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• 2019

  Design, synthesis, and evaluation of N-(4-(4-phenyl piperazin-1-yl)butyl)-4-(thiophen-3-yl)benzamides as selective dopamine D₃ receptor ligands

  Chen, P. J., Taylor, M., Griffin, S. A., Amani, A., Hayatshahi, H., Korzekwa, K., Ye, M., Mach, R. H., Liu, J., Luedtke, R. R., Gordon, J. C. & Blass, B. E., 15 Sep 2019, In: Bioorganic and Medicinal Chemistry Letters. 29, 18, p. 2690-2694 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Benzamides
  • benzamide
  • Dopamine D3 Receptors
  • Pharmacokinetics
  • Rats
  1 Scopus citations

• Leveraging a Low-Affinity Diazaspiro Orthosteric Fragment to Reduce Dopamine D₃ Receptor (D₃R) Ligand Promiscuity across Highly Conserved Aminergic G-Protein-Coupled Receptors (GPCRs)

  Reilly, S. W., Riad, A. A., Hsieh, C. J., Sahlholm, K., Jacome, D. A., Griffin, S., Taylor, M., Weng, C. C., Xu, K., Kirschner, N., Luedtke, R. R., Parry, C., Malhotra, S., Karanicolas, J. & Mach, R. H., 23 May 2019, In: Journal of Medicinal Chemistry. 62, 10, p. 5132-5147 16 p.

  Research output: Contribution to journal › Article › peer-review

  • Dopamine D3 Receptors
  • Piperazine
  • G-Protein-Coupled Receptors
  • undecane
  • Ligands
  1 Scopus citations

• Retraction notice to “Dopamine Ds3 receptor partial agonist LS-3-134 attenuates cocaine-motivated behaviors” [Pharmacology, Biochemistry and Behavior 171 (2018) 46–53](S0091305718300236)(10.1016/j.pbb.2018.05.015)

  Powell, G. L., Bonadonna, J. P., Vannan, A., Xu, K., Mach, R. H., Luedtke, R. T. & Neisewander, J. L., 1 Jan 2019, In: Pharmacology Biochemistry and Behavior. 176, 1 p.

  Research output: Contribution to journal › Comment/debate

  • N-((4-(4-(2-(2-fluoroethoxy)phenyl)-1-piperazinyl)butyl)-4-(3-thienyl)benzamide
  • Animal Care Committees
  • Biochemistry
  • Dopamine Receptors
  • Cocaine
• 2018

  Analogues of Arylamide Phenylpiperazine Ligands to Investigate the Factors Influencing D3 Dopamine Receptor Bitropic Binding and Receptor Subtype Selectivity

  Hayatshahi, H. S., Xu, K., Griffin, S. A., Taylor, M., Mach, R. H., Liu, J. & Luedtke, R. R., 19 Dec 2018, In: ACS Chemical Neuroscience. 9, 12, p. 2972-2983 12 p.

  Research output: Contribution to journal › Article › peer-review

  • phenylpiperazine
  • Dopamine D3 Receptors
  • Ligands
  • Piperazine
  • N-((4-(4-(2-(2-fluoroethoxy)phenyl)-1-piperazinyl)butyl)-4-(3-thienyl)benzamide
  7 Scopus citations

• Challenges in the development of dopamine D2- and D3-selective radiotracers for PET imaging studies

  Mach, R. H. & Luedtke, R. T., 1 Mar 2018, In: Journal of Labelled Compounds and Radiopharmaceuticals. 61, 3, p. 291-298 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Positron emission tomography
  • Positron-Emission Tomography
  • Dopamine D2 Receptors
  • Dopamine
  • Imaging techniques
  6 Scopus citations

• Dissociation of striatal dopamine and tyrosine hydroxylase expression from aging-related motor decline: Evidence from calorie restriction intervention

  Salvatore, M. F., Terrebonne, J., Cantu, M. A., McInnis, T. R., Venable, K., Kelley, P., Kasanga, E. A., Latimer, B., Owens, C. L., Pruett, B. S., Yu, Y., Luedtke, R., Forster, M. J., Sumien, N. & Ingram, D. K., 2018, In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 73, 1, p. 11-20 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Tyrosine 3-Monooxygenase
  • Corpus Striatum
  • Dopamine
  • Locomotion
  • Hypokinesia
  18 Scopus citations

• Dopamine D3 receptor partial agonist LS-3-134 attenuates cocaine-motivated behaviors

  Powell, G. L., Bonadonna, J. P., Vannan, A., Xu, K., Mach, R. H., Luedtke, R. R. & Neisewander, J. L., Aug 2018, In: Pharmacology Biochemistry and Behavior. 171, p. 46-53 8 p.

  Research output: Contribution to journal › Article › peer-review

  • N-((4-(4-(2-(2-fluoroethoxy)phenyl)-1-piperazinyl)butyl)-4-(3-thienyl)benzamide
  • Dopamine D3 Receptors
  • Cocaine
  • Reinforcement Schedule
  • Reinforcement
  1 Scopus citations

• Dopamine D3 receptor partial agonist LS-3-134 attenuates cocaine-motivated behaviors

  Powell, G. L., Bonadonna, J. P., Vannan, A., Xu, K., Mach, R. H., Luedtke, R. R. & Neisewander, J. L., Dec 2018, In: Pharmacology Biochemistry and Behavior. 175, p. 123-129 7 p.

  Research output: Contribution to journal › Article › peer-review

  • N-((4-(4-(2-(2-fluoroethoxy)phenyl)-1-piperazinyl)butyl)-4-(3-thienyl)benzamide
  • Dopamine D3 Receptors
  • Cocaine
  • Reinforcement Schedule
  • Reinforcement
  2 Scopus citations
• 2017

  Dysregulated corticostriatal activity in open-field behavior and the head-twitch response induced by the hallucinogen 2,5-dimethoxy-4-iodoamphetamine

  Rangel-Barajas, C., Estrada-Sánchez, A. M., Barton, S. J., Luedtke, R. R. & Rebec, G. V., 1 Feb 2017, In: Neuropharmacology. 113, p. 502-510 9 p.

  Research output: Contribution to journal › Article › peer-review

  • 4-iodoamphetamine
  • Hallucinogens
  • Head
  • Neurons
  • Amphetamine
  1 Scopus citations

• Highly Selective Dopamine D₃ Receptor Antagonists with Arylated Diazaspiro Alkane Cores

  Reilly, S. W., Griffin, S., Taylor, M., Sahlholm, K., Weng, C. C., Xu, K., Jacome, D. A., Luedtke, R. R. & Mach, R. H., 14 Dec 2017, In: Journal of Medicinal Chemistry. 60, 23, p. 9905-9910 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Alkanes
  • Dopamine D3 Receptors
  • Dopamine Antagonists
  • Ligands
  9 Scopus citations
• 2016

  The effect of the sigma-1 receptor selective compound LS-1-137 on the DOI-induced head twitch response in mice

  Malik, M., Rangel-Barajas, C., Mach, R. H. & Luedtke, R. R., 1 Sep 2016, In: Pharmacology Biochemistry and Behavior. 148, p. 136-144 9 p.

  Research output: Contribution to journal › Article › peer-review

  • N-(1-benzylpiperidin-4-yl)phenylacetamide
  • 4-iodoamphetamine
  • sigma-1 receptor
  • Head
  • sigma-2 receptor
  2 Scopus citations
• 2015

  Bitropic D3 dopamine receptor selective compounds as potential antipsychotics

  Luedtke, R. R., Rangel-Barajas, C., Malik, M., Reichert, D. E. & Mach, R. H., 1 Sep 2015, In: Current Pharmaceutical Design. 21, 26, p. 3700-3724 25 p.

  Research output: Contribution to journal › Article › peer-review

  • Dopamine D3 Receptors
  • Antipsychotic Agents
  • Dopamine D2 Receptors
  • Dopamine D4 Receptors
  • Ligands
  9 Scopus citations

• Pharmacological modulation of abnormal involuntary DOI-induced head twitch response movements in male DBA/2J mice: II. Effects of D3 dopamine receptor selective compounds

  Rangel-Barajas, C., Malik, M., Mach, R. H. & Luedtke, R. R., Jun 2015, In: Neuropharmacology. 93, p. 179-190 12 p.

  Research output: Contribution to journal › Article › peer-review

  • N-(4-(4-(2-methoxyphenyl)-1,4-diazepan-1-yl)butyl)-4-(thiophen-3-yl)benzamide
  • Dopamine D3 Receptors
  • Inbred DBA Mouse
  • WW-III-55
  • Head
  6 Scopus citations

• Synthesis, pharmacological evaluation and molecular modeling studies of triazole containing dopamine D₃ receptor ligands

  Peng, X., Wang, Q., Mishra, Y., Xu, J., Reichert, D. E., Malik, M., Taylor, M., Luedtke, R. R. & Mach, R. H., 1 Feb 2015, In: Bioorganic and Medicinal Chemistry Letters. 25, 3, p. 519-523 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Molecular modeling
  • Dopamine D3 Receptors
  • Triazoles
  • Ligands
  • Pharmacology
  9 Scopus citations

• The effects of sigma (σ1) receptor-selective ligands on muscarinic receptor antagonist-induced cognitive deficits in mice

  Malik, M., Rangel-Barajas, C., Sumien, N., Su, C., Singh, M., Chen, Z., Huang, R. Q., Meunier, J., Maurice, T., Mach, R. H. & Luedtke, R. R., 1 May 2015, In: British Journal of Pharmacology. 172, 10, p. 2519-2531 13 p.

  Research output: Contribution to journal › Article › peer-review

  • N-(1-benzylpiperidin-4-yl)phenylacetamide
  • sigma-1 receptor
  • Muscarinic Antagonists
  • Muscarinic Receptors
  • Ligands
  17 Scopus citations