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2019

Chronic inhibition of mitochondrial dihydrolipoamide dehydrogenase (DLDH) as an approach to managing diabetic oxidative stress

Yang, X., Song, J. & Yan, L-J., 1 Jan 2019, In : Antioxidants. 8, 2, 32.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Dihydrolipoamide Dehydrogenase
Oxidative stress
Oxidative Stress
Medical problems
Type 2 Diabetes Mellitus

The negative and detrimental effects of high fructose on the liver, with special reference to metabolic disorders

Mai, B. H. & Yan, L-J., 1 Jan 2019, In : Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 12, p. 821-826 6 p.

Research output: Contribution to journalReview articleResearchpeer-review

Open Access
Fructose
Liver
Insulin Resistance
Obesity
Eating
2018
3 Citations (Scopus)

Ceruloplasmin, a Potential Therapeutic Agent for Alzheimer's Disease

Zhao, Y. S., Zhang, L. H., Yu, P. P., Gou, Y. J., Zhao, J., You, L. H., Wang, Z. Y., Zheng, X., Yan, L-J., Yu, P. & Chang, Y. Z., 10 May 2018, In : Antioxidants and Redox Signaling. 28, 14, p. 1323-1337 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Ceruloplasmin
Alzheimer Disease
Therapeutics
Iron
Hippocampus
1 Citation (Scopus)

Humanin attenuates NMDA-induced excitotoxicity by inhibiting ROS-dependent JNK/p38 MAPK pathway

Yang, X., Zhang, H., Wu, J., Yin, L., Yan, L-J. & Zhang, C., 1 Oct 2018, In : International journal of molecular sciences. 19, 10, 2982.

Research output: Contribution to journalArticleResearchpeer-review

aspartates
JNK Mitogen-Activated Protein Kinases
p38 Mitogen-Activated Protein Kinases
N-Methylaspartate
Reactive Oxygen Species
6 Citations (Scopus)
Oxidative stress
Reperfusion
Oxidative Stress
Stroke
Wounds and Injuries
1 Citation (Scopus)

Reexploring 5-methoxyindole-2-carboxylic acid (MICA) as a potential antidiabetic agent

Yan, L-J., 1 Jan 2018, In : Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 11, p. 183-186 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Hypoglycemic Agents
Dihydrolipoamide Dehydrogenase
Glucose
Gluconeogenesis
Cricetulus
3 Citations (Scopus)

Role and possible mechanisms of sirt1 in depression

Lu, G., Li, J., Zhang, H., Zhao, X., Yan, L-J. & Yang, X., 1 Jan 2018, In : Oxidative Medicine and Cellular Longevity. 2018, 8596903.

Research output: Contribution to journalReview articleResearchpeer-review

Sirtuin 1
Plague
Neurogenesis
Gene Silencing
Neuroglia
2017
4 Citations (Scopus)

Administration of 5-methoxyindole-2-carboxylic acid that potentially targets mitochondrial dihydrolipoamide dehydrogenase confers cerebral preconditioning against ischemic stroke injury

Wu, J., Li, R., Li, W., Ren, M., Thangthaeng, N., Sumien, N., Liu, R., Yang, S., Simpkins, J. W., Forster, M. J. & Yan, L-J., 1 Dec 2017, In : Free Radical Biology and Medicine. 113, p. 244-254 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Dihydrolipoamide Dehydrogenase
Ischemic Preconditioning
Stroke
Wounds and Injuries
5-methoxyindole-2-carboxylic acid
4 Citations (Scopus)

Non-gradient blue native polyacrylamide gel electrophoresis

Luo, X., Wu, J., Jin, Z. & Yan, L-J., 1 Feb 2017, In : Current Protocols in Protein Science. 2017, p. 19.29.1-19.29.12

Research output: Contribution to journalArticleResearchpeer-review

Native Polyacrylamide Gel Electrophoresis
Electrophoresis
Proteins
Esterases
Dihydrolipoamide Dehydrogenase
6 Citations (Scopus)

Pancreatic mitochondrial complex I exhibits aberrant hyperactivity in diabetes

Wu, J., Luo, X., Thangthaeng, N., Sumien, N., Chen, Z., Rutledge, M. A., Jing, S., Forster, M. J. & Yan, L-J., 1 Sep 2017, In : Biochemistry and Biophysics Reports. 11, p. 119-129 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Medical problems
NAD
Oxidative stress
Pancreas
Reactive Oxygen Species
11 Citations (Scopus)

Potential biochemical mechanisms of lung injury in diabetes

Zheng, H., Wu, J., Jin, Z. & Yan, L-J., 1 Jan 2017, In : Aging and Disease. 8, 1, p. 7-16 10 p.

Research output: Contribution to journalReview articleResearchpeer-review

Lung Injury
Lung
Proto-Oncogene Proteins c-akt
Glycosylation
Type 2 Diabetes Mellitus
11 Citations (Scopus)

Redox imbalance and mitochondrial abnormalities in the diabetic lung

Wu, J., Jin, Z. & Yan, L-J., 1 Apr 2017, In : Redox Biology. 11, p. 51-59 9 p.

Research output: Contribution to journalArticleResearchpeer-review

NAD
Oxidation-Reduction
Medical problems
Oxidative stress
Lung
8 Citations (Scopus)

The Neuroprotective Effects of SIRT1 on NMDA-Induced Excitotoxicity

Yang, X., Si, P., Qin, H., Yin, L., Yan, L-J. & Zhang, C., 1 Jan 2017, In : Oxidative Medicine and Cellular Longevity. 2017, 2823454.

Research output: Contribution to journalArticleResearchpeer-review

Neuroprotective Agents
N-Methylaspartate
Acetylation
L-Lactate Dehydrogenase
Neurons
2016
13 Citations (Scopus)

Chemical conditioning as an approach to ischemic stroke tolerance: Mitochondria as the target

Jin, Z., Wu, J. & Yan, L-J., 8 Mar 2016, In : International Journal of Molecular Sciences. 17, 3, 351.

Research output: Contribution to journalReview articleResearchpeer-review

Mitochondria
mitochondria
conditioning
strokes
Stroke

Chronic mTOR Inhibition by Rapamycin and Diabetes: What is the Role of Mitochondria?

Yan, L-J. & Cai, Z., 26 Feb 2016, Molecules to Medicine with mTOR: Translating Critical Pathways into Novel Therapeutic Strategies. Elsevier Inc., p. 365-378 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review

Sirolimus
Mitochondria
NAD
Oxidation-Reduction
Poly Adenosine Diphosphate Ribose
4 Citations (Scopus)
Chrysanthemum
Column chromatography
Polysaccharides
Chromatography
Antioxidants
11 Citations (Scopus)

Glutaredoxins concomitant with optimal ROS activate AMPK through S-glutathionylation to improve glucose metabolism in type 2 diabetes

Dong, K., Wu, M., Liu, X., Huang, Y., Zhang, D., Wang, Y., Yan, L-J. & Shi, D., 1 Dec 2016, In : Free Radical Biology and Medicine. 101, p. 334-347 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Glutaredoxins
AMP-Activated Protein Kinases
Medical problems
Metabolism
Type 2 Diabetes Mellitus
32 Citations (Scopus)

Hyperglycemic stress and carbon stress in diabetic glucotoxicity

Luo, X., Wu, J., Jing, S. & Yan, L-J., 1 Feb 2016, In : Aging and Disease. 7, 1, p. 90-110 21 p.

Research output: Contribution to journalArticleResearchpeer-review

NAD
Carbon
Diabetes Complications
Proteome
Hyperglycemia
52 Citations (Scopus)

Role of RAGE in Alzheimer’s Disease

Cai, Z., Liu, N., Wang, C., Qin, B., Zhou, Y., Xiao, M., Chang, L., Yan, L-J. & Zhao, B., 1 May 2016, In : Cellular and Molecular Neurobiology. 36, 4, p. 483-495 13 p.

Research output: Contribution to journalReview articleResearchpeer-review

Alzheimer Disease
Cognition
Brain
Oxidative Stress
Advanced Glycosylation End Product-Specific Receptor
13 Citations (Scopus)

Sources and implications of NADH/NAD+ redox imbalance in diabetes and its complications

Wu, J., Jin, Z., Zheng, H. & Yan, L-J., 10 May 2016, In : Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 9, p. 145-153 9 p.

Research output: Contribution to journalReview articleResearchpeer-review

Diabetes Complications
NAD
Oxidation-Reduction
Sirtuins
Citric Acid Cycle
5 Citations (Scopus)

Two-dimensional gel electrophoretic detection of protein carbonyls derivatized with biotin-hydrazide

Wu, J., Luo, X., Jing, S. & Yan, L-J., 15 Apr 2016, In : Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 1019, p. 128-131 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Gels
Proteins
Neurodegenerative diseases
Raphanus
Carbonylation
2015
49 Citations (Scopus)

Activation of mTOR: A culprit of Alzheimer’s disease?

Cai, Z., Chen, G., He, W., Xiao, M. & Yan, L-J., 9 Apr 2015, In : Neuropsychiatric Disease and Treatment. 11, p. 1015-1030 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Sirolimus
Alzheimer Disease
Autophagy
Glycogen Synthase Kinase 3
Amyloid Precursor Protein Secretases
12 Citations (Scopus)

Antioxidant activity, antitumor effect, and antiaging property of proanthocyanidins extracted from Kunlun chrysanthemum flowers

Jing, S., Zhang, X. & Yan, L-J., 1 Jan 2015, In : Oxidative Medicine and Cellular Longevity. 2015, 983484.

Research output: Contribution to journalArticleResearchpeer-review

Chrysanthemum
Proanthocyanidins
Antioxidants
Malondialdehyde
HeLa Cells
21 Citations (Scopus)

Cerebral small vessel disease and Alzheimer’s disease

Cai, Z., Wang, C., He, W., Tu, H., Tang, Z., Xiao, M. & Yan, L-J., 1 Jan 2015, In : Clinical Interventions in Aging. 10, p. 1695-1704 10 p., A196.

Research output: Contribution to journalReview articleResearchpeer-review

Cerebral Small Vessel Diseases
Alzheimer Disease
Lacunar Stroke
Cerebrovascular Disorders
Vascular Dementia
6 Citations (Scopus)

Mitochondrial dihydrolipoamide dehydrogenase is upregulated in response to intermittent hypoxic preconditioning

Li, R., Luo, X., Wu, J., Thangthaeng, N., Jung, E., Jing, S., Li, L., Ellis, D. Z., Liu, L., Ding, Z., Forster, M. J. & Yan, L-J., 23 May 2015, In : International Journal of Medical Sciences. 12, 5, p. 432-440 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Dihydrolipoamide Dehydrogenase
Stroke
Keto Acids
Up-Regulation
Brain Injuries
14 Citations (Scopus)

Role of insulin resistance in Alzheimer’s disease

Cai, Z., Xiao, M., Chang, L. & Yan, L-J., 1 Aug 2015, In : Metabolic Brain Disease. 30, 4, p. 839-851 13 p., A001.

Research output: Contribution to journalReview articleResearchpeer-review

Insulin Resistance
Alzheimer Disease
Insulin
Amyloid Precursor Protein Secretases
Oxidative stress
24 Citations (Scopus)

Roles of Pyruvate, NADH, and Mitochondrial Complex i in Redox Balance and Imbalance in β Cell Function and Dysfunction

Luo, X., Li, R. & Yan, L-J., 1 Jan 2015, In : Journal of Diabetes Research. 2015, 512618.

Research output: Contribution to journalReview articleResearchpeer-review

Pyruvic Acid
NAD
Oxidation-Reduction
Metabolic Networks and Pathways
Insulin
63 Citations (Scopus)
Streptozocin
Type 1 Diabetes Mellitus
Rodentia
Experimental Diabetes Mellitus
Hyperglycemia
12 Citations (Scopus)

Two dimensional blue native/SDS-PAGE to identify mitochondrial complex I subunits modified by 4-hydroxynonenal (HNE)

Wu, J., Luo, X. & Yan, L-J., 1 Jan 2015, In : Frontiers in Physiology. 6, MAR, 098.

Research output: Contribution to journalArticleResearchpeer-review

Sodium Dodecyl Sulfate
Polyacrylamide Gel Electrophoresis
Proteins
Electron Transport Complex I
Native Polyacrylamide Gel Electrophoresis
2014
42 Citations (Scopus)

Cancer-Associated isocitrate dehydrogenase 1 (IDH1) R132H mutation and D-2-hydroxyglutarate stimulate glutamine metabolism under hypoxia

Reitman, Z. J., Duncan, C. G., Poteet, E., Winters, A., Yan, L-J., Gooden, D. M., Spasojevic, I., Boros, L. G., Yang, S. & Yan, H., 1 Jan 2014, In : Journal of Biological Chemistry. 289, 34, p. 23318-23328 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Isocitrate Dehydrogenase
Glutamine
Metabolism
Mutation
Neoplasms

Diagonal gel electrophoretic analysis of protein disulfides: Principles and applications

Luo, X., Li, R. & Yan, L-J., 1 Oct 2014, Reactive Oxygen Species, Lipid Peroxidation and Protein Oxidation. Nova Science Publishers, Inc., p. 87-94 8 p.

Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review

Protein
Oxidative Stress
Proteomics
Analytical Methods
Peptides
105 Citations (Scopus)

Microglia, neuroinflammation, and beta-amyloid protein in Alzheimer's disease

Cai, Z., Hussain, M. D. & Yan, L-J., 1 Jan 2014, In : International Journal of Neuroscience. 124, 5, p. 307-321 15 p.

Research output: Contribution to journalReview articleResearchpeer-review

Amyloid beta-Peptides
Microglia
Alzheimer Disease
Amyloid Plaques
Chemokines
95 Citations (Scopus)

Pathogenesis of chronic hyperglycemia: From reductive stress to oxidative stress

Yan, L-J., 1 Jan 2014, In : Journal of Diabetes Research. 2014, 137919.

Research output: Contribution to journalReview articleResearchpeer-review

Hyperglycemia
Reactive Oxygen Species
Oxidative Stress
NAD
Overnutrition
74 Citations (Scopus)

Positive oxidative stress in aging and aging-related disease tolerance

Yan, L-J., 1 Jan 2014, In : Redox Biology. 2, 1, p. 165-169 5 p.

Research output: Contribution to journalReview articleResearchpeer-review

Oxidative stress
Oxidative Stress
Aging of materials
Reactive Nitrogen Species
Reactive Oxygen Species
19 Citations (Scopus)

Protein redox modification as a cellular defense mechanism against tissue ischemic injury

Yan, L-J., 1 Jan 2014, In : Oxidative Medicine and Cellular Longevity. 2014, 343154.

Research output: Contribution to journalReview articleResearchpeer-review

Oxidation-Reduction
Tissue
Wounds and Injuries
Proteins
Cysteine
13 Citations (Scopus)

PTEN degradation after ischemic stroke: A double-edged sword

Li, W., Huang, R-Q., Chen, Z., Yan, L-J., Simpkins, J. W. & Yang, S., 22 Aug 2014, In : Neuroscience. 274, p. 153-161 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Phosphoric Monoester Hydrolases
Stroke
GABA-A Receptors
Brain Ischemia
Astrocytes
2013
24 Citations (Scopus)

Reversible inactivation of dihydrolipoamide dehydrogenase by mitochondrial hydrogen peroxide.

Yan, L-J., Sumien, N., Thangthaeng, N. & Forster, M. J., 1 Jan 2013, In : Unknown Journal. 47, 2, p. 123-133 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Dihydrolipoamide Dehydrogenase
Hydrogen Peroxide
Reactive Oxygen Species
Sulfenic Acids
Mitochondria
43 Citations (Scopus)

Telomere Shortening and Alzheimer's Disease

Cai, Z., Yan, L-J. & Ratka, A., 1 Mar 2013, In : NeuroMolecular Medicine. 15, 1, p. 25-48 24 p.

Research output: Contribution to journalReview articleResearchpeer-review

Telomere Shortening
Alzheimer Disease
Telomere
Amyloid
Neurodegenerative Diseases
2012
80 Citations (Scopus)

Neuroprotective Actions of Methylene Blue and Its Derivatives

Poteet, E., Winters, A., Yan, L-J., Shufelt, K., Green, K. N., Simpkins, J. W., Wen, Y. & Yang, S., 31 Oct 2012, In : PLoS ONE. 7, 10, e48279.

Research output: Contribution to journalArticleResearchpeer-review

neuroprotective effect
methylene blue
Methylene Blue
chemical derivatives
Derivatives
78 Citations (Scopus)

Roles of AMP-activated protein kinase in Alzheimer's disease

Cai, Z., Yan, L-J., Li, K., Quazi, S. H. & Zhao, B., 1 Mar 2012, In : NeuroMolecular Medicine. 14, 1, p. 1-14 14 p.

Research output: Contribution to journalReview articleResearchpeer-review

AMP-Activated Protein Kinases
Alzheimer Disease
Phosphorylation
Phosphotransferases
Serum Amyloid A Protein
2011
131 Citations (Scopus)

Alternative mitochondrial electron transfer as a novel strategy for neuroprotection

Wen, Y., Li, W., Poteet, E. C., Xie, L., Tan, C., Yan, L-J., Ju, X., Liu, R., Qian, H., Marvin, M. A., Goldberg, M. S., She, H., Mao, Z., Simpkins, J. W. & Yang, S., 6 May 2011, In : Journal of Biological Chemistry. 286, 18, p. 16504-16515 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Methylene Blue
Electrons
Rotenone
Neuroprotection
Animal Disease Models
60 Citations (Scopus)

Chemical probes for analysis of carbonylated proteins: A review

Yan, L-J. & Forster, M. J., 15 May 2011, In : Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 879, 17-18, p. 1308-1315 8 p.

Research output: Contribution to journalReview articleResearchpeer-review

Staphylococcal Protein A
Gels
Fluorescence
Proteins
Proteomics
11 Citations (Scopus)

Ethanol withdrawal acts as an age-specific stressor to activate cerebellar P38 kinase

Jung, E., Ju, X., Simpkins, J. W., Metzger, D. B., Yan, L-J. & Wen, Y., 1 Dec 2011, In : Neurobiology of Aging. 32, 12, p. 2266-2278 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Ethanol
Phosphotransferases
Reactive Oxygen Species
Purkinje Cells
Mitochondrial Proteins
9 Citations (Scopus)

Nongradient blue native gel analysis of serum proteins and in-gel detection of serum esterase activities

Thangthaeng, N., Sumien, N., Forster, M. J., Shah, R. A. & Yan, L-J., 15 Feb 2011, In : Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 879, 5-6, p. 386-394 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Esterases
Blood Proteins
Gels
Serum
Staining and Labeling