Find Research Outputs

Search concepts
Selected Filters
2019

AMPK signaling regulates the age-related decline of hippocampal neurogenesis

Wang, B. Z., Yang, J. J., Zhang, H., Smith, C. A. & Jin, K., 1 Jan 2019, In : Aging and Disease. 10, 5, p. 1058-1074 17 p.

Research output: Contribution to journalArticle

Open Access
AMP-Activated Protein Kinases
Neurogenesis
Hippocampus
Brain
Intrinsic Factor
9 Citations (Scopus)

Exosomes derived from bone mesenchymal stem cells ameliorate early inflammatory responses following traumatic brain injury

Ni, H., Yang, S., Siaw-Debrah, F., Hu, J., Wu, K., He, Z., Yang, J., Pan, S., Lin, X., Ye, H., Xu, Z., Wang, F., Jin, K., Zhuge, Q. & Huang, L., 1 Jan 2019, In : Frontiers in Neuroscience. 13, JAN, 14.

Research output: Contribution to journalArticle

Open Access
Exosomes
Mesenchymal Stromal Cells
Bone and Bones
Microglia
Macrophages

Inhibition of miR-497 improves functional outcome after ischemic stroke by enhancing neuronal autophagy in young and aged rats

Chen, X., Lin, S., Gu, L., Zhu, X., Zhang, Y., Zhang, H., Shao, B., Zhuge, Q. & Jin, K., Jul 2019, In : Neurochemistry International. 127, p. 64-72 9 p.

Research output: Contribution to journalArticle

Autophagy
Stroke
Middle Cerebral Artery Infarction
Young Adult
Up-Regulation

Intracranial atherosclerotic disease

Wang, Y., Meng, R., Liu, G., Cao, C., Chen, F., Jin, K., Ji, X. & Cao, G., Apr 2019, In : Neurobiology of Disease. 124, p. 118-132 15 p.

Research output: Contribution to journalArticle

Intracranial Arteriosclerosis
Stroke
Therapeutics
Recurrence
Risk Management

Models of poststroke depression and assessments of core depressive symptoms in rodents: How to choose?

Tao, X., Yang, W., Zhu, S., Que, R., Liu, C., Fan, T., Wang, J., Mo, D., Zhang, Z., Tan, J., Jin, K., Yenarih, M. A., Song, T. & Wang, Q., Dec 2019, In : Experimental Neurology. 322, 113060.

Research output: Contribution to journalReview article

Rodentia
Stroke
Depression
Animal Models
Anhedonia
1 Citation (Scopus)

Remote ischemic conditioning for stroke: clinical data, challenges, and future directions

Zhao, W., Li, S., Ren, C., Meng, R., Jin, K. & Ji, X., Jan 2019, In : Annals of Clinical and Translational Neurology. 6, 1, p. 186-196 11 p.

Research output: Contribution to journalReview article

Stroke
Brain
Conditioning (Psychology)
Direction compound
Cerebral Small Vessel Diseases
1 Citation (Scopus)

Systemic milieu and age-related deterioration

Zhang, H., Cherian, R. & Jin, K., 15 Jun 2019, In : GeroScience. 41, 3, p. 275-284 10 p.

Research output: Contribution to journalReview article

Biological Phenomena
Neurodegenerative Diseases
Myocardial Infarction
Phenotype
Health
3 Citations (Scopus)

The effect of age, sex and strains on the performance and outcome in animal models of stroke

Zhang, H., Lin, S., Chen, X., Gu, L., Zhu, X., Zhang, Y., Reyes, K., Wang, B. & Jin, K., Jul 2019, In : Neurochemistry International. 127, p. 2-11 10 p.

Research output: Contribution to journalReview article

Animal Models
Stroke
Rodentia
Cerebrovascular Circulation
Brain Infarction
2017
35 Citations (Scopus)

Age-related impairment of vascular structure and functions

Xu, X., Wang, B., Ren, C., Hu, J., Greenberg, D. A., Chen, T., Xie, L. & Jin, K., 1 Oct 2017, In : Aging and Disease. 8, 5, p. 590-610 21 p.

Research output: Contribution to journalReview article

Blood Vessels
Cerebrovascular Disorders
Adventitia
Microvessels
Basement Membrane
3 Citations (Scopus)

Aging systemic milieu impairs outcome after ischemic stroke in rats

Pan, M., Wang, P., Zheng, C., Zhang, H., Lin, S., Shao, B., Zhuge, Q. & Jin, K., 1 Oct 2017, In : Aging and Disease. 8, 5, p. 519-530 12 p.

Research output: Contribution to journalArticle

Stroke
Haptoglobins
Adult Stem Cells
Middle Cerebral Artery Infarction
Cardiomegaly
3 Citations (Scopus)

Boosting Endogenous Resistance of Brain to Ischemia

Sun, F., Johnson, S. R., Jin, K. & Uteshev, V. V., 1 Apr 2017, In : Molecular Neurobiology. 54, 3, p. 2045-2059 15 p.

Research output: Contribution to journalArticle

Nicotinic Receptors
Brain Ischemia
Stroke
Wounds and Injuries
Intranasal Administration
11 Citations (Scopus)

Combining injectable plasma scaffold with mesenchymal stem/stromal cells for repairing infarct cavity after ischemic stroke

Zhang, H., Sun, F., Wang, J., Xie, L., Pan, M., Shao, B., Yang, G. Y., Yang, S. H., ZhuGe, Q. & Jin, K., 1 Jan 2017, In : Aging and Disease. 8, 2, p. 203-214 12 p.

Research output: Contribution to journalArticle

Mesenchymal Stromal Cells
Stroke
Injections
Neural Stem Cells
Brain
33 Citations (Scopus)

Cystatin C as a potential therapeutic mediator against Parkinson's disease via VEGF-induced angiogenesis and enhanced neuronal autophagy in neurovascular units

Zou, J., Chen, Z., Wei, X., Chen, Z., Fu, Y., Yang, X., Chen, D., Wang, R., Jenner, P., Lu, J. H., Li, M., Zhang, Z., Tang, B., Jin, K. & Wang, Q., 1 Jun 2017, In : Cell death & disease. 8, 6, p. e2854

Research output: Contribution to journalArticle

Cystatin C
PC12 Cells
Autophagy
Vascular Endothelial Growth Factor A
Parkinson Disease
13 Citations (Scopus)

Impact of aging immune system on neurodegeneration and potential immunotherapies

Liang, Z., Zhao, Y., Ruan, L., Zhu, L., Jin, K., Zhuge, Q., Su, D. M. & Zhao, Y., Oct 2017, In : Progress in Neurobiology. 157, p. 2-28 27 p.

Research output: Contribution to journalReview article

Immunotherapy
Immune System
Brain Injuries
Nervous System
Inflammation
19 Citations (Scopus)

Limb remote ischemic conditioning promotes myelination by upregulating PTEN/Akt/mTOR signaling activities after chronic cerebral hypoperfusion

Li, X., Ren, C., Li, S., Han, R., Gao, J., Huang, Q., Jin, K., Luo, Y. & Ji, X., 1 Jan 2017, In : Aging and Disease. 8, 4, p. 392-401 10 p.

Research output: Contribution to journalArticle

Extremities
Oligodendroglia
Myelin Sheath
Apoptosis
Corpus Callosum

New perspectives on healthy aging

Jin, K., 1 Oct 2017, In : Progress in Neurobiology. 157, 1 p.

Research output: Contribution to journalEditorial

19 Citations (Scopus)

Plasma cystatin C and high-density lipoprotein are important biomarkers of Alzheimer's disease and vascular dementia: A cross-sectional study

Wang, R., Chen, Z., Fu, Y., Wei, X., Liao, J., Liu, X., He, B., Xu, Y., Zou, J., Yang, X., Weng, R., Tan, S., McElroy, C., Jin, K. & Wang, Q., 7 Feb 2017, In : Frontiers in Aging Neuroscience. 9, FEB, 26.

Research output: Contribution to journalArticle

Cystatin C
Vascular Dementia
HDL Lipoproteins
Alzheimer Disease
Cross-Sectional Studies
18 Citations (Scopus)

Recent progress in vascular aging: Mechanisms and its role in age-related diseases

Xu, X., Wang, B., Ren, C., Hu, J., Greenberg, D. A., Chen, T., Xie, L. & Jin, K., 1 Jan 2017, In : Aging and Disease. 8, 4, 0507.

Research output: Contribution to journalReview article

Blood Vessels
Vascular Dementia
Calpain
Chemokine CCL2
Metalloproteases
4 Citations (Scopus)

Serum YKL-40, a prognostic marker in patients with large-artery atherosclerotic stroke

Chen, X. L., Li, Q., Huang, W. S., Lin, Y. S., Xue, J., Wang, B., Jin, K. L. & Shao, B., Aug 2017, In : Acta Neurologica Scandinavica. 136, 2, p. 97-102 6 p.

Research output: Contribution to journalArticle

Atherosclerosis
Arteries
Stroke
Serum
Biomarkers
3 Citations (Scopus)

Soluble lectin-like oxidized low-density lipoprotein receptor-1 as a novel biomarker for large-artery atherosclerotic stroke

Huang, W., Li, Q., Chen, X., Lin, Y., Xue, J., Cai, Z., Zhang, W., Wang, H., Jin, K. & Shao, B., 3 Oct 2017, In : International Journal of Neuroscience. 127, 10, p. 881-886 6 p.

Research output: Contribution to journalArticle

Class E Scavenger Receptors
Arteries
Biomarkers
Stroke
Serum

Study on CT perfusion surface permeability of cerebral hemorrhage in the basal ganglia region in subacute stage

Wang, J., Xu, H., Liu, S., Zhang, Y., Liu, J., He, W., Qin, X., Yang, Y., Zhuge, Q., Jin, K. & Chen, W., 8 Mar 2017, In : Chinese Journal of Neurology. 50, 3, p. 201-207 7 p.

Research output: Contribution to journalArticle

Cerebral Hemorrhage
Basal Ganglia
Permeability
Perfusion
Perfusion Imaging
2015
20 Citations (Scopus)

Activated regulatory T cell regulates neural stem cell proliferation in the subventricular zone of normal and ischemic mouse brain through interleukin 10

Wang, J., Xie, L., Yang, C., Ren, C., Zhou, K., Wang, B., Zhang, Z., Wang, Y., Jin, K. & Yang, G. Y., 14 Sep 2015, In : Frontiers in Cellular Neuroscience. 9, SEPTEMBER, 361.

Research output: Contribution to journalArticle

Neural Stem Cells
Lateral Ventricles
Regulatory T-Lymphocytes
Bromodeoxyuridine
Interleukin-10
48 Citations (Scopus)

Cerebral regulatory T cells restrain microglia/macrophage-mediated inflammatory responses via IL-10

Xie, L., Choudhury, G. R., Winters, A., Yang, S. & Jin, K., 1 Jan 2015, In : European Journal of Immunology. 45, 1, p. 180-191 12 p.

Research output: Contribution to journalArticle

Microglia
Regulatory T-Lymphocytes
Interleukin-10
Macrophages
Cerebrum
33 Citations (Scopus)

Contra-directional expression of serum homocysteine and uric acid as important biomarkers of multiple system atrophy severity: A cross-sectional study

Chen, D., Wei, X., Zou, J., Wang, R., Liu, X., Xu, X., Lu, J., Wang, Z., Tang, B., Wang, B., Jin, K. & Wang, Q., 6 Jul 2015, In : Frontiers in Cellular Neuroscience. 9, JULY, 247.

Research output: Contribution to journalArticle

Multiple System Atrophy
Homocysteine
Uric Acid
Cross-Sectional Studies
Biomarkers
84 Citations (Scopus)

Coupling of neurogenesis and angiogenesis after ischemic stroke

Ruan, L., Wang, B., Zhuge, Q. & Jin, K., 14 Oct 2015, In : Brain Research. 1623, p. 166-173 8 p.

Research output: Contribution to journalArticle

Neurogenesis
Stroke
Vascular Endothelial Growth Factor A
Brain-Derived Neurotrophic Factor
Fibroblast Growth Factor 2
2 Citations (Scopus)

Cross-talk between human neural stem/progenitor cells and peripheral blood mononuclear cells in an allogeneic co-culture model

Zhang, H., Shao, B., Zhuge, Q., Wang, P., Zheng, C., Huang, W., Yang, C., Wang, B., Su, D. M. & Jin, K., 6 Feb 2015, In : PLoS ONE. 10, 2, e0117432.

Research output: Contribution to journalArticle

Neural Stem Cells
coculture
mononuclear leukocytes
Coculture Techniques
Stem cells
25 Citations (Scopus)

Current perspectives on the link between neuroinflammation and neurogenesis

Wang, B. & Jin, K., 1 Jan 2015, In : Metabolic Brain Disease. 30, 2, p. 355-365 11 p.

Research output: Contribution to journalArticle

Neurogenesis
Chemokines
Brain
Neurosciences
Cytokines
15 Citations (Scopus)

Herbal formula Danggui-Shaoyao-San promotes neurogenesis and angiogenesis in rat following middle cerebral artery occlusion

Ren, C., Wang, B., Li, N., Jin, K. & Ji, X., 1 Jan 2015, In : Aging and Disease. 6, 4, p. 245-253 9 p.

Research output: Contribution to journalArticle

Middle Cerebral Artery Infarction
Neurogenesis
Brain Injuries
Ischemia
danggui-shaoyao-san
5 Citations (Scopus)

Increasing proliferation of intrinsic tubular cells after renal ischemia-reperfusion injury in adult rat

Feng, J., Hu, W., Feng, C., Mao, X. O., Jin, K. & Ye, Y., 1 Jan 2015, In : Aging and Disease. 6, 4, p. 228-235 8 p.

Research output: Contribution to journalArticle

Reperfusion Injury
Kidney
Bromodeoxyuridine
Stem Cells
Wounds and Injuries
30 Citations (Scopus)

Limb ischemic perconditioning attenuates blood-brain barrier disruption by inhibiting activity of MMP-9 and occludin degradation after focal cerebral ischemia

Ren, C., Li, N., Wang, B., Yang, Y., Gao, J., Li, S., Ding, Y., Jin, K. & Ji, X., 1 Jan 2015, In : Aging and Disease. 6, 6, p. 406-417 12 p.

Research output: Contribution to journalArticle

Occludin
Middle Cerebral Artery Infarction
Brain Ischemia
Blood-Brain Barrier
Matrix Metalloproteinases
28 Citations (Scopus)

Limb remote ischemic per-conditioning in combination with post-conditioning reduces brain damage and promotes neuroglobin expression in the rat brain after ischemic stroke

Ren, C., Wang, P., Wang, B., Li, N., Li, W., Zhang, C., Jin, K. & Ji, X., 17 Jun 2015, In : Restorative Neurology and Neuroscience. 33, 3, p. 369-379 11 p.

Research output: Contribution to journalArticle

Reperfusion
Ischemia
Extremities
Ischemic Postconditioning
Reperfusion Injury
70 Citations (Scopus)

The critical need to promote research of aging and aging-related diseases to improve health and longevity of the elderly population

Jin, K., Simpkins, J. W., Ji, X., Leis, M. & Stambler, I., 1 Jan 2015, In : Aging and Disease. 6, 1, p. 1-5 5 p.

Research output: Contribution to journalComment/debate

Health
Research
Population
Cost of Illness
Public Policy

Therapeutic implications of cancer stem cell: Challenges and opportunities in translational studies

Yang, C., Jin, K., Zhang, Y., Sun, H. & Cho, W. C., 1 Jan 2015, Cancer Stem Cells: Emerging Concepts and Future Perspectives in Translational Oncology. Springer International Publishing, p. 533-553 21 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Neoplastic Stem Cells
Stem cells
Neoplasms
Tumors
Therapeutics
17 Citations (Scopus)

Therapeutic potential of cancer stem cells

Yang, C., Jin, K., Tong, Y. & Cho, W. C., 1 May 2015, In : Medical Oncology. 32, 6

Research output: Contribution to journalReview article

Neoplastic Stem Cells
Cell- and Tissue-Based Therapy
Therapeutics
Recurrence
Neoplasms

The role of endogenous neural stem cells in stroke

ZhuGe, Q., Ruan, L. & Jin, K., 1 Jan 2015, Cellular Therapy for Stroke and CNS Injuries. Springer International Publishing, p. 33-46 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Neural Stem Cells
Cell proliferation
Stem cells
Stroke
Recovery
2014
52 Citations (Scopus)

Acceleration of tissue plasminogen activator-mediated thrombolysis by magnetically powered nanomotors

Cheng, R., Huang, W., Huang, L., Yang, B., Mao, L., Jin, K., Zhuge, Q. & Zhao, Y., 1 Jan 2014, In : ACS Nano. 8, 8, p. 7746-7754 9 p.

Research output: Contribution to journalArticle

Tissue Plasminogen Activator
strokes
Tissue
hemorrhages
transport theory
41 Citations (Scopus)

Differential activation of mTOR Complex 1 Signaling in human brain with mild to severe Alzheimer's disease

Sun, Y. X., Ji, X., Mao, X., Xie, L., Jia, J., Galvan, V., Greenberg, D. A. & Jin, K., 2014, In : Journal of Alzheimer's Disease. 38, 2, p. 437-444 8 p.

Research output: Contribution to journalArticle

Alzheimer Disease
Sirolimus
Brain
Raptors
S 6
14 Citations (Scopus)

Evidence of brain tumor stem progenitor-like cells with low proliferative capacity in human benign pituitary adenoma

Chen, L., Ye, H., Wang, X., Tang, X., Mao, Y., Zhao, Y., Wu, Z., Mao, X. O., Xie, L., Jin, K. & Yao, Y., 10 Jul 2014, In : Cancer Letters. 349, 1, p. 61-66 6 p.

Research output: Contribution to journalArticle

Pituitary Neoplasms
Brain Neoplasms
Stem Cells
Neoplastic Stem Cells
Neural Stem Cells
2 Citations (Scopus)

Flow-induced regulation of brain endothelial cells in vitro

Mao, X. O., Xie, L., Greenberg, R. B., Greenberg, J. B., Peng, B., Mieling, I., Jin, K. & Greenberg, D. A., 1 Jan 2014, In : Vascular Pharmacology. 62, 2, p. 82-87 6 p.

Research output: Contribution to journalArticle

Endothelial Cells
Brain
Gasotransmitters
Cerebrovascular Disorders
Hydroxymethylglutaryl-CoA Reductase Inhibitors
54 Citations (Scopus)

Glial scar formation occurs in the human brain after ischemic stroke

Huang, L., Wu, Z. B., ZhuGe, Q., Zheng, W. M., Shao, B., Wang, B., Sun, F. & Jin, K., 11 Feb 2014, In : International Journal of Medical Sciences. 11, 4, p. 344-348 5 p.

Research output: Contribution to journalArticle

Neuroglia
Cicatrix
Chondroitin Sulfate Proteoglycans
Gliosis
Stroke
30 Citations (Scopus)

Inhibition of mammalian target of rapamycin improves neurobehavioral deficit and modulates immune response after intracerebral hemorrhage in rat

Lu, Q., Gao, L., Huang, L., Ruan, L., Yang, J., Huang, W., Li, Z., Zhang, Y., Jin, K. & Zhuge, Q., 6 Mar 2014, In : Journal of neuroinflammation. 11, 44.

Research output: Contribution to journalArticle

Cerebral Hemorrhage
Sirolimus
Cell Growth Processes
Protein-Serine-Threonine Kinases
Transforming Growth Factors
47 Citations (Scopus)

Involvement of p38 MAPK in reactive astrogliosis induced by ischemic stroke

Roy Choudhury, G., Ryou, M. G., Poteet, E., Wen, Y., He, R., Sun, F., Yuan, F., Jin, K. & Yang, S., 10 Mar 2014, In : Brain Research. 1551, p. 45-58 14 p.

Research output: Contribution to journalArticle

p38 Mitogen-Activated Protein Kinases
Stroke
Glial Fibrillary Acidic Protein
Astrocytes
Middle Cerebral Artery Infarction
4 Citations (Scopus)

Methylene blue promotes quiescence of rat neural progenitor cells

Xie, L., Choudhury, G. R., Wang, J., Park, Y., Liu, R., Yuan, F., Zhang, C. L., Yorio, T., Jin, K. & Yang, S. H., 7 Oct 2014, In : Frontiers in Cellular Neuroscience. 8, OCT, 315.

Research output: Contribution to journalArticle

Methylene Blue
Stem Cells
Intraventricular Infusions
Cyclins
Neural Stem Cells
83 Citations (Scopus)

MTOR Signaling inhibition modulates macrophage/microglia-mediated neuroinflammation and secondary injury via regulatory T cells after focal ischemia

Xie, L., Sun, F., Wang, J., Mao, X. O., Xie, L., Yang, S. H., Su, D. M., Simpkins, J. W., Greenberg, D. A. & Jin, K., 15 Jun 2014, In : Journal of Immunology. 192, 12, p. 6009-6019 11 p.

Research output: Contribution to journalArticle

Microglia
Regulatory T-Lymphocytes
Sirolimus
Ischemia
Macrophages
60 Citations (Scopus)

Neural stem cell protects aged rat brain from ischemia-reperfusion injury through neurogenesis and angiogenesis

Tang, Y., Wang, J., Lin, X., Wang, L., Shao, B., Jin, K., Wang, Y. & Yang, G. Y., Jul 2014, In : Journal of Cerebral Blood Flow and Metabolism. 34, 7, p. 1138-1147 10 p.

Research output: Contribution to journalArticle

Neural Stem Cells
Neurogenesis
Reperfusion Injury
Brain Ischemia
Young Adult
48 Citations (Scopus)

Neurogenesis in neurological and psychiatric diseases and brain injury: From bench to bedside

Ruan, L., Lau, B. W. M., Wang, J., Huang, L., ZhuGe, Q., Wang, B., Jin, K. & So, K. F., 1 Jan 2014, In : Progress in Neurobiology. 115, C, p. 116-137 22 p.

Research output: Contribution to journalReview article

Neurogenesis
Brain Injuries
Psychiatry
Neurons
Adult Stem Cells
35 Citations (Scopus)

Timing and Dose Regimens of Marrow Mesenchymal Stem Cell Transplantation Affect the Outcomes and Neuroinflammatory Response After Ischemic Stroke

Wang, L. Q., Lin, Z. Z., Zhang, H. X., Shao, B., Xiao, L., Jiang, H. G., Zhuge, Q. C., Xie, L. K., Wang, B., Su, D. M. & Jin, K. L., Apr 2014, In : CNS Neuroscience and Therapeutics. 20, 4, p. 317-326 10 p.

Research output: Contribution to journalArticle

Mesenchymal Stem Cell Transplantation
Bone Marrow
Stroke
Mesenchymal Stromal Cells
Ischemia
16 Citations (Scopus)

Transplanted neural stem cells modulate regulatory T, γδ T cells and corresponding cytokines after intracerebral hemorrhage in rats

Gao, L., Lu, Q., Huang, L. J., Ruan, L. H., Yang, J. J., Huang, W. L., ZhuGe, W. S., Zhang, Y. L., Fu, B., Jin, K. L. & ZhuGe, Q. C., 13 Mar 2014, In : International journal of molecular sciences. 15, 3, p. 4431-4441 11 p.

Research output: Contribution to journalArticle

hemorrhages
T-cells
Neural Stem Cells
stem cells
Cerebral Hemorrhage
2013
15 Citations (Scopus)

17 β-estradiol attenuates poststroke depression and increases neurogenesis in female ovariectomized rats

Cheng, Y., Su, Q., Shao, B., Cheng, J., Wang, H., Wang, L., Lin, Z., Ruan, L., ZhuGe, Q. & Jin, K., 9 Dec 2013, In : BioMed Research International. 2013, 392434.

Research output: Contribution to journalArticle

Neurogenesis
Rats
Estradiol
Depression
Antidepressive Agents
39 Citations (Scopus)

A positive allosteric modulator of α7 nAChRs augments neuroprotective effects of endogenous nicotinic agonists in cerebral ischaemia

Kalappa, B. I., Sun, F., Johnson, S. R., Jin, K. & Uteshev-Gaard, V. V., 1 Aug 2013, In : British Journal of Pharmacology. 169, 8, p. 1862-1878 17 p.

Research output: Contribution to journalArticle

Nicotinic Agonists
Nicotinic Receptors
Neuroprotective Agents
Brain Ischemia
Choline