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2019
C-Type Natriuretic Peptide
Aqueous Humor
Intraocular Pressure
Ocular Hypertension
Cornea

Inducible rodent models of glaucoma

Pang, I. H. & Clark, A. F., 1 Jan 2019, (Accepted/In press) In : Progress in Retinal and Eye Research. 100799.

Research output: Contribution to journalArticle

Glaucoma
Rodentia
Pressure
Intraocular Pressure
Low Tension Glaucoma
2018
1 Citation (Scopus)

Assessment of aqueous humor dynamics in the rodent by constant flow infusion

Millar, J. C., Phan, T. N. & Pang, I. H., 1 Jan 2018, Methods in Molecular Biology. Humana Press Inc., p. 109-120 12 p. (Methods in Molecular Biology; vol. 1695).

Research output: Chapter in Book/Report/Conference proceedingChapter

Aqueous Humor
Rodentia
Venous Pressure
Intraocular Pressure
Glaucoma
2 Citations (Scopus)

Cataract Preventive Role of Isolated Phytoconstituents: Findings from a Decade of Research

Lim, V., Schneider, E., Wu, H. & Pang, I. H., 26 Oct 2018, In : Nutrients. 10, 11

Research output: Contribution to journalReview article

chemical constituents of plants
cataract
Cataract
Research
eye lens
2 Citations (Scopus)

Effects of lentivirus-mediated C3 expression on trabecular meshwork cells and intraocular pressure

Tan, J., Fan, N., Wang, N., Feng, B., Yang, M., Liu, G., Wang, Y., Zhu, X., Kaufman, P. L., Pang, I. H. & Liu, X., Oct 2018, In : Investigative Ophthalmology and Visual Science. 59, 12, p. 4937-4944 8 p.

Research output: Contribution to journalArticle

Trabecular Meshwork
Lentivirus
Green Fluorescent Proteins
Intraocular Pressure
Injections
6 Citations (Scopus)

Ligandomics: a paradigm shift in biological drug discovery

Li, W., Pang, I-H., Pacheco, M. T. F. & Tian, H., 1 Mar 2018, In : Drug Discovery Today. 23, 3, p. 636-643 8 p.

Research output: Contribution to journalReview article

Drug Discovery
Biological Products
Ligands
Molecular Probes
Therapeutic Uses
2017
16 Citations (Scopus)

Involvement of Nrf2 in ocular diseases

Batliwala, S., Xavier, C., Liu, Y., Wu, H. & Pang, I. H., 1 Jan 2017, In : Oxidative Medicine and Cellular Longevity. 2017, 1703810.

Research output: Contribution to journalReview article

Eye Diseases
Antioxidants
Oxidative stress
Macular Degeneration
Diabetic Retinopathy
2 Citations (Scopus)

Rapid repeatable in vivo detection of retinal reactive oxygen species

Fan, N., Silverman, S. M., Liu, Y., Wang, X., Kim, B. J., Tang, L., Clark, A. F., Liu, X. & Pang, I. H., Aug 2017, In : Experimental eye research. 161, p. 71-81 11 p.

Research output: Contribution to journalShort survey

L 012
Reactive Oxygen Species
Retina
Optic Nerve
Wounds and Injuries
2016
15 Citations (Scopus)

In vitro and in vivo neuroprotective effects of cJun N-terminal kinase inhibitors on retinal ganglion cells

Kim, B. J., Silverman, S. M., Liu, Y., Wordinger, R. J., Pang, I. H. & Clark, A. F., 21 Apr 2016, In : Molecular Neurodegeneration. 11, 1, 93.

Research output: Contribution to journalArticle

Retinal Ganglion Cells
Neuroprotective Agents
Phosphotransferases
Reperfusion
Retina

Novel therapeutic targets for reduction of intraocular pressure in primary open angle glaucoma

Mao, W., Liu, Y., Wordinger, R. J., Clark, A. F. & Pang, I. H., 11 Jun 2016, In : Chinese Journal of Ophthalmology. 52, 6, p. 471-475 5 p.

Research output: Contribution to journalReview article

Intraocular Pressure
Glaucoma
Optic Nerve Diseases
Aqueous Humor
Open Angle Glaucoma
23 Citations (Scopus)

The novel triterpenoid RTA 408 protects human retinal pigment epithelial cells against H2O2-induced cell injury via NF-E2-related factor 2 (Nrf2) activation

Liu, X., Ward, K., Xavier, C., Jann, J., Clark, A. F., Pang, I. H. & Wu, H., 1 Aug 2016, In : Redox Biology. 8, p. 98-109 12 p.

Research output: Contribution to journalArticle

NF-E2-Related Factor 2
Retinal Pigments
Epithelial Cells
Chemical activation
Oxidative stress
2015
2 Citations (Scopus)

A novel frameshift deletion in the COL1A1 gene identified in a Chinese family with osteogenesis imperfecta

Fan, N., Jonas, J. B., He, F., Yan, N. H., Wang, Y., Liu, L., Liu, D. L., Zhao, L., Pang, I. H. & Liu, X. Y., 30 Nov 2015, In : Genetics and Molecular Research. 14, 4, p. 15295-15300 6 p.

Research output: Contribution to journalArticle

Osteogenesis Imperfecta
Sclera
Genes
Exome
Joint Instability
18 Citations (Scopus)

Caspase-7: A critical mediator of optic nerve injury-induced retinal ganglion cell death

Choudhury, S., Liu, Y., Clark, A. F. & Pang, I. H., 26 Aug 2015, In : Molecular Neurodegeneration. 10, 1, 40.

Research output: Contribution to journalArticle

Optic Nerve Injuries
Caspase 7
Retinal Ganglion Cells
Cell Death
Optic Nerve
9 Citations (Scopus)
Trabecular Meshwork
Ocular Hypertension
Intraocular Pressure
Rodentia
Transgenes
15 Citations (Scopus)

Neuritin 1 promotes retinal ganglion cell survival and axonal regeneration following optic nerve crush

Sharma, T. P., Liu, Y., Wordinger, R. J., Pang, I. H. & Clark, A. F., 1 Jan 2015, In : Cell Death and Disease. 6, 2, e1661.

Research output: Contribution to journalArticle

Nerve Crush
Retinal Ganglion Cells
Optic Nerve
Regeneration
Cell Survival
25 Citations (Scopus)

Role of C/EBP homologous protein in retinal ganglion cell death after ischemia/reperfusion injury

Nashine, S., Liu, Y., Kim, B. J., Clark, A. & Pang, I-H., 20 Nov 2015, In : Investigative Ophthalmology and Visual Science. 56, 1, p. 221-231 11 p.

Research output: Contribution to journalArticle

Transcription Factor CHOP
Retinal Ganglion Cells
Reperfusion Injury
Cell Death
Reperfusion
27 Citations (Scopus)

Strain and age effects on aqueous humor dynamics in the mouse

Cameron Millar, J., Phan, T. N., Pang, I. H. & Clark, A. F., 1 Jan 2015, In : Investigative Ophthalmology and Visual Science. 56, 10, p. 5764-5776 13 p.

Research output: Contribution to journalArticle

Aqueous Humor
Intraocular Pressure
Venous Pressure
Pressure
Fluorescein-5-isothiocyanate
2014
2 Citations (Scopus)

Erratum: Characterization of a transformed rat retinal ganglion cell line (Brain Research Molecular Brain Research (2001) 86 (1-12))

Krishnamoorthy, R. R., Agarwal, P., Prasanna, G., Vopat, K., Lambert, W., Sheedlo, H. J., Pang, I. H., Shade, D., Wordinger, R. J., Yorio, T., Clark, A. F. & Agarwal, N., 28 Jan 2014, In : Brain Research. 1544, 1 p.

Research output: Contribution to journalComment/debate

Retinal Ganglion Cells
Cell Line
Brain
Research
6 Citations (Scopus)

In vivo optimization of 2,3-diaminopyrazine Rho Kinase inhibitors for the treatment of glaucoma

Chen, H. H., Namil, A., Severns, B., Ward, J., Kelly, C., Drace, C., McLaughlin, M. A., Yacoub, S., Li, B., Patil, R., Sharif, N., Hellberg, M. R., Rusinko, A., Pang, I. H. & Combrink, K. D., 15 Apr 2014, In : Bioorganic and Medicinal Chemistry Letters. 24, 8, p. 1875-1879 5 p.

Research output: Contribution to journalArticle

Pyrazines
rho-Associated Kinases
Glaucoma
Solubility
Primates
5 Citations (Scopus)

Non-continuous measurement of intraocular pressure in laboratory animals

Millar, J. C. & Pang, I. H., 30 Oct 2014, In : Experimental eye research. 141, p. 74-90 17 p.

Research output: Contribution to journalArticle

Laboratory Animals
Intraocular Pressure
Manometry
Blindness
Circadian Rhythm
19 Citations (Scopus)

TGF-β2-mediated ocular hypertension is attenuated in SPARC-null mice

Swaminathan, S. S., Oh, D. J., Kang, M. H., Shepard, A. R., Pang, I-H. & Rhee, D. J., 1 Jul 2014, In : Investigative Ophthalmology and Visual Science. 55, 7, p. 4084-4097 14 p.

Research output: Contribution to journalArticle

Ocular Hypertension
Transforming Growth Factors
Cysteine
Adenoviridae
Proteins
2013
10 Citations (Scopus)

Challenges in the development of glaucoma neuroprotection therapy

Liu, Y. & Pang, I-H., 1 Aug 2013, In : Cell and Tissue Research. 353, 2, p. 253-260 8 p.

Research output: Contribution to journalReview article

Glaucoma
Optic Nerve Diseases
Clinical Trials
Blindness
Therapeutics
51 Citations (Scopus)

Exon-level expression profiling of ocular tissues

Wagner, A. H., Anand, V. N., Wang, W. H., Chatterton, J. E., Sun, D., Shepard, A. R., Jacobson, N., Pang, I. H., DeLuca, A. P., Casavant, T. L., Scheetz, T. E., Mullins, R. F., Braun, T. A. & Clark, A. F., 1 Jun 2013, In : Experimental eye research. 111, p. 105-111 7 p.

Research output: Contribution to journalArticle

Exons
Genes
RNA Sequence Analysis
Trabecular Meshwork
Ciliary Body
10 Citations (Scopus)

Identification of PDE6D as a molecular target of anecortave acetate via a methotrexate-anchored yeast three-hybrid screen

Shepard, A. R., Conrow, R. E., Pang, I-H., Jacobson, N., Rezwan, M., Rutschmann, K., Auerbach, D., Sriramaratnam, R. & Cornish, V. W., 15 Mar 2013, In : ACS Chemical Biology. 8, 3, p. 549-558 10 p.

Research output: Contribution to journalArticle

Type 6 Cyclic Nucleotide Phosphodiesterases
Methotrexate
Yeast
Yeasts
Intraocular Pressure
35 Citations (Scopus)

Proximal inhibition of p38 MAPK stress signaling prevents distal axonopathy

Dapper, J. D., Crish, S. D., Pang, I-H. & Calkins, D. J., 1 Nov 2013, In : Neurobiology of Disease. 59, p. 26-37 12 p.

Research output: Contribution to journalArticle

p38 Mitogen-Activated Protein Kinases
Retinal Ganglion Cells
Axons
Retina
Optic Nerve Diseases
15 Citations (Scopus)

sCD44 overexpression increases intraocular pressure and aqueous outflow resistance

Giovingo, M., Nolan, M., McCarty, R., Pang, I. H., Clark, A. F., Beverley, R. M., Schwartz, S., Stamer, W. D., Walker, L., Grybauskas, A., Skuran, K., Kuprys, P. V., Yue, B. Y. J. T. & Knepper, P. A., 1 Nov 2013, In : Molecular vision. 19, p. 2151-2164 14 p.

Research output: Contribution to journalArticle

Intraocular Pressure
Trabecular Meshwork
Aqueous Humor
Anterior Eye Segment
Annexins
2012
29 Citations (Scopus)

Existence of the canonical wnt signaling pathway in the human trabecular meshwork

Mao, W., Cameron Millar, J., Wang, W. H., Silverman, S. M., Liu, Y., Wordinger, R. J., Rubin, J. S., Pang, I. H. & Clark, A. F., 1 Oct 2012, In : Investigative Ophthalmology and Visual Science. 53, 11, p. 7043-7051 9 p.

Research output: Contribution to journalArticle

Trabecular Meshwork
Wnt Signaling Pathway
Luciferases
Catenins
Actin Cytoskeleton
80 Citations (Scopus)

JNK2 and JNK3 are major regulators of axonal injury-induced retinal ganglion cell death

Fernandes, K. A., Harder, J. M., Fornarola, L. B., Freeman, R. S., Clark, A., Pang, I-H., John, S. W. M. & Libby, R. T., 1 May 2012, In : Neurobiology of Disease. 46, 2, p. 393-401 9 p.

Research output: Contribution to journalArticle

Retinal Ganglion Cells
Cell Death
Wounds and Injuries
Axons
Glaucoma
40 Citations (Scopus)

Microbead-induced ocular hypertensive mouse model for screening and testing of aqueous production suppressants for Glaucoma

Yang, Q., Cho, K. S., Chen, H., Yu, D., Wang, W. H., Luo, G., Pang, I. H., Guo, W. & Chen, D. F., 1 Jun 2012, In : Investigative Ophthalmology and Visual Science. 53, 7, p. 3733-3741 9 p.

Research output: Contribution to journalArticle

Ocular Hypertension
Microspheres
Glaucoma
latanoprost
Optical Coherence Tomography
34 Citations (Scopus)

Mutant human myocilin induces strain specific differences in ocular hypertension and optic nerve damage in mice

McDowell, C. M., Luan, T., Zhang, Z., Putliwala, T., Wordinger, R. J., Millar, J. C., John, S. W. M., Pang, I-H. & Clark, A., 1 Jul 2012, In : Experimental eye research. 100, p. 65-72 8 p.

Research output: Contribution to journalArticle

Ocular Hypertension
Optic Nerve
Intraocular Pressure
Glaucoma
Superior Colliculi
2011
56 Citations (Scopus)
Aqueous Humor
latanoprost
Hydrodynamics
Pressure
Betaxolol
19 Citations (Scopus)

Characterization of intraocular pressure responses of the Tibetan monkey (Macaca Thibetana)

Liu, G., Zeng, T., Yu, W., Yan, N., Wang, H., Cai, S. P., Pang, I. H. & Liu, X., 22 Jun 2011, In : Molecular vision. 17, p. 1405-1413 9 p.

Research output: Contribution to journalArticle

Macaca
Intraocular Pressure
Haplorhini
Timolol
General Anesthesia
Ophthalmology
Optic Nerve
Astrocytes
Glaucoma
Optics
31 Citations (Scopus)

Protective effect of a JNK inhibitor against retinal ganglion cell loss induced by acute moderate ocular hypertension

Sun, H., Wang, Y., Pang, I-H., Shen, J., Tang, X., Li, Y., Liu, C. & Li, B., 9 May 2011, In : Molecular Vision. 17, p. 864-875 12 p.

Research output: Contribution to journalArticle

Ocular Hypertension
Retinal Ganglion Cells
Phosphotransferases
Intraocular Pressure
Cell Count
2010
101 Citations (Scopus)
Transforming Growth Factors
Intraocular Pressure
Rodentia
Genes
Aqueous Humor
16 Citations (Scopus)

Neuroprotective effects of C-type natriuretic peptide on rat retinal ganglion cells

Ma, J., Yu, W., Wang, Y., Cao, G., Cai, S., Chen, X., Yan, N., Yuan, Y., Zeng, H., Fleenor, D. L., Liu, X. & Pang, I. H., 1 Jul 2010, In : Investigative Ophthalmology and Visual Science. 51, 7, p. 3544-3553 10 p.

Research output: Contribution to journalArticle

C-Type Natriuretic Peptide
Retinal Ganglion Cells
Neuroprotective Agents
Calpain
In Situ Nick-End Labeling
4 Citations (Scopus)

Nonprimate models for glaucoma retinopathy and optic neuropathy

Pang, I-H. & Clark, A., 25 Jan 2010, Animal Models for Retinal Diseases. Pang, L-H. & Clark, A. (eds.). p. 139-164 26 p. (Neuromethods; vol. 46).

Research output: Chapter in Book/Report/Conference proceedingChapter

Optic Nerve Diseases
Glaucoma
Optics
Animals
Animal Models