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2019

Angiotensin type 1a receptors in the median preoptic nucleus support intermittent hypoxia-induced hypertension

Shell, B., Farmer, G. E., Nedungadi, T. P., Wang, L. A., Marciante, A. B., Snyder, B., Cunningham, R. L. & Cunningham, J. T., 1 May 2019, In : American journal of physiology. Regulatory, integrative and comparative physiology. 316, 5, p. R651-R665

Research output: Contribution to journalArticleResearchpeer-review

Angiotensin Type 1 Receptor
Preoptic Area
Hypertension
Small Interfering RNA
Angiotensins

Effects of salt-loading on supraoptic vasopressin neurones assessed by ClopHensorN chloride imaging

Balapattabi, K., Farmer, G. E., Knapp, B. A., Little, J. T., Bachelor, M., Yuan, J. P. & Cunningham, J. T., 1 Jan 2019, In : Journal of Neuroendocrinology. 31, 8, e12752.

Research output: Contribution to journalArticleResearchpeer-review

Supraoptic Nucleus
Vasopressins
Chlorides
Arginine Vasopressin
Salts

Selectively inhibiting the median preoptic nucleus attenuates angiotensin II and hyperosmotic- induced drinking behavior and vasopressin release in adult male rats

Marciante, A. B., Wang, L. A., Farmer, G. E. & Cunningham, J. T., 1 Mar 2019, In : eNeuro. 6, 2, e0473-18.2019.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Drinking Behavior
Preoptic Area
Vasopressins
Angiotensin II
Designer Drugs

Sniffer cells for the detection of neural Angiotensin II in vitro

Farmer, G. E., Amune, A., Bachelor, M. E., Duong, P., Yuan, J. P. & Cunningham, J. T., 1 Dec 2019, In : Scientific Reports. 9, 1, 8820.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Neuropeptides
Angiotensin II
Cultured Cells
Angiotensin III
Optogenetics
2018
1 Citation (Scopus)

AT1a influences GABAA-mediated inhibition through regulation of KCC2 expression

Farmer, G. E., Balapattabi, K., Bachelor, M. E., Little, J. T. & Cunningham, J. T., 1 Nov 2018, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 315, 5, p. R972-R982

Research output: Contribution to journalArticleResearchpeer-review

Preoptic Area
Angiotensins
Angiotensin Type 1 Receptor
Neurons
Angiotensin II

High salt loading increases brain derived neurotrophic factor in supraoptic vasopressin neurones

Balapattabi, K., Little, J. T., Farmer, G. E. & Cunningham, J. T., 1 Nov 2018, In : Journal of Neuroendocrinology. 30, 11, e12639.

Research output: Contribution to journalArticleResearchpeer-review

Brain-Derived Neurotrophic Factor
Vasopressins
Salts
Supraoptic Nucleus
Neurons
2 Citations (Scopus)
Solitary Nucleus
Arterial Pressure
Transcription Factors
Sleep Apnea Syndromes
Green Fluorescent Proteins
2017
5 Citations (Scopus)

Angiotensin converting enzyme 1 in the median preoptic nucleus contributes to chronic intermittent hypoxia hypertension

Faulk, K. E., Nedungadi, T. P. & Cunningham, J. T., 1 May 2017, In : Physiological Reports. 5, 10, e13277.

Research output: Contribution to journalArticleResearchpeer-review

Preoptic Area
Peptidyl-Dipeptidase A
Hypertension
Blood Pressure
Angiotensin I
24 Citations (Scopus)

Chronic intermittent hypoxia induces oxidative stress and inflammation in brain regions associated with early-stage neurodegeneration

Snyder, B., Shell, B., Cunningham, J. T. & Cunningham, R. L., 1 May 2017, In : Physiological Reports. 5, 9, e13258.

Research output: Contribution to journalArticleResearchpeer-review

Encephalitis
Oxidative Stress
Neurodegenerative Diseases
Inflammation
Sleep Apnea Syndromes
5 Citations (Scopus)

Role of angiotensin-converting enzyme 1 within the median preoptic nucleus following chronic intermittent hypoxia

Faulk, K., Shell, B., Nedungadi, T. P. & Cunningham, J. T., 1 Jan 2017, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 312, 2, p. R245-R252

Research output: Contribution to journalArticleResearchpeer-review

Preoptic Area
Peptidyl-Dipeptidase A
Paraventricular Hypothalamic Nucleus
Enzymes
Renin-Angiotensin System
2016
5 Citations (Scopus)

Impaired sodium-evoked paraventricular nucleus neuronal activation and blood pressure regulation in conscious Sprague-Dawley rats lacking central Gαi2 proteins

Carmichael, C. Y., Carmichael, A. C. T., Kuwabara, J. T., Cunningham, J. T. & Wainford, R. D., 1 Jan 2016, In : Acta Physiologica. 216, 3, p. 314-329 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Paraventricular Hypothalamic Nucleus
Oligodeoxyribonucleotides
Sprague Dawley Rats
Sodium
Blood Pressure
20 Citations (Scopus)

Neural Control of Blood Pressure in Chronic Intermittent Hypoxia

Shell, B., Faulk, K. & Cunningham, J. T., 1 Mar 2016, In : Current Hypertension Reports. 18, 3, p. 1-9 9 p., 19.

Research output: Contribution to journalReview articleResearchpeer-review

Sleep Apnea Syndromes
Angiotensin II
Blood Pressure
Rhombencephalon
Paraventricular Hypothalamic Nucleus
2015
18 Citations (Scopus)

Angiotensin II type 1a receptors in subfornical organ contribute towards chronic intermittent hypoxia-associated sustained increase in mean arterial pressure

Saxena, A., Little, J. T., Nedungadi, T. P. & Cunningham, J. T., 1 Mar 2015, In : American Journal of Physiology - Heart and Circulatory Physiology. 308, 5, p. H435-H446

Research output: Contribution to journalArticleResearchpeer-review

Subfornical Organ
Angiotensin Type 1 Receptor
Arterial Pressure
Sleep Apnea Syndromes
Hypoxia
46 Citations (Scopus)

High Salt Intake Increases Blood Pressure via BDNF-Mediated Downregulation of KCC2 and Impaired Baroreflex Inhibition of Vasopressin Neurons

Choe, K. Y., Han, S. Y., Gaub, P., Shell, B., Voisin, D. L., Knapp, B. A., Barker, P. A., Brown, C. H., Cunningham, J. T. & Bourque, C. W., 4 Feb 2015, In : Neuron. 85, 3, p. 549-560 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Baroreflex
Brain-Derived Neurotrophic Factor
Vasopressins
Down-Regulation
Salts
12 Citations (Scopus)

Neurogenic mechanisms underlying the rapid onset of sympathetic responses to intermittent hypoxia

Mifflin, S. W., Cunningham, J. T. & Toney, G. M., 15 Dec 2015, In : Journal of Applied Physiology. 119, 12, p. 1441-1448 8 p.

Research output: Contribution to journalReview articleResearchpeer-review

Paraventricular Hypothalamic Nucleus
Solitary Nucleus
Hypothalamus
Hypertension
Angiotensin II
2014
5 Citations (Scopus)

ANG II receptor subtype 1a gene knockdown in the subfornical organ prevents increased drinking behavior in bile duct-ligated rats

Walch, J. D., Nedungadi, T. P. & Cunningham, J. T., 1 Jan 2014, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 307, 6, p. R597-R607

Research output: Contribution to journalArticleResearchpeer-review

Subfornical Organ
Gene Knockdown Techniques
Drinking Behavior
Bile Ducts
Ligation
11 Citations (Scopus)

Angiotensin II induces membrane trafficking of natively expressed transient receptor potential vanilloid type 4 channels in hypothalamic 4B cells

Saxena, A., Bachelor, M., Park, Y. H., Carreno, F. R., Nedungadi, T. P. & Cunningham, J. T., 1 Jan 2014, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 307, 8, p. R945-R955

Research output: Contribution to journalArticleResearchpeer-review

TRPV Cation Channels
Angiotensin II
Losartan
Membranes
Angiotensin Type 1 Receptor
10 Citations (Scopus)
Water Deprivation
Supraoptic Nucleus
Paraventricular Hypothalamic Nucleus
Vasopressins
Liver Cirrhosis
2013
24 Citations (Scopus)

Central losartan attenuates increases in arterial pressure and expression of FosB/ΔFosB along the autonomic axis associated with chronic intermittent hypoxia

David Knight, W., Saxena, A., Shell, B., Prashant Nedungadi, T., Mifflin, S. W. & Cunningham, J. T., 1 Nov 2013, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 305, 9

Research output: Contribution to journalArticleResearchpeer-review

Losartan
Arterial Pressure
Renin-Angiotensin System
Hypertension
Preoptic Area
33 Citations (Scopus)

Chronic intermittent hypoxia increases sympathetic control of blood pressure: Role of neuronal activity in the hypothalamic paraventricular nucleus

Sharpe, A. L., Calderon, A. S., Andrade, M. A., Cunningham, J. T., Mifflin, S. W. & Toney, G. M., 15 Dec 2013, In : American Journal of Physiology - Heart and Circulatory Physiology. 305, 12

Research output: Contribution to journalArticleResearchpeer-review

Paraventricular Hypothalamic Nucleus
Blood Pressure
Hypertension
Sleep Apnea Syndromes
Body Fluids
4 Citations (Scopus)

Intracerebroventricular losartan infusion modulates angiotensin II type 1 receptor expression in the subfornical organ and drinking behaviour in bile-duct-ligated rats

Walch, J. D., Carreño, F. R. & Cunningham, J. T., 1 Jan 2013, In : Experimental Physiology. 98, 4, p. 922-933 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Subfornical Organ
Intraventricular Infusions
Drinking Behavior
Angiotensin Type 1 Receptor
Losartan
16 Citations (Scopus)

Knockdown of tyrosine hydroxylase in the nucleus of the solitary tract reduces elevated blood pressure during chronic intermittent hypoxia

Bathina, C. S., Rajulapati, A., Franzke, M., Yamamoto, K., Cunningham, J. T. & Mifflin, S. W., 1 Nov 2013, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 305, 9

Research output: Contribution to journalArticleResearchpeer-review

Solitary Nucleus
Tyrosine 3-Monooxygenase
Blood Pressure
Arterial Pressure
Small Interfering RNA
29 Citations (Scopus)

Nuclear factor κB mediates suppression of canonical transient receptor potential 6 expression by reactive oxygen species and protein kinase C in kidney cells

Wang, Y., Ding, M., Chaudhari, S., Ding, Y., Yuan, J. P., Stankowska, D. L., He, S., Krishnamoorthy, R., Cunningham, J. T. & Ma, R., 3 May 2013, In : Journal of Biological Chemistry. 288, 18, p. 12852-12865 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Protein Kinase C
Reactive Oxygen Species
Acetates
Kidney
Phosphorylation
2012
28 Citations (Scopus)

An essential role for ΔFosB in the median preoptic nucleus in the sustained hypertensive effects of chronic intermittent hypoxia

Cunningham, J. T., Knight, W. D., Mifflin, S. W. & Nestler, E. J., 1 Jul 2012, In : Hypertension. 60, 1, p. 179-187 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Preoptic Area
Obstructive Sleep Apnea
Green Fluorescent Proteins
Arterial Pressure
Hypertension
39 Citations (Scopus)

Expression and distribution of TRPV2 in rat brain

Nedungadi, T. P., Dutta, M., Bathina, C. S., Caterina, M. J. & Cunningham, J. T., 1 Sep 2012, In : Experimental Neurology. 237, 1, p. 223-237 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Supraoptic Nucleus
Rhombencephalon
Solitary Nucleus
Arginine Vasopressin
Paraventricular Hypothalamic Nucleus
18 Citations (Scopus)

Region-Specific Changes in Transient Receptor Potential Vanilloid Channel Expression in the Vasopressin Magnocellular System in Hepatic Cirrhosis-Induced Hyponatraemia

Nedungadi, T. P., Carreño, F. R., Walch, J. D., Bathina, C. S. & Cunningham, J. T., 1 Apr 2012, In : Journal of Neuroendocrinology. 24, 4, p. 642-652 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Transient Receptor Potential Channels
Hyponatremia
Supraoptic Nucleus
Bile Ducts
Vasopressins
2 Citations (Scopus)

Selective Up-Regulation of JunD Transcript and Protein Expression in Vasopressinergic Supraoptic Nucleus Neurones in Water-Deprived Rats

Yao, S. T., Gouraud, S. S., Qiu, J., Cunningham, J. T., Paton, J. F. R. & Murphy, D., 1 Dec 2012, In : Journal of Neuroendocrinology. 24, 12, p. 1542-1552 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Supraoptic Nucleus
Up-Regulation
Dehydration
Water Deprivation
Neurons
6 Citations (Scopus)

ΔFosB in the supraoptic nucleus contributes to hyponatremia in rats with cirrhosis

Cunningham, J. T., Nedungadi, T. P., Walch, J. D., Nestler, E. J. & Gottlieb, H. B., 15 Jul 2012, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 303, 2

Research output: Contribution to journalArticleResearchpeer-review

Supraoptic Nucleus
Hyponatremia
Bile Ducts
Ligation
Fibrosis
2011
20 Citations (Scopus)

Brain-Derived Neurotrophic Factor-Tyrosine Kinase B Pathway Mediates NMDA Receptor NR2B Subunit Phosphorylation in the Supraoptic Nuclei Following Progressive Dehydration

Carreño, F. R., Walch, J. D., Dutta, M., Nedungadi, T. P. & Cunningham, J. T., 1 Oct 2011, In : Journal of Neuroendocrinology. 23, 10, p. 894-905 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Supraoptic Nucleus
Brain-Derived Neurotrophic Factor
Dehydration
Water Deprivation
Protein-Tyrosine Kinases
56 Citations (Scopus)

Chronic intermittent hypoxia increases blood pressure and expression of FosB/ΔFosB in central autonomic regions

Knight, W. D., Little, J. T., Carreno, F. R., Toney, G. M., Mifflin, S. W. & Cunningham, J. T., 1 Jul 2011, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 301, 1

Research output: Contribution to journalArticleResearchpeer-review

Blood Pressure
Staining and Labeling
Arterial Pressure
Hypoxia
Transcription Factor AP-1
3 Citations (Scopus)

Role of superior laryngeal nerve and Fos staining following dehydration and rehydration in the rat

Gottlieb, H. B., Ji, L. L. & Cunningham, J. T., 24 Oct 2011, In : Physiology and Behavior. 104, 5, p. 1053-1058 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Laryngeal Nerves
Fluid Therapy
Dehydration
Staining and Labeling
Water Deprivation
2010
8 Citations (Scopus)
Water Deprivation
Fluid Therapy
Dehydration
Neurons
Supraoptic Nucleus