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2019

[ 99 mTc-HYNIC-N-dodecylamide]:a new hydrophobic tracer for labelling reconstituted high-density lipoproteins (rHDL) for radioimaging

Isaac-Olivé, K., Ocampo-García, B. E., Aranda-Lara, L., Santos-Cuevas, C. L., Jiménez-Mancilla, N. P., Luna-Gutiérrez, M. A., Medina, L. A., Nagarajan, B., Sabnis, N., Raut, S. L., Prokai, L. & Lacko, A. G., 14 Jan 2019, In : Nanoscale. 11, 2, p. 541-551 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Lipoproteins
HDL Lipoproteins
Labeling
Imaging techniques
Acids

Different reactivity to glutathione but similar tumor cell toxicity of chalcones and their quinolinone analogues

d’Oliveira, G. D. C., Custodio, J. M. F., Moura, A. F., Napolitano, H. B., Pérez, C. N., Moraes, M. O., Prokai, L. & Perjési, P., 1 Sep 2019, In : Medicinal Chemistry Research. 28, 9, p. 1448-1460 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Chalcones
Chalcone
Quinolones
Glutathione
Toxicity
2018

10β,17α-Dihydroxyestra-1,4-dien-3-one: A Bioprecursor Prodrug Preferentially Producing 17α-Estradiol in the Brain for Targeted Neurotherapy

Prokai-Tatrai, K., Nguyen, V. & Prokai, L., 21 Nov 2018, In : ACS Chemical Neuroscience. 9, 11, p. 2528-2533 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Prodrugs
Estradiol
Brain
Estrogens
Neurology
2 Citations (Scopus)

An exploratory investigation of brain-selective estrogen treatment in males using a mouse model of Alzheimer's disease

Tschiffely, A. E., Schuh, R. A., Prokai-Tatrai, K., Ottinger, M. A. & Prokai, L., 1 Feb 2018, In : Hormones and Behavior. 98, p. 16-21 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Alzheimer Disease
Estrogens
Brain
Estradiol
Amyloid beta-Protein Precursor

Risk-associated and pathway-based method to detect association with Alzheimer's disease

Mitchel, J., Prokai, L., Deng, Y., Zhang, F. & Barber, R. C., 1 Jan 2018, In : International Journal of Computational Biology and Drug Design. 11, 1-2

Research output: Contribution to journalEditorialResearch

Alzheimer Disease
Alleles
Genome-Wide Association Study
Databases
Genes
2017

Effect of short-term DHEA supplementation on serum and hippocampal estrogen concentrations in perimenopausal female rhesus macaques

Urbanski, H. F., Sorwell, K. G., Prokai, L. & Kohama, S. G., 1 Jul 2017, In : Neurobiology of Aging. 55, p. 172-174 3 p.

Research output: Contribution to journalArticleResearchpeer-review

Dehydroepiandrosterone
Macaca mulatta
Estrogens
Estradiol
Hippocampus

Mannich Ketones as Possible Antimycobacterial Agents

Lutz, Z., Orbán, K., Bóna, Á., Márk, L., Maász, G., Prokai, L., Seress, L. & Lóránd, T., 1 Sep 2017, In : Archiv der Pharmazie. 350, 9, 1700102.

Research output: Contribution to journalArticleResearchpeer-review

Gordonia Bacterium
Amino Alcohols
Isoniazid
Microbial Sensitivity Tests
Ketones
10 Citations (Scopus)

Targeting alpha toxin to mitigate its lethal toxicity in ferret and rabbit models of Staphylococcus aureus necrotizing pneumonia

Diep, B. A., Hilliard, J. J., Le, V. T. M., Tkaczyk, C., Le, H. N., Tran, V. G., Rao, R. L., Dip, E. C., Pereira-Franchi, E. P., Cha, P., Jacobson, S., Broome, R., Cheng, L. I., Weiss, W., Prokai, L., Nguyen, V., Stover, C. K. & Sellman, B. R., 1 Apr 2017, In : Antimicrobial Agents and Chemotherapy. 61, 4, 02456-16.

Research output: Contribution to journalArticleResearchpeer-review

Staphylococcal Pneumonia
Ferrets
Rabbits
Linezolid
Passive Immunization
2016
5 Citations (Scopus)

A comparative evaluation of treatments with 17β-estradiol and its brain-selective prodrug in a double-transgenic mouse model of Alzheimer's disease

Tschiffely, A. E., Schuh, R. A., Prokai-Tatrai, K., Prokai, L. & Ottinger, M. A., 1 Jul 2016, In : Hormones and Behavior. 83, p. 39-44 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Prodrugs
Transgenic Mice
Estradiol
Alzheimer Disease
Brain
35 Citations (Scopus)

Cholinergic neurons in the basal forebrain promote wakefulness by actions on neighboring non-cholinergic neurons: An opto-dialysis study

Zant, J. C., Kim, T., Prokai, L., Szarka, S., McNally, J., McKenna, J. T., Shukla, C., Yang, C., Kalinchuk, A. V., McCarley, R. W., Brown, R. E. & Basheer, R., 10 Feb 2016, In : Journal of Neuroscience. 36, 6, p. 2057-2067 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Cholinergic Neurons
Wakefulness
Dialysis
Neurons
Optogenetics
13 Citations (Scopus)

Critical role of alpha-toxin and protective effects of its neutralization by a human antibody in acute bacterial skin and skin structure infections

Le, V. T. M., Tkaczyk, C., Chau, S., Rao, R. L., Dip, E. C., Pereira-Franchi, E. P., Cheng, L., Lee, S., Koelkebeck, H., Hilliard, J. J., Yu, X. Q., Datta, V., Nguyen, V., Weiss, W., Prokai, L., O'Day, T., Stover, C. K., Sellman, B. R. & Diep, B. A., 1 Oct 2016, In : Antimicrobial Agents and Chemotherapy. 60, 10, p. 5640-5648 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Skin
Antibodies
Infection
Linezolid
Methicillin-Resistant Staphylococcus aureus
2 Citations (Scopus)
Organothiophosphates
Cyclotrons
Cyclotron resonance
Fourier Analysis
cyclotron resonance

Mass spectrometric analysis of carisoprodol and meprobamate in rat brain microdialysates

Prokai, L., Fryčák, P., Nguyen, V. & Forster, M. J., 1 Oct 2016, In : Journal of Mass Spectrometry. 51, 10, p. 900-907 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Meprobamate
Carisoprodol
Ionization
Rats
Brain
4 Citations (Scopus)

Treatment with an orally bioavailable prodrug of 17β-estradiol alleviates hot flushes without hormonal effects in the periphery

Merchenthaler, I., Lane, M., Sabnis, G., Brodie, A., Nguyen, V., Prokai, L. & Prokai-Tatrai, K., 1 Aug 2016, In : Scientific Reports. 6, 30721.

Research output: Contribution to journalArticleResearchpeer-review

Prodrugs
Estradiol
Estrogens
Skin Temperature
Brain
2015
30 Citations (Scopus)

Anti-alpha-toxin monoclonal antibody and antibiotic combination therapy improves disease outcome and accelerates healing in a staphylococcus aureus dermonecrosis model

Hilliard, J. J., Datta, V., Tkaczyk, C., Hamilton, M., Sadowska, A., Jones-Nelson, O., O'Day, T., Weiss, W., Szarka, S., Nguyen, V., Prokai, L., Suzich, J. A., Stover, C. K. & Sellmana, B. R., 1 Jan 2015, In : Antimicrobial Agents and Chemotherapy. 59, 1, p. 299-308 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Linezolid
Staphylococcus aureus
Vancomycin
Monoclonal Antibodies
Anti-Bacterial Agents

A survey of the impact of deyolking on biological processes covered by shotgun proteomic analyses of zebrafish embryos

Rahlouni, F., Szarka, S., Shulaev, V. & Prokai, L., 1 Dec 2015, In : Zebrafish. 12, 6, p. 398-407 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Biological Phenomena
Firearms
Zebrafish
Proteome
proteome
4 Citations (Scopus)
Lidocaine
Local Anesthetics
Ionization
Masks
Fourier transforms
15 Citations (Scopus)

The prodrug DHED selectively delivers 17β-estradiol to the brain for treating estrogen-responsive disorders

Prokai, L., Nguyen, V., Szarka, S., Garg, P., Sabnis, G., Bimonte-Nelson, H. A., McLaughlin, K. J., Talboom, J. S., Conrad, C. D., Shughrue, P. J., Gould, T. D., Brodie, A., Merchenthaler, I., Koulen, P. & Prokai-Tatrai, K., 22 Jul 2015, In : Science Translational Medicine. 7, 297, 297ra113.

Research output: Contribution to journalArticleResearchpeer-review

Prodrugs
Estradiol
Estrogens
Brain
Menopause
2014
11 Citations (Scopus)
Liquid chromatography
Liquid Chromatography
Isotopes
Design of experiments
Mass spectrometry
7 Citations (Scopus)

Label-free LC-MS/MS identification of phosphatidylglycerol-regulated proteins in Synechocystis sp. PCC6803

Talamantes, T., Ughy, B., Domonkos, I., Kis, M., Gombos, Z. & Prokai, L., 1 Jan 2014, In : Proteomics. 14, 9, p. 1053-1057 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Synechocystis
Phosphatidylglycerols
Labels
Phospholipids
Proteins
4 Citations (Scopus)

Selective chemoprecipitation to enrich nitropeptides from complex proteomes for mass-spectrometric analysis

Prokai, L., Guo, J. & Prokai-Tatrai, K., 1 Jan 2014, In : Nature Protocols. 9, 4, p. 882-895 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Proteome
Peptides
Nitration
Mass spectrometry
Esters
2013
29 Citations (Scopus)

17β-estradiol eye drops protect the retinal ganglion cell layer and preserve visual function in an in vivo model of glaucoma

Prokai-Tatrai, K., Xin, H., Nguyen, V., Szarka, S., Blazics, B., Prokai, L. & Koulen, P., 5 Aug 2013, In : Molecular Pharmaceutics. 10, 8, p. 3253-3261 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Retinal Ganglion Cells
Ophthalmic Solutions
Intraocular Pressure
Glaucoma
Estradiol
5 Citations (Scopus)

An exploratory evaluation of tyrosine hydroxylase inhibition in planaria as a model for parkinsonism

Prokai, D., Nguyen, T., Kamrowski, K., Chandra, A., Talamantes, T., Baxter, L. R. & Prokai, L., 26 Nov 2013, In : International journal of molecular sciences. 14, 12, p. 23289-23296 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Tropism
Bromocriptine
tyrosine
Tyrosine 3-Monooxygenase
Parkinsonian Disorders
2 Citations (Scopus)

Antifungal Activity of Fused Mannich Ketones Triggers an Oxidative Stress Response and Is Cap1-Dependent in Candida albicans

Rossignol, T., Kocsis, B., Bouquet, O., Kustos, I., Kilár, F., Nyul, A., Jakus, P. B., Rajbhandari, K., Prokai, L., d'Enfert, C. & Lóránd, T., 30 Apr 2013, In : PLoS ONE. 8, 4, e62142.

Research output: Contribution to journalArticleResearchpeer-review

Oxidative stress
Candida
ketones
Ketones
Candida albicans
2 Citations (Scopus)

Design and exploratory neuropharmacological evaluation of novel thyrotropin-releasing hormone analogs and their brain-targeting bioprecursor prodrugs

Prokai-Tatrai, K., Nguyen, V., Szarka, S., Konya, K. & Prokai, L., 22 May 2013, In : Pharmaceutics. 5, 2, p. 318-328 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Thyrotropin-Releasing Hormone
Prodrugs
Brain
Central Nervous System Stimulants
Cholinergic Agents
8 Citations (Scopus)

Proteomic Analysis of Signaling Network Regulation in Renal Cell Carcinomas with Differential Hypoxia-Inducible Factor-2α Expression

Da Nagaprashantha, L., Talamantes, T., Singhal, J., Guo, J., Vatsyayan, R., Rauniyar, N., Awasthi, S., Singhal, S. S. & Prokai, L., 5 Aug 2013, In : PLoS ONE. 8, 8, e71654.

Research output: Contribution to journalArticleResearchpeer-review

kidney cells
Renal Cell Carcinoma
Proteomics
proteomics
carcinoma
6 Citations (Scopus)

Quantitative structure-activity relationships predicting the antioxidant potency of 17β-estradiol-related polycyclic phenols to inhibit lipid peroxidation

Prokai, L., Rivera-Portalatin, N. M. & Prokai-Tatrai, K., 1 Jan 2013, In : International Journal of Molecular Sciences. 14, 1, p. 1443-1454 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Oxidative stress
Quantitative Structure-Activity Relationship
Phenols
antioxidants
Antioxidants
20 Citations (Scopus)

Separation of dansylated 17β-estradiol, 17α-estradiol, and estrone on a single HPLC column for simultaneous quantitation by LC-MS/MS

Szarka, S., Nguyen, V., Prokai, L. & Prokai-Tatrai, K., 1 Apr 2013, In : Analytical and Bioanalytical Chemistry. 405, 10, p. 3399-3406 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Estrone
Estradiol
Assays
Estrogens
High Pressure Liquid Chromatography
12 Citations (Scopus)

Tissue penetration and antimicrobial activity of standard- and high-dose trimethoprim/sulfamethoxazole and linezolid in patients with diabetic foot infection

Stein, G. E., Throckmorton, J. K., Scharmen, A. E., Weiss, W., Prokai, L., Smith, C. L. & Havlichek, D. H., 1 Dec 2013, In : Journal of Antimicrobial Chemotherapy. 68, 12, p. 2852-2858 7 p., dkt267.

Research output: Contribution to journalArticleResearchpeer-review

Linezolid
Diabetic Foot
Sulfamethoxazole Drug Combination Trimethoprim
Infection
Streptococcus
2012
16 Citations (Scopus)
Flecainide
Metabolites
Chromatography
Isotopes
Dilution
3 Citations (Scopus)
Nitration
Electrospray ionization
Mass spectrometry
Tyrosine
Electrons

Mass Spectrometry-Based Methods to Investigate Posttranslational Protein Modifications by Lipid Peroxidation Products

Rauniyar, N. & Prokai, L., 21 May 2012, Mass Spectrometry Handbook. John Wiley and Sons, p. 23-40 18 p.

Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review

Mass spectrometry
Lipids
Proteins
9 Citations (Scopus)

Relative quantitation of protein nitration by liquid chromatography-mass spectrometry using isotope-coded dimethyl labeling and chemoprecipitation

Guo, J., Prokai-Tatrai, K. & Prokai, L., 6 Apr 2012, In : Journal of Chromatography A. 1232, p. 266-275 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Nitration
Methylation
Liquid chromatography
Liquid Chromatography
Isotopes
3 Citations (Scopus)

RimJ-mediated context-dependent N-terminal acetylation of the recombinant Z-domain protein in Escherichia coli

Bernal-Perez, L. F., Sahyouni, F., Prokai, L. & Ryu, Y., 1 Mar 2012, In : Molecular BioSystems. 8, 4, p. 1128-1130 3 p.

Research output: Contribution to journalArticleResearchpeer-review

Escherichia coli Proteins
Acetylation
Escherichia coli
Amino Acids
plasma protein Z
16 Citations (Scopus)

Selective N-terminal fluorescent labeling of proteins using 4-chloro-7-nitrobenzofurazan: A method to distinguish protein N-terminal acetylation

Bernal-Perez, L. F., Prokai, L. & Ryu, Y., 1 Sep 2012, In : Analytical Biochemistry. 428, 1, p. 13-15 3 p.

Research output: Contribution to journalArticleResearchpeer-review

4-Chloro-7-nitrobenzofurazan
Acetylation
Labeling
Proteins
Fluorescence
2011
25 Citations (Scopus)

2′-Hydroxyflavanone inhibits proliferation, tumor vascularization and promotes normal differentiation in VHL-mutant renal cell carcinoma

Nagaprashantha, L. D., Vatsyayan, R., Singhal, J., Lelsani, P., Prokai, L., Awasthi, S. & Singhal, S. S., 1 Apr 2011, In : Carcinogenesis. 32, 4, p. 568-575 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Renal Cell Carcinoma
Neoplasms
Heterografts
2'-hydroxyflavanone
Glutathione S-Transferase pi
30 Citations (Scopus)

Cognitive-impairing effects of medroxyprogesterone acetate in the rat: Independent and interactive effects across time

Braden, B. B., Garcia, A. N., Mennenga, S. E., Prokai, L., Villa, S. R., Acosta, J. I., Lefort, N., Simard, A. R. & Bimonte-Nelson, H. A., 1 Nov 2011, In : Psychopharmacology. 218, 2, p. 405-418 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Medroxyprogesterone Acetate
Therapeutics
Short-Term Memory
Cognition
Rodentia
18 Citations (Scopus)

Isotope-coded dimethyl tagging for differential quantification of posttranslational protein carbonylation by 4-hydroxy-2-nonenal, an end-product of lipid peroxidation

Rauniyar, N. & Prokai, L., 1 Oct 2011, In : Journal of Mass Spectrometry. 46, 10, p. 976-985 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Carbonylation
Isotopes
Lipids
Peptides
Proteins
7 Citations (Scopus)

Prodrug design for brain delivery of small- and medium-sized neuropeptides

Prokai-Tatrai, K. & Prokai, L., 24 Oct 2011, Neuropeptides: Methods and Protocols. Merighi, A. (ed.). p. 313-336 24 p. (Methods in Molecular Biology; vol. 789).

Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review

Prodrugs
Neuropeptides
Brain
Blood-Brain Barrier
Peptides
27 Citations (Scopus)

Protein targets for carbonylation by 4-hydroxy-2-nonenal in rat liver mitochondria

Guo, J., Prokai-Tatrai, K., Nguyen, V., Rauniyar, N., Ughy, B. & Prokai, L., 19 Oct 2011, In : Journal of Proteomics. 74, 11, p. 2370-2379 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Protein Carbonylation
Carbonylation
Mitochondria
Liver Mitochondrion
Liver
23 Citations (Scopus)
Liquid chromatography
Tandem Mass Spectrometry
Liquid Chromatography
Mass spectrometry
Peptides
128 Citations (Scopus)

Targeted delivery of small interfering RNA using reconstituted high-density lipoprotein nanoparticles

Shahzad, M. M. K., Mangala, L. S., Han, H. D., Lu, C., Bottsford-Miller, J., Nishimura, M., Mora, E. M., Lee, J. W., Stone, R. L., Pecot, C. V., Thanapprapasr, D., Roh, J. W., Gaur, P., Nair, M. P., Park, Y. Y., Sabnis, N., Deavers, M. T., Lee, J. S., Ellis, L. M., Lopez-Berestei, G. & 4 others, McConathy, W. J., Prokai, L., Lacko, A. G. & Sood, A. K., 1 Jan 2011, In : Neoplasia. 13, 4, p. 309-319 11 p.

Research output: Contribution to journalArticleResearchpeer-review

HDL Lipoproteins
Nanoparticles
Small Interfering RNA
Scavenger Receptors
Neoplasms
38 Citations (Scopus)

Tonic Premarin dose-dependently enhances memory, affects neurotrophin protein levels and alters gene expression in middle-aged rats

Engler-Chiurazzi, E., Tsang, C., Nonnenmacher, S., Liang, W. S., Corneveaux, J. J., Prokai, L., Huentelman, M. J. & Bimonte-Nelson, H. A., 1 Apr 2011, In : Neurobiology of Aging. 32, 4, p. 680-697 18 p.

Research output: Contribution to journalArticleResearchpeer-review

Conjugated (USP) Estrogens
Nerve Growth Factors
Gene Expression
Proteins
Estrone
25 Citations (Scopus)
Protein Carbonylation
Carbonylation
Tandem Mass Spectrometry
Labeling
Lipid Peroxidation
2010
2 Citations (Scopus)

[Glu2]TRH dose-dependently attenuates TRH-evoked analeptic effect in mice

Nguyen, V., Zharikova, A. D., Prokai-Tatrai, K. & Prokai, L., 1 Apr 2010, In : Brain Research Bulletin. 82, 1-2, p. 83-86 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Central Nervous System Stimulants
Central Nervous System
Thyrotropin-Releasing Hormone
Cholinergic Agents
Acetylcholine
13 Citations (Scopus)

A component of Premarin® enhances multiple cognitive functions and influences nicotinic receptor expression

Talboom, J. S., Engler-Chiurazzi, E. B., Whiteaker, P., Simard, A. R., Lukas, R., Acosta, J. I., Prokai, L. & Bimonte-Nelson, H. A., 1 Nov 2010, In : Hormones and Behavior. 58, 5, p. 917-928 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Conjugated (USP) Estrogens
Equilin
Nicotinic Receptors
Cognition
Estrogens
29 Citations (Scopus)
Carbonylation
Electrospray ionization
Liquid chromatography
Spectrometry
Peptides
52 Citations (Scopus)

Mechanisms of 4-hydroxy-2-nonenal induced pro- and anti-apoptotic signaling

Chaudhary, P., Sharma, R., Sharma, A., Vatsyayan, R., Yadav, S., Singhal, S. S., Rauniyar, N., Prokai, L., Awasthi, S. & Awasthi, Y. C., 27 Jul 2010, In : Biochemistry. 49, 29, p. 6263-6275 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Apoptosis
Hep G2 Cells
Chemical activation
Caspase 3
Toxicity
53 Citations (Scopus)

Medroxyprogesterone acetate impairs memory and alters the GABAergic system in aged surgically menopausal rats

Braden, B. B., Talboom, J. S., Crain, I. D., Simard, A. R., Lukas, R. J., Prokai, L., Scheldrup, M. R., Bowman, B. L. & Bimonte-Nelson, H. A., 1 Mar 2010, In : Neurobiology of Learning and Memory. 93, 3, p. 444-453 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Medroxyprogesterone Acetate
Progestins
Progesterone
Nerve Growth Factors
Brain
8 Citations (Scopus)

Remodeling of phosphatidylglycerol in Synechocystis PCC6803

Laczko-Dobos, H., Fryčák, P., Ughy, B., Domonkos, I., Wada, H., Prokai, L. & Gombos, Z., 1 Feb 2010, In : Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1801, 2, p. 163-170 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Synechocystis
Phosphatidylglycerols
Ions
Lipids
Phospholipases A1