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2019

[ 99 mTc-HYNIC-N-dodecylamide]:a new hydrophobic tracer for labelling reconstituted high-density lipoproteins (rHDL) for radioimaging

Isaac-Olivé, K., Ocampo-García, B. E., Aranda-Lara, L., Santos-Cuevas, C. L., Jiménez-Mancilla, N. P., Luna-Gutiérrez, M. A., Medina, L. A., Nagarajan, B., Sabnis, N., Raut, S. L., Prokai, L. & Lacko, A. G., 14 Jan 2019, In : Nanoscale. 11, 2, p. 541-551 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Lipoproteins
HDL Lipoproteins
Labeling
Imaging techniques
Acids

Different reactivity to glutathione but similar tumor cell toxicity of chalcones and their quinolinone analogues

d’Oliveira, G. D. C., Custodio, J. M. F., Moura, A. F., Napolitano, H. B., Pérez, C. N., Moraes, M. O., Prokai, L. & Perjési, P., 1 Sep 2019, In : Medicinal Chemistry Research. 28, 9, p. 1448-1460 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Chalcones
Chalcone
Quinolones
Glutathione
Toxicity
2018

10β,17α-Dihydroxyestra-1,4-dien-3-one: A Bioprecursor Prodrug Preferentially Producing 17α-Estradiol in the Brain for Targeted Neurotherapy

Prokai-Tatrai, K., Nguyen, V. & Prokai, L., 21 Nov 2018, In : ACS Chemical Neuroscience. 9, 11, p. 2528-2533 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Prodrugs
Estradiol
Brain
Estrogens
Neurology
5 Citations (Scopus)

An exploratory investigation of brain-selective estrogen treatment in males using a mouse model of Alzheimer's disease

Tschiffely, A. E., Schuh, R. A., Prokai-Tatrai, K., Ottinger, M. A. & Prokai, L., 1 Feb 2018, In : Hormones and Behavior. 98, p. 16-21 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Alzheimer Disease
Estrogens
Brain
Estradiol
Amyloid beta-Protein Precursor

Risk-associated and pathway-based method to detect association with Alzheimer's disease

Mitchel, J., Prokai, L., Deng, Y., Zhang, F. & Barber, R. C., 1 Jan 2018, In : International Journal of Computational Biology and Drug Design. 11, 1-2

Research output: Contribution to journalEditorialResearch

Alzheimer Disease
Alleles
Genome-Wide Association Study
Databases
Genes
2017

Effect of short-term DHEA supplementation on serum and hippocampal estrogen concentrations in perimenopausal female rhesus macaques

Urbanski, H. F., Sorwell, K. G., Prokai, L. & Kohama, S. G., 1 Jul 2017, In : Neurobiology of Aging. 55, p. 172-174 3 p.

Research output: Contribution to journalArticleResearchpeer-review

Dehydroepiandrosterone
Macaca mulatta
Estrogens
Estradiol
Hippocampus

Mannich Ketones as Possible Antimycobacterial Agents

Lutz, Z., Orbán, K., Bóna, Á., Márk, L., Maász, G., Prokai, L., Seress, L. & Lóránd, T., 1 Sep 2017, In : Archiv der Pharmazie. 350, 9, 1700102.

Research output: Contribution to journalArticleResearchpeer-review

Gordonia Bacterium
Amino Alcohols
Isoniazid
Microbial Sensitivity Tests
Ketones
10 Citations (Scopus)

Targeting alpha toxin to mitigate its lethal toxicity in ferret and rabbit models of Staphylococcus aureus necrotizing pneumonia

Diep, B. A., Hilliard, J. J., Le, V. T. M., Tkaczyk, C., Le, H. N., Tran, V. G., Rao, R. L., Dip, E. C., Pereira-Franchi, E. P., Cha, P., Jacobson, S., Broome, R., Cheng, L. I., Weiss, W., Prokai, L., Nguyen, V., Stover, C. K. & Sellman, B. R., 1 Apr 2017, In : Antimicrobial agents and chemotherapy. 61, 4, 02456-16.

Research output: Contribution to journalArticleResearchpeer-review

Staphylococcal Pneumonia
Ferrets
Rabbits
Linezolid
Passive Immunization
2016
5 Citations (Scopus)

A comparative evaluation of treatments with 17β-estradiol and its brain-selective prodrug in a double-transgenic mouse model of Alzheimer's disease

Tschiffely, A. E., Schuh, R. A., Prokai-Tatrai, K., Prokai, L. & Ottinger, M. A., 1 Jul 2016, In : Hormones and Behavior. 83, p. 39-44 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Prodrugs
Transgenic Mice
Estradiol
Alzheimer Disease
Brain
35 Citations (Scopus)

Cholinergic neurons in the basal forebrain promote wakefulness by actions on neighboring non-cholinergic neurons: An opto-dialysis study

Zant, J. C., Kim, T., Prokai, L., Szarka, S., McNally, J., McKenna, J. T., Shukla, C., Yang, C., Kalinchuk, A. V., McCarley, R. W., Brown, R. E. & Basheer, R., 10 Feb 2016, In : Journal of Neuroscience. 36, 6, p. 2057-2067 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Cholinergic Neurons
Wakefulness
Dialysis
Neurons
Optogenetics
13 Citations (Scopus)

Critical role of alpha-toxin and protective effects of its neutralization by a human antibody in acute bacterial skin and skin structure infections

Le, V. T. M., Tkaczyk, C., Chau, S., Rao, R. L., Dip, E. C., Pereira-Franchi, E. P., Cheng, L., Lee, S., Koelkebeck, H., Hilliard, J. J., Yu, X. Q., Datta, V., Nguyen, V., Weiss, W., Prokai, L., O'Day, T., Stover, C. K., Sellman, B. R. & Diep, B. A., 1 Oct 2016, In : Antimicrobial agents and chemotherapy. 60, 10, p. 5640-5648 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Skin
Antibodies
Infection
Linezolid
Methicillin-Resistant Staphylococcus aureus
2 Citations (Scopus)
Organothiophosphates
Cyclotrons
Cyclotron resonance
Fourier Analysis
cyclotron resonance

Mass spectrometric analysis of carisoprodol and meprobamate in rat brain microdialysates

Prokai, L., Fryčák, P., Nguyen, V. & Forster, M. J., 1 Oct 2016, In : Journal of Mass Spectrometry. 51, 10, p. 900-907 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Meprobamate
Carisoprodol
Ionization
Rats
Brain
4 Citations (Scopus)

Treatment with an orally bioavailable prodrug of 17β-estradiol alleviates hot flushes without hormonal effects in the periphery

Merchenthaler, I., Lane, M., Sabnis, G., Brodie, A., Nguyen, V., Prokai, L. & Prokai-Tatrai, K., 1 Aug 2016, In : Scientific Reports. 6, 30721.

Research output: Contribution to journalArticleResearchpeer-review

Prodrugs
Estradiol
Estrogens
Skin Temperature
Brain
2015
30 Citations (Scopus)

Anti-alpha-toxin monoclonal antibody and antibiotic combination therapy improves disease outcome and accelerates healing in a staphylococcus aureus dermonecrosis model

Hilliard, J. J., Datta, V., Tkaczyk, C., Hamilton, M., Sadowska, A., Jones-Nelson, O., O'Day, T., Weiss, W., Szarka, S., Nguyen, V., Prokai, L., Suzich, J. A., Stover, C. K. & Sellmana, B. R., 1 Jan 2015, In : Antimicrobial agents and chemotherapy. 59, 1, p. 299-308 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Linezolid
Staphylococcus aureus
Vancomycin
Monoclonal Antibodies
Anti-Bacterial Agents

A survey of the impact of deyolking on biological processes covered by shotgun proteomic analyses of zebrafish embryos

Rahlouni, F., Szarka, S., Shulaev, V. & Prokai, L., 1 Dec 2015, In : Zebrafish. 12, 6, p. 398-407 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Biological Phenomena
Firearms
Zebrafish
Proteome
proteome
4 Citations (Scopus)
Lidocaine
Local Anesthetics
Ionization
Masks
Fourier transforms
15 Citations (Scopus)

The prodrug DHED selectively delivers 17β-estradiol to the brain for treating estrogen-responsive disorders

Prokai, L., Nguyen, V., Szarka, S., Garg, P., Sabnis, G., Bimonte-Nelson, H. A., McLaughlin, K. J., Talboom, J. S., Conrad, C. D., Shughrue, P. J., Gould, T. D., Brodie, A., Merchenthaler, I., Koulen, P. & Prokai-Tatrai, K., 22 Jul 2015, In : Science Translational Medicine. 7, 297, 297ra113.

Research output: Contribution to journalArticleResearchpeer-review

Prodrugs
Estradiol
Estrogens
Brain
Menopause