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2019

Effect of ocular hypertension on the pattern of retinal ganglion cell subtype loss in a mouse model of early-onset glaucoma

Daniel, S., Meyer, K. J., Clark, A., Anderson, M. G. & McDowell, C. M., 1 Aug 2019, In : Experimental eye research. 185, 107703.

Research output: Contribution to journalArticle

Ocular Hypertension
Retinal Ganglion Cells
Glaucoma
Intraocular Pressure
Phenotype
1 Citation (Scopus)
Open Access
Ocular Hypertension
Trabecular Meshwork
Glucocorticoid Receptors
Glaucoma
Transcriptional Activation

Inducible rodent models of glaucoma

Pang, I. H. & Clark, A. F., 1 Jan 2019, (Accepted/In press) In : Progress in Retinal and Eye Research. 100799.

Research output: Contribution to journalArticle

Glaucoma
Rodentia
Pressure
Intraocular Pressure
Low Tension Glaucoma

RE: “Letter to the Editor concerning Webber et al. Exp Eye Res. 148:97–102, 2016”

Webber, H. C., Bermudez, J. Y., Sethi, A., Clark, A. & Mao, W., 1 Jan 2019, In : Experimental eye research. 178, 1 p.

Research output: Contribution to journalLetter

2018
7 Citations (Scopus)

Activation of the NFAT-calcium signaling pathway in human lamina cribrosa cells in glaucoma

Irnaten, M., Zhdanov, A., Brennan, D., Crotty, T., Clark, A., Papkovsky, D. & O’Brien, C., Feb 2018, In : Investigative Ophthalmology and Visual Science. 59, 2, p. 831-842 12 p.

Research output: Contribution to journalArticle

Calcium Signaling
Glaucoma
Extracellular Matrix
Calcineurin
Transforming Growth Factors
6 Citations (Scopus)

BMP and activin membrane bound inhibitor regulates the extracellular matrix in the trabecular meshwork

Hernandez, H., Cameron Millar, J., Curry, S. M., Clark, A. F. & McDowell, C. M., Apr 2018, In : Investigative Ophthalmology and Visual Science. 59, 5, p. 2154-2166 13 p.

Research output: Contribution to journalArticle

Trabecular Meshwork
Activins
Bone Morphogenetic Proteins
Extracellular Matrix
Ocular Hypertension
9 Citations (Scopus)

Consensus recommendations for trabecular meshwork cell isolation, characterization and culture

Keller, K. E., Bhattacharya, S. K., Borrás, T., Brunner, T. M., Chansangpetch, S., Clark, A., Dismuke, W. M., Du, Y., Elliott, M. H., Ethier, C. R., Faralli, J. A., Freddo, T. F., Fuchshofer, R., Giovingo, M., Gong, H., Gonzalez, P., Huang, A., Johnstone, M. A., Kaufman, P. L., Kelley, M. J. & 37 others, Knepper, P. A., Kopczynski, C. C., Kuchtey, J. G., Kuchtey, R. W., Kuehn, M. H., Lieberman, R. L., Lin, S. C., Liton, P., Liu, Y., Lütjen-Drecoll, E., Mao, W., Masis-Solano, M., McDonnell, F., McDowell, C. M., Overby, D. R., Pattabiraman, P. P., Raghunathan, V. K., Rao, P. V., Rhee, D. J., Chowdhury, U. R., Russell, P., Samples, J. R., Schwartz, D., Stubbs, E. B., Tamm, E. R., Tan, J. C., Toris, C. B., Torrejon, K. Y., Vranka, J. A., Wirtz, M. K., Yorio, T., Zhang, J., Zode, G., Fautsch, M. P., Peters, D. M., Acott, T. S. & Stamer, W. D., 1 Jun 2018, In : Experimental eye research. 171, p. 164-173 10 p.

Research output: Contribution to journalShort survey

Trabecular Meshwork
Cell Separation
Cell Culture Techniques
Ocular Hypertension
Intraocular Pressure

Establishment of a conditionally immortalized mouse optic nerve astrocyte line

Liu, Y., Patel, G. C., Mao, W. & Clark, A. F., Nov 2018, In : Experimental eye research. 176, p. 188-195 8 p.

Research output: Contribution to journalArticle

Optic Nerve
Astrocytes
Neural Cell Adhesion Molecules
Viral Tumor Antigens
Glial Fibrillary Acidic Protein
7 Citations (Scopus)

Glucocorticoid receptor GRβ regulates glucocorticoid-induced ocular hypertension in mice

Patel, G. C., Liu, Y., Millar, J. C. & Clark, A. F., 1 Dec 2018, In : Scientific Reports. 8, 1, 862.

Research output: Contribution to journalArticle

Ocular Hypertension
Glucocorticoid Receptors
Glucocorticoids
Trabecular Meshwork
Protein Isoforms

Histological investigation of human glaucomatous eyes: Extracellular fibrotic changes and galectin 3 expression in the trabecular meshwork and optic nerve head

Belmares, R., Raychaudhuri, U., Maansson, S. & Clark, A., 1 Oct 2018, In : Clinical Anatomy. 31, 7, p. 1031-1049 19 p.

Research output: Contribution to journalArticle

Galectin 3
Trabecular Meshwork
Optic Disk
Collagen
Extracellular Matrix Proteins
3 Citations (Scopus)
Ocular Hypertension
Intraocular Pressure
Glaucoma
Trabecular Meshwork
Extracellular Matrix Proteins
1 Citation (Scopus)

The role of wnt/β-catenin signaling and k-cadherin in the regulation of intraocular pressure

Webber, H. C., Bermudez, J. Y., Millar, J. C., Mao, W. & Clark, A. F., Mar 2018, In : Investigative Ophthalmology and Visual Science. 59, 3, p. 1454-1466 13 p.

Research output: Contribution to journalArticle

Catenins
Cadherins
Intraocular Pressure
Trabecular Meshwork
Western Blotting
2017
4 Citations (Scopus)

A comparison of gene expression profiles between glucocorticoid responder and non-responder bovine trabecular meshwork cells using RNA sequencing

Bermudez, J. Y., Webber, H. C., Brown, B., Braun, T. A., Clark, A. F. & Mao, W., Jan 2017, In : PLoS ONE. 12, 1, e0169671.

Research output: Contribution to journalArticle

RNA Sequence Analysis
Trabecular Meshwork
glucocorticoids
Transcriptome
Gene expression
1 Citation (Scopus)

Anterior chamber perfusion versus posterior chamber perfusion does not influence measurement of aqueous outflow facility in living mice by constant flow infusion

Lopez, N. N., Patel, G. C., Raychaudhuri, U., Aryal, S., Phan, T. N., Clark, A. & Millar, J. C., 1 Nov 2017, In : Experimental eye research. 164, p. 95-108 14 p.

Research output: Contribution to journalArticle

Anterior Chamber
Perfusion
Tropicamide
Mydriatics
Euthanasia
31 Citations (Scopus)

CRISPR-Cas9–based treatment of myocilin-associated glaucoma

Jain, A., Zode, G., Kasetti, R. B., Ran, F. A., Yan, W., Sharma, T. P., Bugge, K., Searby, C. C., Fingert, J. H., Zhang, F., Clark, A. F. & Sheffield, V. C., 17 Oct 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 42, p. 11199-11204 6 p.

Research output: Contribution to journalArticle

Clustered Regularly Interspaced Short Palindromic Repeats
Glaucoma
Intraocular Pressure
Trabecular Meshwork
Endoplasmic Reticulum Stress
8 Citations (Scopus)

Cross-linked actin networks (CLANs) in glaucoma

Bermudez, J. Y., Montecchi-Palmer, M., Mao, W. & Clark, A., 1 Jun 2017, In : Experimental eye research. 159, p. 16-22 7 p.

Research output: Contribution to journalReview article

Trabecular Meshwork
Glaucoma
Actins
Intraocular Pressure
Aqueous Humor
9 Citations (Scopus)

Crosstalk between transforming growth factor beta-2 and toll-like receptor 4 in the trabecular meshwork

Hernandez, H., Medina-Ortiz, W. E., Luan, T., Clark, A. F. & McDowell, C. M., Mar 2017, In : Investigative Ophthalmology and Visual Science. 58, 3, p. 1811-1823 13 p.

Research output: Contribution to journalArticle

Trabecular Meshwork
Toll-Like Receptor 4
Transforming Growth Factor beta
Fibronectins
Ocular Hypertension
14 Citations (Scopus)

Dexamethasone-Induced Ocular Hypertension in Mice: Effects of Myocilin and Route of Administration

Patel, G. C., Phan, T. N., Maddineni, P., Kasetti, R. B., Millar, J. C., Clark, A. & Zode, G., 1 Apr 2017, In : American Journal of Pathology. 187, 4, p. 713-723 11 p.

Research output: Contribution to journalArticle

Ocular Hypertension
Dexamethasone
Glucocorticoids
Trabecular Meshwork
Intraocular Pressure
7 Citations (Scopus)
Trabecular Meshwork
Endoplasmic Reticulum Stress
Extracellular Matrix Proteins
Extracellular Matrix
Fibronectins
2 Citations (Scopus)

Rapid repeatable in vivo detection of retinal reactive oxygen species

Fan, N., Silverman, S. M., Liu, Y., Wang, X., Kim, B. J., Tang, L., Clark, A. F., Liu, X. & Pang, I. H., Aug 2017, In : Experimental eye research. 161, p. 71-81 11 p.

Research output: Contribution to journalShort survey

L 012
Reactive Oxygen Species
Retina
Optic Nerve
Wounds and Injuries
5 Citations (Scopus)

Role of ID proteins in BMP4 inhibition of profibrotic effects of TGF-β2 in human TM cells

Mody, A. A., Wordinger, R. J. & Clark, A. F., 1 Feb 2017, In : Investigative Ophthalmology and Visual Science. 58, 2, p. 849-859 11 p.

Research output: Contribution to journalArticle

Trabecular Meshwork
Proteins
Plasminogen Activator Inhibitor 1
Fibronectins
Bone and Bones
9 Citations (Scopus)

TGFβ2 induces the formation of cross-linked actin networks (CLANs) in human trabecular meshwork cells through the smad and non-smad dependent pathways

Montecchi-Palmer, M., Bermudez, J. Y., Webber, H. C., Patel, G. C., Clark, A. F. & Mao, W., Feb 2017, In : Investigative Ophthalmology and Visual Science. 58, 2, p. 1288-1295 8 p.

Research output: Contribution to journalArticle

Trabecular Meshwork
Transforming Growth Factors
Actins
Extracellular Signal-Regulated MAP Kinases
JNK Mitogen-Activated Protein Kinases
17 Citations (Scopus)

The many faces of the trabecular meshwork cell

Stamer, W. D. & Clark, A. F., 1 May 2017, In : Experimental eye research. 158, p. 112-123 12 p.

Research output: Contribution to journalReview article

Trabecular Meshwork
Intraocular Pressure
Mechanical Stress
Physiological Stress
Aptitude
2 Citations (Scopus)

Tissue transglutaminase elevates intraocular pressure in mice

Raychaudhuri, U., Millar, J. C. & Clark, A., 1 Dec 2017, In : Investigative Ophthalmology and Visual Science. 58, 14, p. 6197-6211 15 p.

Research output: Contribution to journalArticle

Trabecular Meshwork
Intraocular Pressure
Inbred C57BL Mouse
Lysine
Immunohistochemistry
2016
15 Citations (Scopus)

C1q propagates microglial activation and neurodegeneration in the visual axis following retinal ischemia/reperfusion injury

Silverman, S. M., Kim, B. J., Howell, G. R., Miller, J., John, S. W. M., Wordinger, R. J. & Clark, A., 24 Mar 2016, In : Molecular Neurodegeneration. 11, 1, 24.

Research output: Contribution to journalArticle

Reperfusion Injury
Superior Colliculi
Neuroglia
Astrocytes
Reperfusion
8 Citations (Scopus)

Crosstalk between TGFβ and Wnt signaling pathways in the human trabecular meshwork

Webber, H. C., Bermudez, J. Y., Sethi, A., Clark, A. & Mao, W., 1 Jul 2016, In : Experimental eye research. 148, p. 97-102 6 p.

Research output: Contribution to journalArticle

Trabecular Meshwork
Wnt Signaling Pathway
Luciferases
Catenins
Wnt3A Protein
3 Citations (Scopus)

HDAC inhibitor-mediated epigenetic regulation of glaucoma-associated TGFβ2 in the trabecular meshwork

Bermudez, J. Y., Webber, H. C., Patel, G. C., Liu, X., Cheng, Y. Q., Clark, A. F. & Mao, W., Jul 2016, In : Investigative Ophthalmology and Visual Science. 57, 8, p. 3698-3707 10 p.

Research output: Contribution to journalArticle

Trabecular Meshwork
Histone Deacetylase Inhibitors
Epigenomics
Glaucoma
Acetylation
8 Citations (Scopus)

Human trabecular meshwork cells express BMP antagonist mRNAs and proteins

Tovar-Vidales, T., Fitzgerald, A. M. & Clark, A., 1 Jun 2016, In : Experimental Eye Research. 147, p. 156-160 5 p.

Research output: Contribution to journalArticle

Trabecular Meshwork
Bone Morphogenetic Proteins
Transforming Growth Factor beta2
Messenger RNA
Proteins
18 Citations (Scopus)

Hypoxia-induced changes in DNA methylation alter RASAL1 and TGFβ1 expression in human trabecular meshwork cells

McDonnell, F., Irnaten, M., Clark, A., O'Brien, C. J. & Wallace, D. M., 1 Apr 2016, In : PLoS ONE. 11, 4, e0153354.

Research output: Contribution to journalArticle

Trabecular Meshwork
ras Proteins
DNA methylation
DNA Methylation
hypoxia
7 Citations (Scopus)

Identification and localization of lamina cribrosa cells in the human optic nerve head

Tovar-Vidales, T., Wordinger, R. J. & Clark, A., 1 Jun 2016, In : Experimental Eye Research. 147, p. 94-97 4 p.

Research output: Contribution to journalArticle

Optic Disk
Glial Fibrillary Acidic Protein
Astrocytes
Glaucoma
Retinal Ganglion Cells
4 Citations (Scopus)

Increased global DNA methylation and decreased TGFβ1 promoter methylation in glaucomatous lamina cribrosa cells

McDonnell, F. S., Mcnally, S. A., Clark, A., O'brien, C. J. & Wallace, D. M., 1 Oct 2016, In : Journal of Glaucoma. 25, 10, p. e834-e842

Research output: Contribution to journalArticle

Transforming Growth Factors
DNA Methylation
Methylation
Glaucoma
Fibrosis
15 Citations (Scopus)

In vitro and in vivo neuroprotective effects of cJun N-terminal kinase inhibitors on retinal ganglion cells

Kim, B. J., Silverman, S. M., Liu, Y., Wordinger, R. J., Pang, I. H. & Clark, A. F., 21 Apr 2016, In : Molecular Neurodegeneration. 11, 1, 93.

Research output: Contribution to journalArticle

Retinal Ganglion Cells
Neuroprotective Agents
Phosphotransferases
Reperfusion
Retina

Novel therapeutic targets for reduction of intraocular pressure in primary open angle glaucoma

Mao, W., Liu, Y., Wordinger, R. J., Clark, A. & Pang, I-H., 11 Jun 2016, In : Chinese Journal of Ophthalmology. 52, 6, p. 471-475 5 p.

Research output: Contribution to journalReview article

Intraocular Pressure
Glaucoma
Optic Nerve Diseases
Aqueous Humor
Open Angle Glaucoma
23 Citations (Scopus)

The novel triterpenoid RTA 408 protects human retinal pigment epithelial cells against H2O2-induced cell injury via NF-E2-related factor 2 (Nrf2) activation

Liu, X., Ward, K., Xavier, C., Jann, J., Clark, A., Pang, I-H. & Wu, H., 1 Aug 2016, In : Redox Biology. 8, p. 98-109 12 p.

Research output: Contribution to journalArticle

NF-E2-Related Factor 2
Retinal Pigments
Epithelial Cells
Chemical activation
Oxidative stress
2015
25 Citations (Scopus)

Animal models of glucocorticoid-induced glaucoma

Overby, D. R. & Clark, A. F., 13 Apr 2015, In : Experimental eye research. 141, p. 15-22 8 p.

Research output: Contribution to journalArticle

Glaucoma
Glucocorticoids
Animal Models
Ocular Hypertension
Open Angle Glaucoma
8 Citations (Scopus)

Calcium channel blockade reduces mechanical strain-induced extracellular matrix gene response in lamina cribrosa cells

Quill, B., Irnaten, M., Docherty, N. G., McElnea, E. M., Wallace, D. M., Clark, A. F. & O'Brien, C. J., 1 Jul 2015, In : British Journal of Ophthalmology. 99, 7, p. 1009-1014 6 p.

Research output: Contribution to journalArticle

Calcium Channels
Extracellular Matrix
Calcium Channel Blockers
Verapamil
Chondroitin Sulfate Proteoglycans
17 Citations (Scopus)

Caspase-7: A critical mediator of optic nerve injury-induced retinal ganglion cell death

Choudhury, S., Liu, Y., Clark, A. F. & Pang, I. H., 26 Aug 2015, In : Molecular Neurodegeneration. 10, 1, 40.

Research output: Contribution to journalArticle

Optic Nerve Injuries
Caspase 7
Retinal Ganglion Cells
Cell Death
Optic Nerve
14 Citations (Scopus)

Corrigendum: Reduction of ER stress via a chemical chaperone prevents disease phenotypes in a mouse model of primary open angle glaucoma (J Clin Investigation (2011) 121, 9 (3542-3553) DOI: 10.1172/JCI82799)

Zode, G. S., Kuehn, M. H., Nishimura, D. Y., Searby, C. C., Mohan, K., Grozdanic, S. D., Bugge, K., Anderson, M. G., Clark, A. F., Stone, E. M. & Sheffield, V. C., 3 Aug 2015, In : Journal of Clinical Investigation. 125, 8, 1 p.

Research output: Contribution to journalComment/debate

Phenotype
corrigendum
Primary Open Angle Glaucoma
9 Citations (Scopus)
Trabecular Meshwork
Ocular Hypertension
Intraocular Pressure
Rodentia
Transgenes
9 Citations (Scopus)

Gremlin induces ocular hypertension in mice through Smad3-dependent signaling

McDowell, C. M., Hernandez, H., Mao, W. & Clark, A. F., 1 Jan 2015, In : Investigative Ophthalmology and Visual Science. 56, 9, p. 5485-5492 8 p.

Research output: Contribution to journalArticle

Trabecular Meshwork
Ocular Hypertension
Fibronectins
Bone Morphogenetic Proteins
Extracellular Matrix Proteins
19 Citations (Scopus)

Increased endoplasmic reticulum stress in human glaucomatous trabecular meshwork cells and tissues

Peters, J. C., Bhattacharya, S., Clark, A. & Zode, G., 1 Jan 2015, In : Investigative Ophthalmology and Visual Science. 56, 6, p. 3860-3868 9 p.

Research output: Contribution to journalArticle

Trabecular Meshwork
Endoplasmic Reticulum Stress
Transcription Factor CHOP
Activating Transcription Factor 4
Glaucoma
1 Citation (Scopus)

Introduction to EER Special Issue on ocular fibrosis

O'Brien, C. & Clark, A., 1 Aug 2015, In : Experimental eye research. 142, 1 p.

Research output: Contribution to journalEditorial

Eye Diseases
Fibrosis
2 Citations (Scopus)

Introduction to special issue on glaucomatous optic neuropathy: In vivo models and techniques

Ethier, C. R., Morrison, J. C. & Clark, A., 20 Jul 2015, In : Experimental eye research. 141, p. 1-2 2 p.

Research output: Contribution to journalEditorial

Animal Disease Models
Optic Nerve Diseases
Optic Nerve
Intraocular Pressure
Glaucoma
15 Citations (Scopus)

Neuritin 1 promotes retinal ganglion cell survival and axonal regeneration following optic nerve crush

Sharma, T. P., Liu, Y., Wordinger, R. J., Pang, I. H. & Clark, A. F., 1 Jan 2015, In : Cell Death and Disease. 6, 2, e1661.

Research output: Contribution to journalArticle

Nerve Crush
Retinal Ganglion Cells
Optic Nerve
Regeneration
Cell Survival
16 Citations (Scopus)

Role of C/EBP homologous protein in retinal ganglion cell death after ischemia/reperfusion injury

Nashine, S., Liu, Y., Kim, B. J., Clark, A. & Pang, I-H., 20 Nov 2015, In : Investigative Ophthalmology and Visual Science. 56, 1, p. 221-231 11 p.

Research output: Contribution to journalArticle

Transcription Factor CHOP
Retinal Ganglion Cells
Reperfusion Injury
Cell Death
Reperfusion
26 Citations (Scopus)

Strain and age effects on aqueous humor dynamics in the mouse

Millar, J. C., Phan, T. N., Pang, I-H. & Clark, A., 1 Jan 2015, In : Investigative Ophthalmology and Visual Science. 56, 10, p. 5764-5776 13 p.

Research output: Contribution to journalArticle

Aqueous Humor
Intraocular Pressure
Venous Pressure
Pressure
Fluorescein-5-isothiocyanate
2014
1 Citation (Scopus)

A useful mouse model of glucocorticoid-induced ocular hypertension

Clark, A. F., 8 Aug 2014, In : Investigative Ophthalmology and Visual Science. 55, 8, 1 p.

Research output: Contribution to journalComment/debate

Ocular Hypertension
Intraocular Pressure
Cornea
Dexamethasone
Glucocorticoids
2 Citations (Scopus)

Erratum: Characterization of a transformed rat retinal ganglion cell line (Brain Research Molecular Brain Research (2001) 86 (1-12))

Krishnamoorthy, R., Agarwal, P., Prasanna, G., Vopat, K., Lambert, W., Sheedlo, H. J., Pang, I-H., Shade, D., Wordinger, R. J., Yorio, T., Clark, A. & Agarwal, N., 28 Jan 2014, In : Brain Research. 1544, 1 p.

Research output: Contribution to journalComment/debate

Retinal Ganglion Cells
Cell Line
Brain
Research
9 Citations (Scopus)

Lipofuscin accumulation and autophagy in glaucomatous human lamina cribrosa cells

McElnea, E. M., Hughes, E., McGoldrick, A., McCann, A., Quill, B., Docherty, N., Irnaten, M., Farrell, M., Clark, A., O'Brien, C. J. & Wallace, D. M., 2 Dec 2014, In : BMC Ophthalmology. 14, 1, 153.

Research output: Contribution to journalArticle

Lipofuscin
Autophagy
Glaucoma
Optic Disk
Cathepsin K
9 Citations (Scopus)

Lysyl oxidases in the trabecular meshwork

Wordinger, R. J. & Clark, A. F., 10 Dec 2014, In : Journal of Glaucoma. 23, 8, p. S55-S58

Research output: Contribution to journalArticle

Protein-Lysine 6-Oxidase
Trabecular Meshwork
Extracellular Matrix
Aqueous Humor
Transforming Growth Factor beta