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  • Johnny He
2019
Open Access

Tat expression led to increased histone 3 tri-methylation at lysine 27 and contributed to HIV latency in astrocytes through regulation of MeCP2 and Ezh2 expression

Liu, Y., Niu, Y., Li, L., Timani, K. A., He, V. L., Sanburns, C., Xie, J. & He, J. J., 1 Aug 2019, In : Journal of NeuroVirology. 25, 4, p. 508-519 12 p.

Research output: Contribution to journalArticle

1 Scopus citations
2018

Doxycycline-inducible and astrocyte-specific HIV-1 Tat transgenic mice (iTat) as an HIV/neuroAIDS model

Langford, D., Kim, B. O., Zou, W., Fan, Y., Rahimain, P., Liu, Y. & He, J. J., 15 Nov 2018, In : Journal of NeuroVirology. 24, 2, p. 168-179 12 p.

Research output: Contribution to journalReview article

9 Scopus citations

miRNA regulation of Tip110 expression and self-renewal and differentiation of human CD34+ hematopoietic cells

Liu, Y., Huang, X., Timani, K. A., Broxmeyer, H. E. & He, J. J., 1 Jan 2018, In : Oncotarget. 9, 4, p. 4823-4832 10 p.

Research output: Contribution to journalArticle

2 Scopus citations

Neo-clerodane diterpenoids from the whole plants of Scutellaria formosana

Chen, X., Chen, W., Chen, G., Han, C., He, J. J., Zhou, X., Yu, Z., Dai, C. & Song, X., Jan 2018, In : Phytochemistry. 145, p. 1-9 9 p.

Research output: Contribution to journalArticle

Regulation of Constitutive Tip110 Expression in Human Cord Blood CD34+ Cells Through Selective Usage of the Proximal and Distal Polyadenylation Sites Within the 3′Untranslated Region

Liu, Y., Huang, X., Timani, K. A., Broxmeyer, H. E. & He, J. J., 15 Apr 2018, In : Stem Cells and Development. 27, 8, p. 566-576 11 p.

Research output: Contribution to journalArticle

Tip110/SART3 regulates IL-8 expression and predicts the clinical outcomes in melanoma

Timani, K. A., Gyorffy, B., Liu, Y., Mohammad, K. S. & He, J. J., 17 Aug 2018, In : Molecular Cancer. 17, 1, 124.

Research output: Contribution to journalLetter

2 Scopus citations
2017

HIV/neuroAIDS biomarkers

Rahimian, P. & He, J. J., Oct 2017, In : Progress in Neurobiology. 157, p. 117-132 16 p.

Research output: Contribution to journalReview article

9 Scopus citations

The anticancer drug sunitinib promotes autophagyand protects from neurotoxicity in an HIV-1 Tat model of neurodegeneration

Fields, J. A., Metcalf, J., Overk, C., Adame, A., Spencer, B., Wrasidlo, W., Florio, J., Rockenstein, E., He, J. J. & Masliah, E., 1 Apr 2017, In : Journal of NeuroVirology. 23, 2, p. 290-303 14 p.

Research output: Contribution to journalArticle

6 Scopus citations

Tip110 Deletion Impaired Embryonic and Stem Cell Development Involving Downregulation of Stem Cell Factors Nanog, Oct4, and Sox2

Whitmill, A., Liu, Y., Timani, K. A., Niu, Y. & He, J. J., Jul 2017, In : Stem Cells. 35, 7, p. 1674-1686 13 p.

Research output: Contribution to journalArticle

3 Scopus citations
2016

Exosome-associated release, uptake, and neurotoxicity of HIV-1 Tat protein

Rahimian, P. & He, J. J., 1 Dec 2016, In : Journal of NeuroVirology. 22, 6, p. 774-788 15 p.

Research output: Contribution to journalArticle

29 Scopus citations

Function of ubiquitin (Ub) specific protease 15 (USP15) in HIV-1 replication and viral protein degradation

Pyeon, D., Timani, K. A., Gulraiz, F., He, J. J. & Park, I. W., 2 Sep 2016, In : Virus Research. 223, p. 161-169 9 p.

Research output: Contribution to journalArticle

4 Scopus citations
27 Scopus citations

HIV-1 tat promotes lysosomal exocytosis in astrocytes and contributes to astrocyte-mediated tat neurotoxicity

Fan, Y. & He, J. J., 21 Oct 2016, In : Journal of Biological Chemistry. 291, 43, p. 22830-22840 11 p.

Research output: Contribution to journalArticle

16 Scopus citations

HIV-1 Tat-shortened neurite outgrowth through regulation of microRNA-132 and its target gene expression

Rahimian, P. & He, J. J., 15 Sep 2016, In : Journal of neuroinflammation. 13, 1, 247.

Research output: Contribution to journalArticle

18 Scopus citations

HIV Tat impairs neurogenesis through functioning as a notch ligand and activation of notch signaling pathway

Fan, Y., Gao, X., Chen, J., Liu, Y. & He, J. J., 2 Nov 2016, In : Journal of Neuroscience. 36, 44, p. 11362-11373 12 p.

Research output: Contribution to journalArticle

17 Scopus citations

Role of Tat-interacting protein of 110kDa and microRNAs in the regulation of hematopoiesis

Liu, Y. & He, J. J., 1 Jul 2016, In : Current Opinion in Hematology. 23, 4, p. 325-330 6 p.

Research output: Contribution to journalReview article

Tip110: Physical properties, primary structure, and biological functions

Whitmill, A., Timani, K. A., Liu, Y. & He, J. J., 15 Mar 2016, In : Life Sciences. 149, p. 79-95 17 p.

Research output: Contribution to journalReview article

10 Scopus citations
2015

Exosomes are unlikely involved in intercellular Nef transfer

Luo, X., Fan, Y., Park, I. W. & He, J. J., 28 Apr 2015, In : PLoS ONE. 10, 4, e0124436.

Research output: Contribution to journalArticle

26 Scopus citations

HIV-1 tat alters neuronal autophagy by modulating autophagosome fusion to the lysosome: Implications for HIV-associated neurocognitive disorders

Fields, J., Dumaop, W., Elueteri, S., Campos, S., Serger, E., Trejo, M., Kosberg, K., Adame, A., Spencer, B., Rockenstein, E., He, J. J. & Masliah, E., 1 Jan 2015, In : Journal of Neuroscience. 35, 5, p. 1921-1938 18 p.

Research output: Contribution to journalArticle

56 Scopus citations

Ionic derivatives of betulinic acid exhibit antiviral activity against herpes simplex virus type-2 (HSV-2), but not HIV-1 reverse transcriptase

Visalli, R. J., Ziobrowski, H., Badri, K. R., He, J. J., Zhang, X., Arumugam, S. R. & Zhao, H., 3 Jul 2015, In : Bioorganic and Medicinal Chemistry Letters. 25, 16, p. 3168-3171 4 p., 22789.

Research output: Contribution to journalArticle

9 Scopus citations

Mechanisms of HIV-1 tat neurotoxicity via CDK5 translocation and hyper-activation: Role in HIV-associated neurocognitive disorders

Fields, J. A., Dumaop, W., Crews, L., Adame, A., Spencer, B., Metcalf, J., He, J., Rockenstein, E. & Masliah, E., 1 Jan 2015, In : Current HIV Research. 13, 1, p. 43-54 12 p.

Research output: Contribution to journalArticle

33 Scopus citations

MicroRNA-124 Targets Tip110 Expression and Regulates Hematopoiesis

Liu, Y., Huang, X., Timani, K. A., Broxmeyer, H. E. & He, J. J., 1 Sep 2015, In : Stem Cells and Development. 24, 17, p. 2009-2017 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

STAT3 and its phosphorylation are involved in HIV-1 tat-induced transactivation of glial fibrillary acidic protein

Fan, Y., Timani, K. A. & He, J. J., 1 Jan 2015, In : Current HIV Research. 13, 1, p. 55-63 9 p.

Research output: Contribution to journalArticle

13 Scopus citations

Tip110 binding to U6 small nuclear RNA and its participation in pre-mRNA splicing

Liu, Y., Liu, J., Wang, Z. & He, J. J., 23 Jul 2015, In : Cell and Bioscience. 5, 1, 40.

Research output: Contribution to journalArticle

4 Scopus citations

Tip110 regulates the cross talk between p53 and hypoxia-inducible factor 1α under hypoxia and promotes survival of cancer cells

Timani, K. A., Liu, Y., Fan, Y., Mohammad, K. S. & He, J. J., 1 Jan 2015, In : Molecular and Cellular Biology. 35, 13, p. 2254-2264 11 p.

Research output: Contribution to journalArticle

11 Scopus citations
2014

Cell–cell contact viral transfer contributes to HIV infection and persistence in astrocytes

Luo, X. & He, J. J., 1 Jan 2014, In : Journal of NeuroVirology. 21, 1, p. 66-80 15 p.

Research output: Contribution to journalArticle

18 Scopus citations

Cellular interactions and signaling in neuroAIDS: Emerging issues colloquium

Al-Harthi, L., Buch, S., Geiger, J. D., Gendelman, H. E., He, J. J., Jordan-Sciutto, K. L., Kolson, D. L., Rappaport, J., Roy, S., Zheng, J. & Fox, H. S., Jun 2014, In : Journal of Neuroimmune Pharmacology. 9, 3, p. 269-276 8 p.

Research output: Contribution to journalReview article

1 Scopus citations

Effects of conditional central expression of HIV-1 tat protein to potentiate cocaine-mediated psychostimulation and reward among male mice

Paris, J. J., Carey, A. N., Shay, C. F., Gomes, S. M., He, J. J. & McLaughlin, J. P., 1 Jan 2014, In : Neuropsychopharmacology. 39, 2, p. 380-388 9 p.

Research output: Contribution to journalArticle

36 Scopus citations

Exosome-associated hepatitis C virus in cell cultures and patient plasma

Liu, Z., Zhang, X., Yu, Q. & He, J. J., 12 Dec 2014, In : Biochemical and Biophysical Research Communications. 455, 3-4, p. 218-222 5 p.

Research output: Contribution to journalArticle

43 Scopus citations

Hepatitis C Virus (HCV) interaction with astrocytes: Nonproductive infection and induction of IL-18

Liu, Z., Zhao, F. & He, J. J., Jun 2014, In : Journal of NeuroVirology. 20, 3, p. 278-293 16 p.

Research output: Contribution to journalArticle

19 Scopus citations

HIV-1 Nef is transferred from expressing T cells to hepatocytic cells through conduits and enhances HCV replication

Park, I. W., Fan, Y., Luo, X., Ryou, M. G., Liu, J., Green, L. & He, J. J., 9 Jun 2014, In : PLoS ONE. 9, 6, e99545.

Research output: Contribution to journalArticle

14 Scopus citations

Involvement of miR-196a in HIV-associated neurocognitive disorders

Bagashev, A., Mukerjee, R., Santerre, M., Del Carpio-Cano, F. E., Shrestha, J., Wang, Y., He, J. J. & Sawaya, B. E., Aug 2014, In : Apoptosis. 19, 8, p. 1202-1214 13 p.

Research output: Contribution to journalArticle

9 Scopus citations

Regulation of ubiquitin-proteasome system-mediated Tip110 protein degradation by USP15

Timani, K. A., Liu, Y., Suvannasankha, A. & He, J. J., Sep 2014, In : International Journal of Biochemistry and Cell Biology. 54, p. 10-19 10 p.

Research output: Contribution to journalArticle

16 Scopus citations

Tip110 protein binds to unphosphorylated RNA polymerase II and promotes its phosphorylation and HIV-1 long terminal repeat transcription

Zhao, W., Liu, Y., Timani, K. A. & He, J. J., 3 Jan 2014, In : Journal of Biological Chemistry. 289, 1, p. 190-202 13 p.

Research output: Contribution to journalArticle

11 Scopus citations
2013
17 Scopus citations

C-MYC controlled TIP110 protein expression regulates OCT4 mRNA splicing in human embryonic stem cells

Liu, Y., Timani, K. A., Ou, X., Broxmeyer, H. E. & He, J. J., 1 Mar 2013, In : Stem Cells and Development. 22, 5, p. 689-694 6 p.

Research output: Contribution to journalArticle

17 Scopus citations

Erratum: HIV-1 Tat protein promotes neuronal dysfunction through disruption of microRNAs (The Journal of Biological Chemistry (2011) 286 (41125-41134))

Chang, J. R., Mukerjee, R., Bagashev, A., Del Valle, L., Chabrashvili, T., Hawkins, B. J., He, J. J. & Sawaya, B. E., 27 Sep 2013, In : Journal of Biological Chemistry. 288, 39, 1 p.

Research output: Contribution to journalComment/debate

Erratum: HIV-1 Tat protein promotes neuronal dysfunction through disruption of microRNAs (Journal of Biological Chemistry (2011) 286 (41125-41134) DOI:10.1074/jbc.A111.268466)

Chang, J. R., Mukerjee, R., Bagashev, A., Del Valle, L., Chabrashvili, T., Hawkins, B. J., He, J. J. & Sawaya, B. E., 22 Mar 2013, In : Journal of Biological Chemistry. 288, 12, 1 p.

Research output: Contribution to journalComment/debate

1 Scopus citations
3 Scopus citations

Inhibition of HCV Replication by Oxysterol-Binding Protein-Related Protein 4 (ORP4) through Interaction with HCV NS5B and Alteration of Lipid Droplet Formation

Park, I. W., Ndjomou, J., Wen, Y., Liu, Z., Ridgway, N. D., Kao, C. C. & He, J. J., 16 Sep 2013, In : PLoS ONE. 8, 9, e75648.

Research output: Contribution to journalArticle

11 Scopus citations

Inhibition of HIV-1 transcription and replication by a newly identified cyclin T1 splice variant

Gao, G., Wu, X., Zhou, J., He, M., He, J. J. & Guo, D., 17 May 2013, In : Journal of Biological Chemistry. 288, 20, p. 14297-14309 13 p.

Research output: Contribution to journalArticle

7 Scopus citations

Tip110 interacts with YB-1 and regulates each other's function

Timani, K. A., Liu, Y. & He, J. J., 4 Jul 2013, In : BMC Molecular Biology. 14, 14.

Research output: Contribution to journalArticle

10 Scopus citations
2012

CD59 incorporation protects hepatitis C virus against complement-mediated destruction

Amet, T., Ghabril, M., Chalasani, N., Byrd, D., Hu, N., Grantham, A., Liu, Z., Qin, X., He, J. J. & Yu, Q., 1 Feb 2012, In : Hepatology. 55, 2, p. 354-363 10 p.

Research output: Contribution to journalArticle

34 Scopus citations

Tip110 maintains expression of pluripotent factors in and pluripotency of human embryonic stem cells

Liu, Y., Lee, M. R., Timani, K. A., He, J. J. & Broxmeyer, H. E., 10 Apr 2012, In : Stem Cells and Development. 21, 6, p. 829-833 5 p.

Research output: Contribution to journalArticle

20 Scopus citations
2011

Activation of Egr-1 expression in astrocytes by HIV-1 Tat: New insights into astrocyte-mediated Tat neurotoxicity

Fan, Y., Zou, W., Green, L. A., Kim, B. O. & He, J. J., 1 Mar 2011, In : Journal of Neuroimmune Pharmacology. 6, 1, p. 121-129 9 p.

Research output: Contribution to journalArticle

33 Scopus citations

Cell signaling pathways and HIV-1 therapeutics

He, J. J., 1 Jun 2011, In : Journal of Neuroimmune Pharmacology. 6, 2, p. 173-176 4 p.

Research output: Contribution to journalReview article

HIV-1 tat protein promotes neuronal dysfunction through disruption of microRNAs

Chang, J. R., Mukerjee, R., Bagashev, A., Del Valle, L., Chabrashvili, T., Hawkins, B. J., He, J. J. & Sawaya, B. E., 25 Nov 2011, In : Journal of Biological Chemistry. 286, 47, p. 41125-41134 10 p.

Research output: Contribution to journalArticle

49 Scopus citations

TIP110/p110nrb/SART3/p110 regulation of hematopoiesis through CMYC

Liu, Y., Timani, K., Mantel, C., Fan, Y., Hangoc, G., Cooper, S., He, J. J. & Broxmeyer, H. E., 26 May 2011, In : Blood. 117, 21, p. 5643-5651 9 p.

Research output: Contribution to journalArticle

19 Scopus citations

Translational regulation of HIV-1 replication by HIV-1 rev cellular cofactors Sam68, eIF5A, hRIP, and DDX3

Liu, J., Henao-Mejia, J., Liu, H., Zhao, Y. & He, J. J., 1 Jun 2011, In : Journal of Neuroimmune Pharmacology. 6, 2, p. 308-321 14 p.

Research output: Contribution to journalArticle

42 Scopus citations