2019
A novel serum free primary astrocyte culture method that mimic quiescent astrocyte phenotype
Prah, J., Winters, A., Chaudhari, K., Hersh, J., Liu, R. & Yang, S., 15 May 2019, In : Journal of Neuroscience Methods. 320, p. 50-63 14 p.Research output: Contribution to journal › Article
Astrocytes
Phenotype
Serum
Fibroblast Growth Factor 2
Epidermal Growth Factor
Cholesterol sulfate alters astrocyte metabolism and provides protection against oxidative stress
Prah, J., Winters, A., Chaudhari, K., Hersh, J., Liu, R. & Yang, S. H., 15 Nov 2019, In : Brain Research. 1723, 146378.Research output: Contribution to journal › Article
Astrocytes
Oxidative Stress
Neuroprotective Agents
Energy Metabolism
Glutamic Acid
6
Citations
(Scopus)
Experimental ischemic stroke induces long-term T cell activation in the brain
Xie, L., Li, W., Hersh, J., Liu, R. & Yang, S. H., 1 Nov 2019, In : Journal of Cerebral Blood Flow and Metabolism. 39, 11, p. 2268-2276 9 p.Research output: Contribution to journal › Article
Stroke
T-Lymphocytes
Brain
Perforin
Interleukin-17
Metformin alters locomotor and cognitive function and brain metabolism in normoglycemic mice
Li, W., Chaudhari, K., Shetty, R., Winters, A., Gao, X., Hu, Z., Ge, W. P., Sumien, N., Forster, M., Liu, R. & Yang, S. H., 1 Jan 2019, In : Aging and Disease. 10, 5, p. 949-963 15 p.Research output: Contribution to journal › Article
Open Access
Metformin
Cognition
Brain
Energy Metabolism
Glycerolphosphate Dehydrogenase
2018
6
Citations
(Scopus)
Artemisinin prevents glutamate-induced neuronal cell death via Akt pathway activation
Lin, S. P., Li, W., Winters, A., Liu, R. & Yang, S., 20 Apr 2018, In : Frontiers in Cellular Neuroscience. 12, 108.Research output: Contribution to journal › Article
Glutamic Acid
Cell Death
artemisinine
Mitochondrial Membrane Potential
Antimalarials
3
Citations
(Scopus)
Hyperglycemia alters astrocyte metabolism and inhibits astrocyte proliferation
Li, W., Choudhury, G. R., Winters, A., Prah, J., Lin, W., Liu, R. & Yang, S. H., 1 Jan 2018, In : Aging and Disease. 9, 4, p. 674-684 11 p.Research output: Contribution to journal › Article
Astrocytes
Hyperglycemia
Glucose
Energy Metabolism
Cyclin D3
2
Citations
(Scopus)
Precision Medicine for Ischemic Stroke, Let Us Move Beyond Time Is Brain
Yang, S., Lou, M., Luo, B., Jiang, W. J. & Liu, R., 1 Apr 2018, In : Translational Stroke Research. 9, 2, p. 93-95 3 p.Research output: Contribution to journal › Editorial
Precision Medicine
Stroke
Brain
2017
5
Citations
(Scopus)
Administration of 5-methoxyindole-2-carboxylic acid that potentially targets mitochondrial dihydrolipoamide dehydrogenase confers cerebral preconditioning against ischemic stroke injury
Wu, J., Li, R., Li, W., Ren, M., Thangthaeng, N., Sumien, N., Liu, R., Yang, S., Simpkins, J. W., Forster, M. J. & Yan, L-J., 1 Dec 2017, In : Free Radical Biology and Medicine. 113, p. 244-254 11 p.Research output: Contribution to journal › Article
Dihydrolipoamide Dehydrogenase
Ischemic Preconditioning
Stroke
Wounds and Injuries
5-methoxyindole-2-carboxylic acid
18
Citations
(Scopus)
Alternative mitochondrial electron transfer for the treatment of neurodegenerative diseases and cancers: Methylene blue connects the dots
Yang, S., Li, W., Sumien, N., Forster, M. J., Simpkins, J. W. & Liu, R., 1 Oct 2017, In : Progress in Neurobiology. 157, p. 273-291 19 p.Research output: Contribution to journal › Review article
Methylene Blue
Neurodegenerative Diseases
Electrons
Energy Metabolism
Oxidative Phosphorylation
2
Citations
(Scopus)
Cerebral Autoregulation
Yang, S. & Liu, R., 7 Mar 2017, Primer on Cerebrovascular Diseases: Second Edition. Elsevier Inc., p. 57-60 4 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter
Homeostasis
Cerebrovascular Circulation
Arterial Pressure
Blood Pressure
Brain
Methylene blue inhibits GABAA receptors by interaction with GABA binding site
Chen, Z., Liu, R., Yang, S., Dillon, G. H. & Huang, R-Q., 1 Jun 2017, In : Neuropharmacology. 119, p. 100-110 11 p.Research output: Contribution to journal › Article
Methylene Blue
GABA-A Receptors
gamma-Aminobutyric Acid
Binding Sites
Picrotoxin
2016
1
Citation
(Scopus)
For the pursuit of oxygen and carbon dioxide channels in mitochondria
Yang, S. & Liu, R., 1 Oct 2016, In : Medical Gas Research. 6, 4, p. 237-238 2 p.Research output: Contribution to journal › Editorial
Carbon Dioxide
Mitochondria
Oxygen
8
Citations
(Scopus)
Methylene blue ameliorates ischemia/reperfusion-induced cerebral edema: An MRI and transmission electron microscope study
Fang, Q., Yan, X., Li, S., Sun, Y., Xu, L., Shi, Z., Wu, M., Lu, Y., Dong, L., Liu, R., Yuan, F. & Yang, S., 1 Jan 2016, Acta Neurochirurgica, Supplementum. Springer-Verlag Wien, p. 227-236 10 p. (Acta Neurochirurgica, Supplementum; vol. 121).Research output: Chapter in Book/Report/Conference proceeding › Chapter
Methylene Blue
Middle Cerebral Artery Infarction
Transient Ischemic Attack
Brain Edema
Neuroprotective Agents
9
Citations
(Scopus)
Neuroglobin Overexpression Inhibits AMPK Signaling and Promotes Cell Anabolism
Cai, B., Li, W., Mao, X. O., Winters, A., Ryou, M. G., Liu, R., Greenberg, D. A., Wang, N., Jin, K. & Yang, S., 1 Mar 2016, In : Molecular Neurobiology. 53, 2, p. 1254-1265 12 p.Research output: Contribution to journal › Article
AMP-Activated Protein Kinases
Glycogen
Globins
Neurons
Brain
2015
18
Citations
(Scopus)
Chemotherapeutic effect of tamoxifen on temozolomide-resistant gliomas
He, W., Liu, R., Yang, S. H. & Yuan, F., Mar 2015, In : Anti-Cancer Drugs. 26, 3, p. 293-300 8 p.Research output: Contribution to journal › Article
temozolomide
Tamoxifen
Glioma
Cell Line
Apoptosis
33
Citations
(Scopus)
Methylene blue-induced neuronal protective mechanism against hypoxia-reoxygenation stress
Ryou, M. G., Choudhury, G. R., Li, W., Winters, A., Yuan, F., Liu, R. & Yang, S., 1 Aug 2015, In : Neuroscience. 301, p. 193-203 11 p.Research output: Contribution to journal › Article
Hypoxia-Inducible Factor 1
Methylene Blue
Glucose
Erythropoietin
Oxygen
15
Citations
(Scopus)
Methylene blue protects astrocytes against glucose oxygen deprivation by improving cellular respiration
Choudhury, G. R., Winters, A., Rich, R. M., Ryou, M. G., Gryczynski, Z., Yuan, F., Yang, S. H. & Liu, R., 7 Apr 2015, In : PLoS ONE. 10, 4, e0123096.Research output: Contribution to journal › Article
Cell Respiration
methylene blue
Methylene Blue
astrocytes
cell respiration
2014
8
Citations
(Scopus)
In vitro protection by pyruvate against cadmium-induced cytotoxicity in hippocampal HT-22 cells
Poteet, E., Winters, A., Xie, L., Ryou, M. G., Liu, R. & Yang, S., 1 Jan 2014, In : Journal of Applied Toxicology. 34, 8, p. 903-913 11 p.Research output: Contribution to journal › Article
Cytotoxicity
Pyruvic Acid
Cadmium
Mitochondrial Membrane Potential
Glycolysis
4
Citations
(Scopus)
Methylene blue promotes quiescence of rat neural progenitor cells
Xie, L., Choudhury, G. R., Wang, J., Park, Y., Liu, R., Yuan, F., Zhang, C. L., Yorio, T., Jin, K. & Yang, S., 7 Oct 2014, In : Frontiers in Cellular Neuroscience. 8, OCT, 315.Research output: Contribution to journal › Article
Methylene Blue
Stem Cells
Intraventricular Infusions
Cyclins
Neural Stem Cells
2013
9
Citations
(Scopus)
Astroglial PTEN loss disrupts neuronal lamination by dysregulating radial glia-guided neuronal migration
Wen, Y., Li, W., Choudhury, G. R., He, R., Yang, T., Liu, R., Jin, K. & Yang, S., 1 Jan 2013, In : Aging and Disease. 4, 3, p. 113-126 14 p.Research output: Contribution to journal › Article
Neuroglia
Transgenic Mice
Cerebellum
Hippocampus
Central Nervous System
Erratum: Reversing the Warburg effect as a treatment for glioblastoma(Journal of Biological Chemistry (2013) 288 (9153–9164) DOI: 10.1074/jbc.M112.440354)
Poteet, E., Choudhury, G. R., Winters, A., Li, W., Ryou, M. G., Liu, R., Tang, L., Ghorpade, A., Wen, Y., Yuan, F., Keir, S. T., Yan, H., Bigner, D. D., Simpkins, J. W. & Yang, S. H., 29 Mar 2013, In : Journal of Biological Chemistry. 293, 39, 1 p.Research output: Contribution to journal › Comment/debate
Glioblastoma
43
Citations
(Scopus)
Reversing the Warburg effect as a treatment for glioblastoma
Poteet, E., Choudhury, G. R., Winters, A., Li, W., Ryou, M. G., Liu, R., Tang, L., Ghorpade, A., Wen, Y., Yuan, F., Keir, S. T., Yan, H., Bigner, D. D., Simpkins, J. W. & Yang, S. H., 29 Mar 2013, In : Journal of Biological Chemistry. 288, 13, p. 9153-9164 12 p.Research output: Contribution to journal › Article
Methylene Blue
Glioblastoma
Cell proliferation
Energy Metabolism
AMP-Activated Protein Kinases
49
Citations
(Scopus)
Transient focal cerebral ischemia induces long-term cognitive function deficit in an experimental ischemic stroke model
Li, W., Huang, R-Q., Shetty, R. A., Thangthaeng, N., Liu, R., Chen, Z., Sumien, N., Rutledge, M., Dillon, G. H., Yuan, F., Forster, M. J., Simpkins, J. W. & Yang, S., 1 Nov 2013, In : Neurobiology of Disease. 59, p. 18-25 8 p.Research output: Contribution to journal › Article
Transient Ischemic Attack
Cognition
Long-Term Potentiation
Stroke
Hippocampus
26
Citations
(Scopus)
Window of opportunity: Estrogen as a treatment for ischemic stroke
Liu, R. & Yang, S. H., 13 Jun 2013, In : Brain Research. 1514, p. 83-90 8 p.Research output: Contribution to journal › Review article
Estrogens
Stroke
Estrogen Replacement Therapy
Clinical Trials
Therapeutics
2012
11
Citations
(Scopus)
Embolic middle cerebral artery occlusion model using thrombin and fibrinogen composed clots in rat
Ren, M., Lin, Z. J., Qian, H., Choudhury, G. R., Liu, R., Liu, H. & Yang, S., 15 Nov 2012, In : Journal of Neuroscience Methods. 211, 2, p. 296-304 9 p.Research output: Contribution to journal › Article
Middle Cerebral Artery Infarction
Thrombin
Fibrinogen
Middle Cerebral Artery
Stroke
47
Citations
(Scopus)
Methylene Blue as a Cerebral Metabolic and Hemodynamic Enhancer
Lin, A. L., Poteet, E., Du, F., Gourav, R. C., Liu, R., Wen, Y., Bresnen, A., Huang, S., Fox, P. T., Yang, S. H. & Duong, T. Q., 9 Oct 2012, In : PLoS ONE. 7, 10, e46585.Research output: Contribution to journal › Article
methylene blue
Methylene Blue
Hemodynamics
hemodynamics
Brain
36
Citations
(Scopus)
Neuroprotection targeting ischemic penumbra and beyond for the treatment of ischemic stroke
Liu, R., Yuan, H., Yuan, F. & Yang, S., 1 Jun 2012, In : Neurological Research. 34, 4, p. 331-337 7 p.Research output: Contribution to journal › Review article
Stroke
Therapeutics
Vascular Dementia
Neuroprotection
Cellular Structures
18
Citations
(Scopus)
Neuroprotective effects of high affinity sigma 1 receptor selective compounds
Luedtke, R. R., Perez, E., Yang, S. H., Liu, R., Vangveravong, S., Tu, Z., MacH, R. H. & Simpkins, J. W., 2 Mar 2012, In : Brain Research. 1441, p. 17-26 10 p.Research output: Contribution to journal › Article
Neuroprotective Agents
Haloperidol
Stroke
sigma Receptors
Pentazocine
56
Citations
(Scopus)
Pyruvate protects the brain against ischemia-reperfusion injury by activating the erythropoietin signaling pathway
Ryou, M. G., Liu, R., Ren, M., Sun, J., Mallet, R. T. & Yang, S. H., 1 Apr 2012, In : Stroke. 43, 4, p. 1101-1107 7 p.Research output: Contribution to journal › Article
Erythropoietin
Reperfusion Injury
Brain Ischemia
Pyruvic Acid
Hypoxia-Inducible Factor 1
15
Citations
(Scopus)
Transient Focal Cerebral Ischemia Induces Long-term Cerebral Vasculature Dysfunction in a Rodent Experimental Stroke Model
Winters, A., Taylor, J. C., Ren, M., Ma, R., Liu, R. & Yang, S., 1 Jun 2012, In : Translational Stroke Research. 3, 2, p. 279-285 7 p.Research output: Contribution to journal › Article
Transient Ischemic Attack
Rodentia
Theoretical Models
Stroke
Phenylephrine
13
Citations
(Scopus)
Upregulation of miR-20a and miR-106b is involved in the acquisition of malignancy of pediatric brainstem gliomas
Wang, X., Zhang, H., Zhang, A., Han, L., Wang, K., Liu, R., Yang, S., Pu, P., Shen, C., Kang, C. & Yu, C., 1 Oct 2012, In : Oncology Reports. 28, 4, p. 1293-1300 8 p.Research output: Contribution to journal › Article
Glioma
Brain Stem
Up-Regulation
Pediatrics
MicroRNAs
2011
143
Citations
(Scopus)
Alternative mitochondrial electron transfer as a novel strategy for neuroprotection
Wen, Y., Li, W., Poteet, E. C., Xie, L., Tan, C., Yan, L. J., Ju, X., Liu, R., Qian, H., Marvin, M. A., Goldberg, M. S., She, H., Mao, Z., Simpkins, J. W. & Yang, S. H., 6 May 2011, In : Journal of Biological Chemistry. 286, 18, p. 16504-16515 12 p.Research output: Contribution to journal › Article
Methylene Blue
Electrons
Rotenone
Neuroprotection
Animal Disease Models
29
Citations
(Scopus)
Regulation of matrix metalloproteinase 2 by oligomeric amyloid β protein
Li, W., Poteet, E., Xie, L., Liu, R., Wen, Y. & Yang, S., 28 Apr 2011, In : Brain Research. 1387, p. 141-148 8 p.Research output: Contribution to journal › Article
Amyloidogenic Proteins
Matrix Metalloproteinase 2
Matrix Metalloproteinases
Astrocytes
Alzheimer Disease
22
Citations
(Scopus)
The assessment of non-feminizing estrogens for use in neuroprotection
Yi, K. D., Perez, E., Yang, S., Liu, R., Covey, D. F. & Simpkins, J. W., 16 Mar 2011, In : Brain Research. 1379, p. 61-70 10 p.Research output: Contribution to journal › Review article
Estrogens
Estrogen Receptor alpha
Steroids
Research
Women's Health
2010
36
Citations
(Scopus)
Combination therapy of 17β-estradiol and recombinant tissue plasminogen activator for experimental ischemic stroke
Liu, R., Liu, Q., He, S., Simpkins, J. W. & Yang, S. H., 1 Mar 2010, In : Journal of Pharmacology and Experimental Therapeutics. 332, 3, p. 1006-1012 7 p.Research output: Contribution to journal › Article
Tissue Plasminogen Activator
Estradiol
Stroke
Middle Cerebral Artery Infarction
Transient Ischemic Attack
17
Citations
(Scopus)
Modulation of polymorphonuclear neutrophil functions by astrocytes
Xie, L., Poteet, E. C., Li, W., Scott, A. E., Liu, R., Wen, Y., Ghorpade, A., Simpkins, J. W. & Yang, S. H., 9 Sep 2010, In : Journal of neuroinflammation. 7, 53.Research output: Contribution to journal › Article
Astrocytes
Neutrophils
Phagocytosis
Respiratory Burst
Inbred C57BL Mouse