2019
1
Citation
(Scopus)
Clotam enhances anti-proliferative effect of vincristine in Ewing sarcoma cells
Shelake, S., Sankpal, U. T., Eslin, D., Bowman, P., Simecka, J., Raut, S. L., Ray, A. & Basha, R. M., 15 Feb 2019, In : Apoptosis. 24, 1-2, p. 21-32 12 p.Research output: Contribution to journal › Article › Research › peer-review
Ewing's Sarcoma
Vincristine
Cells
Caspase 7
Cell Survival
1
Citation
(Scopus)
Copper-tolfenamic acid: evaluation of stability and anti-cancer activity
Hurtado, M., Sankpal, U. T., Chhabra, J., Brown, D. T., Maram, R., Patel, R., Gurung, R. K., Simecka, J., Holder, A. A. & Basha, R. M., 15 Feb 2019, In : Investigational New Drugs. 37, 1, p. 27-34 8 p.Research output: Contribution to journal › Article › Research › peer-review
Copper
Neoplasms
Powders
tolfenamic acid
Cell Line
2018
6
Citations
(Scopus)
Activity of meropenem-vaborbactam against carbapenem- resistant enterobacteriaceae in a murine model of pyelonephritis
Weiss, W., Pulse, M. E., Nguyen, P., Peterson, K., Silva, J., Simecka, J., Valtierra, D., Sabet, M. & Griffith, D. C., 1 Jan 2018, In : Antimicrobial Agents and Chemotherapy. 62, 1, e01439.Research output: Contribution to journal › Article › Research › peer-review
meropenem
Carbapenems
Pyelonephritis
Enterobacteriaceae
Klebsiella pneumoniae
1
Citation
(Scopus)
Interleukin-17A exacerbates disease severity in BALB/c mice susceptible to lung infection with Mycoplasma pulmonis
Mize, M. T., Sun, X. L. & Simecka, J., 1 Sep 2018, In : Infection and Immunity. 86, 9, e00292-18.Research output: Contribution to journal › Article › Research › peer-review
Mycoplasma pulmonis
Interleukin-17
Lung
Mycoplasma Infections
Infection
2016
11
Citations
(Scopus)
Association of Sp1 and survivin in epithelial ovarian cancer: Sp1 inhibitor and cisplatin, a novel combination for inhibiting epithelial ovarian cancer cell proliferation
Sankpal, U. T., Ingersoll, S. B., Ahmad, S., Holloway, R. W., Bhat, V. B., Simecka, J., Daniel, L., Kariali, E., Vishwanatha, J. K. & Basha, R. M., 1 Oct 2016, In : Tumor Biology. 37, 10, p. 14259-14269 11 p.Research output: Contribution to journal › Article › Research › peer-review
Cisplatin
Cell Proliferation
Proteins
Proteomics
Reactive Oxygen Species
28
Citations
(Scopus)
Combination of Tolfenamic acid and curcumin induces colon cancer cell growth inhibition through modulating specific transcription factors and reactive oxygen species
Sankpal, U. T., Nagaraju, G. P., Gottipolu, S. R., Hurtado, M., Jordan, C. G., Simecka, J., Shoji, M., El-Rayes, B. & Basha, R. M., 1 Jan 2016, In : Oncotarget. 7, 3, p. 3186-3200 15 p.Research output: Contribution to journal › Article › Research › peer-review
Curcumin
Colonic Neoplasms
Reactive Oxygen Species
Transcription Factors
Growth
5
Citations
(Scopus)
Regulatory CD4+ CD25+ T cells dampen inflammatory disease in murine mycoplasma pneumonia and promote IL-17 and IFN-γ Responses
Odeh, A. N. & Simecka, J., 1 May 2016, In : PLoS ONE. 11, 5, e0155648.Research output: Contribution to journal › Article › Research › peer-review
Mycoplasma pneumoniae
Mycoplasma Pneumonia
T-cells
Interleukin-17
Mycoplasma
15
Citations
(Scopus)
Small molecule tolfenamic acid and dietary spice curcumin treatment enhances antiproliferative effect in pancreatic cancer cells via suppressing Sp1, disrupting NF-kB translocation to nucleus and cell cycle phase distribution
Basha, R. M., Connelly, S. F., Sankpal, U. T., Nagaraju, G. P., Patel, H., Vishwanatha, J. K., Shelake, S., Tabor-Simecka, L., Shoji, M., Simecka, J. & El-Rayes, B., 1 May 2016, In : Journal of Nutritional Biochemistry. 31, p. 77-87 11 p.Research output: Contribution to journal › Article › Research › peer-review
Spices
Curcumin
NF-kappa B
Pancreatic Neoplasms
Cell Cycle
8
Citations
(Scopus)
Thiopurine prodrugs mediate immunosuppressive effects by interfering with Rac1 protein function
Shin, J. Y., Wey, M., Umutesi, H. G., Sun, X., Simecka, J. & Heo, J., 24 Jun 2016, In : Journal of Biological Chemistry. 291, 26, p. 13699-13714 16 p.Research output: Contribution to journal › Article › Research › peer-review
rac1 GTP-Binding Protein
Prodrugs
6-Mercaptopurine
Immunosuppressive Agents
T-cells
2014
4
Citations
(Scopus)
Antigen-pulsed bone marrow-derived and pulmonary dendritic cells promote Th2 cell responses and immunopathology in lungs during the pathogenesis of murine mycoplasma pneumonia
Dobbs, N. A., Zhou, X., Pulse, M., Hodge, L. M., Schoeb, T. R. & Simecka, J., 1 Aug 2014, In : Journal of Immunology. 193, 3, p. 1353-1363 11 p.Research output: Contribution to journal › Article › Research › peer-review
Mycoplasma Pneumonia
Th2 Cells
Mycoplasma
Dendritic Cells
Bone Marrow
2013
9
Citations
(Scopus)
Dendritic Cells Are the Major Antigen Presenting Cells in Inflammatory Lesions of Murine Mycoplasma Respiratory Disease
Sun, X. L., Jones, H., Dobbs, N., Bodhankar, S. & Simecka, J., 4 Feb 2013, In : PLoS ONE. 8, 2, e55984.Research output: Contribution to journal › Article › Research › peer-review
Pulmonary diseases
antigen-presenting cells
Mycoplasma
Antigen-Presenting Cells
dendritic cells
14
Citations
(Scopus)
Interleukin-23 (IL-23) deficiency disrupts Th17 and Th1-related defenses against Streptococcus pneumoniae infection
Kim, B. J., Lee, S., Berg, R., Simecka, J. & Jones, H., 1 Oct 2013, In : Cytokine. 64, 1, p. 375-381 7 p.Research output: Contribution to journal › Article › Research › peer-review
Interleukin-23
Pneumococcal Infections
Lung
Interleukin-17
Therapeutic Irrigation
22
Citations
(Scopus)
Perturbation of Staphylococcus aureus gene expression by the enoyl-acyl carrier protein reductase inhibitor AFN-1252
Parsons, J. B., Kukula, M., Jackson, P., Pulse, M., Simecka, J., Valtierra, D., Weiss, W., Kaplan, N. & Rock, C. O., 1 May 2013, In : Antimicrobial Agents and Chemotherapy. 57, 5, p. 2182-2190 9 p.Research output: Contribution to journal › Article › Research › peer-review
Acyl Carrier Protein
Staphylococcus aureus
Oxidoreductases
Gene Expression
Virulence Factors
2
Citations
(Scopus)
What we have learned from animal models of Mycoplasma pneumoniae disease: Virulence mechanisms and host responses
Simecka, J., 1 Jan 2013, In : Current Pediatric Reviews. 9, 4, p. 314-323 10 p.Research output: Contribution to journal › Review article › Research › peer-review
Mycoplasma pneumoniae
Virulence
Animal Models
Mycoplasma
Mycoplasma Infections
2012
22
Citations
(Scopus)
Oral Inoculation of Young Dairy Calves with Mycoplasma bovis Results in Colonization of Tonsils, Development of Otitis Media and Local Immunity
Maunsell, F., Brown, M. B., Powe, J., Ivey, J., Woolard, M., Love, W. & Simecka, J., 6 Sep 2012, In : PLoS ONE. 7, 9, e44523.Research output: Contribution to journal › Article › Research › peer-review
Mycoplasma bovis
otitis media
Pulmonary diseases
dairy calves
Dairies
2011
10
Citations
(Scopus)
Corticotropin-releasing hormone receptor-1 and 2 activity produces divergent resistance against stress-induced pulmonary Streptococcus pneumoniae infection
Kim, B. J., Kayembe, K., Simecka, J., Pulse, M. & Jones, H., 15 Aug 2011, In : Journal of Neuroimmunology. 237, 1-2, p. 57-65 9 p.Research output: Contribution to journal › Article › Research › peer-review
Corticotropin-Releasing Hormone Receptors
Pneumococcal Infections
Lung
Sepsis
Growth
37
Citations
(Scopus)
Small molecule inhibitors of staphylococcus aureus RnpA alter cellular mRNA turnover, exhibit antimicrobial activity, and attenuate pathogenesis
Olson, P. D., Kuechenmeister, L. J., Anderson, K. L., Daily, S., Beenken, K. E., Roux, C. M., Reniere, M. L., Lewis, T. L., Weiss, W., Pulse, M., Nguyen, P., Simecka, J., Morrison, J. M., Sayood, K., Asojo, O. A., Smeltzer, M. S., Skaar, E. P. & Dunman, P. M., 1 Feb 2011, In : PLoS Pathogens. 7, 2, e1001287.Research output: Contribution to journal › Article › Research › peer-review
RNA Stability
Staphylococcus aureus
Messenger RNA
Vancomycin
Methicillin-Resistant Staphylococcus aureus
2010
11
Citations
(Scopus)
Interferon γ and interleukin 4 have contrasting effects on immunopathology and the development of protective adaptive immunity against mycoplasma respiratory disease
Bodhankar, S., Sun, X. L., Woolard, M. D. & Simecka, J., 1 Jul 2010, In : Journal of Infectious Diseases. 202, 1, p. 39-51 13 p.Research output: Contribution to journal › Article › Research › peer-review
Mycoplasma
Adaptive Immunity
Interleukin-4
Interferons
Mycoplasma Infections
7
Citations
(Scopus)
Peri- and intra-operative management of the goat during acute surgical experimentation
Flaherty, D. C., Hoxha, B., Nelson, S., Sun, J., Gurji, H., Simecka, J., Mallet, R. T., Yurvati, A. & Daniels, E. Q., 1 Mar 2010, In : Lab Animal. 39, 3, p. 80-85 6 p.Research output: Contribution to journal › Article › Research › peer-review
Goats
goats
Animal Models
animal models
Coxiella burnetii
4
Citations
(Scopus)
Pyruvate-enriched resuscitation protects hindlimb muscle from ischemia-reperfusion injury
Flaherty, D. C., Hoxha, B., Sun, J., Gurji, H., Simecka, J., Yurvati, A. & Mallet, R. T., 1 Jan 2010, In : Military Medicine. 175, 12, p. 1020-1026 7 p.Research output: Contribution to journal › Article › Research › peer-review
Hindlimb
Reperfusion Injury
Pyruvic Acid
Resuscitation
Muscles
24
Citations
(Scopus)
Pyruvate-fortified fluid resuscitation improves hemodynamic stability while suppressing systemic inflammation and myocardial oxidative strees after hemorrhagic shock
Flaherty, D. C., Hoxha, B., Sun, J., Gurji, H., Simecka, J., Mallet, R. T. & Yurvati, A., 1 Jan 2010, In : Military Medicine. 175, 3, p. 166-172 7 p.Research output: Contribution to journal › Article › Research › peer-review
Hemorrhagic Shock
Pyruvic Acid
Resuscitation
Hemodynamics
Inflammation
25
Citations
(Scopus)
Toll-like receptor 2 (TLR2) plays a major role in innate resistance in the lung against murine mycoplasma
Love, W., Dobbs, N., Tabor, L. & Simecka, J., 17 Sep 2010, In : PLoS ONE. 5, 5, e10739.Research output: Contribution to journal › Article › Research › peer-review
Toll-Like Receptor 2
Mycoplasma
Mycoplasma pulmonis
lungs
Lung