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2019
1 Citation (Scopus)

Clotam enhances anti-proliferative effect of vincristine in Ewing sarcoma cells

Shelake, S., Sankpal, U. T., Eslin, D., Bowman, P., Simecka, J., Raut, S. L., Ray, A. & Basha, R. M., 15 Feb 2019, In : Apoptosis. 24, 1-2, p. 21-32 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Ewing's Sarcoma
Vincristine
Cells
Caspase 7
Cell Survival
1 Citation (Scopus)

Copper-tolfenamic acid: evaluation of stability and anti-cancer activity

Hurtado, M., Sankpal, U. T., Chhabra, J., Brown, D. T., Maram, R., Patel, R., Gurung, R. K., Simecka, J., Holder, A. A. & Basha, R. M., 15 Feb 2019, In : Investigational New Drugs. 37, 1, p. 27-34 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Copper
Neoplasms
Powders
tolfenamic acid
Cell Line
2018
6 Citations (Scopus)

Activity of meropenem-vaborbactam against carbapenem- resistant enterobacteriaceae in a murine model of pyelonephritis

Weiss, W., Pulse, M. E., Nguyen, P., Peterson, K., Silva, J., Simecka, J., Valtierra, D., Sabet, M. & Griffith, D. C., 1 Jan 2018, In : Antimicrobial Agents and Chemotherapy. 62, 1, e01439.

Research output: Contribution to journalArticleResearchpeer-review

meropenem
Carbapenems
Pyelonephritis
Enterobacteriaceae
Klebsiella pneumoniae
1 Citation (Scopus)

Interleukin-17A exacerbates disease severity in BALB/c mice susceptible to lung infection with Mycoplasma pulmonis

Mize, M. T., Sun, X. L. & Simecka, J., 1 Sep 2018, In : Infection and Immunity. 86, 9, e00292-18.

Research output: Contribution to journalArticleResearchpeer-review

Mycoplasma pulmonis
Interleukin-17
Lung
Mycoplasma Infections
Infection
2016
11 Citations (Scopus)

Association of Sp1 and survivin in epithelial ovarian cancer: Sp1 inhibitor and cisplatin, a novel combination for inhibiting epithelial ovarian cancer cell proliferation

Sankpal, U. T., Ingersoll, S. B., Ahmad, S., Holloway, R. W., Bhat, V. B., Simecka, J., Daniel, L., Kariali, E., Vishwanatha, J. K. & Basha, R. M., 1 Oct 2016, In : Tumor Biology. 37, 10, p. 14259-14269 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Cisplatin
Cell Proliferation
Proteins
Proteomics
Reactive Oxygen Species
28 Citations (Scopus)

Combination of Tolfenamic acid and curcumin induces colon cancer cell growth inhibition through modulating specific transcription factors and reactive oxygen species

Sankpal, U. T., Nagaraju, G. P., Gottipolu, S. R., Hurtado, M., Jordan, C. G., Simecka, J., Shoji, M., El-Rayes, B. & Basha, R. M., 1 Jan 2016, In : Oncotarget. 7, 3, p. 3186-3200 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Curcumin
Colonic Neoplasms
Reactive Oxygen Species
Transcription Factors
Growth
5 Citations (Scopus)

Regulatory CD4+ CD25+ T cells dampen inflammatory disease in murine mycoplasma pneumonia and promote IL-17 and IFN-γ Responses

Odeh, A. N. & Simecka, J., 1 May 2016, In : PLoS ONE. 11, 5, e0155648.

Research output: Contribution to journalArticleResearchpeer-review

Mycoplasma pneumoniae
Mycoplasma Pneumonia
T-cells
Interleukin-17
Mycoplasma
15 Citations (Scopus)

Small molecule tolfenamic acid and dietary spice curcumin treatment enhances antiproliferative effect in pancreatic cancer cells via suppressing Sp1, disrupting NF-kB translocation to nucleus and cell cycle phase distribution

Basha, R. M., Connelly, S. F., Sankpal, U. T., Nagaraju, G. P., Patel, H., Vishwanatha, J. K., Shelake, S., Tabor-Simecka, L., Shoji, M., Simecka, J. & El-Rayes, B., 1 May 2016, In : Journal of Nutritional Biochemistry. 31, p. 77-87 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Spices
Curcumin
NF-kappa B
Pancreatic Neoplasms
Cell Cycle
8 Citations (Scopus)

Thiopurine prodrugs mediate immunosuppressive effects by interfering with Rac1 protein function

Shin, J. Y., Wey, M., Umutesi, H. G., Sun, X., Simecka, J. & Heo, J., 24 Jun 2016, In : Journal of Biological Chemistry. 291, 26, p. 13699-13714 16 p.

Research output: Contribution to journalArticleResearchpeer-review

rac1 GTP-Binding Protein
Prodrugs
6-Mercaptopurine
Immunosuppressive Agents
T-cells