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2019
Open Access
National Institute of Neurological Disorders and Stroke
Organized Financing
Astrocytes
Histones
Methylation
Astrocytes
Histones
Methylation
Lysine
HIV
2018
6 Citations (Scopus)

Doxycycline-inducible and astrocyte-specific HIV-1 Tat transgenic mice (iTat) as an HIV/neuroAIDS model

Langford, D., Kim, B. O., Zou, W., Fan, Y., Rahimain, P., Liu, Y. & He, J. J., 15 Nov 2018, In : Journal of NeuroVirology. 24, 2, p. 168-179 12 p.

Research output: Contribution to journalReview article

Doxycycline
Astrocytes
Transgenic Mice
HIV-1
HIV
2 Citations (Scopus)

miRNA regulation of Tip110 expression and self-renewal and differentiation of human CD34+ hematopoietic cells

Liu, Y., Huang, X., Timani, K. A., Broxmeyer, H. E. & He, J. J., 1 Jan 2018, In : Oncotarget. 9, 4, p. 4823-4832 10 p.

Research output: Contribution to journalArticle

MicroRNAs
3' Untranslated Regions
Hematopoiesis
Untranslated RNA
Fetal Blood

Neo-clerodane diterpenoids from the whole plants of Scutellaria formosana

Chen, X., Chen, W., Chen, G., Han, C., He, J. J., Zhou, X., Yu, Z., Dai, C. & Song, X., 1 Jan 2018, In : Phytochemistry. 145, p. 1-9 9 p.

Research output: Contribution to journalArticle

Scutellaria
Clerodane Diterpenes
Stereochemistry
Diterpenes
stereochemistry
Cleavage Stimulation Factor
Polyadenylation
3' Untranslated Regions
Fetal Blood
Blood Cells
1 Citation (Scopus)

Tip110/SART3 regulates IL-8 expression and predicts the clinical outcomes in melanoma

Timani, K. A., Gyorffy, B., Liu, Y., Mohammad, K. S. & He, J. J., 17 Aug 2018, In : Molecular Cancer. 17, 1, 124.

Research output: Contribution to journalLetter

Interleukin-8
Melanoma
Carcinogenesis
Autocrine Communication
Neoplasm Metastasis
2017
6 Citations (Scopus)

HIV/neuroAIDS biomarkers

Rahimian, P. & He, J. J., 1 Oct 2017, In : Progress in Neurobiology. 157, p. 117-132 16 p.

Research output: Contribution to journalReview article

Biomarkers
HIV
Symptom Assessment
Neuroaid
Nervous System Trauma
4 Citations (Scopus)

The anticancer drug sunitinib promotes autophagyand protects from neurotoxicity in an HIV-1 Tat model of neurodegeneration

Fields, J. A., Metcalf, J., Overk, C., Adame, A., Spencer, B., Wrasidlo, W., Florio, J., Rockenstein, E., He, J. J. & Masliah, E., 1 Apr 2017, In : Journal of NeuroVirology. 23, 2, p. 290-303 14 p.

Research output: Contribution to journalArticle

Autophagy
HIV-1
Pharmaceutical Preparations
HIV
Transgenic Mice
3 Citations (Scopus)

Tip110 Deletion Impaired Embryonic and Stem Cell Development Involving Downregulation of Stem Cell Factors Nanog, Oct4, and Sox2

Whitmill, A., Liu, Y., Timani, K. A., Niu, Y. & He, J. J., 1 Jul 2017, In : Stem Cells. 35, 7, p. 1674-1686 13 p.

Research output: Contribution to journalArticle

Stem Cell Factor
Embryonic Stem Cells
Blastocyst
Down-Regulation
Embryonic Development
2016
25 Citations (Scopus)

Exosome-associated release, uptake, and neurotoxicity of HIV-1 Tat protein

Rahimian, P. & He, J. J., 1 Dec 2016, In : Journal of NeuroVirology. 22, 6, p. 774-788 15 p.

Research output: Contribution to journalArticle

Human Immunodeficiency Virus tat Gene Products
Exosomes
HIV-1
Astrocytes
HIV Long Terminal Repeat
3 Citations (Scopus)

Function of ubiquitin (Ub) specific protease 15 (USP15) in HIV-1 replication and viral protein degradation

Pyeon, D., Timani, K. A., Gulraiz, F., He, J. J. & Park, I., 2 Sep 2016, In : Virus Research. 223, p. 161-169 9 p.

Research output: Contribution to journalArticle

Ubiquitin-Specific Proteases
Viral Proteins
Proteolysis
HIV-1
Peptide Hydrolases
20 Citations (Scopus)
Unfolded Protein Response
Endoplasmic Reticulum Stress
Glial Fibrillary Acidic Protein
Astrocytes
HIV-1
11 Citations (Scopus)

HIV-1 tat promotes lysosomal exocytosis in astrocytes and contributes to astrocyte-mediated tat neurotoxicity

Fan, Y. & He, J. J., 21 Oct 2016, In : Journal of Biological Chemistry. 291, 43, p. 22830-22840 11 p.

Research output: Contribution to journalArticle

Exocytosis
Astrocytes
HIV-1
Endoplasmic Reticulum Stress
Proteins
13 Citations (Scopus)

HIV-1 Tat-shortened neurite outgrowth through regulation of microRNA-132 and its target gene expression

Rahimian, P. & He, J. J., 15 Sep 2016, In : Journal of neuroinflammation. 13, 1, 247.

Research output: Contribution to journalArticle

MicroRNAs
Astrocytes
HIV-1
Gene Expression
Neurites
13 Citations (Scopus)

HIV Tat impairs neurogenesis through functioning as a notch ligand and activation of notch signaling pathway

Fan, Y., Gao, X., Chen, J., Liu, Y. & He, J. J., 2 Nov 2016, In : Journal of Neuroscience. 36, 44, p. 11362-11373 12 p.

Research output: Contribution to journalArticle

Neurogenesis
HIV
Ligands
Neurons
Stem Cells

Role of Tat-interacting protein of 110kDa and microRNAs in the regulation of hematopoiesis

Liu, Y. & He, J. J., 1 Jul 2016, In : Current Opinion in Hematology. 23, 4, p. 325-330 6 p.

Research output: Contribution to journalReview article

tat Gene Products
Hematopoiesis
Hematopoietic Stem Cells
MicroRNAs
Fetal Blood
8 Citations (Scopus)

Tip110: Physical properties, primary structure, and biological functions

Whitmill, A., Timani, K. A., Liu, Y. & He, J. J., 15 Mar 2016, In : Life Sciences. 149, p. 79-95 17 p.

Research output: Contribution to journalReview article

tat Gene Products
Physical properties
Proteins
RNA Precursors
Cell Biology
2015
25 Citations (Scopus)

Exosomes are unlikely involved in intercellular Nef transfer

Luo, X., Fan, Y., Park, I. W. & He, J. J., 28 Apr 2015, In : PLoS ONE. 10, 4, e0124436.

Research output: Contribution to journalArticle

exosomes
Exosomes
Detergents
Cells
T-cells
46 Citations (Scopus)

HIV-1 tat alters neuronal autophagy by modulating autophagosome fusion to the lysosome: Implications for HIV-associated neurocognitive disorders

Fields, J., Dumaop, W., Elueteri, S., Campos, S., Serger, E., Trejo, M., Kosberg, K., Adame, A., Spencer, B., Rockenstein, E., He, J. J. & Masliah, E., 1 Jan 2015, In : Journal of Neuroscience. 35, 5, p. 1921-1938 18 p.

Research output: Contribution to journalArticle

Autophagy
Lysosomes
HIV-1
HIV
Lysosome-Associated Membrane Glycoproteins
7 Citations (Scopus)

Ionic derivatives of betulinic acid exhibit antiviral activity against herpes simplex virus type-2 (HSV-2), but not HIV-1 reverse transcriptase

Visalli, R. J., Ziobrowski, H., Badri, K. R., He, J. J., Zhang, X., Arumugam, S. R. & Zhao, H., 3 Jul 2015, In : Bioorganic and Medicinal Chemistry Letters. 25, 16, p. 3168-3171 4 p., 22789.

Research output: Contribution to journalArticle

Human Herpesvirus 2
Viruses
Inhibitory Concentration 50
Antiviral Agents
Derivatives
29 Citations (Scopus)

Mechanisms of HIV-1 tat neurotoxicity via CDK5 translocation and hyper-activation: Role in HIV-associated neurocognitive disorders

Fields, J. A., Dumaop, W., Crews, L., Adame, A., Spencer, B., Metcalf, J., He, J., Rockenstein, E. & Masliah, E., 1 Jan 2015, In : Current HIV Research. 13, 1, p. 43-54 12 p.

Research output: Contribution to journalArticle

HIV-1
HIV
Cytoplasm
Cyclin-Dependent Kinase 5
AIDS Dementia Complex
9 Citations (Scopus)

MicroRNA-124 Targets Tip110 Expression and Regulates Hematopoiesis

Liu, Y., Huang, X., Timani, K. A., Broxmeyer, H. E. & He, J. J., 1 Sep 2015, In : Stem Cells and Development. 24, 17, p. 2009-2017 9 p.

Research output: Contribution to journalArticle

Hematopoiesis
MicroRNAs
Fetal Blood
Blood Cells
Cell Differentiation
12 Citations (Scopus)
STAT3 Transcription Factor
Glial Fibrillary Acidic Protein
Transcriptional Activation
HIV-1
Phosphorylation
4 Citations (Scopus)

Tip110 binding to U6 small nuclear RNA and its participation in pre-mRNA splicing

Liu, Y., Liu, J., Wang, Z. & He, J. J., 23 Jul 2015, In : Cell and Bioscience. 5, 1, 40.

Research output: Contribution to journalArticle

RNA Precursors
RNA
Nuclear Localization Signals
Assays
Spliceosomes
11 Citations (Scopus)

Tip110 regulates the cross talk between p53 and hypoxia-inducible factor 1α under hypoxia and promotes survival of cancer cells

Timani, K. A., Liu, Y., Fan, Y., Mohammad, K. S. & He, J. J., 1 Jan 2015, In : Molecular and Cellular Biology. 35, 13, p. 2254-2264 11 p.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
Cell Survival
Neoplasms
Physiological Phenomena
Protein Stability
2014
14 Citations (Scopus)

Cell–cell contact viral transfer contributes to HIV infection and persistence in astrocytes

Luo, X. & He, J. J., 1 Jan 2014, In : Journal of NeuroVirology. 21, 1, p. 66-80 15 p.

Research output: Contribution to journalArticle

Virus Diseases
Astrocytes
HIV
Endocytosis
Central Nervous System
1 Citation (Scopus)

Cellular interactions and signaling in neuroAIDS: Emerging issues colloquium

Al-Harthi, L., Buch, S., Geiger, J. D., Gendelman, H. E., He, J. J., Jordan-Sciutto, K. L., Kolson, D. L., Rappaport, J., Roy, S., Zheng, J. & Fox, H. S., 1 Jan 2014, In : Journal of Neuroimmune Pharmacology. 9, 3, p. 269-276 8 p.

Research output: Contribution to journalReview article

Nervous System
Animal Models
Biomarkers
HIV
Pharmacology
31 Citations (Scopus)

Effects of conditional central expression of HIV-1 tat protein to potentiate cocaine-mediated psychostimulation and reward among male mice

Paris, J. J., Carey, A. N., Shay, C. F., Gomes, S. M., He, J. J. & McLaughlin, J. P., 1 Jan 2014, In : Neuropsychopharmacology. 39, 2, p. 380-388 9 p.

Research output: Contribution to journalArticle

tat Gene Products
Reward
Cocaine
HIV-1
Doxycycline
38 Citations (Scopus)

Exosome-associated hepatitis C virus in cell cultures and patient plasma

Liu, Z., Zhang, X., Yu, Q. & He, J. J., 12 Dec 2014, In : Biochemical and Biophysical Research Communications. 455, 3-4, p. 218-222 5 p.

Research output: Contribution to journalArticle

Exosomes
Satellite Viruses
Viruses
Cell culture
Hepacivirus
19 Citations (Scopus)

Hepatitis C Virus (HCV) interaction with astrocytes: Nonproductive infection and induction of IL-18

Liu, Z., Zhao, F. & He, J. J., 1 Jan 2014, In : Journal of NeuroVirology. 20, 3, p. 278-293 16 p.

Research output: Contribution to journalArticle

Interleukin-18
Astrocytes
Hepacivirus
Infection
Virus Diseases
11 Citations (Scopus)

HIV-1 Nef is transferred from expressing T cells to hepatocytic cells through conduits and enhances HCV replication

Park, I. W., Fan, Y., Luo, X., Ryou, M. G., Liu, J., Green, L. & He, J. J., 9 Jun 2014, In : PLoS ONE. 9, 6, e99545.

Research output: Contribution to journalArticle

T-cells
Human immunodeficiency virus 1
Liver
HIV-1
T-lymphocytes
9 Citations (Scopus)

Involvement of miR-196a in HIV-associated neurocognitive disorders

Bagashev, A., Mukerjee, R., Santerre, M., Del Carpio-Cano, F. E., Shrestha, J., Wang, Y., He, J. J. & Sawaya, B. E., 1 Jan 2014, In : Apoptosis. 19, 8, p. 1202-1214 13 p.

Research output: Contribution to journalArticle

Trans-Activators
Transcription
MicroRNAs
HIV
HIV-1
16 Citations (Scopus)

Regulation of ubiquitin-proteasome system-mediated Tip110 protein degradation by USP15

Timani, K. A., Liu, Y., Suvannasankha, A. & He, J. J., 1 Jan 2014, In : International Journal of Biochemistry and Cell Biology. 54, p. 10-19 10 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Ubiquitin
Proteolysis
Degradation
Proteins
11 Citations (Scopus)
HIV Long Terminal Repeat
Phosphorylation
Terminal Repeat Sequences
RNA Polymerase II
Transcription
2013
17 Citations (Scopus)
Virus Receptors
Hepatitis C virus
Hepacivirus
Infection
infection
17 Citations (Scopus)

C-MYC controlled TIP110 protein expression regulates OCT4 mRNA splicing in human embryonic stem cells

Liu, Y., Timani, K. A., Ou, X., Broxmeyer, H. E. & He, J. J., 1 Mar 2013, In : Stem Cells and Development. 22, 5, p. 689-694 6 p.

Research output: Contribution to journalArticle

Exons
tat Gene Products
Embryonal Carcinoma Stem Cells
Cell Line
Messenger RNA

Erratum: HIV-1 Tat protein promotes neuronal dysfunction through disruption of microRNAs (The Journal of Biological Chemistry (2011) 286 (41125-41134))

Chang, J. R., Mukerjee, R., Bagashev, A., Del Valle, L., Chabrashvili, T., Hawkins, B. J., He, J. J. & Sawaya, B. E., 27 Sep 2013, In : Journal of Biological Chemistry. 288, 39, 1 p.

Research output: Contribution to journalComment/debate

Human Immunodeficiency Virus tat Gene Products
MicroRNAs
HIV-1
1 Citation (Scopus)

Erratum: HIV-1 Tat protein promotes neuronal dysfunction through disruption of microRNAs (Journal of Biological Chemistry (2011) 286 (41125-41134) DOI:10.1074/jbc.A111.268466)

Chang, J. R., Mukerjee, R., Bagashev, A., Del Valle, L., Chabrashvili, T., Hawkins, B. J., He, J. J. & Sawaya, B. E., 22 Mar 2013, In : Journal of Biological Chemistry. 288, 12, 1 p.

Research output: Contribution to journalComment/debate

Human Immunodeficiency Virus tat Gene Products
MicroRNAs
HIV-1
3 Citations (Scopus)
Chemotaxis
HIV-1
T-Lymphocytes
Primates
Cell Movement
10 Citations (Scopus)

Inhibition of HCV Replication by Oxysterol-Binding Protein-Related Protein 4 (ORP4) through Interaction with HCV NS5B and Alteration of Lipid Droplet Formation

Park, I., Ndjomou, J., Wen, Y., Liu, Z., Ridgway, N. D., Kao, C. C. & He, J. J., 16 Sep 2013, In : PLoS ONE. 8, 9, e75648.

Research output: Contribution to journalArticle

Hepatitis C virus
Virus Replication
virus replication
Viruses
Hepacivirus
6 Citations (Scopus)

Inhibition of HIV-1 transcription and replication by a newly identified cyclin T1 splice variant

Gao, G., Wu, X., Zhou, J., He, M., He, J. J. & Guo, D., 17 May 2013, In : Journal of Biological Chemistry. 288, 20, p. 14297-14309 13 p.

Research output: Contribution to journalArticle

Cyclin T
Transcription
HIV-1
Peptide Elongation Factors
Terminal Repeat Sequences
10 Citations (Scopus)

Tip110 interacts with YB-1 and regulates each other's function

Timani, K. A., Liu, Y. & He, J. J., 4 Jul 2013, In : BMC Molecular Biology. 14, 14.

Research output: Contribution to journalArticle

HIV Long Terminal Repeat
Proteins
Y-Box-Binding Protein 1
RNA Precursors
Alternative Splicing
2012
32 Citations (Scopus)

CD59 incorporation protects hepatitis C virus against complement-mediated destruction

Amet, T., Ghabril, M., Chalasani, N., Byrd, D., Hu, N., Grantham, A., Liu, Z., Qin, X., He, J. J. & Yu, Q., 1 Feb 2012, In : Hepatology. 55, 2, p. 354-363 10 p.

Research output: Contribution to journalArticle

Hepacivirus
Virion
Complement Activation
Antibodies
Viruses
20 Citations (Scopus)

Tip110 maintains expression of pluripotent factors in and pluripotency of human embryonic stem cells

Liu, Y., Lee, M. R., Timani, K. A., He, J. J. & Broxmeyer, H. E., 10 Apr 2012, In : Stem Cells and Development. 21, 6, p. 829-833 5 p.

Research output: Contribution to journalArticle

HIV-1
tat Gene Products
RNA-Binding Proteins
RNA Precursors
Hematopoiesis
2011
29 Citations (Scopus)

Activation of Egr-1 expression in astrocytes by HIV-1 Tat: New insights into astrocyte-mediated Tat neurotoxicity

Fan, Y., Zou, W., Green, L. A., Kim, B. O. & He, J. J., 1 Mar 2011, In : Journal of Neuroimmune Pharmacology. 6, 1, p. 121-129 9 p.

Research output: Contribution to journalArticle

Astrocytes
HIV-1
Growth
Glial Fibrillary Acidic Protein
Early Growth Response Protein 1

Cell signaling pathways and HIV-1 therapeutics

He, J. J., 1 Jun 2011, In : Journal of Neuroimmune Pharmacology. 6, 2, p. 173-176 4 p.

Research output: Contribution to journalReview article

HIV-1
HIV
Viruses
Therapeutics
Acquired Immunodeficiency Syndrome
49 Citations (Scopus)

HIV-1 tat protein promotes neuronal dysfunction through disruption of microRNAs

Chang, J. R., Mukerjee, R., Bagashev, A., Del Valle, L., Chabrashvili, T., Hawkins, B. J., He, J. J. & Sawaya, B. E., 25 Nov 2011, In : Journal of Biological Chemistry. 286, 47, p. 41125-41134 10 p.

Research output: Contribution to journalArticle

Human Immunodeficiency Virus tat Gene Products
tat Gene Products
MicroRNAs
HIV-1
Deregulation
19 Citations (Scopus)

TIP110/p110nrb/SART3/p110 regulation of hematopoiesis through CMYC

Liu, Y., Timani, K. A., Mantel, C., Fan, Y., Hangoc, G., Cooper, S., He, J. J. & Broxmeyer, H. E., 26 May 2011, In : Blood. 117, 21, p. 5643-5651 9 p.

Research output: Contribution to journalArticle

Hematopoiesis
Hematopoietic Stem Cells
Stem cells
Genes
Cells
38 Citations (Scopus)

Translational regulation of HIV-1 replication by HIV-1 rev cellular cofactors Sam68, eIF5A, hRIP, and DDX3

Liu, J., Henao-Mejia, J., Liu, H., Zhao, Y. & He, J. J., 1 Jun 2011, In : Journal of Neuroimmune Pharmacology. 6, 2, p. 308-321 14 p.

Research output: Contribution to journalArticle

HIV-1
RNA
Reporter Genes
Gene Expression
Cell Nucleus Active Transport