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2019

A novel serum free primary astrocyte culture method that mimic quiescent astrocyte phenotype

Prah, J., Winters, A., Chaudhari, K., Hersh, J., Liu, R. & Yang, S., 15 May 2019, In : Journal of Neuroscience Methods. 320, p. 50-63 14 p.

Research output: Contribution to journalArticle

Astrocytes
Phenotype
Serum
Fibroblast Growth Factor 2
Epidermal Growth Factor

Cholesterol sulfate alters astrocyte metabolism and provides protection against oxidative stress

Prah, J., Winters, A., Chaudhari, K., Hersh, J., Liu, R. & Yang, S. H., 15 Nov 2019, In : Brain Research. 1723, 146378.

Research output: Contribution to journalArticle

Astrocytes
Oxidative Stress
Neuroprotective Agents
Energy Metabolism
Glutamic Acid
6 Citations (Scopus)

Experimental ischemic stroke induces long-term T cell activation in the brain

Xie, L., Li, W., Hersh, J., Liu, R. & Yang, S. H., 1 Nov 2019, In : Journal of Cerebral Blood Flow and Metabolism. 39, 11, p. 2268-2276 9 p.

Research output: Contribution to journalArticle

Stroke
T-Lymphocytes
Brain
Perforin
Interleukin-17

Metformin alters locomotor and cognitive function and brain metabolism in normoglycemic mice

Li, W., Chaudhari, K., Shetty, R., Winters, A., Gao, X., Hu, Z., Ge, W. P., Sumien, N., Forster, M., Liu, R. & Yang, S. H., 1 Jan 2019, In : Aging and Disease. 10, 5, p. 949-963 15 p.

Research output: Contribution to journalArticle

Open Access
Metformin
Cognition
Brain
Energy Metabolism
Glycerolphosphate Dehydrogenase
2018
6 Citations (Scopus)

Artemisinin prevents glutamate-induced neuronal cell death via Akt pathway activation

Lin, S. P., Li, W., Winters, A., Liu, R. & Yang, S., 20 Apr 2018, In : Frontiers in Cellular Neuroscience. 12, 108.

Research output: Contribution to journalArticle

Glutamic Acid
Cell Death
artemisinine
Mitochondrial Membrane Potential
Antimalarials
3 Citations (Scopus)

Hyperglycemia alters astrocyte metabolism and inhibits astrocyte proliferation

Li, W., Choudhury, G. R., Winters, A., Prah, J., Lin, W., Liu, R. & Yang, S. H., 1 Jan 2018, In : Aging and Disease. 9, 4, p. 674-684 11 p.

Research output: Contribution to journalArticle

Astrocytes
Hyperglycemia
Glucose
Energy Metabolism
Cyclin D3
2 Citations (Scopus)

Precision Medicine for Ischemic Stroke, Let Us Move Beyond Time Is Brain

Yang, S., Lou, M., Luo, B., Jiang, W. J. & Liu, R., 1 Apr 2018, In : Translational Stroke Research. 9, 2, p. 93-95 3 p.

Research output: Contribution to journalEditorial

Precision Medicine
Stroke
Brain
2017
5 Citations (Scopus)
Dihydrolipoamide Dehydrogenase
Ischemic Preconditioning
Stroke
Wounds and Injuries
5-methoxyindole-2-carboxylic acid
18 Citations (Scopus)
Methylene Blue
Neurodegenerative Diseases
Electrons
Energy Metabolism
Oxidative Phosphorylation
2 Citations (Scopus)

Cerebral Autoregulation

Yang, S. & Liu, R., 7 Mar 2017, Primer on Cerebrovascular Diseases: Second Edition. Elsevier Inc., p. 57-60 4 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Homeostasis
Cerebrovascular Circulation
Arterial Pressure
Blood Pressure
Brain

Methylene blue inhibits GABAA receptors by interaction with GABA binding site

Chen, Z., Liu, R., Yang, S., Dillon, G. H. & Huang, R-Q., 1 Jun 2017, In : Neuropharmacology. 119, p. 100-110 11 p.

Research output: Contribution to journalArticle

Methylene Blue
GABA-A Receptors
gamma-Aminobutyric Acid
Binding Sites
Picrotoxin
2016
1 Citation (Scopus)

For the pursuit of oxygen and carbon dioxide channels in mitochondria

Yang, S. & Liu, R., 1 Oct 2016, In : Medical Gas Research. 6, 4, p. 237-238 2 p.

Research output: Contribution to journalEditorial

Carbon Dioxide
Mitochondria
Oxygen
8 Citations (Scopus)

Methylene blue ameliorates ischemia/reperfusion-induced cerebral edema: An MRI and transmission electron microscope study

Fang, Q., Yan, X., Li, S., Sun, Y., Xu, L., Shi, Z., Wu, M., Lu, Y., Dong, L., Liu, R., Yuan, F. & Yang, S., 1 Jan 2016, Acta Neurochirurgica, Supplementum. Springer-Verlag Wien, p. 227-236 10 p. (Acta Neurochirurgica, Supplementum; vol. 121).

Research output: Chapter in Book/Report/Conference proceedingChapter

Methylene Blue
Middle Cerebral Artery Infarction
Transient Ischemic Attack
Brain Edema
Neuroprotective Agents
9 Citations (Scopus)

Neuroglobin Overexpression Inhibits AMPK Signaling and Promotes Cell Anabolism

Cai, B., Li, W., Mao, X. O., Winters, A., Ryou, M. G., Liu, R., Greenberg, D. A., Wang, N., Jin, K. & Yang, S., 1 Mar 2016, In : Molecular Neurobiology. 53, 2, p. 1254-1265 12 p.

Research output: Contribution to journalArticle

AMP-Activated Protein Kinases
Glycogen
Globins
Neurons
Brain
2015
18 Citations (Scopus)

Chemotherapeutic effect of tamoxifen on temozolomide-resistant gliomas

He, W., Liu, R., Yang, S. H. & Yuan, F., Mar 2015, In : Anti-Cancer Drugs. 26, 3, p. 293-300 8 p.

Research output: Contribution to journalArticle

temozolomide
Tamoxifen
Glioma
Cell Line
Apoptosis
33 Citations (Scopus)

Methylene blue-induced neuronal protective mechanism against hypoxia-reoxygenation stress

Ryou, M. G., Choudhury, G. R., Li, W., Winters, A., Yuan, F., Liu, R. & Yang, S., 1 Aug 2015, In : Neuroscience. 301, p. 193-203 11 p.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
Methylene Blue
Glucose
Erythropoietin
Oxygen
15 Citations (Scopus)

Methylene blue protects astrocytes against glucose oxygen deprivation by improving cellular respiration

Choudhury, G. R., Winters, A., Rich, R. M., Ryou, M. G., Gryczynski, Z., Yuan, F., Yang, S. H. & Liu, R., 7 Apr 2015, In : PLoS ONE. 10, 4, e0123096.

Research output: Contribution to journalArticle

Cell Respiration
methylene blue
Methylene Blue
astrocytes
cell respiration
2014
8 Citations (Scopus)

In vitro protection by pyruvate against cadmium-induced cytotoxicity in hippocampal HT-22 cells

Poteet, E., Winters, A., Xie, L., Ryou, M. G., Liu, R. & Yang, S., 1 Jan 2014, In : Journal of Applied Toxicology. 34, 8, p. 903-913 11 p.

Research output: Contribution to journalArticle

Cytotoxicity
Pyruvic Acid
Cadmium
Mitochondrial Membrane Potential
Glycolysis
4 Citations (Scopus)

Methylene blue promotes quiescence of rat neural progenitor cells

Xie, L., Choudhury, G. R., Wang, J., Park, Y., Liu, R., Yuan, F., Zhang, C. L., Yorio, T., Jin, K. & Yang, S., 7 Oct 2014, In : Frontiers in Cellular Neuroscience. 8, OCT, 315.

Research output: Contribution to journalArticle

Methylene Blue
Stem Cells
Intraventricular Infusions
Cyclins
Neural Stem Cells
2013
9 Citations (Scopus)

Astroglial PTEN loss disrupts neuronal lamination by dysregulating radial glia-guided neuronal migration

Wen, Y., Li, W., Choudhury, G. R., He, R., Yang, T., Liu, R., Jin, K. & Yang, S., 1 Jan 2013, In : Aging and Disease. 4, 3, p. 113-126 14 p.

Research output: Contribution to journalArticle

Neuroglia
Transgenic Mice
Cerebellum
Hippocampus
Central Nervous System

Erratum: Reversing the Warburg effect as a treatment for glioblastoma(Journal of Biological Chemistry (2013) 288 (9153–9164) DOI: 10.1074/jbc.M112.440354)

Poteet, E., Choudhury, G. R., Winters, A., Li, W., Ryou, M. G., Liu, R., Tang, L., Ghorpade, A., Wen, Y., Yuan, F., Keir, S. T., Yan, H., Bigner, D. D., Simpkins, J. W. & Yang, S. H., 29 Mar 2013, In : Journal of Biological Chemistry. 293, 39, 1 p.

Research output: Contribution to journalComment/debate

Glioblastoma
43 Citations (Scopus)

Reversing the Warburg effect as a treatment for glioblastoma

Poteet, E., Choudhury, G. R., Winters, A., Li, W., Ryou, M. G., Liu, R., Tang, L., Ghorpade, A., Wen, Y., Yuan, F., Keir, S. T., Yan, H., Bigner, D. D., Simpkins, J. W. & Yang, S. H., 29 Mar 2013, In : Journal of Biological Chemistry. 288, 13, p. 9153-9164 12 p.

Research output: Contribution to journalArticle

Methylene Blue
Glioblastoma
Cell proliferation
Energy Metabolism
AMP-Activated Protein Kinases
49 Citations (Scopus)

Transient focal cerebral ischemia induces long-term cognitive function deficit in an experimental ischemic stroke model

Li, W., Huang, R-Q., Shetty, R. A., Thangthaeng, N., Liu, R., Chen, Z., Sumien, N., Rutledge, M., Dillon, G. H., Yuan, F., Forster, M. J., Simpkins, J. W. & Yang, S., 1 Nov 2013, In : Neurobiology of Disease. 59, p. 18-25 8 p.

Research output: Contribution to journalArticle

Transient Ischemic Attack
Cognition
Long-Term Potentiation
Stroke
Hippocampus
26 Citations (Scopus)

Window of opportunity: Estrogen as a treatment for ischemic stroke

Liu, R. & Yang, S. H., 13 Jun 2013, In : Brain Research. 1514, p. 83-90 8 p.

Research output: Contribution to journalReview article

Estrogens
Stroke
Estrogen Replacement Therapy
Clinical Trials
Therapeutics
2012
11 Citations (Scopus)

Embolic middle cerebral artery occlusion model using thrombin and fibrinogen composed clots in rat

Ren, M., Lin, Z. J., Qian, H., Choudhury, G. R., Liu, R., Liu, H. & Yang, S., 15 Nov 2012, In : Journal of Neuroscience Methods. 211, 2, p. 296-304 9 p.

Research output: Contribution to journalArticle

Middle Cerebral Artery Infarction
Thrombin
Fibrinogen
Middle Cerebral Artery
Stroke
47 Citations (Scopus)

Methylene Blue as a Cerebral Metabolic and Hemodynamic Enhancer

Lin, A. L., Poteet, E., Du, F., Gourav, R. C., Liu, R., Wen, Y., Bresnen, A., Huang, S., Fox, P. T., Yang, S. H. & Duong, T. Q., 9 Oct 2012, In : PLoS ONE. 7, 10, e46585.

Research output: Contribution to journalArticle

methylene blue
Methylene Blue
Hemodynamics
hemodynamics
Brain
36 Citations (Scopus)

Neuroprotection targeting ischemic penumbra and beyond for the treatment of ischemic stroke

Liu, R., Yuan, H., Yuan, F. & Yang, S., 1 Jun 2012, In : Neurological Research. 34, 4, p. 331-337 7 p.

Research output: Contribution to journalReview article

Stroke
Therapeutics
Vascular Dementia
Neuroprotection
Cellular Structures
18 Citations (Scopus)

Neuroprotective effects of high affinity sigma 1 receptor selective compounds

Luedtke, R. R., Perez, E., Yang, S. H., Liu, R., Vangveravong, S., Tu, Z., MacH, R. H. & Simpkins, J. W., 2 Mar 2012, In : Brain Research. 1441, p. 17-26 10 p.

Research output: Contribution to journalArticle

Neuroprotective Agents
Haloperidol
Stroke
sigma Receptors
Pentazocine
56 Citations (Scopus)

Pyruvate protects the brain against ischemia-reperfusion injury by activating the erythropoietin signaling pathway

Ryou, M. G., Liu, R., Ren, M., Sun, J., Mallet, R. T. & Yang, S. H., 1 Apr 2012, In : Stroke. 43, 4, p. 1101-1107 7 p.

Research output: Contribution to journalArticle

Erythropoietin
Reperfusion Injury
Brain Ischemia
Pyruvic Acid
Hypoxia-Inducible Factor 1
15 Citations (Scopus)

Transient Focal Cerebral Ischemia Induces Long-term Cerebral Vasculature Dysfunction in a Rodent Experimental Stroke Model

Winters, A., Taylor, J. C., Ren, M., Ma, R., Liu, R. & Yang, S., 1 Jun 2012, In : Translational Stroke Research. 3, 2, p. 279-285 7 p.

Research output: Contribution to journalArticle

Transient Ischemic Attack
Rodentia
Theoretical Models
Stroke
Phenylephrine
13 Citations (Scopus)

Upregulation of miR-20a and miR-106b is involved in the acquisition of malignancy of pediatric brainstem gliomas

Wang, X., Zhang, H., Zhang, A., Han, L., Wang, K., Liu, R., Yang, S., Pu, P., Shen, C., Kang, C. & Yu, C., 1 Oct 2012, In : Oncology Reports. 28, 4, p. 1293-1300 8 p.

Research output: Contribution to journalArticle

Glioma
Brain Stem
Up-Regulation
Pediatrics
MicroRNAs
2011
143 Citations (Scopus)

Alternative mitochondrial electron transfer as a novel strategy for neuroprotection

Wen, Y., Li, W., Poteet, E. C., Xie, L., Tan, C., Yan, L. J., Ju, X., Liu, R., Qian, H., Marvin, M. A., Goldberg, M. S., She, H., Mao, Z., Simpkins, J. W. & Yang, S. H., 6 May 2011, In : Journal of Biological Chemistry. 286, 18, p. 16504-16515 12 p.

Research output: Contribution to journalArticle

Methylene Blue
Electrons
Rotenone
Neuroprotection
Animal Disease Models
29 Citations (Scopus)

Regulation of matrix metalloproteinase 2 by oligomeric amyloid β protein

Li, W., Poteet, E., Xie, L., Liu, R., Wen, Y. & Yang, S., 28 Apr 2011, In : Brain Research. 1387, p. 141-148 8 p.

Research output: Contribution to journalArticle

Amyloidogenic Proteins
Matrix Metalloproteinase 2
Matrix Metalloproteinases
Astrocytes
Alzheimer Disease
22 Citations (Scopus)

The assessment of non-feminizing estrogens for use in neuroprotection

Yi, K. D., Perez, E., Yang, S., Liu, R., Covey, D. F. & Simpkins, J. W., 16 Mar 2011, In : Brain Research. 1379, p. 61-70 10 p.

Research output: Contribution to journalReview article

Estrogens
Estrogen Receptor alpha
Steroids
Research
Women's Health
2010
36 Citations (Scopus)
Tissue Plasminogen Activator
Estradiol
Stroke
Middle Cerebral Artery Infarction
Transient Ischemic Attack
17 Citations (Scopus)

Modulation of polymorphonuclear neutrophil functions by astrocytes

Xie, L., Poteet, E. C., Li, W., Scott, A. E., Liu, R., Wen, Y., Ghorpade, A., Simpkins, J. W. & Yang, S. H., 9 Sep 2010, In : Journal of neuroinflammation. 7, 53.

Research output: Contribution to journalArticle

Astrocytes
Neutrophils
Phagocytosis
Respiratory Burst
Inbred C57BL Mouse