpeer-review

AMPA Receptors
Retinal Ganglion Cells
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
Caspase 7
Calcium

A new transition

Yorio, T., 1 Jan 2015, In : Investigative Ophthalmology and Visual Science. 56, 5, 1 p.

Research output: Contribution to journalEditorialResearch

Ophthalmology
9 Citations (Scopus)

Endothelin-mediated changes in gene expression in isolated purified rat retinal ganglion cells

He, S., Park, Y. H., Yorio, T. & Krishnamoorthy, R., 1 Jan 2015, In : Investigative Ophthalmology and Visual Science. 56, 10, p. 6144-6161 18 p.

Research output: Contribution to journalArticleResearchpeer-review

Retinal Ganglion Cells
Endothelins
Gene Expression
Endothelin-1
Endothelin-2
10 Citations (Scopus)

Neuroprotective effects of transcription factor brn3b in an ocular hypertension rat model of glaucoma

Stankowska, D. L., Minton, A. Z., Rutledge, M. A., Mueller, B. H., Phatak, N. R., He, S., Ma, H. Y., Forster, M. J., Yorio, T. & Krishnamoorthy, R., 1 Jan 2015, In : Investigative Ophthalmology and Visual Science. 56, 2, p. 893-907 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Ocular Hypertension
Neuroprotective Agents
Intraocular Pressure
Glaucoma
Transcription Factors
1 Citation (Scopus)

Open access coming to IOVS

Yorio, T., 1 Jan 2015, In : Investigative Ophthalmology and Visual Science. 56, 9, 1 p.

Research output: Contribution to journalEditorialResearch