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2019
1 Citation (Scopus)

Clotam enhances anti-proliferative effect of vincristine in Ewing sarcoma cells

Shelake, S., Sankpal, U. T., Eslin, D., Bowman, P., Simecka, J., Raut, S. L., Ray, A. & Basha, R. M., 15 Feb 2019, In : Apoptosis. 24, 1-2, p. 21-32 12 p.

Research output: Contribution to journalArticle

Ewing's Sarcoma
Vincristine
Cells
Caspase 7
Cell Survival
2 Citations (Scopus)

Copper-tolfenamic acid: evaluation of stability and anti-cancer activity

Hurtado, M., Sankpal, U. T., Chhabra, J., Brown, D. T., Maram, R., Patel, R., Gurung, R. K., Simecka, J., Holder, A. A. & Basha, R. M., 15 Feb 2019, In : Investigational New Drugs. 37, 1, p. 27-34 8 p.

Research output: Contribution to journalArticle

Copper
Neoplasms
Powders
tolfenamic acid
Cell Line

Primary care clinics can be a source of exposure to virulent Clostridium (now Clostridioides) difficile: An environmental screening study of hospitals and clinics in Dallas-Fort Worth region

Simecka, J. W., Fulda, K. G., Pulse, M., Lee, J. H., Vitucci, J., Nguyen, P., Taylor, P., Filipetto, F., Espinoza, A. M. & Sharma, S., 1 Jan 2019, In : PLoS ONE. 14, 8, e0220646.

Research output: Contribution to journalArticle

Open Access
Clostridium
Primary Health Care
Screening
Contamination
Pathogens
2018
7 Citations (Scopus)

Activity of meropenem-vaborbactam against carbapenem- resistant enterobacteriaceae in a murine model of pyelonephritis

Weiss, W. J., Pulse, M. E., Nguyen, P., Peterson, K., Silva, J., Simecka, J. W., Valtierra, D., Sabet, M. & Griffith, D. C., Jan 2018, In : Antimicrobial agents and chemotherapy. 62, 1, e01439.

Research output: Contribution to journalArticle

meropenem
Carbapenems
Pyelonephritis
Enterobacteriaceae
Klebsiella pneumoniae
2 Citations (Scopus)

Interleukin-17A exacerbates disease severity in BALB/c mice susceptible to lung infection with Mycoplasma pulmonis

Mize, M. T., Sun, X. L. & Simecka, J., 1 Sep 2018, In : Infection and Immunity. 86, 9, e00292-18.

Research output: Contribution to journalArticle

Mycoplasma pulmonis
Interleukin-17
Lung
Mycoplasma Infections
Infection
2016
13 Citations (Scopus)

Association of Sp1 and survivin in epithelial ovarian cancer: Sp1 inhibitor and cisplatin, a novel combination for inhibiting epithelial ovarian cancer cell proliferation

Sankpal, U. T., Ingersoll, S. B., Ahmad, S., Holloway, R. W., Bhat, V. B., Simecka, J., Daniel, L., Kariali, E., Vishwanatha, J. K. & Basha, R. M., 1 Oct 2016, In : Tumor Biology. 37, 10, p. 14259-14269 11 p.

Research output: Contribution to journalArticle

Cisplatin
Cell Proliferation
Proteins
Proteomics
Reactive Oxygen Species
30 Citations (Scopus)

Combination of Tolfenamic acid and curcumin induces colon cancer cell growth inhibition through modulating specific transcription factors and reactive oxygen species

Sankpal, U. T., Nagaraju, G. P., Gottipolu, S. R., Hurtado, M., Jordan, C. G., Simecka, J. W., Shoji, M., El-Rayes, B. & Basha, R., 1 Jan 2016, In : Oncotarget. 7, 3, p. 3186-3200 15 p.

Research output: Contribution to journalArticle

Curcumin
Colonic Neoplasms
Reactive Oxygen Species
Transcription Factors
Growth
9 Citations (Scopus)

Regulatory CD4+ CD25+ T cells dampen inflammatory disease in murine mycoplasma pneumonia and promote IL-17 and IFN-γ Responses

Odeh, A. N. & Simecka, J., 1 May 2016, In : PLoS ONE. 11, 5, e0155648.

Research output: Contribution to journalArticle

Mycoplasma pneumoniae
Mycoplasma Pneumonia
T-cells
Interleukin-17
Mycoplasma
17 Citations (Scopus)
Spices
Curcumin
NF-kappa B
Pancreatic Neoplasms
Cell Cycle
9 Citations (Scopus)

Thiopurine prodrugs mediate immunosuppressive effects by interfering with Rac1 protein function

Shin, J. Y., Wey, M., Umutesi, H. G., Sun, X., Simecka, J. & Heo, J., 24 Jun 2016, In : Journal of Biological Chemistry. 291, 26, p. 13699-13714 16 p.

Research output: Contribution to journalArticle

rac1 GTP-Binding Protein
Prodrugs
6-Mercaptopurine
Immunosuppressive Agents
T-cells
2014
4 Citations (Scopus)

Antigen-pulsed bone marrow-derived and pulmonary dendritic cells promote Th2 cell responses and immunopathology in lungs during the pathogenesis of murine mycoplasma pneumonia

Dobbs, N. A., Zhou, X., Pulse, M., Hodge, L. M., Schoeb, T. R. & Simecka, J., 1 Aug 2014, In : Journal of Immunology. 193, 3, p. 1353-1363 11 p.

Research output: Contribution to journalArticle

Mycoplasma Pneumonia
Th2 Cells
Mycoplasma
Dendritic Cells
Bone Marrow
2013
11 Citations (Scopus)

Dendritic Cells Are the Major Antigen Presenting Cells in Inflammatory Lesions of Murine Mycoplasma Respiratory Disease

Sun, X., Jones, H. P., Dobbs, N., Bodhankar, S. & Simecka, J. W., 4 Feb 2013, In : PLoS ONE. 8, 2, e55984.

Research output: Contribution to journalArticle

Pulmonary diseases
antigen-presenting cells
Mycoplasma
Antigen-Presenting Cells
dendritic cells
14 Citations (Scopus)

Interleukin-23 (IL-23) deficiency disrupts Th17 and Th1-related defenses against Streptococcus pneumoniae infection

Kim, B. J., Lee, S., Berg, R., Simecka, J. & Jones, H., 1 Oct 2013, In : Cytokine. 64, 1, p. 375-381 7 p.

Research output: Contribution to journalArticle

Interleukin-23
Pneumococcal Infections
Lung
Interleukin-17
Therapeutic Irrigation
23 Citations (Scopus)

Perturbation of Staphylococcus aureus gene expression by the enoyl-acyl carrier protein reductase inhibitor AFN-1252

Parsons, J. B., Kukula, M., Jackson, P., Pulse, M., Simecka, J., Valtierra, D., Weiss, W., Kaplan, N. & Rock, C. O., 1 May 2013, In : Antimicrobial agents and chemotherapy. 57, 5, p. 2182-2190 9 p.

Research output: Contribution to journalArticle

Acyl Carrier Protein
Staphylococcus aureus
Oxidoreductases
Gene Expression
Virulence Factors
2 Citations (Scopus)

What we have learned from animal models of Mycoplasma pneumoniae disease: Virulence mechanisms and host responses

Simecka, J., 1 Jan 2013, In : Current Pediatric Reviews. 9, 4, p. 314-323 10 p.

Research output: Contribution to journalReview article

Mycoplasma pneumoniae
Virulence
Animal Models
Mycoplasma
Mycoplasma Infections
2012
23 Citations (Scopus)

Oral Inoculation of Young Dairy Calves with Mycoplasma bovis Results in Colonization of Tonsils, Development of Otitis Media and Local Immunity

Maunsell, F., Brown, M. B., Powe, J., Ivey, J., Woolard, M., Love, W. & Simecka, J. W., 6 Sep 2012, In : PLoS ONE. 7, 9, e44523.

Research output: Contribution to journalArticle

Mycoplasma bovis
otitis media
Pulmonary diseases
dairy calves
Dairies
2011
10 Citations (Scopus)
Corticotropin-Releasing Hormone Receptors
Pneumococcal Infections
Lung
Sepsis
Growth
38 Citations (Scopus)

Small molecule inhibitors of staphylococcus aureus RnpA alter cellular mRNA turnover, exhibit antimicrobial activity, and attenuate pathogenesis

Olson, P. D., Kuechenmeister, L. J., Anderson, K. L., Daily, S., Beenken, K. E., Roux, C. M., Reniere, M. L., Lewis, T. L., Weiss, W. J., Pulse, M., Nguyen, P., Simecka, J. W., Morrison, J. M., Sayood, K., Asojo, O. A., Smeltzer, M. S., Skaar, E. P. & Dunman, P. M., 1 Feb 2011, In : PLoS Pathogens. 7, 2, e1001287.

Research output: Contribution to journalArticle

RNA Stability
Staphylococcus aureus
Messenger RNA
Vancomycin
Methicillin-Resistant Staphylococcus aureus
2010
13 Citations (Scopus)
Mycoplasma
Adaptive Immunity
Interleukin-4
Interferons
Mycoplasma Infections
7 Citations (Scopus)

Peri- and intra-operative management of the goat during acute surgical experimentation

Flaherty, D. C., Hoxha, B., Nelson, S., Sun, J., Gurji, H., Simecka, J., Mallet, R. T., Yurvati, A. & Daniels, E. Q., 1 Mar 2010, In : Lab Animal. 39, 3, p. 80-85 6 p.

Research output: Contribution to journalArticle

Goats
goats
Animal Models
animal models
Coxiella burnetii
4 Citations (Scopus)

Pyruvate-enriched resuscitation protects hindlimb muscle from ischemia-reperfusion injury

Flaherty, D. C., Hoxha, B., Sun, J., Gurji, H., Simecka, J., Yurvati, A. & Mallet, R. T., 1 Jan 2010, In : Military Medicine. 175, 12, p. 1020-1026 7 p.

Research output: Contribution to journalArticle

Hindlimb
Reperfusion Injury
Pyruvic Acid
Resuscitation
Muscles
24 Citations (Scopus)

Pyruvate-fortified fluid resuscitation improves hemodynamic stability while suppressing systemic inflammation and myocardial oxidative strees after hemorrhagic shock

Flaherty, D. C., Hoxha, B., Sun, J., Gurji, H., Simecka, J., Mallet, R. T. & Yurvati, A., 1 Jan 2010, In : Military Medicine. 175, 3, p. 166-172 7 p.

Research output: Contribution to journalArticle

Hemorrhagic Shock
Pyruvic Acid
Resuscitation
Hemodynamics
Inflammation
25 Citations (Scopus)

Toll-like receptor 2 (TLR2) plays a major role in innate resistance in the lung against murine mycoplasma

Love, W., Dobbs, N., Tabor, L. & Simecka, J. W., 17 Sep 2010, In : PLoS ONE. 5, 5, e10739.

Research output: Contribution to journalArticle

Toll-Like Receptor 2
Mycoplasma
Mycoplasma pulmonis
lungs
Lung