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2019

Design, synthesis, and evaluation of N-(4-(4-phenyl piperazin-1-yl)butyl)-4-(thiophen-3-yl)benzamides as selective dopamine D3 receptor ligands

Chen, P. J., Taylor, M., Griffin, S. A., Amani, A., Hayatshahi, H., Korzekwa, K., Ye, M., Mach, R. H., Liu, J., Luedtke, R. T., Gordon, J. C. & Blass, B. E., 15 Sep 2019, In : Bioorganic and Medicinal Chemistry Letters. 29, 18, p. 2690-2694 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Benzamides
Dopamine D3 Receptors
Pharmacokinetics
Dopamine Receptors
G-Protein-Coupled Receptors

Leveraging a Low-Affinity Diazaspiro Orthosteric Fragment to Reduce Dopamine D 3 Receptor (D 3 R) Ligand Promiscuity across Highly Conserved Aminergic G-Protein-Coupled Receptors (GPCRs)

Reilly, S. W., Riad, A. A., Hsieh, C. J., Sahlholm, K., Jacome, D. A., Griffin, S., Taylor, M., Weng, C. C., Xu, K., Kirschner, N., Luedtke, R. T., Parry, C., Malhotra, S., Karanicolas, J. & Mach, R. H., 23 May 2019, In : Journal of Medicinal Chemistry. 62, 10, p. 5132-5147 16 p.

Research output: Contribution to journalArticleResearchpeer-review

G-Protein-Coupled Receptors
Dopamine
Ligands
Adrenergic Agents
Pharmaceutical Preparations

Retraction notice to “Dopamine Ds3 receptor partial agonist LS-3-134 attenuates cocaine-motivated behaviors” [Pharmacology, Biochemistry and Behavior 171 (2018) 46–53](S0091305718300236)(10.1016/j.pbb.2018.05.015)

Powell, G. L., Bonadonna, J. P., Vannan, A., Xu, K., Mach, R. H., Luedtke, R. T. & Neisewander, J. L., 1 Jan 2019, In : Pharmacology Biochemistry and Behavior. 176, 1 p.

Research output: Contribution to journalComment/debateResearch

Biochemistry
Dopamine Receptors
Cocaine
Animal Care Committees
Pharmacology
2018
1 Citation (Scopus)

Analogues of Arylamide Phenylpiperazine Ligands to Investigate the Factors Influencing D3 Dopamine Receptor Bitropic Binding and Receptor Subtype Selectivity

Hayatshahi, H. S., Xu, K., Griffin, S. A., Taylor, M., Mach, R. H., Liu, J. & Luedtke, R. T., 19 Dec 2018, In : ACS Chemical Neuroscience. 9, 12, p. 2972-2983 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Dopamine D3 Receptors
Ligands
Dopamine D2 Receptors
Dopamine Receptors
Nitrogen
6 Citations (Scopus)

Challenges in the development of dopamine D2- and D3-selective radiotracers for PET imaging studies

Mach, R. H. & Luedtke, R. T., 1 Mar 2018, In : Journal of Labelled Compounds and Radiopharmaceuticals. 61, 3, p. 291-298 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Positron emission tomography
Positron-Emission Tomography
Dopamine D2 Receptors
Dopamine
Dopamine D3 Receptors
12 Citations (Scopus)

Dissociation of striatal dopamine and tyrosine hydroxylase expression from aging-related motor decline: Evidence from calorie restriction intervention

Salvatore, M. F., Terrebonne, J., Cantu, M. A., McInnis, T. R., Venable, K., Kelley, P., Kasanga, E. A., Latimer, B., Owens, C. L., Pruett, B. S., Yu, Y., Luedtke, R. T., Forster, M. J., Sumien, N. & Ingram, D. K., 1 Jan 2018, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 73, 1, p. 11-20 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Corpus Striatum
Tyrosine 3-Monooxygenase
Dopamine
Locomotion
Hypokinesia

Dopamine D3 receptor partial agonist LS-3-134 attenuates cocaine-motivated behaviors

Powell, G. L., Bonadonna, J. P., Vannan, A., Xu, K., Mach, R. H., Luedtke, R. T. & Neisewander, J. L., 1 Dec 2018, In : Pharmacology Biochemistry and Behavior. 175, p. 123-129 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Dopamine D3 Receptors
Cocaine
Reinforcement Schedule
Reinforcement
Locomotion

Dopamine D3 receptor partial agonist LS-3-134 attenuates cocaine-motivated behaviors

Powell, G. L., Bonadonna, J. P., Vannan, A., Xu, K., Mach, R. H., Luedtke, R. T. & Neisewander, J. L., 1 Aug 2018, In : Pharmacology Biochemistry and Behavior. 171, p. 46-53 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Dopamine D3 Receptors
Cocaine
Reinforcement Schedule
Reinforcement
Locomotion
2017

Dysregulated corticostriatal activity in open-field behavior and the head-twitch response induced by the hallucinogen 2,5-dimethoxy-4-iodoamphetamine

Rangel-Barajas, C., Estrada-Sánchez, A. M., Barton, S. J., Luedtke, R. T. & Rebec, G. V., 1 Feb 2017, In : Neuropharmacology. 113, p. 502-510 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Hallucinogens
Head
Neurons
Motor Cortex
Amphetamine
3 Citations (Scopus)

Highly Selective Dopamine D3 Receptor Antagonists with Arylated Diazaspiro Alkane Cores

Reilly, S. W., Griffin, S., Taylor, M., Sahlholm, K., Weng, C. C., Xu, K., Jacome, D. A., Luedtke, R. T. & Mach, R. H., 14 Dec 2017, In : Journal of Medicinal Chemistry. 60, 23, p. 9905-9910 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Dopamine D3 Receptors
Alkanes
Dopamine Antagonists
Ligands
2016
1 Citation (Scopus)

The effect of the sigma-1 receptor selective compound LS-1-137 on the DOI-induced head twitch response in mice

Malik, M., Rangel-Barajas, C., Mach, R. H. & Luedtke, R. T., 1 Sep 2016, In : Pharmacology Biochemistry and Behavior. 148, p. 136-144 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Head
Receptor, Serotonin, 5-HT2C
sigma Receptors
sigma-1 receptor
N-(1-benzylpiperidin-4-yl)phenylacetamide
2015
7 Citations (Scopus)

Bitropic D3 dopamine receptor selective compounds as potential antipsychotics

Luedtke, R. T., Rangel-Barajas, C., Malik, M., Reichert, D. E. & Mach, R. H., 1 Sep 2015, In : Current Pharmaceutical Design. 21, 26, p. 3700-3724 25 p.

Research output: Contribution to journalArticleResearchpeer-review

Dopamine D3 Receptors
Antipsychotic Agents
Dopamine D2 Receptors
Dopamine D4 Receptors
Ligands
5 Citations (Scopus)

Pharmacological modulation of abnormal involuntary DOI-induced head twitch response movements in male DBA/2J mice: II. Effects of D3 dopamine receptor selective compounds

Rangel-Barajas, C., Malik, M., Mach, R. H. & Luedtke, R. T., 1 Jan 2015, In : Neuropharmacology. 93, p. 179-190 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Dopamine D3 Receptors
Inbred DBA Mouse
Head
Pharmacology
Dopamine D2 Receptors
6 Citations (Scopus)

Synthesis, pharmacological evaluation and molecular modeling studies of triazole containing dopamine D3 receptor ligands

Peng, X., Wang, Q., Mishra, Y., Xu, J., Reichert, D. E., Malik, M., Taylor, M., Luedtke, R. T. & Mach, R. H., 1 Feb 2015, In : Bioorganic and Medicinal Chemistry Letters. 25, 3, p. 519-523 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Dopamine D3 Receptors
Triazoles
Molecular modeling
Pharmacology
Ligands
16 Citations (Scopus)

The effects of sigma (σ1) receptor-selective ligands on muscarinic receptor antagonist-induced cognitive deficits in mice

Malik, M., Rangel-Barajas, C., Sumien, N., Su, C., Singh, M., Chen, Z., Huang, R-Q., Meunier, J., Maurice, T., Mach, R. H. & Luedtke, R. T., 1 May 2015, In : British Journal of Pharmacology. 172, 10, p. 2519-2531 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Muscarinic Antagonists
Muscarinic Receptors
Ligands
Scopolamine Hydrobromide
Nootropic Agents