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2019

A novel serum free primary astrocyte culture method that mimic quiescent astrocyte phenotype

Prah, J., Winters, A., Chaudhari, K., Hersh, J., Liu, R. & Yang, S., 15 May 2019, In : Journal of Neuroscience Methods. 320, p. 50-63 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Astrocytes
Phenotype
Serum
Fibroblast Growth Factor 2
Epidermal Growth Factor
2018
3 Citations (Scopus)

Artemisinin prevents glutamate-induced neuronal cell death via Akt pathway activation

Lin, S. P., Li, W., Winters, A., Liu, R. & Yang, S., 20 Apr 2018, In : Frontiers in Cellular Neuroscience. 12, 108.

Research output: Contribution to journalArticleResearchpeer-review

Glutamic Acid
Cell Death
artemisinine
Mitochondrial Membrane Potential
Antimalarials
2 Citations (Scopus)

Experimental ischemic stroke induces long-term T cell activation in the brain

Xie, L., Li, W., Hersh, J., Liu, R. & Yang, S., 1 Jan 2018, (Accepted/In press) In : Journal of Cerebral Blood Flow and Metabolism.

Research output: Contribution to journalArticleResearchpeer-review

Stroke
T-Lymphocytes
Brain
Perforin
Interleukin-17
3 Citations (Scopus)

Hyperglycemia alters astrocyte metabolism and inhibits astrocyte proliferation

Li, W., Choudhury, G. R., Winters, A., Prah, J., Lin, W., Liu, R. & Yang, S., 1 Jan 2018, In : Aging and Disease. 9, 4, p. 674-684 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Astrocytes
Hyperglycemia
Glucose
Energy Metabolism
Cyclin D3
1 Citation (Scopus)

Precision Medicine for Ischemic Stroke, Let Us Move Beyond Time Is Brain

Yang, S., Lou, M., Luo, B., Jiang, W. J. & Liu, R., 1 Apr 2018, In : Translational Stroke Research. 9, 2, p. 93-95 3 p.

Research output: Contribution to journalEditorialResearch

Precision Medicine
Stroke
Brain
2017
4 Citations (Scopus)

Administration of 5-methoxyindole-2-carboxylic acid that potentially targets mitochondrial dihydrolipoamide dehydrogenase confers cerebral preconditioning against ischemic stroke injury

Wu, J., Li, R., Li, W., Ren, M., Thangthaeng, N., Sumien, N., Liu, R., Yang, S., Simpkins, J. W., Forster, M. J. & Yan, L-J., 1 Dec 2017, In : Free Radical Biology and Medicine. 113, p. 244-254 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Dihydrolipoamide Dehydrogenase
Ischemic Preconditioning
Stroke
Wounds and Injuries
5-methoxyindole-2-carboxylic acid
15 Citations (Scopus)

Alternative mitochondrial electron transfer for the treatment of neurodegenerative diseases and cancers: Methylene blue connects the dots

Yang, S., Li, W., Sumien, N., Forster, M. J., Simpkins, J. W. & Liu, R., 1 Oct 2017, In : Progress in Neurobiology. 157, p. 273-291 19 p.

Research output: Contribution to journalReview articleResearchpeer-review

Methylene Blue
Neurodegenerative Diseases
Electrons
Energy Metabolism
Oxidative Phosphorylation
1 Citation (Scopus)

Cerebral Autoregulation

Yang, S. & Liu, R., 7 Mar 2017, Primer on Cerebrovascular Diseases: Second Edition. Elsevier Inc., p. 57-60 4 p.

Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review

Homeostasis
Cerebrovascular Circulation
Arterial Pressure
Blood Pressure
Brain

Methylene blue inhibits GABAA receptors by interaction with GABA binding site

Chen, Z., Liu, R., Yang, S., Dillon, G. H. & Huang, R-Q., 1 Jun 2017, In : Neuropharmacology. 119, p. 100-110 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Methylene Blue
GABA-A Receptors
gamma-Aminobutyric Acid
Binding Sites
Picrotoxin
2016
1 Citation (Scopus)

For the pursuit of oxygen and carbon dioxide channels in mitochondria

Yang, S. & Liu, R., 1 Oct 2016, In : Medical Gas Research. 6, 4, p. 237-238 2 p.

Research output: Contribution to journalEditorialResearch

Carbon Dioxide
Mitochondria
Oxygen
8 Citations (Scopus)

Methylene blue ameliorates ischemia/reperfusion-induced cerebral edema: An MRI and transmission electron microscope study

Fang, Q., Yan, X., Li, S., Sun, Y., Xu, L., Shi, Z., Wu, M., Lu, Y., Dong, L., Liu, R., Yuan, F. & Yang, S., 1 Jan 2016, Acta Neurochirurgica, Supplementum. Springer-Verlag Wien, p. 227-236 10 p. (Acta Neurochirurgica, Supplementum; vol. 121).

Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review

Methylene Blue
Middle Cerebral Artery Infarction
Transient Ischemic Attack
Brain Edema
Neuroprotective Agents
6 Citations (Scopus)

Neuroglobin Overexpression Inhibits AMPK Signaling and Promotes Cell Anabolism

Cai, B., Li, W., Mao, X. O., Winters, A., Ryou, M. G., Liu, R., Greenberg, D. A., Wang, N., Jin, K. & Yang, S., 1 Mar 2016, In : Molecular Neurobiology. 53, 2, p. 1254-1265 12 p.

Research output: Contribution to journalArticleResearchpeer-review

AMP-Activated Protein Kinases
Glycogen
Globins
Neurons
Brain
2015
14 Citations (Scopus)

Chemotherapeutic effect of tamoxifen on temozolomide-resistant gliomas

He, W., Liu, R., Yang, S. & Yuan, F., 1 Jan 2015, In : Anti-Cancer Drugs. 26, 3, p. 293-300 8 p.

Research output: Contribution to journalArticleResearchpeer-review

temozolomide
Tamoxifen
Glioma
Cell Line
Apoptosis
30 Citations (Scopus)

Methylene blue-induced neuronal protective mechanism against hypoxia-reoxygenation stress

Ryou, M. G., Choudhury, G. R., Li, W., Winters, A., Yuan, F., Liu, R. & Yang, S., 1 Aug 2015, In : Neuroscience. 301, p. 193-203 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Hypoxia-Inducible Factor 1
Methylene Blue
Glucose
Erythropoietin
Oxygen
14 Citations (Scopus)

Methylene blue protects astrocytes against glucose oxygen deprivation by improving cellular respiration

Choudhury, G. R., Winters, A., Rich, R. M., Ryou, M. G., Gryczynski, Z., Yuan, F., Yang, S. & Liu, R., 7 Apr 2015, In : PLoS ONE. 10, 4, e0123096.

Research output: Contribution to journalArticleResearchpeer-review

Cell Respiration
methylene blue
Methylene Blue
astrocytes
cell respiration
2014
8 Citations (Scopus)

In vitro protection by pyruvate against cadmium-induced cytotoxicity in hippocampal HT-22 cells

Poteet, E., Winters, A., Xie, L., Ryou, M. G., Liu, R. & Yang, S., 1 Jan 2014, In : Journal of Applied Toxicology. 34, 8, p. 903-913 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Cytotoxicity
Pyruvic Acid
Cadmium
Mitochondrial Membrane Potential
Glycolysis
4 Citations (Scopus)

Methylene blue promotes quiescence of rat neural progenitor cells

Xie, L., Choudhury, G. R., Wang, J., Park, Y., Liu, R., Yuan, F., Zhang, C. L., Yorio, T., Jin, K. & Yang, S., 7 Oct 2014, In : Frontiers in Cellular Neuroscience. 8, OCT, 315.

Research output: Contribution to journalArticleResearchpeer-review

Methylene Blue
Stem Cells
Intraventricular Infusions
Cyclins
Neural Stem Cells
2013
7 Citations (Scopus)

Astroglial PTEN loss disrupts neuronal lamination by dysregulating radial glia-guided neuronal migration

Wen, Y., Li, W., Choudhury, G. R., He, R., Yang, T., Liu, R., Jin, K. & Yang, S., 1 Jan 2013, In : Aging and Disease. 4, 3, p. 113-126 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Neuroglia
Transgenic Mice
Cerebellum
Hippocampus
Central Nervous System

Erratum: Reversing the Warburg effect as a treatment for glioblastoma(Journal of Biological Chemistry (2013) 288 (9153–9164) DOI: 10.1074/jbc.M112.440354)

Poteet, E., Choudhury, G. R., Winters, A., Li, W., Ryou, M. G., Liu, R., Tang, L., Ghorpade, A., Wen, Y., Yuan, F., Keir, S. T., Yan, H., Bigner, D. D., Simpkins, J. W. & Yang, S. H., 29 Mar 2013, In : Journal of Biological Chemistry. 293, 39, 1 p.

Research output: Contribution to journalComment/debateResearch

Glioblastoma
39 Citations (Scopus)

Reversing the Warburg effect as a treatment for glioblastoma

Poteet, E., Choudhury, G. R., Winters, A., Li, W., Ryou, M. G., Liu, R., Tang, L., Ghorpade, A., Wen, Y., Yuan, F., Keir, S. T., Yan, H., Bigner, D. D., Simpkins, J. W. & Yang, S., 29 Mar 2013, In : Journal of Biological Chemistry. 288, 13, p. 9153-9164 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Methylene Blue
Glioblastoma
Cell proliferation
Energy Metabolism
AMP-Activated Protein Kinases
41 Citations (Scopus)

Transient focal cerebral ischemia induces long-term cognitive function deficit in an experimental ischemic stroke model

Li, W., Huang, R-Q., Shetty, R. A., Thangthaeng, N., Liu, R., Chen, Z., Sumien, N., Rutledge, M., Dillon, G. H., Yuan, F., Forster, M. J., Simpkins, J. W. & Yang, S., 1 Nov 2013, In : Neurobiology of Disease. 59, p. 18-25 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Transient Ischemic Attack
Cognition
Long-Term Potentiation
Stroke
Hippocampus
25 Citations (Scopus)

Window of opportunity: Estrogen as a treatment for ischemic stroke

Liu, R. & Yang, S., 13 Jun 2013, In : Brain Research. 1514, p. 83-90 8 p.

Research output: Contribution to journalReview articleResearchpeer-review

Estrogens
Stroke
Estrogen Replacement Therapy
Clinical Trials
Therapeutics
2012
11 Citations (Scopus)

Embolic middle cerebral artery occlusion model using thrombin and fibrinogen composed clots in rat

Ren, M., Lin, Z. J., Qian, H., Choudhury, G. R., Liu, R., Liu, H. & Yang, S., 15 Nov 2012, In : Journal of Neuroscience Methods. 211, 2, p. 296-304 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Middle Cerebral Artery Infarction
Thrombin
Fibrinogen
Middle Cerebral Artery
Stroke
45 Citations (Scopus)

Methylene Blue as a Cerebral Metabolic and Hemodynamic Enhancer

Lin, A. L., Poteet, E., Du, F., Gourav, R. C., Liu, R., Wen, Y., Bresnen, A., Huang, S., Fox, P. T., Yang, S. & Duong, T. Q., 9 Oct 2012, In : PLoS ONE. 7, 10, e46585.

Research output: Contribution to journalArticleResearchpeer-review

methylene blue
Methylene Blue
Hemodynamics
hemodynamics
Brain
33 Citations (Scopus)

Neuroprotection targeting ischemic penumbra and beyond for the treatment of ischemic stroke

Liu, R., Yuan, H., Yuan, F. & Yang, S., 1 Jun 2012, In : Neurological Research. 34, 4, p. 331-337 7 p.

Research output: Contribution to journalReview articleResearchpeer-review

Stroke
Therapeutics
Vascular Dementia
Neuroprotection
Cellular Structures
17 Citations (Scopus)

Neuroprotective effects of high affinity sigma 1 receptor selective compounds

Luedtke, R. T., Perez, E., Yang, S., Liu, R., Vangveravong, S., Tu, Z., MacH, R. H. & Simpkins, J. W., 2 Mar 2012, In : Brain Research. 1441, p. 17-26 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Neuroprotective Agents
Haloperidol
Stroke
sigma Receptors
Pentazocine
54 Citations (Scopus)

Pyruvate protects the brain against ischemia-reperfusion injury by activating the erythropoietin signaling pathway

Ryou, M. G., Liu, R., Ren, M., Sun, J., Mallet, R. T. & Yang, S., 1 Apr 2012, In : Stroke. 43, 4, p. 1101-1107 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Erythropoietin
Reperfusion Injury
Brain Ischemia
Pyruvic Acid
Hypoxia-Inducible Factor 1
15 Citations (Scopus)

Transient Focal Cerebral Ischemia Induces Long-term Cerebral Vasculature Dysfunction in a Rodent Experimental Stroke Model

Winters, A., Taylor, J. C., Ren, M., Ma, R., Liu, R. & Yang, S., 1 Jun 2012, In : Translational Stroke Research. 3, 2, p. 279-285 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Transient Ischemic Attack
Rodentia
Theoretical Models
Stroke
Phenylephrine
12 Citations (Scopus)

Upregulation of miR-20a and miR-106b is involved in the acquisition of malignancy of pediatric brainstem gliomas

Wang, X., Zhang, H., Zhang, A., Han, L., Wang, K., Liu, R., Yang, S., Pu, P., Shen, C., Kang, C. & Yu, C., 1 Oct 2012, In : Oncology Reports. 28, 4, p. 1293-1300 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Glioma
Brain Stem
Up-Regulation
Pediatrics
MicroRNAs
2011
131 Citations (Scopus)

Alternative mitochondrial electron transfer as a novel strategy for neuroprotection

Wen, Y., Li, W., Poteet, E. C., Xie, L., Tan, C., Yan, L-J., Ju, X., Liu, R., Qian, H., Marvin, M. A., Goldberg, M. S., She, H., Mao, Z., Simpkins, J. W. & Yang, S., 6 May 2011, In : Journal of Biological Chemistry. 286, 18, p. 16504-16515 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Methylene Blue
Electrons
Rotenone
Neuroprotection
Animal Disease Models
28 Citations (Scopus)

Regulation of matrix metalloproteinase 2 by oligomeric amyloid β protein

Li, W., Poteet, E., Xie, L., Liu, R., Wen, Y. & Yang, S., 28 Apr 2011, In : Brain Research. 1387, p. 141-148 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Amyloidogenic Proteins
Matrix Metalloproteinase 2
Matrix Metalloproteinases
Astrocytes
Alzheimer Disease
21 Citations (Scopus)

The assessment of non-feminizing estrogens for use in neuroprotection

Yi, K. D., Perez, E., Yang, S., Liu, R., Covey, D. F. & Simpkins, J. W., 16 Mar 2011, In : Brain Research. 1379, p. 61-70 10 p.

Research output: Contribution to journalReview articleResearchpeer-review

Estrogens
Estrogen Receptor alpha
Steroids
Research
Women's Health
2010
34 Citations (Scopus)

Combination therapy of 17β-estradiol and recombinant tissue plasminogen activator for experimental ischemic stroke

Liu, R., Liu, Q., He, S., Simpkins, J. W. & Yang, S., 1 Mar 2010, In : Journal of Pharmacology and Experimental Therapeutics. 332, 3, p. 1006-1012 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Tissue Plasminogen Activator
Estradiol
Stroke
Middle Cerebral Artery Infarction
Transient Ischemic Attack
17 Citations (Scopus)

Modulation of polymorphonuclear neutrophil functions by astrocytes

Xie, L., Poteet, E. C., Li, W., Scott, A. E., Liu, R., Wen, Y., Ghorpade, A., Simpkins, J. W. & Yang, S., 9 Sep 2010, In : Journal of Neuroinflammation. 7, 53.

Research output: Contribution to journalArticleResearchpeer-review

Astrocytes
Neutrophils
Phagocytosis
Respiratory Burst
Inbred C57BL Mouse