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2019

Breakthroughs in medicinal chemistry: New targets and mechanisms, new drugs, new hopes-4

Mangoni, A. A., Guillou, C., Eynde, J. J. V., Hulme, C., Jampilek, J., Li, W., Prokai-Tatrai, K., Rautio, J., Collina, S., Tuccinardi, T., Sousa, M. E., Sabatier, J. M., Galdiero, S., Karaman, R., Kokotos, G., Torri, G., Javier Luque, F., Helena Vasconcelos, M., Hadjipavlou-Litina, D., Siciliano, C. & 5 others, Gütschow, M., Ragno, R., Gomes, P. A. C., Agrofoglio, L. A. & Muñoz-Torrero, D., 1 Jan 2019, In : Molecules. 24, 1, p. 1-12 12 p.

Research output: Contribution to journalReview articleResearchpeer-review

Pharmaceutical Chemistry
drugs
chemistry
Pharmaceutical Preparations

Breakthroughs in medicinal chemistry: New targets and mechanisms, New Drugs, New Hopes-5

Mangoni, A. A., Eynde, J. J. V., Jampilek, J., Hadjipavlou-Litina, D., Liu, H., Reynisson, J., Sousa, M. E., Gomes, P. A. C., Prokai-Tatrai, K., Tuccinardi, T., Sabatier, J. M., Luque, F. J., Rautio, J., Karaman, R., Vasconcelos, M. H., Gemma, S., Galdiero, S., Hulme, C., Collina, S., Gütschow, M. & 6 others, Kokotos, G., Siciliano, C., Capasso, R., Agrofoglio, L. A., Ragno, R. & Muñoz-Torrero, D., 1 Jan 2019, In : Molecules. 24, 13, 2415.

Research output: Contribution to journalReview articleResearchpeer-review

Open Access
Pharmaceutical Chemistry
drugs
chemistry
Pharmaceutical Preparations
2018

10β,17α-Dihydroxyestra-1,4-dien-3-one: A Bioprecursor Prodrug Preferentially Producing 17α-Estradiol in the Brain for Targeted Neurotherapy

Prokai-Tatrai, K., Nguyen, V. & Prokai, L., 21 Nov 2018, In : ACS Chemical Neuroscience. 9, 11, p. 2528-2533 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Prodrugs
Estradiol
Brain
Estrogens
Neurology
2 Citations (Scopus)

An exploratory investigation of brain-selective estrogen treatment in males using a mouse model of Alzheimer's disease

Tschiffely, A. E., Schuh, R. A., Prokai-Tatrai, K., Ottinger, M. A. & Prokai, L., 1 Feb 2018, In : Hormones and Behavior. 98, p. 16-21 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Alzheimer Disease
Estrogens
Brain
Estradiol
Amyloid beta-Protein Precursor

Breakthroughs in medicinal chemistry: New targets and mechanisms, new drugs, new hopes-3

Mangoni, A. A., Tuccinardi, T., Collina, S., Vanden Eynde, J. J., Mu oz-Torrero, D., Karaman, R., Siciliano, C., Emília de Sousa, M., Prokai-Tatrai, K., Rautio, J., Guillou, C., G tschow, M., Galdiero, S., Liu, H., Agrofoglio, L. A., Sabatier, J. M., Hulme, C., Kokotos, G., You, Q. & Gomes, P. A. C., 1 Jan 2018, In : Molecules. 23, 7, 1596.

Research output: Contribution to journalReview articleResearchpeer-review

Pharmaceutical Chemistry
drugs
chemistry
Pharmaceutical Preparations
1 Citation (Scopus)

Breakthroughs in medicinal chemistry: New targets and mechanisms, new drugs, new hopes–2

Muñoz-Torrero, D., Mangoni, A. A., Liu, H., Hulme, C., Rautio, J., Karaman, R., De Sousa, M. E., Prokai-Tatrai, K., Sabatier, J. M., Siciliano, C., Luque, F. J., Kokotos, G., Ragno, R., Collina, S., Guillou, C., Tschow, M. G. & Agrofoglio, L. A., 1 Jan 2018, In : Molecules. 23, 1, 65.

Research output: Contribution to journalReview articleResearchpeer-review

Molecular Targeted Therapy
Pharmaceutical Chemistry
Drug Discovery
drugs
chemistry
2016
5 Citations (Scopus)

A comparative evaluation of treatments with 17β-estradiol and its brain-selective prodrug in a double-transgenic mouse model of Alzheimer's disease

Tschiffely, A. E., Schuh, R. A., Prokai-Tatrai, K., Prokai, L. & Ottinger, M. A., 1 Jul 2016, In : Hormones and Behavior. 83, p. 39-44 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Prodrugs
Transgenic Mice
Estradiol
Alzheimer Disease
Brain
4 Citations (Scopus)

Treatment with an orally bioavailable prodrug of 17β-estradiol alleviates hot flushes without hormonal effects in the periphery

Merchenthaler, I., Lane, M., Sabnis, G., Brodie, A., Nguyen, V., Prokai, L. & Prokai-Tatrai, K., 1 Aug 2016, In : Scientific Reports. 6, 30721.

Research output: Contribution to journalArticleResearchpeer-review

Prodrugs
Estradiol
Estrogens
Skin Temperature
Brain
2015
15 Citations (Scopus)

The prodrug DHED selectively delivers 17β-estradiol to the brain for treating estrogen-responsive disorders

Prokai, L., Nguyen, V., Szarka, S., Garg, P., Sabnis, G., Bimonte-Nelson, H. A., McLaughlin, K. J., Talboom, J. S., Conrad, C. D., Shughrue, P. J., Gould, T. D., Brodie, A., Merchenthaler, I., Koulen, P. & Prokai-Tatrai, K., 22 Jul 2015, In : Science Translational Medicine. 7, 297, 297ra113.

Research output: Contribution to journalArticleResearchpeer-review

Prodrugs
Estradiol
Estrogens
Brain
Menopause
2014
11 Citations (Scopus)
Liquid chromatography
Liquid Chromatography
Isotopes
Design of experiments
Mass spectrometry
4 Citations (Scopus)

Selective chemoprecipitation to enrich nitropeptides from complex proteomes for mass-spectrometric analysis

Prokai, L., Guo, J. & Prokai-Tatrai, K., 1 Jan 2014, In : Nature Protocols. 9, 4, p. 882-895 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Proteome
Peptides
Nitration
Mass spectrometry
Esters
2013
29 Citations (Scopus)

17β-estradiol eye drops protect the retinal ganglion cell layer and preserve visual function in an in vivo model of glaucoma

Prokai-Tatrai, K., Xin, H., Nguyen, V., Szarka, S., Blazics, B., Prokai, L. & Koulen, P., 5 Aug 2013, In : Molecular Pharmaceutics. 10, 8, p. 3253-3261 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Retinal Ganglion Cells
Ophthalmic Solutions
Intraocular Pressure
Glaucoma
Estradiol
2 Citations (Scopus)

Design and exploratory neuropharmacological evaluation of novel thyrotropin-releasing hormone analogs and their brain-targeting bioprecursor prodrugs

Prokai-Tatrai, K., Nguyen, V., Szarka, S., Konya, K. & Prokai, L., 22 May 2013, In : Pharmaceutics. 5, 2, p. 318-328 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Thyrotropin-Releasing Hormone
Prodrugs
Brain
Central Nervous System Stimulants
Cholinergic Agents
6 Citations (Scopus)

Quantitative structure-activity relationships predicting the antioxidant potency of 17β-estradiol-related polycyclic phenols to inhibit lipid peroxidation

Prokai, L., Rivera-Portalatin, N. M. & Prokai-Tatrai, K., 1 Jan 2013, In : International Journal of Molecular Sciences. 14, 1, p. 1443-1454 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Oxidative stress
Quantitative Structure-Activity Relationship
Phenols
antioxidants
Antioxidants
20 Citations (Scopus)

Separation of dansylated 17β-estradiol, 17α-estradiol, and estrone on a single HPLC column for simultaneous quantitation by LC-MS/MS

Szarka, S., Nguyen, V., Prokai, L. & Prokai-Tatrai, K., 1 Apr 2013, In : Analytical and Bioanalytical Chemistry. 405, 10, p. 3399-3406 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Estrone
Estradiol
Assays
Estrogens
High Pressure Liquid Chromatography
2012
16 Citations (Scopus)
Flecainide
Metabolites
Chromatography
Isotopes
Dilution
9 Citations (Scopus)

Relative quantitation of protein nitration by liquid chromatography-mass spectrometry using isotope-coded dimethyl labeling and chemoprecipitation

Guo, J., Prokai-Tatrai, K. & Prokai, L., 6 Apr 2012, In : Journal of Chromatography A. 1232, p. 266-275 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Nitration
Methylation
Liquid chromatography
Liquid Chromatography
Isotopes
2011
7 Citations (Scopus)

Prodrug design for brain delivery of small- and medium-sized neuropeptides

Prokai-Tatrai, K. & Prokai, L., 24 Oct 2011, Neuropeptides: Methods and Protocols. Merighi, A. (ed.). p. 313-336 24 p. (Methods in Molecular Biology; vol. 789).

Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review

Prodrugs
Neuropeptides
Brain
Blood-Brain Barrier
Peptides
27 Citations (Scopus)

Protein targets for carbonylation by 4-hydroxy-2-nonenal in rat liver mitochondria

Guo, J., Prokai-Tatrai, K., Nguyen, V., Rauniyar, N., Ughy, B. & Prokai, L., 19 Oct 2011, In : Journal of Proteomics. 74, 11, p. 2370-2379 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Protein Carbonylation
Carbonylation
Mitochondria
Liver Mitochondrion
Liver
23 Citations (Scopus)
Liquid chromatography
Tandem Mass Spectrometry
Liquid Chromatography
Mass spectrometry
Peptides
2010
2 Citations (Scopus)

[Glu2]TRH dose-dependently attenuates TRH-evoked analeptic effect in mice

Nguyen, V., Zharikova, A. D., Prokai-Tatrai, K. & Prokai, L., 1 Apr 2010, In : Brain Research Bulletin. 82, 1-2, p. 83-86 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Central Nervous System Stimulants
Central Nervous System
Thyrotropin-Releasing Hormone
Cholinergic Agents
Acetylcholine
29 Citations (Scopus)
Carbonylation
Electrospray ionization
Liquid chromatography
Spectrometry
Peptides
7 Citations (Scopus)

Simultaneous measurement of 17β-estradiol, 17α-estradiol and estrone by GC-isotope dilution MS-MS

Prokai-Tatrai, K., Bonds, D. & Prokai, L., 1 Feb 2010, In : Chromatographia. 71, 3-4, p. 311-315 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Estrone
Isotopes
Dilution
Estradiol
Estrogens