Find Research Outputs

Search concepts
Selected Filters
2015

The role of endogenous neural stem cells in stroke

ZhuGe, Q., Ruan, L. & Jin, K., 1 Jan 2015, Cellular Therapy for Stroke and CNS Injuries. Springer International Publishing, p. 33-46 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Neural Stem Cells
Cell proliferation
Stem cells
Stroke
Recovery
2014
52 Citations (Scopus)

Acceleration of tissue plasminogen activator-mediated thrombolysis by magnetically powered nanomotors

Cheng, R., Huang, W., Huang, L., Yang, B., Mao, L., Jin, K., Zhuge, Q. & Zhao, Y., 1 Jan 2014, In : ACS Nano. 8, 8, p. 7746-7754 9 p.

Research output: Contribution to journalArticle

Tissue Plasminogen Activator
strokes
Tissue
hemorrhages
transport theory
41 Citations (Scopus)

Differential activation of mTOR Complex 1 Signaling in human brain with mild to severe Alzheimer's disease

Sun, Y. X., Ji, X., Mao, X., Xie, L., Jia, J., Galvan, V., Greenberg, D. A. & Jin, K., 2014, In : Journal of Alzheimer's Disease. 38, 2, p. 437-444 8 p.

Research output: Contribution to journalArticle

Alzheimer Disease
Sirolimus
Brain
Raptors
S 6
14 Citations (Scopus)

Evidence of brain tumor stem progenitor-like cells with low proliferative capacity in human benign pituitary adenoma

Chen, L., Ye, H., Wang, X., Tang, X., Mao, Y., Zhao, Y., Wu, Z., Mao, X. O., Xie, L., Jin, K. & Yao, Y., 10 Jul 2014, In : Cancer Letters. 349, 1, p. 61-66 6 p.

Research output: Contribution to journalArticle

Pituitary Neoplasms
Brain Neoplasms
Stem Cells
Neoplastic Stem Cells
Neural Stem Cells
2 Citations (Scopus)

Flow-induced regulation of brain endothelial cells in vitro

Mao, X. O., Xie, L., Greenberg, R. B., Greenberg, J. B., Peng, B., Mieling, I., Jin, K. & Greenberg, D. A., 1 Jan 2014, In : Vascular Pharmacology. 62, 2, p. 82-87 6 p.

Research output: Contribution to journalArticle

Endothelial Cells
Brain
Gasotransmitters
Cerebrovascular Disorders
Hydroxymethylglutaryl-CoA Reductase Inhibitors
54 Citations (Scopus)

Glial scar formation occurs in the human brain after ischemic stroke

Huang, L., Wu, Z. B., ZhuGe, Q., Zheng, W. M., Shao, B., Wang, B., Sun, F. & Jin, K., 11 Feb 2014, In : International Journal of Medical Sciences. 11, 4, p. 344-348 5 p.

Research output: Contribution to journalArticle

Neuroglia
Cicatrix
Chondroitin Sulfate Proteoglycans
Gliosis
Stroke
30 Citations (Scopus)

Inhibition of mammalian target of rapamycin improves neurobehavioral deficit and modulates immune response after intracerebral hemorrhage in rat

Lu, Q., Gao, L., Huang, L., Ruan, L., Yang, J., Huang, W., Li, Z., Zhang, Y., Jin, K. & Zhuge, Q., 6 Mar 2014, In : Journal of neuroinflammation. 11, 44.

Research output: Contribution to journalArticle

Cerebral Hemorrhage
Sirolimus
Cell Growth Processes
Protein-Serine-Threonine Kinases
Transforming Growth Factors
47 Citations (Scopus)

Involvement of p38 MAPK in reactive astrogliosis induced by ischemic stroke

Roy Choudhury, G., Ryou, M. G., Poteet, E., Wen, Y., He, R., Sun, F., Yuan, F., Jin, K. & Yang, S., 10 Mar 2014, In : Brain Research. 1551, p. 45-58 14 p.

Research output: Contribution to journalArticle

p38 Mitogen-Activated Protein Kinases
Stroke
Glial Fibrillary Acidic Protein
Astrocytes
Middle Cerebral Artery Infarction
4 Citations (Scopus)

Methylene blue promotes quiescence of rat neural progenitor cells

Xie, L., Choudhury, G. R., Wang, J., Park, Y., Liu, R., Yuan, F., Zhang, C. L., Yorio, T., Jin, K. & Yang, S. H., 7 Oct 2014, In : Frontiers in Cellular Neuroscience. 8, OCT, 315.

Research output: Contribution to journalArticle

Methylene Blue
Stem Cells
Intraventricular Infusions
Cyclins
Neural Stem Cells
83 Citations (Scopus)

MTOR Signaling inhibition modulates macrophage/microglia-mediated neuroinflammation and secondary injury via regulatory T cells after focal ischemia

Xie, L., Sun, F., Wang, J., Mao, X. O., Xie, L., Yang, S. H., Su, D. M., Simpkins, J. W., Greenberg, D. A. & Jin, K., 15 Jun 2014, In : Journal of Immunology. 192, 12, p. 6009-6019 11 p.

Research output: Contribution to journalArticle

Microglia
Regulatory T-Lymphocytes
Sirolimus
Ischemia
Macrophages
60 Citations (Scopus)

Neural stem cell protects aged rat brain from ischemia-reperfusion injury through neurogenesis and angiogenesis

Tang, Y., Wang, J., Lin, X., Wang, L., Shao, B., Jin, K., Wang, Y. & Yang, G. Y., Jul 2014, In : Journal of Cerebral Blood Flow and Metabolism. 34, 7, p. 1138-1147 10 p.

Research output: Contribution to journalArticle

Neural Stem Cells
Neurogenesis
Reperfusion Injury
Brain Ischemia
Young Adult
48 Citations (Scopus)

Neurogenesis in neurological and psychiatric diseases and brain injury: From bench to bedside

Ruan, L., Lau, B. W. M., Wang, J., Huang, L., ZhuGe, Q., Wang, B., Jin, K. & So, K. F., 1 Jan 2014, In : Progress in Neurobiology. 115, C, p. 116-137 22 p.

Research output: Contribution to journalReview article

Neurogenesis
Brain Injuries
Psychiatry
Neurons
Adult Stem Cells
35 Citations (Scopus)

Timing and Dose Regimens of Marrow Mesenchymal Stem Cell Transplantation Affect the Outcomes and Neuroinflammatory Response After Ischemic Stroke

Wang, L. Q., Lin, Z. Z., Zhang, H. X., Shao, B., Xiao, L., Jiang, H. G., Zhuge, Q. C., Xie, L. K., Wang, B., Su, D. M. & Jin, K. L., Apr 2014, In : CNS Neuroscience and Therapeutics. 20, 4, p. 317-326 10 p.

Research output: Contribution to journalArticle

Mesenchymal Stem Cell Transplantation
Bone Marrow
Stroke
Mesenchymal Stromal Cells
Ischemia
16 Citations (Scopus)

Transplanted neural stem cells modulate regulatory T, γδ T cells and corresponding cytokines after intracerebral hemorrhage in rats

Gao, L., Lu, Q., Huang, L. J., Ruan, L. H., Yang, J. J., Huang, W. L., ZhuGe, W. S., Zhang, Y. L., Fu, B., Jin, K. L. & ZhuGe, Q. C., 13 Mar 2014, In : International journal of molecular sciences. 15, 3, p. 4431-4441 11 p.

Research output: Contribution to journalArticle

hemorrhages
T-cells
Neural Stem Cells
stem cells
Cerebral Hemorrhage
2013
15 Citations (Scopus)

17 β-estradiol attenuates poststroke depression and increases neurogenesis in female ovariectomized rats

Cheng, Y., Su, Q., Shao, B., Cheng, J., Wang, H., Wang, L., Lin, Z., Ruan, L., ZhuGe, Q. & Jin, K., 9 Dec 2013, In : BioMed Research International. 2013, 392434.

Research output: Contribution to journalArticle

Neurogenesis
Rats
Estradiol
Depression
Antidepressive Agents
39 Citations (Scopus)

A positive allosteric modulator of α7 nAChRs augments neuroprotective effects of endogenous nicotinic agonists in cerebral ischaemia

Kalappa, B. I., Sun, F., Johnson, S. R., Jin, K. & Uteshev-Gaard, V. V., 1 Aug 2013, In : British Journal of Pharmacology. 169, 8, p. 1862-1878 17 p.

Research output: Contribution to journalArticle

Nicotinic Agonists
Nicotinic Receptors
Neuroprotective Agents
Brain Ischemia
Choline
10 Citations (Scopus)

Astroglial PTEN loss disrupts neuronal lamination by dysregulating radial glia-guided neuronal migration

Wen, Y., Li, W., Choudhury, G. R., He, R., Yang, T., Liu, R., Jin, K. & Yang, S., 1 Jan 2013, In : Aging and Disease. 4, 3, p. 113-126 14 p.

Research output: Contribution to journalArticle

Neuroglia
Transgenic Mice
Cerebellum
Hippocampus
Central Nervous System
32 Citations (Scopus)
cholinergic receptors
Middle Cerebral Artery Infarction
Nicotinic Receptors
ischemia
Brain Ischemia
22 Citations (Scopus)

Expression level of vascular endothelial growth factor in hippocampus is associated with cognitive impairment in patients with Alzheimer's disease

Tang, H., Mao, X. O., Xie, L., Greenberg, D. A. & Jin, K., 1 May 2013, In : Neurobiology of Aging. 34, 5, p. 1412-1415 4 p.

Research output: Contribution to journalArticle

Vascular Endothelial Growth Factor A
Hippocampus
Alzheimer Disease
Entorhinal Cortex
Parahippocampal Gyrus
27 Citations (Scopus)
Methylene Blue
Autophagy
Adenosine Monophosphate
Protein Kinases
Neurons
9 Citations (Scopus)

MTOR activation in immature cells of primary nasopharyngeal carcinoma and anti-tumor effect of rapamycin in vitro and in vivo

Yang, C., Peng, J., Jiang, W. J., Zhang, Y., Chen, X., Wu, X., Zhu, Y., Zhang, H., Chen, J., Wang, J., Cho, W. C. S. & Jin, K., 1 Dec 2013, In : Cancer Letters. 341, 2, p. 186-194 9 p.

Research output: Contribution to journalArticle

Sirolimus
Embryonic Stem Cells
Neoplasms
Neoplastic Stem Cells
Growth
69 Citations (Scopus)

Neurogenesis in adult human brain after traumatic brain injury

Zheng, W., Zhuge, Q., Zhong, M., Chen, G., Shao, B., Wang, H., Mao, X., Xie, L. & Jin, K., 15 Nov 2013, In : Journal of Neurotrauma. 30, 22, p. 1872-1880 9 p.

Research output: Contribution to journalArticle

Neurogenesis
Brain
Neural Stem Cells
Stem Cells
Proteins
11 Citations (Scopus)

Neuroglobin expression in neurogenesis

Haines, B., Mao, X. O., Xie, L., Spusta, S., Zeng, X., Jin, K. & Greenberg, D. A., 9 Aug 2013, In : Neuroscience Letters. 549, p. 3-6 4 p.

Research output: Contribution to journalComment/debate

Neurogenesis
Lateral Ventricles
Proteins
Neural Stem Cells
Myoglobin
20 Citations (Scopus)

Neuroglobin protein is upregulated in Alzheimer's disease

Sun, F., Mao, X. O., Xie, L., Greenberg, D. A. & Jin, K., 1 Jan 2013, In : Journal of Alzheimer's Disease. 36, 4, p. 659-663 5 p.

Research output: Contribution to journalArticle

Alzheimer Disease
Proteins
Amyloidogenic Proteins
Amyloid Plaques
Transgenic Mice
32 Citations (Scopus)

Notch1 signaling modulates neuronal progenitor activity in the subventricular zone in response to aging and focal ischemia

Sun, F., Mao, X., Xie, L., Ding, M., Shao, B. & Jin, K., 1 Dec 2013, In : Aging cell. 12, 6, p. 978-987 10 p.

Research output: Contribution to journalArticle

Lateral Ventricles
Ischemia
Neurogenesis
Brain
Young Adult
11 Citations (Scopus)

Notch4 is activated in endothelial and smooth muscle cells in human brain arteriovenous malformations

Zhuge, Q., Wu, Z., Huang, L., Zhao, B., Zhong, M., Zheng, W., Gourong, C., Mao, X., Xie, L., Wang, X. & Jin, K., 1 Nov 2013, In : Journal of Cellular and Molecular Medicine. 17, 11, p. 1458-1464 7 p.

Research output: Contribution to journalArticle

Arteriovenous Malformations
Smooth Muscle Myocytes
Brain
Blood Vessels
Middle Cerebral Artery
20 Citations (Scopus)

Overexpression of adiponectin improves neurobehavioral outcomes after focal cerebral ischemia in aged mice

Miao, J., Shen, L. H., Tang, Y. H., Wang, Y. T., Tao, M. X., Jin, K. L., Zhao, Y. J. & Yang, G. Y., 1 Dec 2013, In : CNS Neuroscience and Therapeutics. 19, 12, p. 969-977 9 p.

Research output: Contribution to journalArticle

Adiponectin
Brain Ischemia
Young Adult
Middle Cerebral Artery Infarction
Stroke
15 Citations (Scopus)

Therapeutic applications of bone marrow-derived stem cells in ischemic stroke

Wang, L., Lin, Z., Shao, B., Zhuge, Q. & Jin, K., 1 Jun 2013, In : Neurological Research. 35, 5, p. 470-478 9 p.

Research output: Contribution to journalReview article

Stem Cells
Bone Marrow
Stroke
Therapeutics
Tissue Plasminogen Activator
13 Citations (Scopus)

Vascular endothelial growth factor-B expression in postischemic rat brain

Xie, L., Mao, X., Jin, K. & Greenberg, D. A., 8 May 2013, In : Vascular Cell. 5, 1, 8.

Research output: Contribution to journalArticle

Vascular Endothelial Growth Factor B
Rats
Brain
Middle Cerebral Artery Infarction
Stroke
119 Citations (Scopus)

Vascular endothelial growth factors (VEGFs) and stroke

Greenberg, D. A. & Jin, K., 11 Mar 2013, In : Cellular and Molecular Life Sciences. 70, 10, p. 1753-1761 9 p.

Research output: Contribution to journalReview article

Vascular Endothelial Growth Factors
Vascular Endothelial Growth Factor B
Stroke
Vascular Endothelial Growth Factor Receptor-1
Vascular Endothelial Growth Factor Receptor-2
2012
40 Citations (Scopus)

Ablation of Neurogenesis Attenuates Recovery of Motor Function after Focal Cerebral Ischemia in Middle-Aged Mice

Sun, F., Wang, X., Mao, X. O., Xie, L. & Jin, K., 26 Oct 2012, In : PLoS ONE. 7, 10, e46326.

Research output: Contribution to journalArticle

middle-aged adults
Ganciclovir
neurogenesis
Neurogenesis
Recovery of Function
6 Citations (Scopus)

Comparative protein interactomics of neuroglobin and myoglobin

Haines, B. A., Davis, D. A., Zykovich, A., Peng, B., Rao, R., Mooney, S. D., Jin, K. & Greenberg, D. A., 1 Oct 2012, In : Journal of Neurochemistry. 123, 1, p. 192-198 7 p.

Research output: Contribution to journalArticle

Myoglobin
Proteins
Neurodegenerative diseases
Neurochemistry
Neuroprotective Agents
60 Citations (Scopus)

Conditional depletion of neurogenesis inhibits long-term recovery after experimental stroke in mice

Wang, X., Mao, X. O., Xie, L., Sun, F., Greenberg, D. A. & Jin, K., 19 Jun 2012, In : PLoS ONE. 7, 6, e38932.

Research output: Contribution to journalArticle

Ganciclovir
neurogenesis
Neurogenesis
stroke
Transgenic Mice
6 Citations (Scopus)

Differential effects of nerve growth factor on expression of dopamine 2 receptor subtypes in GH3 rat pituitary tumor cells

Su, Z., Jiang, X., Wang, C., Liu, J., Chen, Y., Li, Q., Wu, J., Zheng, W., Zhuge, Q., Jin, K. & Wu, Z., 1 Dec 2012, In : Endocrine. 42, 3, p. 670-675 6 p.

Research output: Contribution to journalArticle

Dopamine Receptors
Pituitary Neoplasms
Nerve Growth Factor
Bromocriptine
Messenger RNA
5 Citations (Scopus)

Differential proliferative index of cancer stem-like cells in primary and recurrent medulloblastoma in human

Tang, X., Yao, Y., Zhu, J., Jin, K., Wang, Y., Mao, Y. & Zhou, L., 1 Nov 2012, In : Child's Nervous System. 28, 11, p. 1869-1877 9 p.

Research output: Contribution to journalArticle

Medulloblastoma
Neoplastic Stem Cells
Recurrence
Nestin
Primitive Neuroectodermal Tumors
12 Citations (Scopus)

Effect of a contralateral lesion on neurological recovery from stroke in rats

Sun, F., Xie, L., Mao, X., Hill, J., Greenberg, D. A. & Jin, K., 1 Dec 2012, In : Restorative Neurology and Neuroscience. 30, 6, p. 491-495 5 p.

Research output: Contribution to journalArticle

Middle Cerebral Artery Infarction
Stroke
Cerebral Cortex
Walking
Sprague Dawley Rats
41 Citations (Scopus)

Effect of suture properties on stability of middle cerebral artery occlusion evaluated by synchrotron radiation angiography

Guan, Y., Wang, Y., Yuan, F., Lu, H., Ren, Y., Xiao, T., Chen, K., Greenberg, D. A., Jin, K. & Yang, G. Y., 1 Mar 2012, In : Stroke. 43, 3, p. 888-891 4 p.

Research output: Contribution to journalArticle

Synchrotrons
Middle Cerebral Artery Infarction
Sutures
Angiography
Radiation
18 Citations (Scopus)

Estrogen, neuroprotection and neurogenesis after ischemic stroke

Shao, B., Cheng, Y. & Jin, K., 1 Feb 2012, In : Current Drug Targets. 13, 2, p. 188-198 11 p.

Research output: Contribution to journalReview article

Neurogenesis
Estrogens
Stroke
Animals
Gonadal Steroid Hormones
39 Citations (Scopus)

Hypoxia-inducible factor-1 and neuroglobin expression

Haines, B., Demaria, M., Mao, X., Xie, L., Campisi, J., Jin, K. & Greenberg, D. A., 18 Apr 2012, In : Neuroscience Letters. 514, 2, p. 137-140 4 p.

Research output: Contribution to journalComment/debate

Hypoxia-Inducible Factor 1
Nervous System Diseases
Small Interfering RNA
Alzheimer Disease
Animal Models
16 Citations (Scopus)

Interactions between vascular endothelial growth factor and neuroglobin

Jin, K., Mao, X., Xie, L. & Greenberg, D. A., 21 Jun 2012, In : Neuroscience Letters. 519, 1, p. 47-50 4 p.

Research output: Contribution to journalArticle

Vascular Endothelial Growth Factor A
Transgenic Mice
Ischemia
neuroglobin
Hypoxia
67 Citations (Scopus)

Intracerebral chondroitinase ABC and heparan sulfate proteoglycan glypican improve outcome from chronic stroke in rats

Hill, J. J., Jin, K., Mao, X. O., Xie, L. & Greenberg, D. A., 5 Jun 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 23, p. 9155-9160 6 p.

Research output: Contribution to journalArticle

Glypicans
Chondroitin ABC Lyase
Heparan Sulfate Proteoglycans
Neurocan
Stroke
66 Citations (Scopus)

Netrin-1 hyperexpression in mouse brain promotes angiogenesis and long-term neurological recovery after transient focal ischemia

Lu, H., Wang, Y., He, X., Yuan, F., Lin, X., Xie, B., Tang, G., Huang, J., Tang, Y., Jin, K., Chen, S. & Yang, G. Y., 1 Mar 2012, In : Stroke. 43, 3, p. 838-843 6 p.

Research output: Contribution to journalArticle

Middle Cerebral Artery Infarction
Ischemia
Brain
Synchrotrons
Genes
30 Citations (Scopus)

The implications of cancer stem cells for cancer therapy

Jiang, W., Peng, J., Zhang, Y., Cho, W. C. S. & Jin, K., Dec 2012, In : International journal of molecular sciences. 13, 12, p. 16636-16657 22 p.

Research output: Contribution to journalReview article

Neoplastic Stem Cells
stem cells
Cell- and Tissue-Based Therapy
Stem cells
therapy
2011
7 Citations (Scopus)

Corpus callosum and experimental stroke: Studies in callosotomized rats and acallosal mice

Jin, K., Xie, L., Sun, F., Mao, X. & Greenberg, D. A., 1 Sep 2011, In : Stroke. 42, 9, p. 2584-2588 5 p.

Research output: Contribution to journalArticle

Corpus Callosum
Middle Cerebral Artery Infarction
Stroke
Agenesis of Corpus Callosum
Brain Ischemia
65 Citations (Scopus)

Effect of human neural precursor cell transplantation on endogenous neurogenesis after focal cerebral ischemia in the rat

Jin, K., Xie, L., Mao, X., Greenberg, M. B., Moore, A., Peng, B., Greenberg, R. B. & Greenberg, D. A., 16 Feb 2011, In : Brain Research. 1374, p. 56-62 7 p.

Research output: Contribution to journalArticle

Lateral Ventricles
Cell Transplantation
Neurogenesis
Brain Ischemia
Transplantation
2 Citations (Scopus)

Endogenously EGFP-labeled mouse embryonic stem cells

Zhang, J., Rao, R. V., Spilman, P., Mangada, J., Xie, L., Vitelli, C., Gorostiza, O. F., Madden, D. T., Zeng, X., Jin, K., Hart, M. J., Bredesen, D. E. & Galvan, V., 1 Jan 2011, In : Aging and Disease. 2, 1, p. 18-29 12 p.

Research output: Contribution to journalArticle

Embryonic Stem Cells
Transplantation
Embryonic Structures
Clone Cells
Germ Layers
6 Citations (Scopus)

Neuroglobin expression in human arteriovenous malformation and intracerebral hemorrhage

Jin, K., Mao, X., Xie, L. & Greenberg, D. A., 1 Jan 2011, Intracerebral Hemorrhage Research: From Bench to Bedside. 111 ed. Springer-Verlag Wien, p. 315-319 5 p. (Acta Neurochirurgica, Supplementum; no. 111).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Arteriovenous Malformations
Cerebral Hemorrhage
Neurogenesis
Brain Injuries
Stroke
30 Citations (Scopus)

Pharmacological induction of neuroglobin expression

Jin, K., Mao, X. O., Xie, L., John, V. & Greenberg, D. A., 1 Feb 2011, In : Pharmacology. 87, 1-2, p. 81-84 4 p.

Research output: Contribution to journalArticle

Pharmacology
Volatile Fatty Acids
Histone Deacetylase Inhibitors
Deferoxamine
Valproic Acid
18 Citations (Scopus)

Proliferative capacity of stem/progenitor-like cells in the kidney may associate with the outcome of patients with acute tubular necrosis

Ye, Y., Wang, B., Jiang, X., Hu, W., Feng, J., Li, H., Jin, M., Ying, Y., Wang, W., Mao, X. & Jin, K., 1 Aug 2011, In : Human Pathology. 42, 8, p. 1132-1141 10 p.

Research output: Contribution to journalArticle

Necrosis
Stem Cells
Kidney
Bowman Capsule
PAX2 Transcription Factor
2010

A&D, a bridge between aging and age-related disease

Jin, K., Shetty, A. K. & Greenberg, D. A., 1 Jan 2010, In : Aging and Disease. 1, 1, 1 p.

Research output: Contribution to journalEditorial