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2019
Open Access
National Institute of Neurological Disorders and Stroke
Organized Financing
Astrocytes
Histones
Methylation

Tat expression led to increased histone 3 tri-methylation at lysine 27 and contributed to HIV latency in astrocytes through regulation of MeCP2 and Ezh2 expression

Liu, Y., Niu, Y., Li, L., Timani, K. A., He, V. L., Sanburns, C., Xie, J. & He, J. J., 1 Jan 2019, In : Journal of NeuroVirology.

Research output: Contribution to journalArticleResearchpeer-review

Astrocytes
Histones
Methylation
Lysine
HIV
2018
4 Citations (Scopus)

Doxycycline-inducible and astrocyte-specific HIV-1 Tat transgenic mice (iTat) as an HIV/neuroAIDS model

Langford, D., Kim, B. O., Zou, W., Fan, Y., Rahimain, P., Liu, Y. & He, J. J., 15 Nov 2018, In : Journal of NeuroVirology. 24, 2, p. 168-179 12 p.

Research output: Contribution to journalReview articleResearchpeer-review

Doxycycline
Astrocytes
Transgenic Mice
HIV-1
HIV
1 Citation (Scopus)

miRNA regulation of Tip110 expression and self-renewal and differentiation of human CD34+ hematopoietic cells

Liu, Y., Huang, X., Timani, K. A., Broxmeyer, H. E. & He, J. J., 1 Jan 2018, In : Oncotarget. 9, 4, p. 4823-4832 10 p.

Research output: Contribution to journalArticleResearchpeer-review

MicroRNAs
3' Untranslated Regions
Hematopoiesis
Untranslated RNA
Fetal Blood

Neo-clerodane diterpenoids from the whole plants of Scutellaria formosana

Chen, X., Chen, W., Chen, G., Han, C., He, J. J., Zhou, X., Yu, Z., Dai, C. & Song, X., 1 Jan 2018, In : Phytochemistry. 145, p. 1-9 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Scutellaria
Clerodane Diterpenes
Stereochemistry
Diterpenes
stereochemistry
Cleavage Stimulation Factor
Polyadenylation
3' Untranslated Regions
Fetal Blood
Blood Cells

Tip110/SART3 regulates IL-8 expression and predicts the clinical outcomes in melanoma

Timani, K. A., Gyorffy, B., Liu, Y., Mohammad, K. S. & He, J. J., 17 Aug 2018, In : Molecular Cancer. 17, 1, 124.

Research output: Contribution to journalLetterResearchpeer-review

Interleukin-8
Melanoma
Carcinogenesis
Autocrine Communication
Neoplasm Metastasis
2017
4 Citations (Scopus)

HIV/neuroAIDS biomarkers

Rahimian, P. & He, J. J., 1 Oct 2017, In : Progress in Neurobiology. 157, p. 117-132 16 p.

Research output: Contribution to journalReview articleResearchpeer-review

Biomarkers
HIV
Symptom Assessment
Neuroaid
Nervous System Trauma
4 Citations (Scopus)

The anticancer drug sunitinib promotes autophagyand protects from neurotoxicity in an HIV-1 Tat model of neurodegeneration

Fields, J. A., Metcalf, J., Overk, C., Adame, A., Spencer, B., Wrasidlo, W., Florio, J., Rockenstein, E., He, J. J. & Masliah, E., 1 Apr 2017, In : Journal of NeuroVirology. 23, 2, p. 290-303 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Autophagy
HIV-1
Pharmaceutical Preparations
HIV
Transgenic Mice
3 Citations (Scopus)

Tip110 Deletion Impaired Embryonic and Stem Cell Development Involving Downregulation of Stem Cell Factors Nanog, Oct4, and Sox2

Whitmill, A., Liu, Y., Timani, K. A., Niu, Y. & He, J. J., 1 Jul 2017, In : Stem Cells. 35, 7, p. 1674-1686 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Stem Cell Factor
Embryonic Stem Cells
Blastocyst
Down-Regulation
Embryonic Development
2016
15 Citations (Scopus)

Exosome-associated release, uptake, and neurotoxicity of HIV-1 Tat protein

Rahimian, P. & He, J. J., 1 Dec 2016, In : Journal of NeuroVirology. 22, 6, p. 774-788 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Human Immunodeficiency Virus tat Gene Products
Exosomes
HIV-1
Astrocytes
HIV Long Terminal Repeat
3 Citations (Scopus)

Function of ubiquitin (Ub) specific protease 15 (USP15) in HIV-1 replication and viral protein degradation

Pyeon, D., Timani, K. A., Gulraiz, F., He, J. J. & Park, I., 2 Sep 2016, In : Virus Research. 223, p. 161-169 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Ubiquitin-Specific Proteases
Viral Proteins
Proteolysis
HIV-1
Peptide Hydrolases
18 Citations (Scopus)
Unfolded Protein Response
Endoplasmic Reticulum Stress
Glial Fibrillary Acidic Protein
Astrocytes
HIV-1
7 Citations (Scopus)

HIV-1 tat promotes lysosomal exocytosis in astrocytes and contributes to astrocyte-mediated tat neurotoxicity

Fan, Y. & He, J. J., 21 Oct 2016, In : Journal of Biological Chemistry. 291, 43, p. 22830-22840 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Exocytosis
Astrocytes
HIV-1
Endoplasmic Reticulum Stress
Proteins
13 Citations (Scopus)

HIV-1 Tat-shortened neurite outgrowth through regulation of microRNA-132 and its target gene expression

Rahimian, P. & He, J. J., 15 Sep 2016, In : Journal of Neuroinflammation. 13, 1, 247.

Research output: Contribution to journalArticleResearchpeer-review

MicroRNAs
Astrocytes
HIV-1
Gene Expression
Neurites
10 Citations (Scopus)

HIV Tat impairs neurogenesis through functioning as a notch ligand and activation of notch signaling pathway

Fan, Y., Gao, X., Chen, J., Liu, Y. & He, J. J., 2 Nov 2016, In : Journal of Neuroscience. 36, 44, p. 11362-11373 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Neurogenesis
HIV
Ligands
Neurons
Stem Cells

Role of Tat-interacting protein of 110kDa and microRNAs in the regulation of hematopoiesis

Liu, Y. & He, J. J., 1 Jul 2016, In : Current Opinion in Hematology. 23, 4, p. 325-330 6 p.

Research output: Contribution to journalReview articleResearchpeer-review

tat Gene Products
Hematopoiesis
Hematopoietic Stem Cells
MicroRNAs
Fetal Blood
7 Citations (Scopus)

Tip110: Physical properties, primary structure, and biological functions

Whitmill, A., Timani, K. A., Liu, Y. & He, J. J., 15 Mar 2016, In : Life Sciences. 149, p. 79-95 17 p.

Research output: Contribution to journalReview articleResearchpeer-review

tat Gene Products
Physical properties
Proteins
RNA Precursors
Cell Biology
2015
23 Citations (Scopus)

Exosomes are unlikely involved in intercellular Nef transfer

Luo, X., Fan, Y., Park, I. & He, J. J., 28 Apr 2015, In : PLoS ONE. 10, 4, e0124436.

Research output: Contribution to journalArticleResearchpeer-review

exosomes
Exosomes
Detergents
Cells
T-cells
40 Citations (Scopus)

HIV-1 tat alters neuronal autophagy by modulating autophagosome fusion to the lysosome: Implications for HIV-associated neurocognitive disorders

Fields, J., Dumaop, W., Elueteri, S., Campos, S., Serger, E., Trejo, M., Kosberg, K., Adame, A., Spencer, B., Rockenstein, E., He, J. J. & Masliah, E., 1 Jan 2015, In : Journal of Neuroscience. 35, 5, p. 1921-1938 18 p.

Research output: Contribution to journalArticleResearchpeer-review

Autophagy
Lysosomes
HIV-1
HIV
Lysosome-Associated Membrane Glycoproteins
5 Citations (Scopus)

Ionic derivatives of betulinic acid exhibit antiviral activity against herpes simplex virus type-2 (HSV-2), but not HIV-1 reverse transcriptase

Visalli, R. J., Ziobrowski, H., Badri, K. R., He, J. J., Zhang, X., Arumugam, S. R. & Zhao, H., 3 Jul 2015, In : Bioorganic and Medicinal Chemistry Letters. 25, 16, p. 3168-3171 4 p., 22789.

Research output: Contribution to journalArticleResearchpeer-review

Human Herpesvirus 2
Viruses
Inhibitory Concentration 50
Antiviral Agents
Derivatives
25 Citations (Scopus)

Mechanisms of HIV-1 tat neurotoxicity via CDK5 translocation and hyper-activation: Role in HIV-associated neurocognitive disorders

Fields, J. A., Dumaop, W., Crews, L., Adame, A., Spencer, B., Metcalf, J., He, J. J., Rockenstein, E. & Masliah, E., 1 Jan 2015, In : Current HIV Research. 13, 1, p. 43-54 12 p.

Research output: Contribution to journalArticleResearchpeer-review

HIV-1
HIV
Cytoplasm
Cyclin-Dependent Kinase 5
AIDS Dementia Complex
9 Citations (Scopus)

MicroRNA-124 Targets Tip110 Expression and Regulates Hematopoiesis

Liu, Y., Huang, X., Timani, K. A., Broxmeyer, H. E. & He, J. J., 1 Sep 2015, In : Stem Cells and Development. 24, 17, p. 2009-2017 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Hematopoiesis
MicroRNAs
Fetal Blood
Blood Cells
Cell Differentiation
11 Citations (Scopus)

STAT3 and its phosphorylation are involved in HIV-1 tat-induced transactivation of glial fibrillary acidic protein

Fan, Y., Timani, K. A. & He, J. J., 1 Jan 2015, In : Current HIV Research. 13, 1, p. 55-63 9 p.

Research output: Contribution to journalArticleResearchpeer-review

STAT3 Transcription Factor
Glial Fibrillary Acidic Protein
Transcriptional Activation
HIV-1
Phosphorylation
4 Citations (Scopus)

Tip110 binding to U6 small nuclear RNA and its participation in pre-mRNA splicing

Liu, Y., Liu, J., Wang, Z. & He, J. J., 23 Jul 2015, In : Cell and Bioscience. 5, 1, 40.

Research output: Contribution to journalArticleResearchpeer-review

RNA Precursors
RNA
Nuclear Localization Signals
Assays
Spliceosomes
11 Citations (Scopus)

Tip110 regulates the cross talk between p53 and hypoxia-inducible factor 1α under hypoxia and promotes survival of cancer cells

Timani, K. A., Liu, Y., Fan, Y., Mohammad, K. S. & He, J. J., 1 Jan 2015, In : Molecular and Cellular Biology. 35, 13, p. 2254-2264 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Hypoxia-Inducible Factor 1
Cell Survival
Neoplasms
Physiological Phenomena
Protein Stability