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2019

Hybrid compound sa-2 is neuroprotective in animal models of retinal ganglion cell death

Stankowska, D. L., Dibas, A., Li, L., Zhang, W., Krishnamoorthy, V. R., Chavala, S., Nguyen, T. P., Yorio, T., Ellis, D. Z. & Acharya, S., 1 Jul 2019, In : Investigative Ophthalmology and Visual Science. 60, 8, p. 3064-3073 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Retinal Ganglion Cells
Cell Death
Nerve Crush
Animal Models
Retina
2018
9 Citations (Scopus)

Consensus recommendations for trabecular meshwork cell isolation, characterization and culture

Keller, K. E., Bhattacharya, S. K., Borrás, T., Brunner, T. M., Chansangpetch, S., Clark, A., Dismuke, W. M., Du, Y., Elliott, M. H., Ethier, C. R., Faralli, J. A., Freddo, T. F., Fuchshofer, R., Giovingo, M., Gong, H., Gonzalez, P., Huang, A., Johnstone, M. A., Kaufman, P. L., Kelley, M. J. & 37 others, Knepper, P. A., Kopczynski, C. C., Kuchtey, J. G., Kuchtey, R. W., Kuehn, M. H., Lieberman, R. L., Lin, S. C., Liton, P., Liu, Y., Lütjen-Drecoll, E., Mao, W., Masis-Solano, M., McDonnell, F., McDowell, C. M., Overby, D. R., Pattabiraman, P. P., Raghunathan, V. K., Rao, P. V., Rhee, D. J., Chowdhury, U. R., Russell, P., Samples, J. R., Schwartz, D., Stubbs, E. B., Tamm, E. R., Tan, J. C., Toris, C. B., Torrejon, K. Y., Vranka, J. A., Wirtz, M. K., Yorio, T., Zhang, J., Zode, G., Fautsch, M. P., Peters, D. M., Acott, T. S. & Stamer, W. D., 1 Jun 2018, In : Experimental eye research. 171, p. 164-173 10 p.

Research output: Contribution to journalShort surveyResearchpeer-review

Trabecular Meshwork
Cell Separation
Cell Culture Techniques
Ocular Hypertension
Intraocular Pressure

Introduction to volume 1 of JOPT special issue

Sharif, N., Ohia, S. & Yorio, T., 1 Jan 2018, In : Journal of Ocular Pharmacology and Therapeutics. 34, 1-2, p. 1-2 2 p.

Research output: Contribution to journalEditorialResearch

Introduction to volume 2 of JOPT special issue

Sharif, N., Ohia, S. & Yorio, T., 1 Jan 2018, In : Journal of Ocular Pharmacology and Therapeutics. 34, 1-2, 1 p.

Research output: Contribution to journalEditorialResearch

3 Citations (Scopus)

Neuroprotective Effects of Psalmotoxin-1, an Acid-Sensing Ion Channel (ASIC) Inhibitor, in Ischemia Reperfusion in Mouse Eyes

Dibas, A., Millar, J. C., Al-Farra, A. & Yorio, T., 3 Jul 2018, In : Current Eye Research. 43, 7, p. 921-933 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Acid Sensing Ion Channel Blockers
Retinal Ganglion Cells
Neuroprotective Agents
Reperfusion
Ischemia
4 Citations (Scopus)

Targets of neuroprotection in glaucoma

He, S., Stankowska, D. L., Ellis, D. Z., Krishnamoorthy, R. & Yorio, T., 1 Jan 2018, In : Journal of Ocular Pharmacology and Therapeutics. 34, 1-2, p. 85-106 22 p.

Research output: Contribution to journalArticleResearchpeer-review

Glaucoma
Retinal Diseases
Western World
Retinal Ganglion Cells
Aqueous Humor
2017

A feed-forward regulation of endothelin receptors by c-Jun in human non-pigmented ciliary epithelial cells and retinal ganglion cells

Wang, J., Ma, H. Y., Krishnamoorthy, R., Yorio, T. & He, S., 1 Sep 2017, In : PLoS ONE. 12, 9, e0185390.

Research output: Contribution to journalArticleResearchpeer-review

CCAAT-Enhancer-Binding Proteins
Endothelin Receptors
food law
endothelins
Endothelin B Receptors

Principles of ocular pharmacology

Park, Y., Ellis, D. Z., Mueller, B., Stankowska, D. L. & Yorio, T., 1 Jan 2017, Handbook of Experimental Pharmacology. Springer New York LLC, p. 3-30 28 p. (Handbook of Experimental Pharmacology; vol. 242).

Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review

Eye Diseases
Pharmacology
Pharmaceutical Preparations
Memory Disorders
Macular Degeneration
4 Citations (Scopus)

Sigma-1 receptor regulates mitochondrial function in glucose-and oxygen-deprived retinal ganglion cells

Ellis, D. Z., Li, L., Park, Y., He, S., Mueller, B. & Yorio, T., 1 May 2017, In : Investigative Ophthalmology and Visual Science. 58, 5, p. 2755-2764 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Retinal Ganglion Cells
Oxygen
Glucose
Mitochondrial Membrane Potential
Electron Transport Complex IV
2016
4 Citations (Scopus)

Design and synthesis of novel hybrid sydnonimine and prodrug useful for glaucomatous optic neuropathy

Acharya, S., Rogers, P., Krishnamoorthy, R., Stankowska, D. L., Dias, H. V. R. & Yorio, T., 1 Mar 2016, In : Bioorganic and Medicinal Chemistry Letters. 26, 5, p. 1490-1494 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Optic Nerve Diseases
Prodrugs
Optics
Photoreceptor Cells
Molecules
14 Citations (Scopus)

Glucocorticoid therapy and ocular hypertension

Dibas, A. & Yorio, T., 1 Jan 2016, In : European Journal of Pharmacology. 787, p. 57-71 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Ocular Hypertension
Glucocorticoids
Macular Degeneration
Diabetic Retinopathy
Glaucoma
4 Citations (Scopus)

Involvement of ampa receptor and its flip and flop isoforms in retinal ganglion cell death following oxygen/glucose deprivation

Park, Y. H., Broyles, H. V., He, S., McGrady, N. R., Li, L. & Yorio, T., 1 Feb 2016, In : Investigative Ophthalmology and Visual Science. 57, 2, p. 508-526 19 p.

Research output: Contribution to journalArticleResearchpeer-review

AMPA Receptors
Retinal Ganglion Cells
Protein Isoforms
Cell Death
Oxygen

Thank you to our reviewers

Yorio, T., 1 Jun 2016, In : Investigative Ophthalmology and Visual Science. 57, 7, 1 p.

Research output: Contribution to journalEditorialResearch

2015
11 Citations (Scopus)

AMPA receptor desensitization is the determinant of AMPA receptor mediated excitotoxicity in purified retinal ganglion cells

Park, Y. H., Mueller, B. H., McGrady, N. R., Ma, H. Y. & Yorio, T., 1 Mar 2015, In : Experimental eye research. 132, p. 136-150 15 p.

Research output: Contribution to journalArticleResearchpeer-review

AMPA Receptors
Retinal Ganglion Cells
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
Caspase 7
Calcium

A new transition

Yorio, T., 1 Jan 2015, In : Investigative Ophthalmology and Visual Science. 56, 5, 1 p.

Research output: Contribution to journalEditorialResearch

Ophthalmology
9 Citations (Scopus)

Endothelin-mediated changes in gene expression in isolated purified rat retinal ganglion cells

He, S., Park, Y. H., Yorio, T. & Krishnamoorthy, R., 1 Jan 2015, In : Investigative Ophthalmology and Visual Science. 56, 10, p. 6144-6161 18 p.

Research output: Contribution to journalArticleResearchpeer-review

Retinal Ganglion Cells
Endothelins
Gene Expression
Endothelin-1
Endothelin-2
10 Citations (Scopus)

Neuroprotective effects of transcription factor brn3b in an ocular hypertension rat model of glaucoma

Stankowska, D. L., Minton, A. Z., Rutledge, M. A., Mueller, B. H., Phatak, N. R., He, S., Ma, H. Y., Forster, M. J., Yorio, T. & Krishnamoorthy, R., 1 Jan 2015, In : Investigative Ophthalmology and Visual Science. 56, 2, p. 893-907 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Ocular Hypertension
Neuroprotective Agents
Intraocular Pressure
Glaucoma
Transcription Factors
1 Citation (Scopus)

Open access coming to IOVS

Yorio, T., 1 Jan 2015, In : Investigative Ophthalmology and Visual Science. 56, 9, 1 p.

Research output: Contribution to journalEditorialResearch

2014
2 Citations (Scopus)

Erratum: Characterization of a transformed rat retinal ganglion cell line (Brain Research Molecular Brain Research (2001) 86 (1-12))

Krishnamoorthy, R., Agarwal, P., Prasanna, G., Vopat, K., Lambert, W., Sheedlo, H. J., Pang, I-H., Shade, D., Wordinger, R. J., Yorio, T., Clark, A. & Agarwal, N., 28 Jan 2014, In : Brain Research. 1544, 1 p.

Research output: Contribution to journalComment/debateResearch

Retinal Ganglion Cells
Cell Line
Brain
Research
4 Citations (Scopus)

Methylene blue promotes quiescence of rat neural progenitor cells

Xie, L., Choudhury, G. R., Wang, J., Park, Y., Liu, R., Yuan, F., Zhang, C. L., Yorio, T., Jin, K. & Yang, S., 7 Oct 2014, In : Frontiers in Cellular Neuroscience. 8, OCT, 315.

Research output: Contribution to journalArticleResearchpeer-review

Methylene Blue
Stem Cells
Intraventricular Infusions
Cyclins
Neural Stem Cells
12 Citations (Scopus)

Role of the alternatively spliced glucocorticoid receptor isoform GRβ in steroid responsiveness and glaucoma

Jain, A., Wordinger, R. J., Yorio, T. & Clark, A., 1 Mar 2014, In : Journal of Ocular Pharmacology and Therapeutics. 30, 2-3, p. 121-127 7 p.

Research output: Contribution to journalReview articleResearchpeer-review

Glucocorticoid Receptors
Glaucoma
Glucocorticoids
Protein Isoforms
Trabecular Meshwork
17 Citations (Scopus)

Sigma-1 receptor stimulation protects retinal ganglion cells from ischemia-like insult through the activation of extracellular-signal-regulated kinases 1/2

Mueller, B. H., Park, Y., Ma, H. Y., Dibas, A., Ellis, D. Z., Clark, A. & Yorio, T., 1 Nov 2014, In : Experimental Eye Research. 128, p. 156-169 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Mitogen-Activated Protein Kinase 3
Retinal Ganglion Cells
Mitogen-Activated Protein Kinase 1
Ischemia
Pentazocine
2013
73 Citations (Scopus)

A forensic path to RGC-5 cell line identification: Lessons learned

Krishnamoorthy, R., Clark, A., Daudt, D., Vishwanatha, J. K. & Yorio, T., 30 Aug 2013, In : Investigative Ophthalmology and Visual Science. 54, 8, p. 5712-5719 8 p.

Research output: Contribution to journalEditorialResearch

Retinal Ganglion Cells
Cell Line
Transformed Cell Line
Karyotyping
Photoreceptor Cells
9 Citations (Scopus)

Effects of thailanstatins on glucocorticoid response in trabecular meshwork and steroid-induced glaucoma

Jain, A., Liu, X., Wordinger, R. J., Yorio, T., Cheng, Y. & Clark, A., 10 May 2013, In : Investigative Ophthalmology and Visual Science. 54, 5, p. 3137-3142 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Trabecular Meshwork
Glaucoma
Glucocorticoids
Steroids
Intraocular Pressure
34 Citations (Scopus)

Sigma-1 receptor stimulation attenuates calcium influx through activated L-type Voltage Gated Calcium Channels in purified retinal ganglion cells

Mueller, B. H., Park, Y., Daudt, D. R., Ma, H. Y., Akopova, I., Stankowska, D. L., Clark, A. F. & Yorio, T., 1 Feb 2013, In : Experimental Eye Research. 107, p. 21-31 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Retinal Ganglion Cells
Calcium Channels
Calcium
Calcium Channel Blockers
Ions
2012
3 Citations (Scopus)

Fluorescent protein-labeled glucocorticoid receptor alpha isoform trafficking in cultured human trabecular meshwork cells.

Dibas, A., Jiang, M., Fudala, R., Gryczynski, I., Gryczynski, Z., Clark, A. & Yorio, T., 1 Jan 2012, In : Investigative ophthalmology & visual science. 53, 6, p. 2938-2950 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Trabecular Meshwork
Protein Isoforms
Dexamethasone
Proteins
tanespimycin
22 Citations (Scopus)

Methylene blue protects primary rat retinal ganglion cells from cellular senescence

Daudt, D. R., Mueller, B., Park, Y. H., Wen, Y. & Yorio, T., 1 Jul 2012, In : Investigative Ophthalmology and Visual Science. 53, 8, p. 4657-4667 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Retinal Ganglion Cells
Cell Aging
Methylene Blue
Electron Transport Complex IV
Rotenone
23 Citations (Scopus)

Spliceosome protein (SRp) regulation of glucocorticoid receptor isoforms and glucocorticoid response in human trabecular meshwork cells

Jain, A., Wordinger, R. J., Yorio, T. & Clark, A., 1 Feb 2012, In : Investigative Ophthalmology and Visual Science. 53, 2, p. 857-866 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Spliceosomes
Trabecular Meshwork
Glucocorticoid Receptors
Glucocorticoids
Protein Isoforms
2011
42 Citations (Scopus)

Endothelin, astrocytes and glaucoma

Prasanna, G., Krishnamoorthy, R. & Yorio, T., 1 Aug 2011, In : Experimental eye research. 93, 2, p. 170-177 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Endothelins
Astrocytes
Glaucoma
Gliosis
Central Nervous System
10 Citations (Scopus)

FKBP51 protects 661w cell culture from staurosporine-induced apoptosis

Daudt, D. R. & Yorio, T., 30 May 2011, In : Molecular Vision. 17, p. 1172-1181 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Tacrolimus Binding Proteins
Staurosporine
Cell Culture Techniques
Tacrolimus
Apoptosis
25 Citations (Scopus)

Perfusion-cultured bovine anterior segments as an ex vivo model for studying glucocorticoid-induced ocular hypertension and glaucoma

Mao, W., Tovar-Vidales, T., Yorio, T., Wordinger, R. J. & Clark, A., 1 Oct 2011, In : Investigative Ophthalmology and Visual Science. 52, 11, p. 8068-8075 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Ocular Hypertension
Glaucoma
Dexamethasone
Glucocorticoids
Perfusion
5 Citations (Scopus)

Protein Profiling of human nonpigmented ciliary epithelium cell secretome: The differentiation factors characterization for retinal ganglion cell line

Chung, T. W., Yang, M. H., Krishnamoorthy, R., Jong, S. B., Chu, P. Y., Yang, Y. H., Chen, W. C., Chen, S. C. J., Dibas, A., Yorio, T. & Tyan, Y. C., 12 Oct 2011, In : Journal of Biomedicine and Biotechnology. 2011, 901329.

Research output: Contribution to journalArticleResearchpeer-review

Retinal Ganglion Cells
Epithelium
Cell Line
Epithelial Cells
Proteins
2010
23 Citations (Scopus)

Assessment of SNPs associated with the human glucocorticoid receptor in primary open-angle glaucoma and steroid responders

Fingert, J. H., Alward, W. L., Wang, K., Yorio, T. & Clark, A., 23 Aug 2010, In : Molecular Vision. 16, p. 596-601 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Glucocorticoid Receptors
Single Nucleotide Polymorphism
Steroids
Glucocorticoids
Ocular Hypertension
53 Citations (Scopus)

Canonical Transient Receptor Potential 6 (TRPC6), a redox-regulated cation channel

Graham, S., Ding, M., Ding, Y., Sours-Brothers, S., Luchowski, R., Gryczynski, Z., Yorio, T., Ma, H. & Ma, R., 23 Jul 2010, In : Journal of Biological Chemistry. 285, 30, p. 23466-23476 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Arginine Vasopressin
Oxidation-Reduction
Cations
Vasopressin Receptors
Ethylmaleimide
21 Citations (Scopus)

Changes in ocular aquaporin expression following optic nerve crush

Dibas, A., Oku, H., Fukuhara, M., Kurimoto, T., Ikeda, T., Patil, R. V., Sharif, N. A. & Yorio, T., 20 Aug 2010, In : Molecular Vision. 16, p. 330-340 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Nerve Crush
Aquaporins
Optic Nerve
Retinal Ganglion Cells
Glial Fibrillary Acidic Protein
4 Citations (Scopus)

Steroid-induced glaucoma

Clark, A., Zhang, X. & Yorio, T., 1 Dec 2010, Ocular Disease: Mechanisms and Management. Elsevier Inc., p. 146-152 7 p.

Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review

Glaucoma
Steroids
6 Citations (Scopus)

Thrombin-induced endothelin-1 synthesis and secretion in retinal pigment epithelial cells is Rho kinase dependent

Narayan, S., Prasanna, G., Tchedre, K., Krishnamoorthy, R. & Yorio, T., 1 Oct 2010, In : Journal of Ocular Pharmacology and Therapeutics. 26, 5, p. 389-397 9 p.

Research output: Contribution to journalArticleResearchpeer-review

rho-Associated Kinases
Retinal Pigments
Endothelin-1
Thrombin
Epithelial Cells